当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Identification of epithelial stromal interaction 1 as a novel effector downstream of Krüppel-like factor 8 in breast cancer invasion and metastasis.

Identification of epithelial stromal interaction 1 as a novel effector downstream of Krüppel-like factor 8 in breast cancer invasion and metastasis.

Abstract：

:Krüppel-like factor 8 (KLF8) is a transcriptional factor critical for metastatic progression of breast cancer. Epithelial stromal interaction 1 (EPSTI1), a recently identified stromal fibroblast-induced gene in non-invasive breast cancer cells is highly overexpressed in invasive breast carcinomas. The function and regulation of EPSTI1, however, remain largely unknown. In this paper, we report a novel KLF8 to EPSTI1 signaling pathway in breast cancer. Using various expression analyses, we revealed a high co-overexpression of KLF8 and EPSTI1 in invasive human breast cancer cells and patient tumors. Ectopic overexpression of KLF8 in the non-invasive MCF-10A cells induced the EPSTI1 expression, whereas KLF8 knockdown from the invasive, MDA-MB-231 cells decreased the EPSTI1 expression. Promoter activation and binding analyses indicated that KLF8 promoted the EPSTI1 expression by directly acting on the EPSTI1 gene promoter. EPSTI1 knockdown dramatically reduced the KLF8-promoted MCF-10A cell invasion, and ectopic expression of EPSTI1 in the non-invasive MCF-7 cells is sufficient to induce the cell invasion. Experiments using nude mice demonstrated that the ectopic EPSTI1 granted the MCF-7 cells capability of both invasive growth in the breasts and metastasis to the lungs. Using co-immunoprecipitation coupled with mass spectrometry, we discovered that EPSTI1 interacts with the valosin-containing protein (VCP), resulting in the degradation of IκBα and subsequent activation of NF-κB in the nucleus. These findings suggest a novel KLF8 to EPSTI1 to VCP to NF-κB signaling mechanism potentially critical for breast cancer invasion and metastasis.

journal_name

Oncogene

journal_title

Oncogene

authors

Li T,Lu H,Shen C,Lahiri SK,Wason MS,Mukherjee D,Yu L,Zhao J

doi

10.1038/onc.2013.415

subject

Has Abstract

pub_date

2014-09-25 00:00:00

pages

4746-55

issue

39

eissn

0950-9232

issn

1476-5594

pii

onc2013415

journal_volume

33

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Detection of PTEN nonsense mutation and psiPTEN expression in central nervous system high-grade astrocytic tumors by a yeast-based stop codon assay.

    abstract：:We have developed a new yeast-based assay for the detection of PTEN nonsense mutation, and applied it to a total of 42 astrocytic tumors. The assay utilizes homologous recombination of PCR-amplified PTEN cDNA samples to a yeast vector which expresses an in-frame PTEN::ADE2 chimera protein. An allele of nonsense mutati...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203795

    authors： Zhang CL,Tada M,Kobayashi H,Nozaki M,Moriuchi T,Abe H

    更新日期：2000-09-07 00:00:00

  • Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos promoter.

    abstract：:REF cells transformed by oncogenes E1A and cHa-ras reveal high and constitutive DNA-binding activity of AP-1 factor lacking in c-Fos protein. Consistently, the transcription of c-fos gene has been found to be downregulated. To elucidate the mechanisms of c-fos downregulation in E1A+cHa-ras transformants, we studied th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205118

    authors： Kukushkin AN,Abramova MV,Svetlikova SB,Darieva ZA,Pospelova TV,Pospelov VA

    更新日期：2002-01-24 00:00:00

  • Post-transcriptional processing suggests that c-mos functions as a maternal message in mouse eggs.

    abstract：:Transcripts of the c-mos proto-oncogene were recently found to accumulate to high levels in mouse oocytes. We report here that the oocyte c-mos RNA is polyadenylated in concert with oocyte maturation, retained in mature ovulated eggs and zygotes but degraded by the late two cell embryo stage. These results suggest tha...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Goldman DS,Kiessling AA,Cooper GM

    更新日期：1988-08-01 00:00:00

  • Allelic deletions at chromosome 11q22-q23.1 and 11q25-qterm are frequent in sporadic breast but not colorectal cancers.

    abstract：:We identified the chromosome 11q23 region as containing a putative tumour suppressor gene(s) frequently deleted in nonfamilial breast and other cancers. To define this region(s) further, we performed a systematic genetic analysis at chromosome 11q14-qterm in sporadic breast and colorectal cancer. Tumour and constituti...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1200847

    authors： Koreth J,Bakkenist CJ,McGee JO

    更新日期：1997-01-30 00:00:00

  • Current role of antibody therapy in patients with metastatic colorectal cancer.

    abstract：:In less than 10 years, the number and importance of non-surgical treatment modalities in patients with colorectal cancer (CRC) have increased dramatically, both in the adjuvant and the advanced settings. However, despite the improvement of cytotoxic therapy in CRC, many patients still develop progressive disease and u...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1210377

    authors： Pfeiffer P,Qvortrup C,Eriksen JG

    更新日期：2007-05-28 00:00:00

  • DNA: leukemia's secret weapon of bone mass destruction.

    abstract：:Interaction of tumour cells with their microenvironment impacts on all aspects of cancer, ranging from development through to treatment response. In this issue, Dvorak and colleagues(1) reveal a novel tumour/microenvironment relationship that may drive leukemia pathogenesis. Specifically, they find that leukemic cells...

    journal_title：Oncogene

    pub_type： 评论,杂志文章

    doi：10.1038/onc.2012.639

    authors： Tait S

    更新日期：2013-10-31 00:00:00

  • c-Myc inhibits myogenic differentiation and myoD expression by a mechanism which can be dissociated from cell transformation.

    abstract：:The c-Myc oncoprotein is a basic-helix-loop-helix-leucine zipper (b-HLH-LZ) transcription factor involved in regulating cell proliferation and differentiation. We have used retrovirus-mediated gene transfer to investigate the effect of ectopic c-Myc expression on the spontaneous differentiation of primary quail myobla...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： La Rocca SA,Crouch DH,Gillespie DA

    更新日期：1994-12-01 00:00:00

  • The non-catalytic domain of ras-GAP inhibits transformation induced by G protein coupled receptors.

    abstract：:We have studied the relationship between ras-GAP and G protein coupled receptors in a proliferative setting comprised of NIH3T3 expressing transfected muscarinic receptors (mAChRs). GAP expression plasmids were engineered to encode wild-type GAP, its carboxyl-terminal catalytic domain, a mutant lacking a portion of th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Xu N,McCormick F,Gutkind JS

    更新日期：1994-02-01 00:00:00

  • Hepatitis B virus X protein induces the expression of MTA1 and HDAC1, which enhances hypoxia signaling in hepatocellular carcinoma cells.

    abstract：:Expression level of metastasis-associated protein 1 (MTA1) is closely related to tumor growth and metastasis in various cancers. Although increased expression level of MTA1 was observed in hepatocellular carcinoma (HCC), role of MTA1 complex containing histone deacetylase (HDAC) in hepatitis B virus (HBV)-associated h...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1211000

    authors： Yoo YG,Na TY,Seo HW,Seong JK,Park CK,Shin YK,Lee MO

    更新日期：2008-05-29 00:00:00

  • Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras.

    abstract：:Expression of constitutively activated M-Ras in normal murine bone-marrow cells was sufficient to induce the factor-independent, in vitro growth and differentiation of colonies of macrophages and neutrophils, and the generation of immortal lines of factor-independent mast cells, and, upon in vivo injection of the tran...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208441

    authors： Guo X,Schrader KA,Xu Y,Schrader JW

    更新日期：2005-03-31 00:00:00

  • Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex.

    abstract：:Mammalian Mip/LIN-9 is a cell cycle regulatory protein that is negatively regulated by CDK4/cyclin D. It has been demonstrated that Mip/LIN-9 collaborates with B-Myb during S and G(2)/M in the induction of cyclins A and B, and CDK1. The ortholog of Mip/LIN-9 in Drosophila, Mip130, is part of a large multisubunit prote...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210562

    authors： Pilkinton M,Sandoval R,Colamonici OR

    更新日期：2007-11-29 00:00:00

  • In vitro differentiation of epithelial cells from cervical neoplasias resembles in vivo lesions.

    abstract：:Cell lines derived from cervical neoplasias, as well as cells from normal cervix and neonatal foreskin were examined in an in vitro culture system (raft system) that allows for stratification and differentiation of epithelial cells at an air-liquid interface. Epithelial cells from human foreskin and ectocervix were ob...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Rader JS,Golub TR,Hudson JB,Patel D,Bedell MA,Laimins LA

    更新日期：1990-04-01 00:00:00

  • Interaction of HTLV-1 Tax and methyl-CpG-binding domain 2 positively regulates the gene expression from the hypermethylated LTR.

    abstract：:Epigenetic regulation of gene expression is critical in the maintenance of cellular homeostasis. Dysregulation of normal epigenetic transcription occurs in abnormal physiological conditions, such as those seen in cancer cells and cells infected with parasites, making the mechanism underlying abnormal epigenetic transc...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208394

    authors： Ego T,Tanaka Y,Shimotohno K

    更新日期：2005-03-10 00:00:00

  • The role of STATs in myeloid differentiation and leukemia.

    abstract：:Myeloid differentiation is a highly regulated process governed by various cytokines, such as EPO, TPO, G-CSF, IL-3, IL-5 and GM-CSF. These cytokines act in part through activation of the STAT transcription factor family. In particular, various isoforms of STAT3 and STAT5 are activated during myeloid differentiation in...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1203479

    authors： Coffer PJ,Koenderman L,de Groot RP

    更新日期：2000-05-15 00:00:00

  • SLUG in cancer development.

    abstract：:The SNAIL-related zinc-finger transcription factor, SLUG (SNAI2), is critical for the normal development of neural crest-derived cells and loss-of-function SLUG mutations have been proven to contribute to piebaldism and Waardenburg syndrome type 2 in a dose-dependent fashion. While aberrant induction of SLUG has been ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208505

    authors： Pérez-Mancera PA,González-Herrero I,Pérez-Caro M,Gutiérrez-Cianca N,Flores T,Gutiérrez-Adán A,Pintado B,Sánchez-Martín M,Sánchez-García I

    更新日期：2005-04-28 00:00:00

  • Met-induced membrane blebbing leads to amoeboid cell motility and invasion.

    abstract：:Met tyrosine kinase has been implicated in tumorigenesis and metastasis; its overexpression and deregulation is often observed in cancer. Although Met's functions in cell motility has been studied extensively, its involvement in bleb-based, amoeboid motility is yet to be determined. The aim of this work is to study th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.138

    authors： Laser-Azogui A,Diamant-Levi T,Israeli S,Roytman Y,Tsarfaty I

    更新日期：2014-04-03 00:00:00

  • Structure and chromosomal assignment of the mouse fra-1 gene, and its exclusion as a candidate gene for oc (osteosclerosis).

    abstract：:We have determined the genomic structure of the mouse fra-1 gene, which consists of four exons and three introns at positions also found in the other members of the fos gene family. Fra-1 is expressed rather highly in the brain and testes of adult mice, and at low levels in most other tissues. Absence of c-Fos leads t...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201460

    authors： Schreiber M,Poirier C,Franchi A,Kurzbauer R,Guenet JL,Carle GF,Wagner EF

    更新日期：1997-09-04 00:00:00

  • NF-kappa B precursor p100 inhibits nuclear translocation and DNA binding of NF-kappa B/rel-factors.

    abstract：:The NF-kappa B precursor p100 (lyt-10, p97, p98) generates after proteolytic processing a 52 kDa subunit, which can bind to kappa B-motifs. A deregulated form of the p100 gene, which is structurally altered by a t(10;14) translocation, has a potential oncogenic role in certain human B cell lymphomas. In this study p10...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Naumann M,Nieters A,Hatada EN,Scheidereit C

    更新日期：1993-08-01 00:00:00

  • LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein.

    abstract：:We previously reported cloning the rLot1 gene, and its human homolog (hLOT1), through analysis of differential gene expression in normal and malignant rat ovarian surface epithelial cells. Both human and rat ovarian carcinoma cell lines exhibited lost or decreased expression of this gene. Interestingly, the LOT1 gene ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203067

    authors： Abdollahi A,Bao R,Hamilton TC

    更新日期：1999-11-11 00:00:00

  • TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation.

    abstract：:The biological outcome of TMPRSS2:ERG chromosomal translocations in prostate cancer (PC) remains poorly understood. To address this, we compared the transcriptional effects of TMPRSS2:ERG expression in a transgenic mouse model with those of ERG knockdown in a TMPRSS2:ERG-positive PC cell line. This reveals that ERG re...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2014.308

    authors： Mounir Z,Lin F,Lin VG,Korn JM,Yu Y,Valdez R,Aina OH,Buchwalter G,Jaffe AB,Korpal M,Zhu P,Brown M,Cardiff RD,Rocnik JL,Yang Y,Pagliarini R

    更新日期：2015-07-01 00:00:00

  • Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis.

    abstract：:VEGFR-1 (Flt-1), VEGFR-2 (KDR) and VEGFR-3 (Flt4) are endothelial specific receptor tyrosine kinases, regulated by members of the vascular endothelial growth factor family. VEGFRs are indispensable for embryonic vascular development, and are involved in the regulation of many aspects of physiological and pathological ...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1203855

    authors： Karkkainen MJ,Petrova TV

    更新日期：2000-11-20 00:00:00

  • Human and mouse mesotheliomas exhibit elevated AKT/PKB activity, which can be targeted pharmacologically to inhibit tumor cell growth.

    abstract：:Malignant mesotheliomas (MMs) are very aggressive tumors that respond poorly to standard chemotherapeutic approaches. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been implicated in tumor aggressiveness, in part by mediating cell survival and reducing sensitivity to chemotherapy. Using antibodies recognizi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208744

    authors： Altomare DA,You H,Xiao GH,Ramos-Nino ME,Skele KL,De Rienzo A,Jhanwar SC,Mossman BT,Kane AB,Testa JR

    更新日期：2005-09-08 00:00:00

  • The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia.

    abstract：:The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion with FUS/TLS resulting in the expression of a FUS-ERG oncofusion protein. How this oncofusion protein deregulat...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2015.261

    authors： Sotoca AM,Prange KH,Reijnders B,Mandoli A,Nguyen LN,Stunnenberg HG,Martens JH

    更新日期：2016-04-14 00:00:00

  • Characterization of an E2F1-specific binding domain in pRB and its implications for apoptotic regulation.

    abstract：:The retinoblastoma protein (pRB) has the dual capability to negatively regulate both E2F-induced cell cycle entry and E2F1-induced apoptosis. In this report, we characterize a unique pRB-E2F1 interaction. Using mutagenesis to disrupt E2F1 binding, we find that the ability of pRB to regulate E2F1-induced apoptosis is d...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210803

    authors： Julian LM,Palander O,Seifried LA,Foster JE,Dick FA

    更新日期：2008-03-06 00:00:00

  • ApoC1 promotes the metastasis of clear cell renal cell carcinoma via activation of STAT3.

    abstract：:Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer and frequently diagnosed at an advanced stage. It is prone to develop unpredictable metastases even with proper treatment. Antiangiogenic therapy is the most effective medical treatment for metastatic ccRCC. Thus, exploration of novel approaches t...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-01428-3

    authors： Li YL,Wu LW,Zeng LH,Zhang ZY,Wang W,Zhang C,Lin NM

    更新日期：2020-09-01 00:00:00

  • Dissection of the cytoplasmic domains of cytokine receptors involved in STAT and Ras dependent proliferation.

    abstract：:Cytokine receptors have different signaling requirements which ultimately lead to various physiological responses. In an effort to precisely characterize the molecular determinants involved in the proliferative response mediated by cytokines, we examine dose-dependent proliferation of the betac (GM-CSF, IL-3, IL-5) an...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205444

    authors： Piu F,Magnani M,Ader ME

    更新日期：2002-05-16 00:00:00

  • ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response.

    abstract：:Tumor stroma has an active role in the initiation, growth, and propagation of many tumor types by secreting growth factors and modulating redox status of the microenvironment. Although PPARβ/δ in fibroblasts was shown to modulate oxidative stress in the wound microenvironment, there has been no evidence of a similar e...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-017-0109-8

    authors： Tan EHP,Sng MK,How ISB,Chan JSK,Chen J,Tan CK,Wahli W,Tan NS

    更新日期：2018-04-01 00:00:00

  • Canonical WNT signalling determines lineage specificity in Wilms tumour.

    abstract：:Wilms tumours (WTs) have two distinct types of histology with or without ectopic mesenchymal elements, suggesting that WTs arise from either the mesenchymal or epithelial nephrogenic lineages. Regardless of the presence or absence of CTNNB1 mutations, nuclear accumulation of beta-catenin is often observed in WTs with ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.455

    authors： Fukuzawa R,Anaka MR,Weeks RJ,Morison IM,Reeve AE

    更新日期：2009-02-26 00:00:00

  • Retroviral heterogeneity in mouse lymphomas.

    abstract：:Provirus modifications which can occur in tumors may lead to tumor antigenic variants. To investigate this possibility we compared the restriction fragment length patterns of mouse mammary tumor virus (MMTV), murine leukemia virus and xenotropic and mink cell-focus inducing (MCF)-related sequences, using Southern blot...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Colombo MP,Ferrari G,Parmiani G,Wettstein PJ

    更新日期：1988-04-01 00:00:00

  • Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation.

    abstract：:Osteochondroma, the most common benign bone tumor, may occur as a sporadic lesion or as multiple neoplasms in the context of multiple osteochondromas syndrome. The most severe complication is malignant transformation into peripheral secondary chondrosarcoma. Although both benign conditions have been linked to defects ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.135

    authors： Zuntini M,Pedrini E,Parra A,Sgariglia F,Gentile FV,Pandolfi M,Alberghini M,Sangiorgi L

    更新日期：2010-07-01 00:00:00