The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family.


:Apoptosis is essential for normal development and maintenance of homeostasis, and disruption of apoptotic pathways is associated with multiple disease states, including cancer. Although initially identified as central regulators of apoptosis at the level of mitochondria, an important role for BCL-2 proteins at the endoplasmic reticulum is now well established. Signaling pathways emanating from the endoplasmic reticulum (ER) are involved in apoptosis initiated by stimuli as diverse as ER stress, oncogene expression, death receptor (DR) ligation and oxidative stress, and the BCL-2 family is almost invariably implicated in the regulation of these pathways. This also includes Ca(2+)-mediated cross talk between ER and mitochondria during apoptosis, which contributes to the mitochondrial dynamics that support the core mitochondrial apoptosis pathway. In addition to the regulation of apoptosis, BCL-2 proteins at the ER also regulate autophagy, a survival pathway that limits metabolic stress, genomic instability and tumorigenesis. In cases where apoptosis is inhibited, however, prolonged autophagy can lead to cell death. This review provides an overview of ER-associated apoptotic and autophagic signaling pathways, with particular emphasis on the BCL-2 family proteins.






Heath-Engel HM,Chang NC,Shore GC




Has Abstract


2008-10-27 00:00:00
















  • Four tumor suppressor loci on chromosome 9q in bladder cancer: evidence for two novel candidate regions at 9q22.3 and 9q31.

    abstract::The most common genetic alteration identified in transitional cell carcinoma (TCC) of the bladder is loss of heterozygosity (LOH) on chromosome 9. However, localization of tumor suppressor genes on 9q has been hampered by the low frequency of subchromosomal deletions. We have analysed 139 primary, initial low stage TC...


    pub_type: 杂志文章


    authors: Simoneau M,Aboulkassim TO,LaRue H,Rousseau F,Fradet Y

    更新日期:1999-01-07 00:00:00

  • ZNF185, an actin-cytoskeleton-associated growth inhibitory LIM protein in prostate cancer.

    abstract::We have recently identified ZNF185 as a gene that is downregulated in prostate cancer (PCa), in part via epigenetic alteration, and maybe associated with disease progression. In this study, we cloned the ZNF185 cDNA from normal human prostate tissues and investigated its biological function. We show that ZNF185 is a n...


    pub_type: 杂志文章


    authors: Zhang JS,Gong A,Young CY

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  • Regulation of Fas-dependent activation-induced T cell apoptosis by cAMP signaling: a potential role for transcription factor NF-kappa B.

    abstract::TCR-mediated activation of T cell hybridomas induces programmed cell death by a Fas-dependent pathway. We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-ind...


    pub_type: 杂志文章


    authors: Ivanov VN,Lee RK,Podack ER,Malek TR

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  • Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.

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    pub_type: 杂志文章


    authors: Noble JR,Zhong ZH,Neumann AA,Melki JR,Clark SJ,Reddel RR

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  • aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia.

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    pub_type: 杂志文章


    authors: Grifoni D,Garoia F,Bellosta P,Parisi F,De Biase D,Collina G,Strand D,Cavicchi S,Pession A

    更新日期:2007-08-30 00:00:00

  • Promoter specificity and stability control of the p53-related protein p73.

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    pub_type: 杂志文章


    authors: Lee CW,La Thangue NB

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  • Differential contributions of ERK and PI3-kinase to the regulation of cyclin D1 expression and to the control of the G1/S transition in mouse embryonic stem cells.

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    pub_type: 杂志文章


    authors: Jirmanova L,Afanassieff M,Gobert-Gosse S,Markossian S,Savatier P

    更新日期:2002-08-15 00:00:00

  • Initiation of adult myelopoiesis can occur in the absence of c-Myb whereas subsequent development is strictly dependent on the transcription factor.

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    pub_type: 杂志文章


    authors: Sumner R,Crawford A,Mucenski M,Frampton J

    更新日期:2000-07-13 00:00:00

  • Two genes associated with liver cancer are regulated by different mechanisms in rasT24 transformed liver epithelial cells.

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    pub_type: 杂志文章


    authors: Li YC,Lieberman MW

    更新日期:1989-06-01 00:00:00

  • Cloning and sequencing of the human c-abl 3' untranslated region.

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    pub_type: 杂志文章


    authors: Andrews DF 3rd,Tompkins CK,Hendrickson SL,Singer JW

    更新日期:1990-03-01 00:00:00

  • Surfactant protein D inhibits activation of non-small cell lung cancer-associated mutant EGFR and affects clinical outcomes of patients.

    abstract::Tyrosine kinase inhibitor (TKI)-sensitive and TKI-resistant mutations of epidermal growth factor receptor (EGFR) are associated with lung adenocarcinoma. EGFR mutants were previously shown to exhibit ligand-independent activation. We have previously demonstrated that pulmonary surfactant protein D (SP-D, SFTPD) suppre...


    pub_type: 杂志文章


    authors: Umeda Y,Hasegawa Y,Otsuka M,Ariki S,Takamiya R,Saito A,Uehara Y,Saijo H,Kuronuma K,Chiba H,Ohnishi H,Sakuma Y,Takahashi H,Kuroki Y,Takahashi M

    更新日期:2017-11-16 00:00:00

  • A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells.

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    pub_type: 杂志文章


    authors: Yao R,Kondoh Y,Natsume Y,Yamanaka H,Inoue M,Toki H,Takagi R,Shimizu T,Yamori T,Osada H,Noda T

    更新日期:2014-08-14 00:00:00

  • Characterization of the mouse Ron/Stk receptor tyrosine kinase gene.

    abstract::In an effort to understand the mechanisms governing the regulation of the mouse Ron receptor gene, a mouse genomic library was screened and overlapping clones coding for the Ron gene and flanking DNA were identified. Continuous DNA sequence was obtained for approximately 16.4 kilobases. The gene, from the initiator me...


    pub_type: 杂志文章


    authors: Waltz SE,Toms CL,McDowell SA,Clay LA,Muraoka RS,Air EL,Sun WY,Thomas MB,Degen SJ

    更新日期:1998-01-08 00:00:00

  • Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.

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    pub_type: 杂志文章


    authors: Jeng YM,Cai-Ng S,Li A,Furuta S,Chew H,Chen PL,Lee EY,Lee WH

    更新日期:2007-09-13 00:00:00

  • Human c-FES is a nuclear tyrosine kinase.

    abstract::FES is a non-receptor protein tyrosine kinase expressed in hematopoietic progenitors and differentiated myeloid cells. It has recently been implicated in granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) and erythropoietin signal transduction. To better understand the role played by FES i...


    pub_type: 杂志文章


    authors: Yates KE,Lynch MR,Wong SG,Slamon DJ,Gasson JC

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  • Functional characterization of uveal melanoma oncogenes.

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    pub_type: 杂志文章


    authors: Ma J,Weng L,Bastian BC,Chen X

    更新日期:2021-01-01 00:00:00

  • MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers.

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    pub_type: 杂志文章


    authors: Imam JS,Buddavarapu K,Lee-Chang JS,Ganapathy S,Camosy C,Chen Y,Rao MK

    更新日期:2010-09-02 00:00:00

  • TGFβ signaling in head and neck squamous cell carcinoma.

    abstract::Transforming growth factor beta (TGFβ) is a key regulator of epithelial cell proliferation, immune function and angiogenesis. Because TGFβ signaling maintains epithelial homeostasis, dysregulated TGFβ signaling is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Defective TGFβ sign...


    pub_type: 杂志文章,评审


    authors: White RA,Malkoski SP,Wang XJ

    更新日期:2010-10-07 00:00:00

  • Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.

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    pub_type: 杂志文章


    authors: Maglione D,Guerriero V,Viglietto G,Ferraro MG,Aprelikova O,Alitalo K,Del Vecchio S,Lei KJ,Chou JY,Persico MG

    更新日期:1993-04-01 00:00:00

  • Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells.

    abstract::Ret is a receptor tyrosine kinase predominantly expressed in tissue derived from the neuroectoderm and is involved in multiple endocrine neoplasia type 2A and 2B, familiar medullary thyroid carcinoma, and Hirschsprung's disease. The ligand for the receptor is still unknown. Previously, using a human epidermal growth f...


    pub_type: 杂志文章


    authors: van Weering DH,Medema JP,van Puijenbroek A,Burgering BM,Baas PD,Bos JL

    更新日期:1995-12-07 00:00:00

  • A possible role for c-Myc oncoproteins in post-transcriptional regulation of ribosomal RNA.

    abstract::Overexpression of members of the myc family of oncogenes contributes to the development of many vertebrate malignancies. Although several functions for myc gene products have been proposed, the targets for Myc activity during oncogenesis or normal development remain to be identified. Oocytes of Xenopus laevis, which a...


    pub_type: 杂志文章


    authors: Gibson AW,Ye R,Johnston RN,Browder LW

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  • Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation.

    abstract::Cell proliferation and differentiation are closely coupled. However, we previously showed that overexpression of cyclin-dependent kinase (Cdk6) blocks chondrocyte differentiation without affecting cell-cycle progression in vitro. To investigate whether Cdk6 inhibits chondrocyte differentiation in vivo, we generated ch...


    pub_type: 杂志文章


    authors: Ito K,Maruyama Z,Sakai A,Izumi S,Moriishi T,Yoshida CA,Miyazaki T,Komori H,Takada K,Kawaguchi H,Komori T

    更新日期:2014-04-03 00:00:00

  • The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells.

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    pub_type: 杂志文章


    authors: Zhang CC,Yang JM,White E,Murphy M,Levine A,Hait WN

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  • Targeting the RB-E2F pathway in breast cancer.

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    pub_type: 杂志文章,评审


    authors: Johnson J,Thijssen B,McDermott U,Garnett M,Wessels LF,Bernards R

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  • Epigenetic regulations in hematopoietic Hox code.

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    pub_type: 杂志文章,评审


    authors: He H,Hua X,Yan J

    更新日期:2011-01-27 00:00:00

  • CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3.

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    pub_type: 杂志文章


    authors: Block I,Müller C,Sdogati D,Pedersen H,List M,Jaskot AM,Syse SD,Lund Hansen P,Schmidt S,Christiansen H,Casella C,Bering Olsen S,Blomstrøm MM,Riedel A,Thomassen M,Kruse TA,Karlskov Hansen SW,Kioschis P,Mollenhauer J

    更新日期:2019-06-01 00:00:00

  • The induction of uterine leiomyomas and mammary tumors in transgenic mice expressing polyomavirus (PyV) large T (LT) antigen is associated with the ability of PyV LT antigen to form specific complexes with retinoblastoma and CUTL1 family members.

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    pub_type: 杂志文章


    authors: Webster MA,Martin-Soudant N,Nepveu A,Cardiff RD,Muller WJ

    更新日期:1998-04-16 00:00:00

  • Integrative analysis of genomic amplification-dependent expression and loss-of-function screen identifies ASAP1 as a driver gene in triple-negative breast cancer progression.

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    pub_type: 杂志文章


    authors: He J,McLaughlin RP,van der Beek L,Canisius S,Wessels L,Smid M,Martens JWM,Foekens JA,Zhang Y,van de Water B

    更新日期:2020-05-01 00:00:00

  • HIF-1-dependent expression of angiopoietin-like 4 and L1CAM mediates vascular metastasis of hypoxic breast cancer cells to the lungs.

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    pub_type: 杂志文章


    authors: Zhang H,Wong CC,Wei H,Gilkes DM,Korangath P,Chaturvedi P,Schito L,Chen J,Krishnamachary B,Winnard PT Jr,Raman V,Zhen L,Mitzner WA,Sukumar S,Semenza GL

    更新日期:2012-04-05 00:00:00

  • Function for p300 and not CBP in the apoptotic response to DNA damage.

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    pub_type: 杂志文章


    authors: Yuan ZM,Huang Y,Ishiko T,Nakada S,Utsugisawa T,Shioya H,Utsugisawa Y,Shi Y,Weichselbaum R,Kufe D

    更新日期:1999-10-07 00:00:00