Abstract:
:The function of Bcl-2 family members on the endoplasmic reticulum has received increasing attention in recent years. The endoplasmic reticulum is the major organelle involved in intracellular calcium homeostasis and calcium signaling, including calcium signals that mediate apoptosis induction by anticancer drugs. But currently a controversy exists regarding reported effects of Bcl-2 on the calcium concentration within the lumen of the endoplasmic reticulum. Although several prominent reports indicate that Bcl-2 overexpression is associated with a decrease in luminal calcium, there are a large number of reports indicating that Bcl-2 either does not decrease luminal calcium or actually increases luminal calcium. This review summarizes this vast array of conflicting findings, and analyses potential reasons why different conclusions have been reached by different laboratories. Future directions are emphasized that might bring clarity to this important area of apoptosis biology.
journal_name
Oncogenejournal_title
Oncogeneauthors
Distelhorst CW,Shore GCdoi
10.1038/sj.onc.1207519subject
Has Abstractpub_date
2004-04-12 00:00:00pages
2875-80issue
16eissn
0950-9232issn
1476-5594pii
1207519journal_volume
23pub_type
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