Abstract:
:Genetic amplification at chromosome 8p23.1 has been reported in some solid tumors. Translocation of 8p23.1 has also been reported in hematological malignancies and head and neck squamous cell cancer. In an attempt to clarify whether this translocation is implicated in lymphomagenesis, we performed FISH analysis of the immunoblastic B-cell lymphoma cell line OCI-LY8, which has chromosome translocation at 8p23.1, with various BAC clones. We found split signals on BAC, RP11-18L2 where the MASL1 gene is located. This translocation was found to produce a chimeric transcript of MASL1 exon 1 with a cryptic exon from the genome region at 14q21. Our study indicates that MASL1 is not only a target gene for genomic amplification but also for chromosomal translocation. Since tumorigenic activity of the MASL1 has not been proven, its in vitro transforming activity was studied and in vivo nude mice assay were performed. Although no in vitro transforming activity was detected by focus formation, the in vivo tumorigenesis assay with nude mice showed that both MASL1 and chimeric MASL1 possess tumorigenic activity. This suggests that MASL1 is an important oncogene not only for solid tumors but also for hematologic malignancies.
journal_name
Oncogenejournal_title
Oncogeneauthors
Tagawa H,Karnan S,Kasugai Y,Tuzuki S,Suzuki R,Hosokawa Y,Seto Mdoi
10.1038/sj.onc.1207352subject
Has Abstractpub_date
2004-04-01 00:00:00pages
2576-81issue
14eissn
0950-9232issn
1476-5594pii
1207352journal_volume
23pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::EBP1 was identified as a protein that interacts with the ErbB-3 receptor and possibly contributes to transducing growth regulatory signals. The existence of EBP1 homologs across species from simple eukaryotes to humans and its wide tissue expression pattern suggest that EBP1 acts as a general signaling molecule. We pr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207579
更新日期:2004-05-27 00:00:00
abstract::Mitochondrial membrane permeabilization is a critical event in the process leading to physiological or chemotherapy-induced apoptosis. This permeabilization event is at least in part under the control of the permeability transition pore complex (PTPC), which interacts with oncoproteins from the Bcl-2 family as well as...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203299
更新日期:2000-01-13 00:00:00
abstract::Basal cell carcinoma (BCC) is one of the most common skin neoplasms in humans and is usually characterized by local aggressiveness with little metastatic potential, although deep invasion, recurrence, and regional and distant metastases may occur. Here, we studied the mechanism of BCC invasion. We found that human BCC...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210040
更新日期:2007-04-12 00:00:00
abstract::p53 is a multifunctional protein that has been shown to inhibit the growth of transformed cells, arrest the cell cycle of normal cells, regulate gene transcription and influence cellular differentiation, apoptosis and senescence. This study was undertaken to determine if the expression of p53 in keratinocytes varied d...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Intraductal papillary mucinous neoplasm (IPMN), the most common pancreatic cystic neoplasm, is known to progress to invasive ductal adenocarcinoma. IPMNs commonly harbor activating somatic mutations in GNAS and KRAS, primarily GNAS(R201H) and KRAS(G12D). GNAS encodes the stimulatory G-protein α subunit (Gsα) that medi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.294
更新日期:2016-05-05 00:00:00
abstract::In breast cancer (BC) patients, local recurrences often arise in proximity of the surgical scar, suggesting that response to surgery may have a causative role. Radiotherapy (RT) after lumpectomy significantly reduces the risk of recurrence. We investigated the direct effects of surgery and of RT delivered intraoperati...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.23
更新日期:2016-09-15 00:00:00
abstract::The protein kinase encoded by the ataxia telangiectasia and Rad3-related (ATR) gene is activated by DNA-damaging agents that are frequently used as anticancer therapeutics. Inhibition of ATR expression in cultured cancer cells has been demonstrated to increase sensitivity to chemotherapeutic drugs, including the DNA-c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.624
更新日期:2011-06-02 00:00:00
abstract::Chronic infection by hepatitis C virus (HCV) is a major risk factor for the onset and development of hepatocellular carcinoma (HCC), although the underlying mechanisms are unclear. The c-Myc oncogene contributes to the genesis of many types of cancers, including HCC, partly via the induction of genetic damage and the ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.484
更新日期:2013-09-26 00:00:00
abstract::Antioxidant response element (ARE)-mediated expression and coordinated induction of genes encoding detoxifying enzymes is one mechanism of critical importance to cellular protection against oxidative stress. In the present report, we demonstrate that nuclear transcription factors Nrf2 and Nrf1 associate with Jun (c-Ju...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202237
更新日期:1998-12-17 00:00:00
abstract::TNFα is a pleiotropic cytokine which fuels tumor cell growth, invasion, and metastasis in some malignancies, while in others it induces cytotoxic cell death. However, the molecular mechanism by which TNFα exerts its diverse effects on breast cancer subtypes remains elusive. Using in vitro assays and mouse xenografts, ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0472-0
更新日期:2019-01-01 00:00:00
abstract::Although established cell lines can be transformed with oncogenic ras, primary epithelial cells cannot, but require the coexpression of an immortalizing oncogene, such as the E1A region of adenovirus. We have previously shown that immortalization of primary epithelial cells by E1A 12S requires the expression of five r...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-12-19 00:00:00
abstract::The current model for colorectal tumorigenesis defines four specific mutations (activation of a ras proto-oncogene and inactivation of the APC, p53 and DCC tumor-suppressor genes) that accumulate in a colonic epithelial cell as it progresses towards a carcinoma. However, further mutations must be needed for progressio...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract::The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Although Stat5 is the best-characterized mediator of PRL signals, PRL also activates multiple other signals, whose roles in normal and pathologic pro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210454
更新日期:2007-09-20 00:00:00
abstract::Glioblastoma (GBM) is a highly malignant glioma, which has the propensity to infiltrate throughout the brain in contrast to pilocytic astrocytoma (PA) of the posterior fossa, which does not spread and can be cured by surgery. We have used Suppression Subtractive Hybridization to define markers that better delineate th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209305
更新日期:2006-05-04 00:00:00
abstract::Ubiquitin-conjugation targets numerous cellular regulators for proteasome-mediated degradation. Thus, the identification of ubiquitin ligases and their physiological substrates is crucially important, especially for those cases in which aberrant levels of regulatory proteins (e.g., beta-catenin, p27) result from a der...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202653
更新日期:1999-01-28 00:00:00
abstract::Inactivation of the tumor suppressor NF2/merlin underlies neurofibromatosis type 2 (NF2) and some sporadic tumors. Previous studies have established that merlin mediates contact inhibition of proliferation; however, the exact mechanisms remain obscure and multiple pathways have been implicated. We have previously repo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0883-6
更新日期:2019-09-01 00:00:00
abstract::Small cell lung cancer (SCLC) invades locally and metastasizes distantly extremely early when compared with nonsmall cell lung cancer (NSCLC). The underlying molecular mechanisms, however, have not been elucidated. Accumulating evidence suggests that downregulation of several members of tetraspanins is associated with...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206106
更新日期:2003-02-06 00:00:00
abstract::A hallmark of human cancer is heterogeneity, reflecting the complex series of changes resulting in the activation of oncogenes coupled with inactivation of tumor suppressor genes. Breast cancer is no exception and indeed, many studies have revealed considerable complexity and heterogeneity in the population of primary...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.433
更新日期:2012-05-17 00:00:00
abstract::Aneuploidy is frequently detected in solid tumors but the mechanisms regulating the generation of aneuploidy and their relevance in cancer initiation remain under debate and are incompletely characterized. Spatial and temporal regulation of integrin traffic is critical for cell migration and cytokinesis. Impaired inte...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.527
更新日期:2012-08-02 00:00:00
abstract::A33 antigen is a membrane-bound protein that is expressed only in intestinal epithelium and in most human colon cancers. Thus, A33 antigen has been explored as a potential therapeutic target for the treatment of colon cancers. However, little is known about the mechanism responsible for the tissue-specific pattern of ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206508
更新日期:2003-07-10 00:00:00
abstract::A large body of physiological evidence shows that either upregulation or downregulation of intracellular c-Myc activity has profound consequences on cell cycle progression. Recent work suggests that c-Myc may stimulate the activity of cyclin E/cyclin-dependent kinase 2 (Cdk2) complexes and antagonize the action of the...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1202749
更新日期:1999-05-13 00:00:00
abstract::Recent studies have revealed that Ras can associate physically with Raf. In the present study, we tested 34 mutants of Ha-Ras carrying substitution(s) in the region of residues 23-71 for their ability to associate with Raf-1. Mouse Ba/F3 cell lysates were incubated with each mutant Ras protein, in either the guanosine...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract::PSP94, for prostatic secretory protein of 94 amino acids, is secreted by the prostate gland and functions as a suppressor of tumor growth and metastasis. The expression of PSP94 is lost in advanced, hormone-refractory prostate cancer and this correlates with an increased expression of the Polycomb protein EZH2 (enhanc...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210248
更新日期:2007-07-05 00:00:00
abstract::The myb family of genes encodes highly homologous nuclear transcription factors that play distinct roles in the development of breast, germ cells and hematoid organs. While the mechanisms associated with the regulation of these genes remain unknown, the transactivation of c-Myb was previously shown to be upregulated b...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207537
更新日期:2004-05-20 00:00:00
abstract::Recently, we identified Insulinoma-Glucagonoma clone 20 (IG20) that can render cells more susceptible to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. In addition, it can slow cell proliferation, and enhance drug- and radiation-induced cell death. TNF-related apoptosis-inducing ligand (TRAIL) can selectiv...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207804
更新日期:2004-08-12 00:00:00
abstract::Drug-resistant clones selected from FR3T3 rat cells after transfer of neo-BPV1 (Bovine Papillomavirus Type 1) DNA constructs became phenotypically transformed (focal transformation, growth in suspension and tumor formation) soon after selection (approximately 5 generations in culture). A frameshift mutation in ORF E5 ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::P21waf1/cip1 is a potent inhibitor of cell cycle progression and can inhibit the growth of both normal cells and cells transformed by a number of oncogenes. However, the ability of p21waf1/cip1 to inhibit the growth of cells that overexpress the transcriptional transactivator E2F1 is controversial: it has been reporte...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201849
更新日期:1998-06-18 00:00:00
abstract::The mitotic spindle is assembled by the coordinated action of centrosomes and kinetochore microtubules. An evolutionally conserved protein family, transforming acidic coiled-coil (TACC), has been shown to be involved in this process. In humans, TACC3 is aberrantly expressed in a variety of human cancers, but its biolo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.382
更新日期:2014-08-14 00:00:00
abstract::It has recently been shown that the high-risk human papillomavirus (HPV) E6 proteins can target the PDZ-domain containing proteins, Dlg, MUPP-1, MAGI-1 and hScrib for proteasome-mediated degradation. However, the E6 proteins from HPV-16 and HPV-18 (the two most common high-risk virus types) differ in their ability to ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204719
更新日期:2001-09-06 00:00:00
abstract::Observations that genome-wide DNA hypomethylation induces genome instability and tumors in animals caution against the indiscriminate use of demethylating agents, such as 5-aza-2'-deoxycytidine (5-Aza-dC). Using primary mouse embryonic fibroblasts harboring a lacZ mutational reporter construct that allows the quantifi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.9
更新日期:2012-12-13 00:00:00