DNA: leukemia's secret weapon of bone mass destruction.

Abstract:

:Interaction of tumour cells with their microenvironment impacts on all aspects of cancer, ranging from development through to treatment response. In this issue, Dvorak and colleagues(1) reveal a novel tumour/microenvironment relationship that may drive leukemia pathogenesis. Specifically, they find that leukemic cells secrete chromatin-complexed DNA that, in turn, triggers a variety of harmful effects, including cell death, in neighbouring stromal cells. Through this toxicity, DNA-mediated bone marrow destruction could promote disease progression by allowing leukemic cells to exit the bone marrow into the circulation.

journal_name

Oncogene

journal_title

Oncogene

authors

Tait S

doi

10.1038/onc.2012.639

subject

Has Abstract

pub_date

2013-10-31 00:00:00

pages

5199-200

issue

44

eissn

0950-9232

issn

1476-5594

pii

onc2012639

journal_volume

32

pub_type

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