Abstract:
:We have previously reported the isolation of several temperature-sensitive (ts) mutants of F9 cells. Further investigations showed that some mutants were induced to differentiate at non-permissive temperature of cell growth, accompanied by changes in the expression of various genes, whereas others were not. During the differentiation induced by shifting up to the non-permissive temperature, a rapid and transient decrease in both c-myc and p53 mRNA levels and rapid induction of c-jun mRNA were observed. These changes were specific in differentiation-inducible mutants and were not observed in a non-inducible mutant. In both types of mutants, the level of c-myc mRNA decreased in association with growth retardation at the non-permissive temperature. The p53 mRNA, however, showed specific increase in the differentiation-inducible ts mutants. These observations suggest distinct roles for p53 and c-myc from proliferation to differentiation in teratocarcinoma stem cells.
journal_name
Oncogenejournal_title
Oncogeneauthors
Kosaka M,Iwai SA,Nishina Y,Sumi T,Nishimune Ysubject
Has Abstractpub_date
1992-12-01 00:00:00pages
2455-60issue
12eissn
0950-9232issn
1476-5594journal_volume
7pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Members of the Wnt family induce mouse mammary tumors and partially transform mammary epithelial cells in culture. However, their mechanism of transformation remains to be elucidated. In NIH3T3 mouse embryo fibroblasts, a standard transformation model, Wnt-1 and Wnt-2 were shown to induce altered properties including ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201797
更新日期:1998-05-28 00:00:00
abstract::The phosphatase Cdc25A was shown to be a target of the transcription factor c-Myc. Myc-induced apoptosis appeared dependent on Cdc25A expression and Cdc25A over-expression could substitute for Myc-triggered apoptosis. These findings suggested that an important downstream component of Myc-mediated apoptosis was identif...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204499
更新日期:2001-07-27 00:00:00
abstract::Murine radiation-induced acute myeloid leukaemia (AML) is characterized by loss of one copy of chromosome 2. Previously, we positioned the critical haematopoietic-specific transcription factor PU.1 within a minimally deleted region. We now report a high frequency (>65%) of missense mutation at codon 235 in the DNA-bin...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208422
更新日期:2005-05-19 00:00:00
abstract::Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human cancers. It has become increasingly clear that the resulting mutant p53 proteins do not represent only the mere loss of wild-type p53 tumor s...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210296
更新日期:2007-04-02 00:00:00
abstract::The RASSF8 gene, which maps close to the KRAS2 gene, contains a RAS-associated domain and encodes a protein that is evolutionarily conserved from fish to humans. Analysis of the RASSF8 transcript revealed a complex expression pattern of 5'-UTR mRNA isoforms in normal lung and in lung adenocarcinomas (ADCAs), with no a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209422
更新日期:2006-06-29 00:00:00
abstract::The balance of activities between the proto-oncogene phosphoinositide 3-kinase (PI3K) and the tumour suppressor gene PTEN has been shown to affect cellular growth and proliferation, as well as tumorigenesis. Previously, PTEN expression in the PTEN-null Jurkat T cell leukaemia line was shown to cause reduced proliferat...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206872
更新日期:2003-11-06 00:00:00
abstract::Prostate cancer is the most common malignancy of elderly men in the United States. Since there is no curative treatment for advanced prostate cancer, exploration of novel modalities of treatment is essential. Telomerase, a ribonucleoprotein, is detected in the vast majority of prostate cancer, but not in normal or ben...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203538
更新日期:2000-04-27 00:00:00
abstract::Loss of heterozygosity on chromosome 10p was observed frequently in human prostate cancers. Studies have demonstrated that the introduction of the short arm of human chromosome 10 into a human prostate cancer cell line, PPC-1, by microcell-mediated chromosome transfer (MMCT), suppressed the malignant phenotype, sugges...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204079
更新日期:2001-01-18 00:00:00
abstract::Receptor tyrosine kinases (RTKs) control proliferation and differentiation through their ability to bind and/or phosphorylate intracellular substrates. The repertoire of substrates recruited by different RTK is largely overlapping. It is not clear, therefore, how a cell distinguishes among signals originating from dif...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-09-21 00:00:00
abstract::Mantle cell lymphoma (MCL) is a B-cell lymphoma characterized by overexpression of cyclin D1 due to the t(11;14) chromosomal translocation. While expression of cyclin D1 correlates with MCL development, expression of wild-type (WT) cyclin D1 transgene in murine lymphocytes is unable to drive B-cell lymphoma. As cyclin...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209147
更新日期:2006-02-16 00:00:00
abstract::Cell migration is an integral component of metastatic disease. The ability of cells to transit between mesenchymal and amoeboid modes of migration has complicated the development of successful therapies designed to target cell migration as a means of inhibiting metastasis. Therefore, investigations of the mechanisms t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.516
更新日期:2011-03-10 00:00:00
abstract::Amplification of HER-2 oncogene was analysed in DNAs obtained from 291 primary human mammary carcinomas. 52/291 (18%) were found to contain amplified HER-2 oncogene. Moderate amplification (2- to 5-fold) was noted in 36/291 (12%). Thirteen tumors (4.5%) had a copy number of 5 to 10. A 10- to 20-fold and greater than 2...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Activator protein one (AP1) (jun/fos) factors comprise a family of transcriptional regulators (c-jun, junB, junD, c-fos, FosB, Fra-1 and Fra-2) that are key controllers of epidermal keratinocyte survival and differentiation, and are important drivers of cancer development. Understanding the role of these factors in ep...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.315
更新日期:2010-11-04 00:00:00
abstract::Mouse Developmental Kinase 1 (MDK1) is a receptor tyrosine kinase of the eck/eph subfamily expressed in a variety of tissues during early mouse embryogenesis. To obtain further insight into the function of MDK1, we determined identity and localisation of its physiological ligand(s). Staining whole embryos with fusion ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200800
更新日期:1997-01-09 00:00:00
abstract::Genetic amplification at chromosome 8p23.1 has been reported in some solid tumors. Translocation of 8p23.1 has also been reported in hematological malignancies and head and neck squamous cell cancer. In an attempt to clarify whether this translocation is implicated in lymphomagenesis, we performed FISH analysis of the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207352
更新日期:2004-04-01 00:00:00
abstract::Damage induced in the DNA after exposure of cells to ionizing radiation activates checkpoint pathways that inhibit progression of cells through the G1 and G2 phases and induce a transient delay in the progression through S phase. Checkpoints together with repair and apoptosis are integrated in a circuitry that determi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206682
更新日期:2003-09-01 00:00:00
abstract::Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positioning of chromosomes within the nuclear three-dimensional space involves interaction...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0723-8
更新日期:2019-05-01 00:00:00
abstract::The oncoprotein Qin is a member of the winged helix family of transcriptional regulators. The region C-terminal to its winged helix DNA-binding domain is required for transformation of chicken embryo fibroblasts. We isolated the corepressor TLE1 as a binding partner for Qin in a yeast two-hybrid screen and localized t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206308
更新日期:2003-03-27 00:00:00
abstract::Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). By quantitative real-time polymerase chain reaction array, we found that one potential TSG, angiopoietin-like 4 (ANGPTL4), was expressed at very low levels in all bladder cancer cell ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.375
更新日期:2018-02-01 00:00:00
abstract::Oxygen is the ultimate source of oxidizing power for disulfide bond formation, suggesting that under limiting oxygen proper protein folding might be compromised. We show that secretion of vascular endothelial growth factor (VEGF), a protein with multiple disulfide bonds, was indeed impeded under hypoxia and was partia...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208325
更新日期:2005-02-03 00:00:00
abstract::Gastrin and its precursors promote proliferation in different gastrointestinal cells. Since mature, amidated gastrin (G-17) can induce cyclin D1, we determined whether G-17-mediated induction of cyclin D1 transcription involved Wnt signaling and CRE-binding protein (CREB) pathways. Our studies indicate that G-17 induc...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207454
更新日期:2004-04-29 00:00:00
abstract::The anti-p185(her2/neu) peptidomimetic (AHNP) is a small exo-cyclic peptide derived from the anti-p185(her2/neu) rhumAb 4D5 (h4D5). AHNP mimics many but not all of the antitumor characteristics exhibited by h4D5. However, the pharmacokinetic profiles of AHNP are less than optimal for therapeutic or diagnostic purposes...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209745
更新日期:2006-12-14 00:00:00
abstract::The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins, p16(INK4a) and p14(ARF), which are frequently inactivated in human cancer. Whereas p16(INK4a) acts through engagement of the Rb-cdk4/6-cyclin D pathway, both the pro-apoptotic and cell cycle-regulatory functions of p14(ARF) were s...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205458
更新日期:2002-05-09 00:00:00
abstract::Resistance to anti-HER2 (human epithelial growth factor receptor 2) trastuzumab therapy occurs commonly in HER2-positive breast cancer and involves overactivation of HER2 and/or AKT1. Using the model of trastuzumab-sensitive or trastuzumab-resistant HER2-positive cells with wild-type PTEN, negative regulator of AKT1, ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.422
更新日期:2010-03-04 00:00:00
abstract::Tat protein is an early nonstructural protein necessary for virus replication, which is secreted by infected cells and taken up by uninfected cells. Extensive evidence indicates that Tat may be a cofactor in the development of AIDS-related neoplasms. The molecular mechanism underlying Tat's oncogenic activity may incl...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206637
更新日期:2003-09-18 00:00:00
abstract::SAP-1 (stomach cancer-associated protein tyrosine phosphatase-1) is a transmembrane-type protein tyrosine phosphatase that has been implicated as a negative regulator of integrin-mediated signaling. The potential role of this enzyme in hepatocarcinogenesis has now been investigated by examining its expression in 32 su...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206588
更新日期:2003-07-24 00:00:00
abstract::Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the homeostasis of a healthy network of functioning mitochondria and prevents excessive production of cytotoxic reactive oxygen species from damaged mitochondria. The mitochondrially targeted PTEN-induced kinase-1 (PINK1) and the E3 ub...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.302
更新日期:2017-03-01 00:00:00
abstract::The human ETS2 gene is a member of the ets gene family (ETS1, ETS2, ERG, ELK1 and ELK2) with amino acid similarity to the v-ets oncogene of the avian leukemia virus, E26. The ETS2 gene is composed of 10 exons, nine of which contribute to the open reading frame encoding 469 amino acids. The ETS2 gene directs the synthe...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::Phosphorylation of linker histone H1(S)-3 (previously named H1b) and core histone H3 is elevated in mouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein kinase (MAPK) kinase (MEK). H1(S)-3 phosphorylation is the only histone modification known to be dependent upon transcripti...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206029
更新日期:2002-12-05 00:00:00
abstract::Induction of interstrand crosslinks (ICLs) in chromosomal DNA is considered a major reason for the antiproliferative effect of psoralen plus ultraviolet A (PUVA). It is unclear as to whether PUVA-induced cell cycle arrest is caused by ICLs mechanically stalling replication forks or by triggering cell cycle checkpoints...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206613
更新日期:2003-09-18 00:00:00