Post-transcriptional processing suggests that c-mos functions as a maternal message in mouse eggs.

Abstract:

:Transcripts of the c-mos proto-oncogene were recently found to accumulate to high levels in mouse oocytes. We report here that the oocyte c-mos RNA is polyadenylated in concert with oocyte maturation, retained in mature ovulated eggs and zygotes but degraded by the late two cell embryo stage. These results suggest that c-mos functions as a maternal mRNA which is translated during oocyte maturation or fertilization and may play a role in these or other early developmental processes.

journal_name

Oncogene

journal_title

Oncogene

authors

Goldman DS,Kiessling AA,Cooper GM

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

159-62

issue

2

eissn

0950-9232

issn

1476-5594

journal_volume

3

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Effect of glycogen synthase kinase-3 inactivation on mouse mammary gland development and oncogenesis.

    abstract::Many components of the Wnt/β-catenin signaling pathway have critical functions in mammary gland development and tumor formation, yet the contribution of glycogen synthase kinase-3 (GSK-3α and GSK-3β) to mammopoiesis and oncogenesis is unclear. Here, we report that WAP-Cre-mediated deletion of GSK-3 in the mammary epit...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2014.279

    authors: Dembowy J,Adissu HA,Liu JC,Zacksenhaus E,Woodgett JR

    更新日期:2015-07-01 00:00:00

  • Regulation of cell migration, invasion and metastasis by IAP proteins and their antagonists.

    abstract::Inhibitor of apoptosis (IAP) proteins are a family comprised of a total of eight mammalian members that were initially described to act as endogenous inhibitors of caspases. In addition, extensive evidence has been accumulated over the last years showing that IAP proteins can regulate various signal transduction pathw...

    journal_title:Oncogene

    pub_type: 杂志文章,评审

    doi:10.1038/onc.2013.63

    authors: Fulda S

    更新日期:2014-02-06 00:00:00

  • cdc2-like kinase is associated with the retinoblastoma protein.

    abstract::The growth-suppressive activity of the retinoblastoma (RB) protein is suggested to be regulated by phosphorylation. In studies on the kinase that phosphorylates the RB proteins, we have previously found that RB proteins can be phosphorylated by purified cdc2 kinase. In this study, we noted that RB proteins immunopreci...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Kitagawa M,Saitoh S,Ogino H,Okabe T,Matsumoto H,Okuyama A,Tamai K,Ohba Y,Yasuda H,Nishimura S

    更新日期:1992-06-01 00:00:00

  • Transformation by v-Myb.

    abstract::The v-myb oncogene of the avian myeloblastosis virus (AMV) is unique among known oncogenes in that it causes only acute leukemia in animals and transforms only hematopoietic cells in culture. AMV was discovered in the 1930s as a virus that caused a disease in chickens that is similar to acute myelogenous leukemia in h...

    journal_title:Oncogene

    pub_type: 杂志文章,评审

    doi:10.1038/sj.onc.1202745

    authors: Lipsick JS,Wang DM

    更新日期:1999-05-13 00:00:00

  • The EndoA enhancer contains multiple ETS binding site repeats and is regulated by ETS proteins.

    abstract::EndoA is a type II keratin and with EndoB (type I keratin), constitutes intermediate filaments in various simple epithelial tissues. EndoA is developmentally regulated and has an enhancer that is located at the 3'- end of the gene. This enhancer contains two single and five dual Ets binding sites. Thus far, no other p...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Seth A,Robinson L,Panayiotakis A,Thompson DM,Hodge DR,Zhang XK,Watson DK,Ozato K,Papas TS

    更新日期:1994-02-01 00:00:00

  • Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis.

    abstract::To understand the function of the individual oncogenes of HPV16 in modulating the cellular response to apoptogenic signals, we used human keratinocytes immortalized with either E6, E7 or E6/E7 oncoproteins as model system. Applying CD95 antibodies or recombinant CD95 ligand, only the E7-immortalized cells underwent ex...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1204979

    authors: Aguilar-Lemarroy A,Gariglio P,Whitaker NJ,Eichhorst ST,zur Hausen H,Krammer PH,Rösl F

    更新日期:2002-01-10 00:00:00

  • A subclass of tumor-inhibitory monoclonal antibodies to ErbB-2/HER2 blocks crosstalk with growth factor receptors.

    abstract::ErbB-2 is an orphan receptor that belongs to a family of tyrosine kinase receptors for either epidermal growth factor (EGF) or Neu differentiation factor (NDF/neuregulin). Because overexpression of the erbB-2 proto-oncogene is frequently associated with an aggressive clinical course of certain human adenocarcinomas, t...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1201029

    authors: Klapper LN,Vaisman N,Hurwitz E,Pinkas-Kramarski R,Yarden Y,Sela M

    更新日期:1997-05-01 00:00:00

  • miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.

    abstract::The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully characterized, and the mechanisms of DAB2 dysregulation in lung cancer are not defined. Here we show that low D...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2013.381

    authors: Du L,Zhao Z,Ma X,Hsiao TH,Chen Y,Young E,Suraokar M,Wistuba I,Minna JD,Pertsemlidis A

    更新日期:2014-08-21 00:00:00

  • Transcription of the RelB gene is regulated by NF-kappaB.

    abstract::RelA and RelB are two members of the NF-kappaB family that differ structurally and functionally. While RelA is regulated through its cytosolic localization by inhibitor proteins or IkappaB and not through transcriptional mechanisms, the regulation of RelB is poorly understood. In this study we demonstrate that stimuli...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1204868

    authors: Bren GD,Solan NJ,Miyoshi H,Pennington KN,Pobst LJ,Paya CV

    更新日期:2001-11-22 00:00:00

  • Retinoic acid and arsenic trioxide cooperate for apoptosis through phosphorylated RXR alpha.

    abstract::Arsenite trioxide (As2O3) induces apoptosis in several cell lines by disturbing key signal transduction pathways through its oxidative properties. Here, we report that As2O3 also induces the phosphorylation of the retinoid receptor RXRalpha, subsequent to oxidative damages and the activation of the stress-activated pr...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1208402

    authors: Tarrade A,Bastien J,Bruck N,Bauer A,Gianni M,Rochette-Egly C

    更新日期:2005-03-31 00:00:00

  • SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells.

    abstract::Here we show that pemetrexed-treated mesothelioma cells undergo accelerated senescence. This is characterized by the secretion of proinflammatory and mitogenic cytokines, reminiscent of an SASP (senescence-associated secretory phenotype). Conditioned media from senescent MPM (malignant pleural mesothelioma) cells trig...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2011.485

    authors: Canino C,Mori F,Cambria A,Diamantini A,Germoni S,Alessandrini G,Borsellino G,Galati R,Battistini L,Blandino R,Facciolo F,Citro G,Strano S,Muti P,Blandino G,Cioce M

    更新日期:2012-06-28 00:00:00

  • Human INT6 interacts with MCM7 and regulates its stability during S phase of the cell cycle.

    abstract::The mouse int6 gene is a frequent integration site of the mouse mammary tumor virus and INT6 silencing by RNA interference in HeLa cells causes an increased number of cells in the G2/M phases of the cell cycle, along with mitotic defects. In this report, we investigated the functional significance of the interaction b...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1210314

    authors: Buchsbaum S,Morris C,Bochard V,Jalinot P

    更新日期:2007-08-02 00:00:00

  • Mechanisms of transcription factor deregulation in lymphoid cell transformation.

    abstract::The most frequent targets of genetic alterations in human lymphoid leukemias are transcription factor genes with essential functions in blood cell development. TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemi...

    journal_title:Oncogene

    pub_type: 杂志文章,评审

    doi:10.1038/sj.onc.1210766

    authors: O'Neil J,Look AT

    更新日期:2007-10-15 00:00:00

  • Identifying LRRC16B as an oncofetal gene with transforming enhancing capability using a combined bioinformatics and experimental approach.

    abstract::Oncofetal genes are expressed in embryos or fetuses, are downregulated or undetectable in adult tissues, and then re-expressed in tumors. Known oncofetal genes, such as AFP, GCB, FGF18, IMP-1 and SOX1, often have important clinical applications or pivotal biological functions. To find new oncofetal-like genes, we used...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2010.451

    authors: Hsu CC,Chiang CW,Cheng HC,Chang WT,Chou CY,Tsai HW,Lee CT,Wu ZH,Lee TY,Chao A,Chow NH,Ho CL

    更新日期:2011-02-10 00:00:00

  • Overcoming chemoresistance of non-small cell lung carcinoma through restoration of an AIF-dependent apoptotic pathway.

    abstract::Non-small cell lung carcinomas (NSCLCs) are typically resistant against apoptosis induced by standard chemotherapy. We evaluated the effects of the two potential antitumor agents of the lamellarin class on a highly apoptosis-resistant NSCLC cell line. Both the marine alkaloid lamellarin-D and its synthetic amino deriv...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1210833

    authors: Gallego MA,Ballot C,Kluza J,Hajji N,Martoriati A,Castéra L,Cuevas C,Formstecher P,Joseph B,Kroemer G,Bailly C,Marchetti P

    更新日期:2008-03-27 00:00:00

  • Pim kinase-dependent inhibition of c-Myc degradation.

    abstract::Pim kinases are found to be highly expressed in leukemia, lymphoma, prostate and pancreatic cancer. Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc succumb to pre-B-cell lymphoma at a strikingly accelerated speed. Despite that Pim-1/Pim-2 has long been recognized as a strong synergistic partner with c...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2008.123

    authors: Zhang Y,Wang Z,Li X,Magnuson NS

    更新日期:2008-08-14 00:00:00

  • The uric acid transporter SLC2A9 is a direct target gene of the tumor suppressor p53 contributing to antioxidant defense.

    abstract::Only humans and higher primates have high uric acid blood levels. Although high uric acid causes gout, it has been linked with human longevity because of its hypothetical antioxidant function. Recent studies reveal that p53 has significant roles in cellular metabolism. One example of this is an antioxidant function th...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2014.119

    authors: Itahana Y,Han R,Barbier S,Lei Z,Rozen S,Itahana K

    更新日期:2015-04-02 00:00:00

  • Nodal promotes growth and invasion in human gliomas.

    abstract::Uncontrolled growth and diffused invasion are major causes of mortality in patients with malignant gliomas. Nodal has been shown to have a central role in the tumorigenic signaling pathways of malignant melanoma. In this study, we show that grade IV human glioma cell lines expressed different levels of Nodal, parallel...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2010.55

    authors: Lee CC,Jan HJ,Lai JH,Ma HI,Hueng DY,Lee YC,Cheng YY,Liu LW,Wei HW,Lee HM

    更新日期:2010-05-27 00:00:00

  • Human S100A4 (p9Ka) induces the metastatic phenotype upon benign tumour cells.

    abstract::The rodent S100-related calcium-binding protein, S100A4 induces metastasis in non-metastatic rat and mouse benign mammary cells and co-operates with benign-tumour-inducing changes in two transgenic mouse models, to yield metastatic mammary tumours. Co-transfection of the human gene for S100A4 with pSV2neo into the ben...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1201948

    authors: Lloyd BH,Platt-Higgins A,Rudland PS,Barraclough R

    更新日期:1998-07-30 00:00:00

  • Evidence for GEAPS, novel Glial E2F1-Associated Proteins in hamster glioma cells induced by the human neurotropic polyomavirus, JCV.

    abstract::Injection of the human neurotropic polyomavirus, JCV, into neonatal hamsters causes tumors of glial origin. Previously, a rapidly proliferating cell line, HJC-15, which expresses high levels of the viral T-antigen, had been established from JCV-induced hamster glial tumors. In our analyses of the mechanisms involved i...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Raj GV,Ansari SA,Khalili K

    更新日期:1996-03-21 00:00:00

  • Apoptosis is antagonized by large T antigens in the pathway to immortalization by polyomaviruses.

    abstract::The viability of rat embryo cells immortalized by thermosensitive mutants of SV40 or polyoma Large T antigen is impaired at the non-permissive temperature thus demonstrating that the immortal phenotype is dominantly maintained by Large T antigens. We have observed that exposing these cells to the restrictive temperatu...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Zheng DQ,Vayssière JL,Petit PX,LeCoeur H,Spatz A,Mignotte B,Feunteun J

    更新日期:1994-11-01 00:00:00

  • Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer.

    abstract::E2F transcription factors are important regulators of the cell cycle, and unrestrained activation of E2F-dependent transcription is considered to be an important driver of tumor formation and progression. Although highly expressed in normal skin and skin cancer, the role of the atypical E2Fs, E2F7 and E2F8, in keratin...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2016.251

    authors: Thurlings I,Martínez-López LM,Westendorp B,Zijp M,Kuiper R,Tooten P,Kent LN,Leone G,Vos HJ,Burgering B,de Bruin A

    更新日期:2017-02-09 00:00:00

  • v-Src activates both protein kinase C-dependent and independent signaling pathways in murine fibroblasts.

    abstract::Activating the protein-tyrosine kinase activity of v-Src rapidly induced expression of the two 'primary response' genes, TIS10 and Egr-1, in Balb/c 3T3 cells. Depleting cells of protein kinase C (PKC) by prolonged exposure to 12-O-tetradecanoylphorbol 13-acetate (TPA), blocked v-Src-induced TIS10 expression, but had n...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Qureshi SA,Joseph CK,Rim M,Maroney A,Foster DA

    更新日期:1991-06-01 00:00:00

  • 5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.

    abstract::Observations that genome-wide DNA hypomethylation induces genome instability and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-aza-2'-deoxycytidine (5-Aza-dC). Using primary mouse embryonic fibroblasts harboring a lacZ mutational reporter construct that allows the quantifi...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2012.9

    authors: Maslov AY,Lee M,Gundry M,Gravina S,Strogonova N,Tazearslan C,Bendebury A,Suh Y,Vijg J

    更新日期:2012-12-13 00:00:00

  • Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer.

    abstract::D-type cyclins are important cell cycle regulators that promote cellular proliferation in response to growth factors by inactivation of the retinoblastoma protein (Rb). Cyclin D1 has been shown to be overexpressed in several cancer types and to act as an oncogene in breast cancers. As D-type cyclins are rate limiting ...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1202511

    authors: Russell A,Thompson MA,Hendley J,Trute L,Armes J,Germain D

    更新日期:1999-03-18 00:00:00

  • Rap1A protein interferes with various MAP kinase activating pathways in skeletal myogenic cells.

    abstract::Constitutive expression of the activated Rap1A protein inhibits differentiation of myogenic C2 cells whereas the inactivated Rap1A protein favours cell differentiation and induces late endocytic compartments clustering. Although the role of Rap1A in MAPK activation has been analysed in various cell types, the signalli...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1203984

    authors: Pizon V,Baldacci G

    更新日期:2000-12-07 00:00:00

  • Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.

    abstract::Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cell...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1202608

    authors: Nakamura N,Fujii M,Tsukahara T,Arai M,Ohashi T,Wakao H,Kannagi M,Yamamoto N

    更新日期:1999-04-29 00:00:00

  • Carcinoma of the vulva: HPV and p53 mutations.

    abstract::Recent evidence suggests that squamous cell carcinoma of the vulva may have more than one etiology, with only some tumors associated with human papillomavirus (HPV). Cells infected with HPV produce a viral protein (E6) which binds to and causes rapid degradation of p53, possibly contributing to cellular transformation...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:

    authors: Lee YY,Wilczynski SP,Chumakov A,Chih D,Koeffler HP

    更新日期:1994-06-01 00:00:00

  • Molecular mechanism of cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type I.

    abstract::The trans-activator protein Tax of human T-cell leukemia virus type I (HTLV-I) plays an important role in the development of adult T-cell leukemia through, at least in part, its ability to stimulate cell growth. We previously reported that Tax induced cell cycle progression from G0/G1 phase to S and G2/M phases in hum...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/sj.onc.1204304

    authors: Iwanaga R,Ohtani K,Hayashi T,Nakamura M

    更新日期:2001-04-19 00:00:00

  • Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms.

    abstract::Mutant p53 frequently accumulates in cancer cells and promotes tumor cell invasion, as part of its gain of function. Its accumulation is partially due to enhanced stability, but little is known about how the mRNA levels of mutant p53 can be regulated. Likewise, the impact of cancer therapy on the levels of mutant p53 ...

    journal_title:Oncogene

    pub_type: 杂志文章

    doi:10.1038/onc.2011.72

    authors: Bug M,Dobbelstein M

    更新日期:2011-08-18 00:00:00