Abstract:
:Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects occurring in both the irradiated and nonirradiated cells in the population. This phenomenon, termed the 'bystander response', has been shown to occur both in vitro and in vivo and has been postulated to impact both the estimation of risks of exposure to low doses/low fluences of ionizing radiation and radiotherapy. Several mechanisms involving secreted soluble factors, oxidative metabolism and gap-junction intercellular communication have been proposed to regulate the radiation-induced bystander effect. Our current knowledge of the biochemical and molecular events involved in the latter two processes is reviewed in this article.
journal_name
Oncogenejournal_title
Oncogeneauthors
Azzam EI,de Toledo SM,Little JBdoi
10.1038/sj.onc.1206961subject
Has Abstractpub_date
2003-10-13 00:00:00pages
7050-7issue
45eissn
0950-9232issn
1476-5594pii
1206961journal_volume
22pub_type
杂志文章,评审相关文献
ONCOGENE文献大全abstract::The transcriptional activity of the androgen receptor (AR) is regulated by both ligand binding and post-translational modifications, including acetylation and small ubiquitin-like modifier (SUMO)ylation. Histone deacetylases (HDACs) are known to catalyze the removal of acetyl groups from both histones and non-histone ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.600
更新日期:2011-05-12 00:00:00
abstract::Ras oncogenes (Hras, Kras and Nras) are important drivers of carcinogenesis. However, tumors with Ras mutations often show loss of the corresponding wild-type (WT) allele, suggesting that proto-oncogenic forms of Ras can function as a suppressor of carcinogenesis. In vitro studies also suggest that WT Ras proteins can...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.404
更新日期:2013-08-22 00:00:00
abstract::Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the homeostasis of a healthy network of functioning mitochondria and prevents excessive production of cytotoxic reactive oxygen species from damaged mitochondria. The mitochondrially targeted PTEN-induced kinase-1 (PINK1) and the E3 ub...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.302
更新日期:2017-03-01 00:00:00
abstract::The oncoprotein c-Myc contains two dimerization motifs- the helix-loop-helix (HLH) and the leucine zipper (LZ) - through which c-Myc specifically dimerizes with Max. We substituted regions of the c-Myc HLH and LZ motifs with the corresponding regions of structurally related proteins that do not interact with Max. Spec...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::A cloned line of S + L- mink lung cells (A clone), which exhibited a flat morphology, was superinfected with a novel dual-tropic virus (E1BX-MuLV) showing a broad host range and a B-tropism. These cells gave rise to transformed cells with two phenotypes: those which were still anchorage-dependent (AD), and those which...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract::The BCL6 gene, mapped at the chromosomal band 3q27, encodes a POZ/Zinc finger transcription repressor protein. It is frequently activated in Non-Hodgkin's lymphomas (NHL) by translocations with breakpoints clustering in the 5' major breakpoint region (MBR) as well as by mutations in the same region. The translocations...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202098
更新日期:1998-10-01 00:00:00
abstract::Oncogene-induced senescence (OIS) is an intrinsic tumor suppression mechanism that requires the p53 and RB pathways and post-translational activation of C/EBPβ through the RAS-ERK cascade. We previously reported that in transformed/proliferating cells, C/EBPβ activation is inhibited by G/U-rich elements (GREs) in its ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0190-7
更新日期:2018-06-01 00:00:00
abstract::Mouse embryonal carcinoma (EC) cells of the P19 line can be induced to differentiate into neurons, astrocytes and fibroblasts by exposure to retinoic acid (RA), whereas treatment of the EC cells with dimethyl sulfoxide (DMSO) leads to differentiation into mesodermal tissues, including cardiac and skeletal muscle. In R...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1988-11-01 00:00:00
abstract::The growth and dissemination of tumors rely on an altered vascular network, which supports their survival and expansion and provides accessibility to the vasculature and a route of transport for metastasizing tumor cells. The remodeling of vascular structures through generation of new vessels (for example, via tumor a...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.304
更新日期:2014-07-03 00:00:00
abstract::Recent genetic investigations have established that RhoB gain-of-function is sufficient to mediate the antitransforming effects of farnesyltransferase inhibitors (FTIs) in H-Ras-transformed fibroblast systems. In this study, we addressed the breadth and mechanism of RhoB action in epithelial cells transformed by oncop...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206181
更新日期:2003-02-27 00:00:00
abstract::The matricellular protein CCN5/WISP-2 represents a promising target in triple-negative breast cancer (TNBC) because treatment or induced activation of CCN5 in TNBC cells promotes cell growth arrest at the G0/G1 phase, reduces cell proliferation and delays tumor growth in the xenograft model. Our studies found that the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.250
更新日期:2015-06-11 00:00:00
abstract::The nucleolus is one of the functional nuclear compartments in which the ribosome biogenesis takes place. Proteomic analysis revealed a large number of nucleolar proteins that are involved in diverse cellular processes, including biogenesis of ribonucleoprotein particles, stress responses, cell proliferation and cell ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.473
更新日期:2010-03-25 00:00:00
abstract::Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however,...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0624-2
更新日期:2019-04-01 00:00:00
abstract::Resistance and relapse are still primary causes that result in poor effectiveness of chemotherapy in malignant gliomas. Therefore, development of new therapeutic strategies requires the identification of key molecular pathways regulating chemoresistance. We previously found that abnormal high expression of the Tie2 re...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.103
更新日期:2009-06-18 00:00:00
abstract::In this study, we show that the ETS transcription factor ER81 directly binds to and activates the promoter of the matrix metalloproteinase gene, MMP-1. Further, the oncoprotein HER2/Neu synergizes with ER81 to stimulate MMP-1 transcription. The activation of ER81 by HER2/Neu is mediated by MAP kinases, which phosphory...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204820
更新日期:2001-09-27 00:00:00
abstract::The p53 gene has been implicated as a tumor suppressor gene with mutations found in common human cancers. We examined 51 early stage, primary, resected non-small cell lung cancer specimens using an RNAase protection assay and cDNA sequencing. Mutations changing the p53 coding sequence were found in 23/51 (45%) tumor s...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH+ subpopulations, decreases stemness-re...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.368
更新日期:2018-02-22 00:00:00
abstract::A hallmark of plasma cells is the expression of syndecan-1, which has major functions in epithelial cells, in particular as the coreceptor of heparin-binding growth factors. We previously found that heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a growth factor for malignant plasma cells. As am...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208536
更新日期:2005-05-12 00:00:00
abstract::The breast cancer susceptibility gene 1 (BRCA1) is mutated in approximately 50% of hereditary breast cancers, and its expression is decreased in 30-40% of sporadic breast cancers, suggesting a general role in breast cancer development. BRCA1 physically and functionally interacts with estrogen receptor-alpha (ERalpha) ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.405
更新日期:2009-01-29 00:00:00
abstract::The Rel/NF-kappaB transcription factors regulate the expression of many genes. The activity of RelA, a member of the Rel/NF-kappaB transcription factor family, is constitutively activated in the majority of pancreatic adenocarcinomas and cell lines. We report that the urokinase-type plasminogen activator (uPA), one of...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202833
更新日期:1999-08-12 00:00:00
abstract::T-cell antigen receptor stimulation results in phosphorylation of the SH2 containing Shc proteins and recruitment of the Grb2/mSos complex suggesting that Shc proteins are involved in transducing T-cell activating signals to Ras. We have measured the effects of the isolated Shc-SH2 domain and the dominant negative Ras...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-03-16 00:00:00
abstract::Fanconi anemia is a hereditary cancer susceptibility disorder characterized at the cellular level by spontaneous chromosomal instability and specific hypersensitivity to DNA cross-linking agents such as mitomycin C. This phenotype suggests a possible role for the Fanconi anemia proteins in the repair of DNA lesions in...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205656
更新日期:2002-07-25 00:00:00
abstract::Alu sequences are the most abundant short interspersed repeated elements in the human genome. Here we show that in a cell culture model of colorectal cancer (CRC) progression, we observe accumulation of Alu RNA that is associated with reduced DICER1 levels. Alu RNA induces epithelial-to-mesenchymal transition (EMT) by...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.369
更新日期:2018-02-01 00:00:00
abstract::P63, a p53 family member, is expressed as TA and ΔN isoforms. Interestingly, both TAp63 and ΔNp63 are transcription factors, and regulate both common and distinct sets of target genes. p63 is required for survival of some epithelial cell lineages, and lack of p63 leads to loss of epidermis and other epithelia in human...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.101
更新日期:2014-03-20 00:00:00
abstract::The release of cytochrome c from the intermembrane space of mitochondria into the cytosol is one of the critical events in apoptotic cell death. In the present study, it is shown that release of cytochrome c and apoptosis induced by tumor necrosis factor alpha (TNF) in HeLa cells can be inhibited by (i) overexpression...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206053
更新日期:2002-11-21 00:00:00
abstract::Arg and c-Abl represent the mammalian member of the Abelson family of nonreceptor protein tyrosine kinases. The two proteins are composed of SH2, SH3, kinase and C-terminal domains. To examine Arg structure-function relationships we analysed a Gag-Arg fusion protein, analogous to the oncogenic Gag-Abl fusion protein o...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract::We have previously reported the isolation of several temperature-sensitive (ts) mutants of F9 cells. Further investigations showed that some mutants were induced to differentiate at non-permissive temperature of cell growth, accompanied by changes in the expression of various genes, whereas others were not. During the...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::Treatment of mice with the carcinogen azoxymethane (AOM) induces a number of lesions in the colon, including hyperplastic lesions, as well adenomas and carcinomas in situ. Inbred strains of mice show different responses to AOM-induced carcinogenesis. A/J mice are highly susceptible and develop a greater number of hype...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.369
更新日期:2010-02-04 00:00:00
abstract::Mxi1 is a basic region helix-loop-helix leucine zipper (bHLH/LZ) protein that, in association with Max, antagonizes Myc oncogenic activities. A possible mechanistic basis for Mxi1-mediated repression was provided by the recent demonstration that the repressive potential of Mxi1 correlates with its ability to physicall...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-03-07 00:00:00
abstract::Oncogenic RAS promotes production of reactive oxygen species (ROS), which mediate pro-malignant signaling but can also trigger DNA damage-induced tumor suppression. Thus RAS-driven tumor cells require redox-protective mechanisms to mitigate the damaging aspects of ROS. Here, we show that MutT Homolog 1 (MTH1), the mam...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.195
更新日期:2015-05-14 00:00:00