Abstract:
:Many chromosomal regions undergo loss of heterozygosity (LOH) in ovarian adenocarcinomas but few of the target regions have been finely mapped. One of the chromosome arms likely to harbour one or more tumour suppressor genes inactivated in ovarian cancer is the short arm of chromosome 8 which is frequently deleted in many other solid tumours. We have examined a large panel of microsatellite markers on 8p for LOH in 53 ovarian adenocarcinomas. LOH was observed in 27 tumours (51%), with a significant trend towards a higher frequency of LOH in more advanced tumours. Detailed examination of nine tumours with partial deletions defined three regions of overlap, two in 8p23 and one in 8p22, which suggests that there might be as many as three tumour or metastasis suppressor genes on 8p which are inactivated during ovarian tumorigenesis. LOH on 8p was significantly associated with 9p LOH which suggests that inactivation of target genes on these chromosomes may be cooperative events.
journal_name
Oncogenejournal_title
Oncogeneauthors
Wright K,Wilson PJ,Kerr J,Do K,Hurst T,Khoo SK,Ward B,Chenevix-Trench Gdoi
10.1038/sj.onc.1202028subject
Has Abstractpub_date
1998-09-03 00:00:00pages
1185-8issue
9eissn
0950-9232issn
1476-5594journal_volume
17pub_type
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