Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.

abstract：:Apoptosis is essential for normal development and maintenance of homeostasis, and disruption of apoptotic pathways is associated with multiple disease states, including cancer. Although initially identified as central regulators of apoptosis at the level of mitochondria, an important role for BCL-2 proteins at the end...

journal_title：Oncogene

authors： Heath-Engel HM,Chang NC,Shore GC

更新日期：2008-10-27 00:00:00

abstract：:As apoptosis defects limit efficacy of anticancer agents, autophagy has been proposed as a novel strategy for radiotherapy enhancement. We previously showed that caspase-3/7 inhibition induces autophagy and promotes radiosensitivity in vitro and in vivo. Therefore, we further investigated the mechanism by which radiat...

journal_title：Oncogene

authors： Kim KW,Moretti L,Mitchell LR,Jung DK,Lu B

更新日期：2010-06-03 00:00:00

abstract：:Activation of the TAL1 (or SCL) gene, originally identified through its involvement by a recurrent chromosomal translocation, is the most frequent gain-of-function mutation recognized in T-cell acute lymphoblastic leukemia (T-ALL). The TAL1 proteins contain a basic helix - loop - helix (bHLH) motif characteristic of a...

journal_title：Oncogene

authors： Huang S,Qiu Y,Stein RW,Brandt SJ

更新日期：1999-09-02 00:00:00

abstract：:There have been few studies on the specific signaling pathways involved in the transformation of epithelial cells by oncogenic protein tyrosine kinases. Here we investigate the requirement of MAP (MAPK) and phosphatidylinositol 3- (PI3K) kinases in the transformation of rat intestinal epithelial (RIE) cells by oncogen...

journal_title：Oncogene

authors： Nguyen KT,Wang WJ,Chan JL,Wang LH

更新日期：2000-11-09 00:00:00

abstract：:We previously reported cell cycle-dependent negative regulation of p185neu (decreased tyrosine phosphorylation and kinase activity, with electrophoretic mobility retarded by serine/threonine phosphorylation) in M phase and the escape of mutation-activated p185neu* from this regulation. Our present results showed that ...

journal_title：Oncogene

authors： Kiyokawa N,Karunagaran D,Lee EK,Xie Y,Yan DH,Hung MC

更新日期：1997-11-27 00:00:00

abstract：:In this study, alterations in gene expression patterns have been examined in v-Rel-transformed avian bone marrow cells. Using a conditional v-Rel estrogen receptor chimera (v-RelER) which transforms cells in an estrogen-dependent manner, we constructed subtraction cDNA libraries from v-RelER-transformed bone marrow ce...

journal_title：Oncogene

authors： Petrenko O,Ischenko I,Enrietto PJ

更新日期：1997-10-02 00:00:00

abstract：:Ras oncogenes (Hras, Kras and Nras) are important drivers of carcinogenesis. However, tumors with Ras mutations often show loss of the corresponding wild-type (WT) allele, suggesting that proto-oncogenic forms of Ras can function as a suppressor of carcinogenesis. In vitro studies also suggest that WT Ras proteins can...

journal_title：Oncogene

authors： To MD,Rosario RD,Westcott PM,Banta KL,Balmain A

更新日期：2013-08-22 00:00:00

abstract：:p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2). Interestingly, p53 is frequently mutated in tumors wherein iron is often accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism. In this st...

journal_title：Oncogene

authors： Zhang Y,Feng X,Zhang J,Chen M,Huang E,Chen X

更新日期：2019-08-01 00:00:00

abstract：:Krüppel-like factor 8 (KLF8) is a transcriptional factor critical for metastatic progression of breast cancer. Epithelial stromal interaction 1 (EPSTI1), a recently identified stromal fibroblast-induced gene in non-invasive breast cancer cells is highly overexpressed in invasive breast carcinomas. The function and reg...

journal_title：Oncogene

authors： Li T,Lu H,Shen C,Lahiri SK,Wason MS,Mukherjee D,Yu L,Zhao J

更新日期：2014-09-25 00:00:00

abstract：:High-grade serous carcinoma, accounts for up to 70% of all ovarian cases. Furin, a proprotein convertase, is highly expressed in high-grade serous carcinoma of ovarian cancer patients, and its expression is even higher in tumor omentum than in normal omentum, the preferred site of ovarian cancer metastasis. The proteo...

journal_title：Oncogene

authors： Chen C,Gupta P,Parashar D,Nair GG,George J,Geethadevi A,Wang W,Tsaih SW,Bradley W,Ramchandran R,Rader JS,Chaluvally-Raghavan P,Pradeep S

更新日期：2020-04-01 00:00:00

abstract：:Polyomavirus infection of adolescent athymic female mice causes a high incidence of mammary adenocarcinomas. We have examined the role of ovarian hormones, age and mammary gland developmental stage at infection on subsequent tumor induction, viral replication and gene expression. Ovariectomy (OVX) of adolescent mice 1...

journal_title：Oncogene

authors： Rondinelli RH,Haslam SZ,Fluck MM

更新日期：1995-11-02 00:00:00

abstract：:High frequencies of allelic loss on the short arm of chromosome 3 in small cell lung cancer (SCLC) and a number of other tumors suggest the existence of a tumor suppressor gene(s) within the deleted regions. Two small cell lung cancer lines, NCI H740 and GLC20, have been described which have homozygous deletions in th...

journal_title：Oncogene

authors： Todd MC,Xiang RH,Garcia DK,Kerbacher KE,Moore SL,Hensel CH,Liu P,Siciliano MJ,Kok K,van den Berg A,Veldhuis P,Buys CH,Killary AM,Naylor SL

更新日期：1996-12-05 00:00:00

abstract：:Although apoptosis can be induced by the enforced expression of exogenously introduced c-myc genes, it is not clear whether overexpression resulting from the amplification of the resident c-myc gene in tumor cells is sufficient to induce apoptosis. We have investigated the relationship between c-myc gene amplification...

journal_title：Oncogene

authors： Donzelli M,Bernardi R,Negri C,Prosperi E,Padovan L,Lavialle C,Brison O,Scovassi AI

更新日期：1999-01-14 00:00:00

abstract：:The function of Bcl-2 family members on the endoplasmic reticulum has received increasing attention in recent years. The endoplasmic reticulum is the major organelle involved in intracellular calcium homeostasis and calcium signaling, including calcium signals that mediate apoptosis induction by anticancer drugs. But ...

journal_title：Oncogene

authors： Distelhorst CW,Shore GC

更新日期：2004-04-12 00:00:00

abstract：:Telomerase activation is crucial in human carcinogenesis. The limiting component of telomerase, the catalytic subunit (hTERT), is undetectable in normal somatic cells but present in most tumor cells, including the earliest stages of colon carcinoma. The mechanisms involved in the differential expression in normal and ...

journal_title：Oncogene

authors： Szutorisz H,Palmqvist R,Roos G,Stenling R,Schorderet DF,Reddel R,Lingner J,Nabholz M

更新日期：2001-05-03 00:00:00

abstract：:The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but not by SUMO2/3 at multiple sites. We show that FOXM1 SUMOylation...

journal_title：Oncogene

authors： Myatt SS,Kongsema M,Man CW,Kelly DJ,Gomes AR,Khongkow P,Karunarathna U,Zona S,Langer JK,Dunsby CW,Coombes RC,French PM,Brosens JJ,Lam EW

更新日期：2014-08-21 00:00:00

abstract：:Targeted cancer therapies, although often effective, have limited utility owing to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics are excellent therapeutic candidates because of their ability to rep...

journal_title：Oncogene

authors： Kasinski AL,Kelnar K,Stahlhut C,Orellana E,Zhao J,Shimer E,Dysart S,Chen X,Bader AG,Slack FJ

更新日期：2015-07-01 00:00:00

abstract：:Tumor suppressor p53 forms a homo-tetramer through its COOH-terminal oligomerization domain and acts as a sequence-specific transcription factor. We have analysed the interrelation among the transcriptional activities, the structure and the cancer-related mutations in the oligomerization domain by using a comprehensiv...

journal_title：Oncogene

authors： Kawaguchi T,Kato S,Otsuka K,Watanabe G,Kumabe T,Tominaga T,Yoshimoto T,Ishioka C

更新日期：2005-10-20 00:00:00

abstract：:The BTB/POZ family of proteins has been implicated in multiple biological processes, including tumourigenesis, DNA damage responses and cell cycle progression and development. MIZ-1 (Myc-interacting zinc-finger protein 1) is known to activate transcription of CDKN1A. We recently found that a kidney cancer-related POK ...

journal_title：Oncogene

authors： Lee KM,Choi WI,Koh DI,Kim YJ,Jeon BN,Yoon JH,Lee CE,Kim SH,Oh J,Hur MW

更新日期：2012-03-15 00:00:00

abstract：:Defining apoptosis-regulatory cascades of the epithelium is important for understanding carcinogenesis, since cancer cells are considered to arise as a result of the collapse of the cascades. We previously reported that a novel gene GASDERMIN (GSDM) is expressed in the stomach but suppressed in gastric cancer cell lin...

journal_title：Oncogene

authors： Saeki N,Kim DH,Usui T,Aoyagi K,Tatsuta T,Aoki K,Yanagihara K,Tamura M,Mizushima H,Sakamoto H,Ogawa K,Ohki M,Shiroishi T,Yoshida T,Sasaki H

更新日期：2007-10-04 00:00:00

abstract：:Local intravitreal or intra-arterial chemotherapy has improved therapeutic success for the pediatric cancer retinoblastoma (RB), but toxicity remains a major caveat. RB initiates primarily with RB1 loss or, rarely, MYCN amplification, but the critical downstream networks are incompletely understood. We set out to unco...

journal_title：Oncogene

authors： Aubry A,Pearson JD,Huang K,Livne-Bar I,Ahmad M,Jagadeesan M,Khetan V,Ketela T,Brown KR,Yu T,Lu S,Wrana JL,Moffat J,Bremner R

更新日期：2020-07-01 00:00:00

abstract：:The temperature-sensitive mutant tsp53val135 accumulates in the cytoplasm of cells kept at the non-permissive temperature (39 degrees C), but is rapidly transported into the cell nucleus at the permissive temperature (30 degrees C). tsp53 thus may serve as a model for analysing cellular parameters influencing the subc...

journal_title：Oncogene

authors： Klotzsche O,Etzrodt D,Hohenberg H,Bohn W,Deppert W

更新日期：1998-07-02 00:00:00

abstract：:A key hallmark of many cancers, particularly the most aggressive, is the capacity to metabolize glucose at an elevated rate, a phenotype detected clinically using positron emission tomography (PET). This phenotype provides cancer cells, including those that participate in metastasis, a distinct competitive edge over n...

journal_title：Oncogene

authors： Mathupala SP,Ko YH,Pedersen PL

更新日期：2006-08-07 00:00:00

abstract：:Epigenetic regulation of gene expression is critical in the maintenance of cellular homeostasis. Dysregulation of normal epigenetic transcription occurs in abnormal physiological conditions, such as those seen in cancer cells and cells infected with parasites, making the mechanism underlying abnormal epigenetic transc...

journal_title：Oncogene

authors： Ego T,Tanaka Y,Shimotohno K

更新日期：2005-03-10 00:00:00

abstract：:Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by ...

journal_title：Oncogene

authors： Gupta A,Jha S,Engel DA,Ornelles DA,Dutta A

更新日期：2013-10-17 00:00:00

abstract：:P63, a p53 family member, is expressed as TA and ΔN isoforms. Interestingly, both TAp63 and ΔNp63 are transcription factors, and regulate both common and distinct sets of target genes. p63 is required for survival of some epithelial cell lineages, and lack of p63 leads to loss of epidermis and other epithelia in human...

journal_title：Oncogene

authors： Zhang Y,Yan W,Chen X

更新日期：2014-03-20 00:00:00

abstract：:The exact functions of BRCA1 have not been fully described but it now seems apparent that it has roles in DNA damage repair, transcriptional regulation, cell cycle control and most recently in ubiquitylation. These functions of BRCA1 are most likely interdependent but this review will focus on the role of BRCA1 in rel...

journal_title：Oncogene

authors： Mullan PB,Quinn JE,Harkin DP

更新日期：2006-09-25 00:00:00

abstract：:Snail is a zinc finger transcription factor that triggers the epithelial-mesenchymal transition (EMT) by directly repressing E-cadherin expression. Snail is required for mesoderm and neural crest formation during embryonic development and has recently been implicated in the EMT associated with tumour progression. In a...

journal_title：Oncogene

authors： Blanco MJ,Moreno-Bueno G,Sarrio D,Locascio A,Cano A,Palacios J,Nieto MA

更新日期：2002-05-09 00:00:00

abstract：:Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a slowly growing tumor with propensity for neuroinvasion and late recurrence, are limited to surgery and radiotherapy. Based on expression analysis performed on clinical specimens of salivary cancers, we identified in ACC expression of the neu...

journal_title：Oncogene

authors： Ivanov SV,Panaccione A,Brown B,Guo Y,Moskaluk CA,Wick MJ,Brown JL,Ivanova AV,Issaeva N,El-Naggar AK,Yarbrough WG

更新日期：2013-08-08 00:00:00

abstract：:ETS is a family of transcription factors that contain a highly conserved ETS DNA binding domain. Various members of the ETS family are expressed in cells of hematopoietic lineage. ETS-1, ETS-2 and ERGB/FLI-1 are expressed at high levels in T-lymphocytes. HIV-1 infects T-cells and it has been shown that its LTR contain...

journal_title：Oncogene

authors： Hodge DR,Robinson L,Watson D,Lautenberger J,Zhang XK,Venanzoni M,Seth A

更新日期：1996-01-04 00:00:00