Abstract:
:Expression level of metastasis-associated protein 1 (MTA1) is closely related to tumor growth and metastasis in various cancers. Although increased expression level of MTA1 was observed in hepatocellular carcinoma (HCC), role of MTA1 complex containing histone deacetylase (HDAC) in hepatitis B virus (HBV)-associated hepatocarcinogenesis has not been studied. Here, we demonstrated that HBx strongly induced the expression of MTA1 and HDAC1 genes at transcription level. MTA1 and HDAC1/2 physically associated with hypoxia-inducible factor-1 alpha (HIF-1 alpha) in vivo in the presence of HBx, which was abolished by knockdown of MTA1 by short interfering RNA (siRNA). HBx induced deacetylation of the oxygen-dependent degradation domain of HIF-1 alpha, which was accompanied with dissociation of prolyl hydroxylases and von Hippel-Lindau tumor suppressor from HIF-1 alpha. These results indicate that HBx-induced deacetylation is important for proteasomal degradation of HIF-1 alpha. Further, we observed that protein levels of MTA1 and HDAC1 were increased in the liver of HBx-transgenic mice. Also, there was a higher expression of HDAC1 in HCC than in the adjacent non-tumorous cirrhotic nodules in 10 out of 12 human HBV-associated HCC specimens. Together, our data indicate a positive cross talk between HBx and the MTA1/HDAC complex in stabilizing HIF-1 alpha, which may play a critical role in angiogenesis and metastasis of HBV-associated HCC.
journal_name
Oncogenejournal_title
Oncogeneauthors
Yoo YG,Na TY,Seo HW,Seong JK,Park CK,Shin YK,Lee MOdoi
10.1038/sj.onc.1211000subject
Has Abstractpub_date
2008-05-29 00:00:00pages
3405-13issue
24eissn
0950-9232issn
1476-5594pii
1211000journal_volume
27pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::The zinc-finger transcription factor Krox24 was analysed for its role in differentiation in P19 embryonal carcinoma cells. Reciprocal dominant negative mutants consisting of Krox24 deleted for a crucial region of the zinc-finger domain (delta Krox24) or of the zinc-finger region alone (delta Krox24Zf) abolished the ac...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202166
更新日期:1998-11-12 00:00:00
abstract::Hox genes encode DNA-binding proteins that are deployed in overlapping domains along various body axes during embryonic development. This sequential activation of Hox genes in temporal and spatial mode, the Hox code, is critical for the proper positioning of segmented structures along those axes, which include the ver...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2010.484
更新日期:2011-01-27 00:00:00
abstract::The simian double strand DNA tumor virus SV40 encodes the 90-kDa multi-functional protein, large T antigen (LT). LT functions by binding to DNA, as well as to many cellular target proteins such as p53 and retinoblastoma protein (pRB). We report here the identification of a cellular heat shock protein, HSP90, as a prev...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203475
更新日期:2000-03-09 00:00:00
abstract::SHP-2 protein tyrosine phosphatase plays an important role in activation of the RAS-dependent signaling. Gain-of-function mutations in the PTPN11 gene, which encodes SHP-2, have been found in the leukemia-prone developmental disorder Noonan syndrome as well as sporadic childhood leukemias, indicating that SHP-2 is a b...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1211019
更新日期:2008-06-05 00:00:00
abstract::Basal type breast cancer is the most aggressive and has mesenchymal features with a high metastatic ability. However, the signaling node that determines the basal type features in breast cancer remains obscure. Here, we report that FYN among SRC family kinases is required for the maintenance of basal type breast cance...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-017-0114-y
更新日期:2018-04-01 00:00:00
abstract::The tumor microenvironment plays a critical role in prostate cancer (PC) development and progression. Inappropriate activation of the stroma potentiates the growth and transformation of epithelial tumor cells. Here, we show that upregulation of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades monoamine...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1217-4
更新日期:2020-04-01 00:00:00
abstract::The c-Myb transcriptional regulator is crucial to the development and functioning of haemopoietic cells, so much so that mouse embryos homozygous for an inactivated c-myb allele die from anaemia at about day 15 of gestation. By analysing c-myb(-/-) chimaeras we show that no mature cells of any lymphoid or myeloid line...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203660
更新日期:2000-07-13 00:00:00
abstract::A variety of factors cooperate to regulate neovessel formation and persistence. Proangiogenic growth factors have remained an area of intense interest due to their capacity to promote endothelial cell (EC) proliferation and to initiate the angiogenic program. These growth factors are associated with increased cell sur...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1207110
更新日期:2003-12-08 00:00:00
abstract::Density-enhanced protein-tyrosine phosphatase-1 (DEP-1 also CD148) is a transmembrane molecule with a single intracellular PTP domain. It has recently been proposed to function as a tumor suppressor. We have previously shown that DEP-1 dephosphorylates the activated platelet-derived growth factor (PDGF) beta-receptor ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206652
更新日期:2003-07-03 00:00:00
abstract::Mutant p53 proteins were shown to exert complex DNA-interactions in vitro, like binding to MAR-DNA, but so far it is unknown whether such interactions also occur in vivo. Therefore we analysed the binding of mutant (mut) p53 (Gly245-->Ser) in Onda 11 glioma cells to cellular DNA in vivo, using p53-specific chromatin i...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203745
更新日期:2000-08-24 00:00:00
abstract::Ras oncogenes (Hras, Kras and Nras) are important drivers of carcinogenesis. However, tumors with Ras mutations often show loss of the corresponding wild-type (WT) allele, suggesting that proto-oncogenic forms of Ras can function as a suppressor of carcinogenesis. In vitro studies also suggest that WT Ras proteins can...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.404
更新日期:2013-08-22 00:00:00
abstract::In order to examine the role of p53 expression on the sensitivity of cells to radiation-induced reproductive failure, we examined the radiosensitivity of a human diploid fibroblast cell strain (AG1521) before and after transfection with the E6 or E6/E7 genes of human papillomavirus 16 (HPV16)3. HPV E6 binds to p53, pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-06-15 00:00:00
abstract::The naked mole rat (nmr) is cancer resistant due to the abundant production of extremely high-molecular-weight hyaluronan (EHMW-HA). However, whether EHMW-HA has similar anti-cancer effects in mice and humans remains to be determined. The present study used breast cancer cells to clarify the effect of EHMW-HA on breas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0719-4
更新日期:2019-05-01 00:00:00
abstract::An integrative functional genomics study of multiple forms of data are vital for discovering molecular drivers of cancer development and progression. Here, we present an integrated genomic strategy utilizing DNA methylation and transcriptome profile data to discover epigenetically regulated genes implicated in cancer ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.176
更新日期:2017-01-05 00:00:00
abstract::MicroRNAs (miRNAs) may function as either oncogenes or tumor suppressors in the malignant progression of different tumor types. MiR-663 was recently reported to be decreased and identified as a tumor suppressor in gastric cancer. We also verified its role in repressing cell proliferation of a gastric cancer cell line....
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.629
更新日期:2012-10-11 00:00:00
abstract::We have isolated a candidate tumor suppressor gene from a 600-kb region on chromosome 8p21.3-p22 that is commonly deleted in sporadic hepatocellular carcinomas (HCC), colorectal cancers (CRC), and non-small cell lung cancers (NSCLC). As this gene encodes a protein of 375 amino acids that bears significant sequence sim...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-03-02 00:00:00
abstract::Gastrin and its precursors promote proliferation in different gastrointestinal cells. Since mature, amidated gastrin (G-17) can induce cyclin D1, we determined whether G-17-mediated induction of cyclin D1 transcription involved Wnt signaling and CRE-binding protein (CREB) pathways. Our studies indicate that G-17 induc...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207454
更新日期:2004-04-29 00:00:00
abstract::eIF4E is essential for translation initiation, but its overexpression causes malignant transformation. Recent work demonstrated that eIF4E/F participates in exposing and locating alternate translation start codons during scanning. Translation initiation of several important protooncogenes and growth-regulators, such a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202890
更新日期:1999-07-29 00:00:00
abstract::Degradation of chromosomal DNA into nucleosome-sized fragments is one of the characteristics of apoptotic cell death. Here, we examined whether caspase-activated DNase (CAD) is responsible for the DNA fragmentation that occurs upon exposure to various apoptotic stimuli. When human Jurkat cells were exposed to etoposid...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202868
更新日期:1999-08-05 00:00:00
abstract::SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes that includes HACS1. HACS1 encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and has...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204698
更新日期:2001-08-30 00:00:00
abstract::Aneuploidy is frequently detected in solid tumors but the mechanisms regulating the generation of aneuploidy and their relevance in cancer initiation remain under debate and are incompletely characterized. Spatial and temporal regulation of integrin traffic is critical for cell migration and cytokinesis. Impaired inte...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.527
更新日期:2012-08-02 00:00:00
abstract::Tuftelin1 (TUFT1), an acidic protein constituent of developing and mineralizing tooth tissues, is regulated by hypoxia and the Hedgehog signaling pathway. We investigated the role of TUFT1 in hepatocellular carcinoma (HCC). qRT-PCR, immunohistochemistry and western blot were employed to evaluate TUFT1 level in HCC. MT...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0505-8
更新日期:2019-02-01 00:00:00
abstract::The BRCA1-associated RING domain protein BARD1 acts with BRCA1 in double-strand break repair and ubiquitination. BARD1 plays a role as mediator of apoptosis by binding to and stabilizing p53, and BARD1-repressed cells are resistant to apoptosis. We therefore investigated the mechanism by which BARD1 induces p53 stabil...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208491
更新日期:2005-05-26 00:00:00
abstract::Tuberin is the protein product of the tuberous sclerosis-2 (TSC2) gene, which is associated with tuberous sclerosis (TSC), a human genetic syndrome characterized by the development of tumors in a variety of tissues. We have previously shown that tuberin is a widely expressed 180 kDa protein which exhibits specific GTP...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-09-05 00:00:00
abstract::Basic helix-loop-helix (bHLH) transcription factors play a pivotal role in the regulation of tumorigenesis, and also in a wide range of other developmental processes in diverse species from yeast to humans. Here we demonstrate for the first time that Ret finger protein (RFP), a member of the TRIM family of proteins in...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208828
更新日期:2005-10-13 00:00:00
abstract::Squamous cell carcinoma (SCC) cells of the head and neck specifically express collagenase-3 (matrix metalloproteinase-13 (MMP-13)), the expression of which correlates with their invasion capacity. Transforming growth factor-beta (TGF-beta) enhances MMP-13 and collagenase-1 (MMP-1) expression and invasion of SCC cells ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209291
更新日期:2006-04-27 00:00:00
abstract::Non-small cell lung cancer (NSCLC) accounts for ∼80% of all lung cancers. Although some advances in lung cancer therapy have been made, patient survival is still quite poor. Two microRNAs, miR-221 and miR-222, upregulated by the MET proto-oncogene, have been already described to enhance cell survival and to induce TNF...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.260
更新日期:2012-02-02 00:00:00
abstract::Using a temperature-sensitive mutant of the p210 BCR-ABL gene, transfected into a growth factor-dependent cell line (BaF3), we show that transient BCR-ABL kinase expression increases single cell and clonogenic resistance to apoptosis arising from genotoxic damage induced by ionizing radiation and VP-16/etoposide. This...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-11-21 00:00:00
abstract::The MT-2 cell-line, which had been established through in vitro cell to cell transmission of human T-cell leukemia virus type I (HTLV-I) among human primary lymphocytes, was shown to possess multiple copies of integrated proviruses, including defective proviral genomes. By analysing a genomic clone, we identified the ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-04-04 00:00:00
abstract::Nuclear-targeted high molecular weight 24 kDa fibroblast growth factor 2 (FGF-2) may induce specific cell functions through intracrine mechanisms. The role of nuclear FGF-2 on the metastatic potential of carcinoma cells was examined by conditional FGF-2 expression, which demonstrated that spontaneous metastasis in nud...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207638
更新日期:2004-06-10 00:00:00