Abstract：
:The understanding of the organisation of cell cycle events is of utmost importance to devise effective therapeutic strategies for cancer. In this article we gather evidences from the literature in support of a system model of the cell cycle, in which a growth-sensitive threshold controls entry into S phase and the sequential activation of cyclin-dependent kinases. The cycle is terminated by an End function, that comprises events from the onset of mitosis to cell division and that may also be modulated by the increase of cell size. This blueprint allows quantitative predictions by computer simulations of steady and transitory states. In fact, we show that the proposed control system applies to budding yeast populations during nutritional shift-up and following hyperactivation of the cAMP signalling pathway. Besides the growth-sensitive control system it is shown to apply to mammalian cells both in the exit from quiescence and in active proliferation. The putative molecular determinants that set the threshold controlling S phase entry are consistently altered in cancer cells. Finally, we discuss an input/output analysis based on the simulated behaviour derived from the blueprint as a new tool to investigate the road to cancer.
journal_name
Oncogenejournal_title
Oncogeneauthors
Alberghina L,Porro D,Cazzador Ldoi
10.1038/sj.onc.1204263subject
Has Abstractpub_date
2001-03-01 00:00:00pages
1128-34issue
9eissn
0950-9232issn
1476-5594journal_volume
20pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:IL-4 and IL-13 are related cytokines which induce both pro- and anti-inflammatory effects depending on the cell type they act upon and the nature of the receptors expressed. The type I receptor complex is composed of the IL-4Ralpha and gammac and only binds IL-4, whereas, in the type II receptor, IL-4Ralpha dimerizes ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204629
更新日期：2001-10-11 00:00:00
abstract：:One of the key events in tumor initiation in mouse skin is mutational activation of the H-ras gene. Papillomas induced by the most carcinogenic environmental polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DB[a,l]P), in SENCAR mouse skin contain a specific H-ras codon 61 (CAA-->CTA) mutation. We describe he...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201853
更新日期：1998-06-18 00:00:00
abstract：:The transforming potential of adenovirus E1A oncogene products derives largely from the formation of complexes with cellular proteins, including the p105Rb tumor suppressor and a related p107 species, p130 and p300 proteins, and cyclin A (p60cycA). Extensive quantitative analyses using E1A deletion mutants identified ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1994-02-01 00:00:00
abstract：:The autosomal dominantly inherited disease tuberous sclerosis (TSC) affects approximately 1 in 6000 individuals and is characterized by the development of tumors, named hamartomas, in different organs. TSC1, encoding hamartin, and TSC2, encoding tuberin are tumor suppressor genes responsible for TSC. Hamartin and tube...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209812
更新日期：2007-01-25 00:00:00
abstract：:The mammalian target of rapamycin (mTOR) is a highly conserved serine-threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling pathway in diverse human cancers, this kinase is a key therapeutic target. Redd1 is a negative regulator of mTOR, mediati...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.102
更新日期：2011-09-01 00:00:00
abstract：:Inflammation can act as a crucial mediator of epithelial-to-mesenchymal transition (EMT). In this study, we show that oncostatin M (OSM) is expressed in an autocrine/paracrine fashion in invasive breast carcinoma. OSM stimulation promotes spontaneous lung metastasis of MCF-7 xenografts in nude mice. A conspicuous epig...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.573
更新日期：2013-11-07 00:00:00
abstract：:The epidermal growth factor receptor (EGFR) is activated by a variety of ligands including EGF and transforming growth factor-alpha (TGFalpha), whereas no ligand for the homologous ErbB2 oncoprotein has yet been identified. Here we use both an ErbB2 phosphoantibody (aPY1222) and an activation-specific EGFR antibody to...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201595
更新日期：1997-10-01 00:00:00
abstract：:Although activating mutations of fibroblast growth factor receptor 3 (FGFR3) are frequent in bladder tumors, little information is available on their specific effects in urothelial cells or the basis for the observed mutation spectrum. We investigated the phenotypic and signaling consequences of three FGFR3 mutations ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2009.280
更新日期：2009-12-03 00:00:00
abstract：:Polymorphisms and somatic mutations in Flap Endonuclease 1 (FEN1), an essential enzyme involved in DNA replication and repair, can lead to functional deficiencies of the FEN1 protein and a predisposition to cancer. We identified a FEN1 germline mutation that changed residue E359 to K in a patient whose family had a hi...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2014.19
更新日期：2015-02-12 00:00:00
abstract：:Genomic imprinting at 11p15 is suggested to play a role in certain pediatric tumors such as Wilms' tumor, based on the findings of selective maternal loss of this chromosomal region. Although the allele loss at 11p15 is also frequent in a number of cancers of adults including lung, breast, and bladder cancers, possibl...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-03-21 00:00:00
abstract：:The proto-oncogene BMI1 and its product, Bmi1, is overexpressed in various types of tumors, particularly in aggressive tumors and tumors resistant to conventional chemotherapy. BMI1/Bmi1 is also crucially involved in cancer-initiating cell maintenance, and is recurrently upregulated in mantle cell lymphoma (MCL), espe...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2013.177
更新日期：2014-04-24 00:00:00
abstract：:Protein kinases are known to undergo phosphorylation to regulate their activity. To determine whether the protein kinase activity of p37v-mos was similarly regulated, we investigated the influence of two well known protein kinases, namely protein kinase C and protein kinase A, on the activity of p37v-mos in vivo. NIH3...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：:Density-enhanced protein-tyrosine phosphatase-1 (DEP-1 also CD148) is a transmembrane molecule with a single intracellular PTP domain. It has recently been proposed to function as a tumor suppressor. We have previously shown that DEP-1 dephosphorylates the activated platelet-derived growth factor (PDGF) beta-receptor ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206652
更新日期：2003-07-03 00:00:00
abstract：:Post-translational acetylation of lysines is most extensively studied in histones, but this modification is also found in many other proteins and is implicated in a wide range of biological processes in both the cell nucleus and the cytoplasm. Like phosphorylation, acetylation patterns and levels are often altered in ...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/onc.2014.453
更新日期：2015-09-17 00:00:00
abstract：:Colony-stimulating factors and other cytokines signal via their cognate receptors to regulate hematopoiesis. In many developmental systems, inductive signalling determines cell fate and, by analogy with this, it has been postulated that cytokines, signalling via their cognate receptors, may play an instructive role in...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1210756
更新日期：2007-10-15 00:00:00
abstract：:The carboxyl terminus of c-Myb contains a negative regulatory domain that is absent in the v-Myb oncoprotein, but conserved among all the known Myb proteins of animals. This domain inhibits transcriptional activation by c-Myb in animal cells, but not in budding yeast, suggesting that additional protein(s) present in a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204048
更新日期：2001-01-04 00:00:00
abstract：:MEN 2B (multiple endocrine neoplasia type 2B) is an autosomal dominant cancer syndrome caused by an oncogenic form of the receptor tyrosine kinase REarranged during transfection (RET). The MEN 2B syndrome is associated with an abnormal autophosphorylation of the mutated receptor even without ligand-stimulation. Here, ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210591
更新日期：2007-12-13 00:00:00
abstract：:Survivin is a member of the inhibitor of apoptosis (IAP) gene family that has attracted attention from several viewpoints of basic and translational research. Its cell cycle-regulated expression at mitosis and association with the mitotic apparatus have been of interest to cell biologists studying faithful segregation...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1207113
更新日期：2003-11-24 00:00:00
abstract：:The p16 gene (MTS1 or CDK4I) encoding an inhibitor of cyclin-dependent kinase 4 (cdk4), has been reported to be deleted in various tumor cell lines, including lines derived from leukemic cells. The reported frequency of p16 gene loss is much higher in established cell lines than in primary tumor specimens. We investig...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-05-16 00:00:00
abstract：:SCC-S2/GG2-1/NDED is a recently discovered antiapoptotic molecule induced by the activation of the transcription factor NF-kappaB. Here we have examined a role of SCC-S2 in cell growth regulation in vitro and in vivo. Western blotting using an antipeptide antibody revealed endogenous SCC-S2 as a approximately 21 kDa c...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207123
更新日期：2004-01-15 00:00:00
abstract：:We have characterized a chromosomal translocation in a cell line (SU-DUL5) established from a patient with lymphoblastic lymphoma in which the c-myc gene on chromosome 8 was juxtaposed to a t(14;18). Cytogenetic analysis of this cell line showed 14q+, 18q-, and 8p+q+ marker chromosomes in the absence of t(14;18). Geno...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:The cysteine protease cathepsin B (CTSB) is frequently overexpressed in human breast cancer and correlated with a poor prognosis. Genetic deficiency or pharmacological inhibition of CTSB attenuates tumor growth, invasion and metastasis in mouse models of human cancers. CTSB is expressed in both cancer cells and cells ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2013.395
更新日期：2014-09-04 00:00:00
abstract：:BPV-4 E5 inhibits transcription of the bovine MHC class I heavy chain (HC) gene, increases degradation of HC and downregulates surface expression of MHC class I by retaining the complex in the Golgi apparatus (GA). Here we report that transcription inhibition can be alleviated by interferon treatment and the degradati...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209245
更新日期：2006-04-06 00:00:00
abstract：:MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression post-transcriptionally, are involved in many complex cellular processes. Several miRNAs are differentially expressed in hematopoietic tissues and play important roles in normal differentiation, but, when aberrantly regulated, contribute to the abn...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.398
更新日期：2013-08-01 00:00:00
abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are extracellular lipid mediators that signal through distinct members of the Edg/LP subfamily of G protein-coupled receptors (GPCRs). LPA and S1P receptors are expressed in almost every cell type and can couple to multiple G proteins (G(i), G(q) and G(12/1...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1204187
更新日期：2001-03-26 00:00:00
abstract：:We have analysed the immortalizing function of Human Papillomavirus type 16 (HPV16) in a rat cell line which has been derived by immortalizing rat embryo fibroblasts with a thermolabile SV40 large T antigen and is temperature sensitive for growth. Introduction of wild type SV40 large T antigen or the adenovirus E1a 12...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：:The temperature-sensitive mutant tsp53val135 accumulates in the cytoplasm of cells kept at the non-permissive temperature (39 degrees C), but is rapidly transported into the cell nucleus at the permissive temperature (30 degrees C). tsp53 thus may serve as a model for analysing cellular parameters influencing the subc...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202155
更新日期：1998-07-02 00:00:00
abstract：:Chromosomal deletions are a common feature of epithelial tumours and when further defined by homozygous deletions, are often the location of tumour suppressor genes. Deletions within the short arm of chromosome 3 occur very frequently in human carcinomas: a minimal region of loss at 3p21.3 (the Luca) region has been d...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205530
更新日期：2002-07-04 00:00:00
abstract：:Previous work by others has revealed homology between the rel oncogene and the transcription factor NF-kappa B. Further, in vitro-translated v-rel protein and c-rel protein are able to bind to an oligonucleotide containing the kappa B binding site. Unlike the in vitro-translated product, cellular Rel protein exists in...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:The RBTN1 and RBTN2 genes are activated by distinct translocations involving chromosome 11 in some T cell acute leukaemias. The RBTN proteins belong to the LIM family which comprises proteins with one, two or three cysteine-rich LIM domains, sometimes together with homeodomains or protein kinase domains. The RBTN1 and...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-04-06 00:00:00
