The proto-oncoprotein KR-POK represses transcriptional activation of CDKN1A by MIZ-1 through competitive binding.

abstract：:RNF8 is a ubiquitin ligase with a FHA domain near its N terminus, and a RING-finger domain at its C terminus, through which it recruits several ubiquitin-conjugating enzymes. In metazoans, only the mitotic checkpoint regulator CHFR shares this domain architecture. Here we show that RNF8 is a nuclear protein that follo...

journal_title：Oncogene

authors： Plans V,Guerra-Rebollo M,Thomson TM

更新日期：2008-02-28 00:00:00

abstract：:The von Hippel-Lindau tumor suppressor pVHL regulates the stability of hypoxia-inducible factors (HIF)-1 and -2, oxygen-sensitive basic helix-loop-helix transcription factors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial growth factor. Loss of pVHL function results in c...

journal_title：Oncogene

authors： Rankin EB,Rha J,Unger TL,Wu CH,Shutt HP,Johnson RS,Simon MC,Keith B,Haase VH

更新日期：2008-09-11 00:00:00

abstract：:TrkA is the receptor tyrosine kinase (RTK) for nerve growth factor (NGF) and stimulates NGF-dependent cell survival and differentiation in primary neurons. TrkA expression in neuronal tumors also supports NGF-dependent differentiation of neuroblastomas and apoptosis of medulloblastomas. Phosphorylation of the activati...

journal_title：Oncogene

authors： Gryz EA,Meakin SO

更新日期：2000-01-20 00:00:00

abstract：:Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward trans...

journal_title：Oncogene

authors： Chen Y,Xu L,Lin RY,Müschen M,Koeffler HP

更新日期：2020-10-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are extracellular lipid mediators that signal through distinct members of the Edg/LP subfamily of G protein-coupled receptors (GPCRs). LPA and S1P receptors are expressed in almost every cell type and can couple to multiple G proteins (G(i), G(q) and G(12/1...

journal_title：Oncogene

authors： Kranenburg O,Moolenaar WH

更新日期：2001-03-26 00:00:00

abstract：:In most eukaryotic cells, a link between S and M phases of the cell cycle must be assured in order to maintain the ploidy of newly divided cells. However, in some cell l/pes, e.g. the precursors of platelets megakaryocytes, extra S-phases can occur in the absence of concomitant mitoses, resulting in polyploidy. We hav...

journal_title：Oncogene

authors： García P,Calés C

更新日期：1996-08-15 00:00:00

abstract：:Integrins are adhesion receptors that mediate both cell-extracellular matrix and cell-cell interactions. It has also been reported that the loss of integrin alpha4 expression might be associated with metastasis in several cancers. However, the molecular mechanism for loss of their expression in cancers has not been ex...

journal_title：Oncogene

authors： Park J,Song SH,Kim TY,Choi MC,Jong HS,Kim TY,Lee JW,Kim NK,Kim WH,Bang YJ

更新日期：2004-04-22 00:00:00

abstract：:Recurrent and hormone-refractory prostate cancer (PCA) exhibits aggressive behaviors while current therapeutic approaches show little effect of prolonging the survival of patients with PCA. Thus, a deeper understanding of the patho-molecular mechanisms underlying the disease progression in PCA is crucial to identify n...

journal_title：Oncogene

authors： Pai VC,Hsu CC,Chan TS,Liao WY,Chuu CP,Chen WY,Li CR,Lin CY,Huang SP,Chen LT,Tsai KK

更新日期：2019-02-01 00:00:00

abstract：:Proteolytic cleavage of the extracellular domain of CD44 from the surface of cells has been observed recently in different cell types. In cell culture supernatants of human melanoma cell lines a 70 kDa soluble CD44 protein (solCD44) was detected at concentrations of 250-300 ng/ml. Protease inhibitor studies revealed t...

journal_title：Oncogene

authors： Ahrens T,Sleeman JP,Schempp CM,Howells N,Hofmann M,Ponta H,Herrlich P,Simon JC

更新日期：2001-06-07 00:00:00

abstract：:Chromosome 1p36.23 is frequently deleted in glioblastoma multiforme (GBM). miR-34a localizes in this region. Our experiments found that miR-34a was often deleted and epidermal growth factor receptor (EGFR) was frequently amplified in genomic DNA of 55 GBMs using single-nucleotide polymorphism DNA microarray. Notably, ...

journal_title：Oncogene

authors： Yin D,Ogawa S,Kawamata N,Leiter A,Ham M,Li D,Doan NB,Said JW,Black KL,Phillip Koeffler H

更新日期：2013-02-28 00:00:00

abstract：:Cancer-Associated Fibroblasts (CAFs) are the most prominent stromal cell type in breast tumors. CAFs promote tumor growth and metastasis by multiple mechanisms, including by mediating tumor-promoting inflammation. Immune modulation in the tumor microenvironment plays a central role in determining disease outcome. Howe...

journal_title：Oncogene

authors： Cohen N,Shani O,Raz Y,Sharon Y,Hoffman D,Abramovitz L,Erez N

更新日期：2017-08-01 00:00:00

abstract：:Epithelial-to-mesenchymal transition (EMT) promotes cell motility, which is important for the metastasis of malignant cells, and blocks CD95-mediated apoptotic signaling triggered by immune cells and chemotherapeutic regimens. CD95L, the cognate ligand of CD95, can be cleaved by metalloproteases and released as a solu...

journal_title：Oncogene

authors： Edmond V,Dufour F,Poiroux G,Shoji K,Malleter M,Fouqué A,Tauzin S,Rimokh R,Sergent O,Penna A,Dupuy A,Levade T,Theret N,Micheau O,Ségui B,Legembre P

更新日期：2015-02-19 00:00:00

abstract：:The forkhead transcription factor FOXM1 has a key role in DNA damage response, and its deregulated overexpression is associated with genotoxic drug resistance in breast cancer. However, little is known about the posttranslational mechanisms by which FOXM1 expression is regulated by genotoxic agents and how they are de...

journal_title：Oncogene

authors： Karunarathna U,Kongsema M,Zona S,Gong C,Cabrera E,Gomes AR,Man EP,Khongkow P,Tsang JW,Khoo US,Medema RH,Freire R,Lam EW

更新日期：2016-03-17 00:00:00

abstract：:Genetic and biochemical evidence suggest that conserved region 3 (CR3) of the adenovirus Ela polypeptide can provide two distinct and separable functions: an N-terminal transcriptional activation region and a C-terminal promoter targeting region. It is thought that the promoter targeting region of Ela CR3 interacts wi...

journal_title：Oncogene

authors： Agoff SN,Wu B

更新日期：1994-12-01 00:00:00

abstract：:We have found that the differentiation inducer butyric acid causes the synthesis of a cellular protein(s) that mediates a rapid decline in the level of myc RNA in SW837, a cell line derived from a human adenocarcinoma of the rectum. This effect was dose-dependent and was maximal at 1 mM. Among the short chain fatty ac...

journal_title：Oncogene

authors： Herold KM,Rothberg PG

更新日期：1988-10-01 00:00:00

abstract：:The v-myb oncogene of the avian myeloblastosis virus (AMV) is unique among known oncogenes in that it causes only acute leukemia in animals and transforms only hematopoietic cells in culture. AMV was discovered in the 1930s as a virus that caused a disease in chickens that is similar to acute myelogenous leukemia in h...

journal_title：Oncogene

authors： Lipsick JS,Wang DM

更新日期：1999-05-13 00:00:00

abstract：:Infection by HTLV-1 has been correlated with the appearance of various proliferative or degenerative diseases. Some of these disorders have been observed in transgenic mice expressing the Tax protein, which is known to transactivate various viral and cellular promoters through interactions with several transcription f...

journal_title：Oncogene

authors： Rousset R,Fabre S,Desbois C,Bantignies F,Jalinot P

更新日期：1998-02-05 00:00:00

abstract：:Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia. Here, we found that leukemic stem cells (LSCs) were highly differentiated, and leukemia progression was severely impaire...

journal_title：Oncogene

authors： Sari IN,Yang YG,Wijaya YT,Jun N,Lee S,Kim KS,Bajaj J,Oehler VG,Kim SH,Choi SY,Park SH,Kim DW,Reya T,Han J,Kwon HY

更新日期：2021-01-01 00:00:00

abstract：:Uracil in DNA results from deamination of cytosine, resulting in mutagenic U : G mispairs, and misincorporation of dUMP, which gives a less harmful U : A pair. At least four different human DNA glycosylases may remove uracil and thus generate an abasic site, which is itself cytotoxic and potentially mutagenic. These e...

journal_title：Oncogene

authors： Krokan HE,Drabløs F,Slupphaug G

更新日期：2002-12-16 00:00:00

abstract：:Although transforming ras oncogenes have been implicated as causative factors in liver cell transformation, the exact function and phenotypic alterations generated by the expression of such transforming genes in liver epithelial cells has yet to be defined. We have utilized a retroviral vector system to deliver an ind...

journal_title：Oncogene

authors： Huber BE,Cordingley MG

更新日期：1988-09-01 00:00:00

abstract：:The activities of E2F transcription factors are inhibited by interactions with members of the retinoblastoma (RB) tumor suppressor family, p105RB, p107 and p130. In cycling cells p107 and p130 also interact with heterodimers comprised of Cdk2 and either A or E cyclins. We characterized E2F complexes present in C2C12 a...

journal_title：Oncogene

authors： Corbeil HB,Whyte P,Branton PE

更新日期：1995-09-07 00:00:00

abstract：:Temozolomide was recognized as the first-line therapy for glioblastoma to prolong the survival of patients noticeably, while recent clinical studies found that some patients were not sensitive to temozolomide treatment. The possible mechanisms seemed to be methylguanine-DNA-methyltransferase (MGMT), mismatch repair, P...

journal_title：Oncogene

authors： Nie E,Miao F,Jin X,Wu W,Zhou X,Zeng A,Yu T,Zhi T,Shi Z,Wang Y,Zhang J,Liu N,You Y

更新日期：2019-04-01 00:00:00

abstract：:Fos protein heterodimerizes through one surface of an alpha-helical domain called the leucine zipper. We have investigated the effect of destabilizing this domain by multiply substituting small residues of its non-interacting surface with glycine. Ternary complex formation between mutated Fos, Jun and DNA was determin...

journal_title：Oncogene

authors： Nicklin MJ,Zechner D,Kislyakova T

更新日期：1993-07-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) facilitates cancer invasion and metastasis and thus accelerates cancer progression. p21-activated kinase 4 (PAK4) is a critical regulator of prostate cancer (PC) progression. Here, we report that PAK4 activation promotes PC progression through the EMT regulator Slug. We find tha...

journal_title：Oncogene

authors： Park JJ,Park MH,Oh EH,Soung NK,Lee SJ,Jung JK,Lee OJ,Yun SJ,Kim WJ,Shin EY,Kim EG

更新日期：2018-09-01 00:00:00

abstract：:Amplification of the N-myc gene is a significant adverse prognostic factor in neuroblastoma, a common childhood tumor. In non-transformed cells, myc expression is controlled through an autoregulatory circuit, through which elevated Myc protein levels lead to down-regulation of myc transcription. The precise mechanism ...

journal_title：Oncogene

authors： Sivak LE,Tai KF,Smith RS,Dillon PA,Brodeur GM,Carroll WL

更新日期：1997-10-16 00:00:00

abstract：:Atypical protein kinase C (aPKC) and Lethal giant larvae (Lgl) regulate apical-basal polarity in Drosophila and mammalian epithelia. At the apical domain, aPKC phosphorylates and displaces Lgl that, in turn, maintains aPKC inactive at the basolateral region. The mutual exclusion of these two proteins seems to be cruci...

journal_title：Oncogene

authors： Grifoni D,Garoia F,Bellosta P,Parisi F,De Biase D,Collina G,Strand D,Cavicchi S,Pession A

更新日期：2007-08-30 00:00:00

abstract：:Epstein-Barr virus (EBV)-encoded Latent Membrane Protein 2A (LMP2A) is an EBV latency-associated protein regularly expressed in nasopharyngeal carcinoma (NPC). In B cells, LMP2A activity resembles that of a constitutively activated antigen receptor, which recruits the Syk tyrosine kinase to activate a set of downstrea...

journal_title：Oncogene

authors： Zhou X,Matskova L,Rathje LS,Xiao X,Gish G,Werner M,Ignatyev I,Yu N,Zhao W,Tian F,Hou B,Zhang Z,Pawson T,Chen F,Ernberg I

更新日期：2015-08-20 00:00:00

abstract：:Proliferating cells need to produce a large amount of energy and, at the same time, need to maintain a constant supply of biosynthetic precursors of macromolecules that are used as building blocks for generating new cells. Indeed, many cancer cells undergo a switch from mitochondrial to glycolytic metabolism and displ...

journal_title：Oncogene

authors： Deblois G,St-Pierre J,Giguère V

更新日期：2013-07-25 00:00:00

abstract：:Sam68 phosphorylation correlates with Fyn but not Lck expression in T cells. This substrate has been used here to explore the possible basis of the specificity of Fyn versus Lck. We show that this specificity is not based on a spatial segregation of the two kinases, since a chimeric Lck molecule containing the membran...

journal_title：Oncogene

authors： Feuillet V,Semichon M,Restouin A,Harriague J,Janzen J,Magee A,Collette Y,Bismuth G

更新日期：2002-10-17 00:00:00

abstract：:A previous report demonstrated that AP-2alpha favors the survival of ovarian cancer patients by clinical findings. However, the functional roles of AP-2alpha in human ovarian cancers have not been determined. To clarify the roles, we overexpressed AP-2alpha in SKOV3 human ovarian cancer cells, which originally possess...

journal_title：Oncogene

authors： Sumigama S,Ito T,Kajiyama H,Shibata K,Tamakoshi K,Kikkawa F,Williams T,Tainsky MA,Nomura S,Mizutani S

更新日期：2004-07-15 00:00:00