Resistance to antifolates.

abstract：:For many years the precise genetic etiology of the majority of Wilms' tumors has remained unexplained. Recently, the WTX gene, mapped to chromosome Xq11.1, has been reported to be lost or mutated in approximately one-third of Wilms' tumors. Moreover, in female cases, the somatically inactivated alleles were found to i...

journal_title：Oncogene

authors： Perotti D,Gamba B,Sardella M,Spreafico F,Terenziani M,Collini P,Pession A,Nantron M,Fossati-Bellani F,Radice P

更新日期：2008-07-31 00:00:00

abstract：:Rad51 protein plays a pivotal role in homologous recombination (HR), which is involved in double-strand break repair and in genome maintenance. Despite interactions with tumor suppressor proteins, the role of mammalian Rad51 and more generally of HR in tumor prevention is not clearly established. Indeed, both high and...

journal_title：Oncogene

authors： Bertrand P,Lambert S,Joubert C,Lopez BS

更新日期：2003-10-23 00:00:00

abstract：:Transcription from the rat transforming growth factor alpha (TGF-alpha) promoter initiates at multiple sites within a 200-bp G+C-rich region that lacks TATA and CAAT motifs but contains multiple potential binding sites for the transcription factor Sp1. In the present study, we used deletion analysis to establish the 5...

journal_title：Oncogene

authors： Chen X,Azizkhan JC,Lee DC

更新日期：1992-09-01 00:00:00

abstract：:The hyperactivated Wnt/β-catenin signaling acts as a switch to induce epithelial to mesenchymal transition and promote colorectal cancer. However, due to its essential role in gut homeostasis, therapeutic targeting of this pathway has proven challenging. Additionally, IL-6/Stat-3 signaling, activated by microbial tran...

journal_title：Oncogene

authors： Ahmad R,Kumar B,Chen Z,Chen X,Müller D,Lele SM,Washington MK,Batra SK,Dhawan P,Singh AB

更新日期：2017-11-23 00:00:00

abstract：:The identification of target mRNAs is a key step for assessing the role of aberrantly expressed microRNAs in human cancer. MiR-221 is upregulated in human hepatocellular carcinoma (HCC) as well as in other malignancies. One proven target of miR-221 is CDKN1B/p27, whose downregulation affects HCC prognosis. Here, we pr...

journal_title：Oncogene

authors： Fornari F,Gramantieri L,Ferracin M,Veronese A,Sabbioni S,Calin GA,Grazi GL,Giovannini C,Croce CM,Bolondi L,Negrini M

更新日期：2008-09-25 00:00:00

abstract：:MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively control expression of target genes in animals and plants. The microRNA-21 gene (mir-21) has been identified as the only miRNA commonly overexpressed in solid tumors of the lung, breast, stomach, prostate, colon, brain, head and neck, esophagus and pa...

journal_title：Oncogene

authors： Lu Z,Liu M,Stribinskis V,Klinge CM,Ramos KS,Colburn NH,Li Y

更新日期：2008-07-17 00:00:00

abstract：:BCR-ABL1 is a fusion tyrosine kinase, which causes multiple types of leukemia. We used an integrated proteomic approach that includes label-free quantitative protein complex and phosphorylation profiling by mass spectrometry to systematically characterize the proximal signaling network of this oncogenic kinase. The pr...

journal_title：Oncogene

authors： Titz B,Low T,Komisopoulou E,Chen SS,Rubbi L,Graeber TG

更新日期：2010-11-04 00:00:00

abstract：:Interleukin-6 (IL-6) is a cytokine that regulates the proliferation of some tumor cells including multiple myeloma (MM). Ectopic expression of fibroblast growth factor receptor 3 (FGFR 3) associated with the chromosomal translocation, t(4;14)(p16.3;q32), is frequently found in MM, and therefore, has been implicated in...

journal_title：Oncogene

authors： Ishikawa H,Tsuyama N,Liu S,Abroun S,Li FJ,Otsuyama K,Zheng X,Ma Z,Maki Y,Iqbal MS,Obata M,Kawano MM

更新日期：2005-09-15 00:00:00

abstract：:The Epstein-Barr virus (EBV) encoded latent membrane protein, LMP1, is oncogenic in rodent fibroblasts and is an essential effector protein in EBV-induced growth-transformation of human B lymphocytes. Previous structure-function studies with LMP1 have relied largely on rodent fibroblast transformation as a functional ...

journal_title：Oncogene

authors： Huen DS,Henderson SA,Croom-Carter D,Rowe M

更新日期：1995-02-02 00:00:00

abstract：:Cancer cells are known to adopt aerobic glycolysis in order to fuel tumor growth, but the molecular basis of this metabolic shift remains largely undefined. O-GlcNAcase (OGA) is an enzyme harboring O-linked β-N-acetylglucosamine (O-GlcNAc) hydrolase and cryptic lysine acetyltransferase activities. Here, we report that...

journal_title：Oncogene

authors： Singh JP,Qian K,Lee JS,Zhou J,Han X,Zhang B,Ong Q,Ni W,Jiang M,Ruan HB,Li MD,Zhang K,Ding Z,Lee P,Singh K,Wu J,Herzog RI,Kaech S,Wendel HG,Yates JR 3rd,Han W,Sherwin RS,Nie Y,Yang X

更新日期：2020-01-01 00:00:00

abstract：:Oncogenesis results from changes in kinetics or in abundance of proteins in signal transduction networks. Recently, it was shown that control of signalling cannot reside in a single gene product, and might well be dispersed over many components. Which of the reactions in these complex networks are most important, and ...

journal_title：Oncogene

authors： Hornberg JJ,Binder B,Bruggeman FJ,Schoeberl B,Heinrich R,Westerhoff HV

更新日期：2005-08-25 00:00:00

abstract：:The growth-suppressive activity of the retinoblastoma (RB) protein is suggested to be regulated by phosphorylation. In studies on the kinase that phosphorylates the RB proteins, we have previously found that RB proteins can be phosphorylated by purified cdc2 kinase. In this study, we noted that RB proteins immunopreci...

journal_title：Oncogene

authors： Kitagawa M,Saitoh S,Ogino H,Okabe T,Matsumoto H,Okuyama A,Tamai K,Ohba Y,Yasuda H,Nishimura S

更新日期：1992-06-01 00:00:00

abstract：:Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward trans...

journal_title：Oncogene

authors： Chen Y,Xu L,Lin RY,Müschen M,Koeffler HP

更新日期：2020-10-01 00:00:00

abstract：:Cancer stem cell (CSC), the primary source of cancer-initiating population, is involved in cancer recurrence and drug-resistant phenotypes. This study demonstrates that the loss of DAB2IP, a novel Ras-GTPase activating protein frequently found in many cancer types, is associated with CSC properties. Mechanistically, D...

journal_title：Oncogene

authors： Yun EJ,Baek ST,Xie D,Tseng SF,Dobin T,Hernandez E,Zhou J,Zhang L,Yang J,Sun H,Xiao G,He D,Kittler R,Hsieh JT

更新日期：2015-05-21 00:00:00

abstract：:tal-1 deletions are caused by a site specific recombination, which exclusively occurs in 12-26% of T-cell acute lymphoblastic leukemias (T-ALL). In a previous study on a large series of T-ALL we demonstrated an apparent preferential occurrence of tal-1 deletions in CD3- and CD3+ alpha beta lineage T-ALL with TcR-delta...

journal_title：Oncogene

authors： Breit TM,Wolvers-Tettero IL,van Dongen JJ

更新日期：1994-07-01 00:00:00

abstract：:Scribble complex proteins maintain apicobasal polarity, regulate cell fate determination and function as tumour suppressors in epithelial tissue. Despite evidence that the function of Scribble is maintained in the lymphocyte lineage, we still understand little about its role as a tumour suppressor in haematological ma...

journal_title：Oncogene

authors： Hawkins ED,Oliaro J,Ramsbottom KM,Newbold A,Humbert PO,Johnstone RW,Russell SM

更新日期：2016-03-03 00:00:00

abstract：:A seven-transmembrane protein, frizzled, has been implicated in a planar cell polarity (PCP) pathway as well as the canonical Wnt signaling pathway. Although both pathways require a cytoplasmic protein, dishevelled, the molecular mechanism by which frizzled regulates intracellular signaling remains to be elucidated. I...

journal_title：Oncogene

authors： Yao R,Natsume Y,Noda T

更新日期：2004-08-12 00:00:00

abstract：:Increased glucose consumption is a hallmark of cancer cells. The increased consumption and subsequent metabolism of glucose during proliferation creates the need for a constant supply of NAD, a co-factor in glycolysis. Regeneration of the NAD required to support enhanced glycolysis has been attributed to the terminal ...

journal_title：Oncogene

authors： Hanse EA,Ruan C,Kachman M,Wang D,Lowman XH,Kelekar A

更新日期：2017-07-06 00:00:00

abstract：:The autosomal dominantly inherited disease tuberous sclerosis (TSC) affects approximately 1 in 6000 individuals and is characterized by the development of tumors, named hamartomas, in different organs. TSC1, encoding hamartin, and TSC2, encoding tuberin are tumor suppressor genes responsible for TSC. Hamartin and tube...

journal_title：Oncogene

authors： Rosner M,Freilinger A,Hengstschläger M

更新日期：2007-01-25 00:00:00

abstract：:Emerging evidence has shown that cancer stem cells (CSCs) are the cellular determinants to promote cancer invasion and metastasis. However, the mechanism underlying CSC invasion remains unknown. MicroRNAs are evolutionally conserved small noncoding RNAs that are critical for the regulation of gene expression, and thei...

journal_title：Oncogene

authors： Wang Z,Wang B,Shi Y,Xu C,Xiao HL,Ma LN,Xu SL,Yang L,Wang QL,Dang WQ,Cui W,Yu SC,Ping YF,Cui YH,Kung HF,Qian C,Zhang X,Bian XW

更新日期：2015-03-12 00:00:00

abstract：:The checkpoint sliding-clamp complex, Rad9/Rad1/Hus1, plays a critical role during initiation of checkpoint signals in response to DNA damage and replication disruption. We investigated the impact of loss of Rad1 on checkpoint function and on DNA replication in mammalian cells. We show that RAD1 is an essential gene f...

journal_title：Oncogene

authors： Bao S,Lu T,Wang X,Zheng H,Wang LE,Wei Q,Hittelman WN,Li L

更新日期：2004-07-22 00:00:00

abstract：:Death receptor 5 (DR5) is a receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). TRAIL is a promising candidate for cancer therapeutics due to its ability to induce apoptosis selectively in cancer cells. Here, we report that histone deacetylase inhibitors (HDACIs) such as trichostatin A (TSA),...

journal_title：Oncogene

authors： Nakata S,Yoshida T,Horinaka M,Shiraishi T,Wakada M,Sakai T

更新日期：2004-08-19 00:00:00

abstract：:The human papovaviruses BK virus (BKV) and JC virus (JCV) both encode a large-tumor (T) antigen which are highly homologous to each other as well as to simian virus 40 (SV40) large-T antigen. This high conservation of amino acid sequence has resulted in overlapping antigenicity such that immunological differentiation ...

journal_title：Oncogene

authors： Marshall J,Smith AE,Cheng SH

更新日期：1991-09-01 00:00:00

abstract：:Deletions involving chromosome 9 occur in more than 50% of human bladder cancers of all grades and stages. Most involve loss of the whole chromosome or of an entire chromosome arm but some small deletions are found which can be used to define critical regions which may contain tumour suppressor genes. We have localize...

journal_title：Oncogene

authors： Hornigold N,Devlin J,Davies AM,Aveyard JS,Habuchi T,Knowles MA

更新日期：1999-04-22 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developing recurrences and thus selecting patients who would benefit from more...

journal_title：Oncogene

authors： Fessler E,Jansen M,De Sousa E Melo F,Zhao L,Prasetyanti PR,Rodermond H,Kandimalla R,Linnekamp JF,Franitza M,van Hooff SR,de Jong JH,Oppeneer SC,van Noesel CJ,Dekker E,Stassi G,Wang X,Medema JP,Vermeulen L

更新日期：2016-11-17 00:00:00

abstract：:SMARCB1 (Snf5/Ini1/Baf47) is a potent tumor suppressor, the loss of which serves as the diagnostic feature in malignant rhabdoid tumors (MRT) and atypical teratoid/rhabdoid tumors (AT/RT), two highly aggressive forms of pediatric neoplasms. SMARCB1 is a core subunit of Swi/Snf chromatin remodeling complexes, and loss ...

journal_title：Oncogene

authors： Darr J,Klochendler A,Isaac S,Eden A

更新日期：2014-06-05 00:00:00

abstract：:This study examines whether the serine/threonine protein kinase, Akt, is involved in the crosstalk between the ErbB2 and estrogen receptor-alpha (ER-alpha) pathways. Treatment of MCF-7 cells with 10(-9) M heregulin-beta1 (HRG-beta1) resulted in a rapid phosphorylation of Akt and a 15-fold increase in Akt activity. Akt...

journal_title：Oncogene

authors： Stoica GE,Franke TF,Wellstein A,Morgan E,Czubayko F,List HJ,Reiter R,Martin MB,Stoica A

更新日期：2003-04-10 00:00:00

abstract：:Matrilysin (MMP-7) is thought to contribute to invasive growth and metastasis of colon carcinoma and many other human cancers. The present study demonstrates that treatment of human colon carcinoma cells with active matrilysin induces cell aggregation in vitro and promotes liver metastasis in nude mice. When two kinds...

journal_title：Oncogene

authors： Kioi M,Yamamoto K,Higashi S,Koshikawa N,Fujita K,Miyazaki K

更新日期：2003-11-27 00:00:00

abstract：:Wild-type (wt) p53 acts as a tumor suppressor, while certain mutant type (mt) p53 may exhibit 'oncogenic' function. We have recently demonstrated that human papillomavirus type 18 (HPV-18) E6 can partially overcome the growth-suppressive effects of wt p53, but it remains unclear what role p53 plays in cervical carcino...

journal_title：Oncogene

authors： Chen TM,Chen CA,Hsieh CY,Chang DY,Chen YH,Defendi V

更新日期：1993-06-01 00:00:00

abstract：:The most frequent genetic alterations described in neuroblastoma (NB) are amplification of MYCN oncogene and deletion of chromosome 1p, although somatic deletions have been demonstrated at other chromosomal intervals. Since loss of heterozygosity (LOH) at distal 4p has been observed in about 20-29% of neuroblastomas, ...

journal_title：Oncogene

authors： Perri P,Longo L,Cusano R,McConville CM,Rees SA,Devoto M,Conte M,Ferrara GB,Seri M,Romeo G,Tonini GP

更新日期：2002-11-28 00:00:00