Abstract:
:BPV-4 E5 inhibits transcription of the bovine MHC class I heavy chain (HC) gene, increases degradation of HC and downregulates surface expression of MHC class I by retaining the complex in the Golgi apparatus (GA). Here we report that transcription inhibition can be alleviated by interferon treatment and the degradation of HC can be reversed by treatment with inhibitors of proteasomes and lysosomes. However, the inhibition of transport of MHC class I to the cell surface is irreversible. We show that E5 is capable of physically interacting with HC. Together with the inhibition of the vacuolar ATPase (due to the interaction between E5 and 16k subunit c), the interaction between E5 and HC is likely to be responsible for retention of MHC class I in the GA. C-terminus deletion mutants of E5 are incapable of either downregulating surface MHC class I or interacting with HC, establishing that the C-terminus domain of E5 is important in the inhibition of MHC class I.
journal_name
Oncogenejournal_title
Oncogeneauthors
Marchetti B,Ashrafi GH,Dornan ES,Araibi EH,Ellis SA,Campo MSdoi
10.1038/sj.onc.1209245subject
Has Abstractpub_date
2006-04-06 00:00:00pages
2254-63issue
15eissn
0950-9232issn
1476-5594pii
1209245journal_volume
25pub_type
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