Parkin and mitophagy in cancer.

abstract：:Epithelial-mesenchymal transition (EMT) has pivotal roles during embryonic development and carcinoma progression. Members of the Snai1 family of zinc finger transcription factors are central mediators of EMT and induce EMT in part by directly repressing epithelial markers such as E-cadherin, a gatekeeper of the epithe...

journal_title：Oncogene

authors： Lin T,Ponn A,Hu X,Law BK,Lu J

更新日期：2010-09-02 00:00:00

abstract：:We present an approach making use of technology established in the context of the genome project to describe a pancreatic cancer-specific expression profile and to identify new potential disease genes or disease-associated-genes. By use of gridded arrays of pancreatic cancer cDNA libraries and differential hybridizati...

journal_title：Oncogene

authors： Gress TM,Müller-Pillasch F,Geng M,Zimmerhackl F,Zehetner G,Friess H,Büchler M,Adler G,Lehrach H

更新日期：1996-10-17 00:00:00

abstract：:Inhibitor of DNA-binding (Id) proteins prevent cell differentiation, promote growth and sustain tumour development. They do so by binding to E proteins and other transcription factors through the helix-loop-helix (HLH) domain, and inhibiting transcription. This makes HLH-mediated Id protein interactions an appealing t...

journal_title：Oncogene

authors： Ciarapica R,Annibali D,Raimondi L,Savino M,Nasi S,Rota R

更新日期：2009-04-30 00:00:00

abstract：:The simian double strand DNA tumor virus SV40 encodes the 90-kDa multi-functional protein, large T antigen (LT). LT functions by binding to DNA, as well as to many cellular target proteins such as p53 and retinoblastoma protein (pRB). We report here the identification of a cellular heat shock protein, HSP90, as a prev...

journal_title：Oncogene

authors： Miyata Y,Yahara I

更新日期：2000-03-09 00:00:00

abstract：:NF-kappaB is known to exert a cytoprotective action against TNF-alpha-induced apoptosis. To study the role of NF-kappaB in various TNF-alpha-treated epithelial cell lines, we generated stable transfectants overexpressing a mutated unresponsive form of the IkappaBalpha inhibitor (MT cells). As NF-kappaB prevented TNF-a...

journal_title：Oncogene

authors： Delhalle S,Deregowski V,Benoit V,Merville MP,Bours V

更新日期：2002-05-30 00:00:00

abstract：:Hematopoiesis involves a complex array of growth factors that regulate the survival and proliferation of immature progenitors, influence differentiation commitment, and modulate end-stage cell functions. This mini-review is focused on the role of Stat activation in the development of myeloid cells in response to hemat...

journal_title：Oncogene

authors： Smithgall TE,Briggs SD,Schreiner S,Lerner EC,Cheng H,Wilson MB

更新日期：2000-05-15 00:00:00

abstract：:The B-raf/c-Rmil proto-oncogene belongs to the raf/mil family of serine/threonine protein kinases. It encodes multiple protein isoforms resulting from alternative splicing of two exons located upstream of the kinase domain. Recent studies suggested that B-Raf could be the intermediate molecule between Ras and Mek-1 (M...

journal_title：Oncogene

authors： Papin C,Eychène A,Brunet A,Pagès G,Pouysségur J,Calothy G,Barnier JV

更新日期：1995-04-20 00:00:00

abstract：:There have been few studies on the specific signaling pathways involved in the transformation of epithelial cells by oncogenic protein tyrosine kinases. Here we investigate the requirement of MAP (MAPK) and phosphatidylinositol 3- (PI3K) kinases in the transformation of rat intestinal epithelial (RIE) cells by oncogen...

journal_title：Oncogene

authors： Nguyen KT,Wang WJ,Chan JL,Wang LH

更新日期：2000-11-09 00:00:00

abstract：:Transforming growth factor beta1 (TGF-beta1) belongs to a family of polypeptide factors, whose cytostatic and apoptotic functions help restrain the growth of mammalian cells. Although solid data established the role of TGF-beta's as suppressor factors in tumorigenic processes, in the context of an advanced stage of di...

journal_title：Oncogene

authors： Murillo MM,del Castillo G,Sánchez A,Fernández M,Fabregat I

更新日期：2005-06-30 00:00:00

abstract：:Common fragile sites are specific genomic loci that form constrictions and gaps on metaphase chromosomes under conditions that slow, but do not arrest, DNA replication. These sites have been shown to have a role in various chromosomal rearrangements in tumors. Different DNA damage response proteins were shown to regul...

journal_title：Oncogene

authors： Ozeri-Galai E,Schwartz M,Rahat A,Kerem B

更新日期：2008-04-03 00:00:00

abstract：:The quail Pax-6 gene is expressed from two promoters named P0 and P1. P0 promoter is under the control of a neuroretina-specific enhancer (EP). This enhancer activates the P0 promoter specifically in neuroretina cells and in a developmental stage-dependent manner. The EP enhancer binds efficiently, as revealed by sout...

journal_title：Oncogene

authors： Plaza S,Aumercier M,Bailly M,Dozier C,Saule S

更新日期：1999-01-28 00:00:00

abstract：:Increasing evidence supports that long noncoding RNAs (lncRNAs) act as master regulators involved in tumorigenesis and development at the N6-methyladenine (m6A) epigenetic modification level. However, the underlying regulatory mechanism in breast cancer (BRCA) remains elusive. Here, we unveil that LINC00942 (LNC942) e...

journal_title：Oncogene

authors： Sun T,Wu Z,Wang X,Wang Y,Hu X,Qin W,Lu S,Xu D,Wu Y,Chen Q,Ding X,Guo H,Li Y,Wang Y,Fu B,Yao W,Wei M,Wu H

更新日期：2020-07-01 00:00:00

abstract：:Fos protein heterodimerizes through one surface of an alpha-helical domain called the leucine zipper. We have investigated the effect of destabilizing this domain by multiply substituting small residues of its non-interacting surface with glycine. Ternary complex formation between mutated Fos, Jun and DNA was determin...

journal_title：Oncogene

authors： Nicklin MJ,Zechner D,Kislyakova T

更新日期：1993-07-01 00:00:00

abstract：:Transcription factors of the Maf proto-oncogene family have been shown to participate in the regulation of several differentiation specific genes. We previously reported that a member(s) of this family is involved in the regulation of the neuroretina specific gene, QR1, through a promoter region, designated the A box,...

journal_title：Oncogene

authors： Benkhelifa S,Provot S,Lecoq O,Pouponnot C,Calothy G,Felder-Schmittbuhl MP

更新日期：1998-07-16 00:00:00

abstract：:Loss of the DNA mismatch repair (MMR) protein MSH3 leads to the development of a variety of tumors in mice without significantly affecting survival rates, suggesting a modulating role for the MutSβ (MSH2-MSH3) complex in late-onset tumorigenesis. To better study the role of MSH3 in tumor progression, we crossed Msh3(-...

journal_title：Oncogene

authors： van Oers JM,Edwards Y,Chahwan R,Zhang W,Smith C,Pechuan X,Schaetzlein S,Jin B,Wang Y,Bergman A,Scharff MD,Edelmann W

更新日期：2014-07-24 00:00:00

abstract：:p73 and p63 are two recently discovered p53 homologs. Like p53, these proteins can recognize canonical p53 DNA-binding sites and, when overproduced, can activate p53-responsive target genes and induce apoptosis. Unlike p53, these genes undergo complex alternative splicing which, at least in the case of p63, yields pro...

journal_title：Oncogene

authors： Kaelin WG Jr

更新日期：1999-12-13 00:00:00

abstract：:Apoptosis resistance is crucially involved in cancer development and progression, represents the leading cause for failure of anticancer therapy and is caused, for example, by downregulation of proapoptotic intracellular signaling molecules such as caspase-8. We found that the cytotoxic drugs methotrexate (MTX) and 5-...

journal_title：Oncogene

authors： Ehrhardt H,Häcker S,Wittmann S,Maurer M,Borkhardt A,Toloczko A,Debatin KM,Fulda S,Jeremias I

更新日期：2008-01-31 00:00:00

abstract：:Antimicrobial peptides, such as the cathelicidin LL-37/hCAP-18 and its mouse homolog cathelicidin-related antimicrobial peptide (CRAMP), are important effectors of the innate immune system with direct anti-bacterial activity. Cathelicidin is possibly involved in the regulation of tumor cell growth. The aim of this stu...

journal_title：Oncogene

authors： Li D,Beisswenger C,Herr C,Schmid RM,Gallo RL,Han G,Zakharkina T,Bals R

更新日期：2014-05-22 00:00:00

abstract：:The ability of glioma cells to migrate great distances from a primary tumor mass is the primary cause of tumor recurrence. The urokinase-type plasminogen activator (uPA) is a serine protease that can initiate proteolytic cascades, which result in remodeling of extracellular matrix and basement membrane, allowing cells...

journal_title：Oncogene

authors： Chandrasekar N,Mohanam S,Gujrati M,Olivero WC,Dinh DH,Rao JS

更新日期：2003-01-23 00:00:00

abstract：:A vector, derived from the human K1 keratin gene, has been employed to target v-fos expression exclusively in the epidermis of transgenic mice. Adult transgenic mice expressors (3-4 months) displayed hyperplasia and hyperkeratosis, initially in wounded (tagged) ears, which later became bilateral. This phenotype appear...

journal_title：Oncogene

authors： Greenhalgh DA,Rothnagel JA,Wang XJ,Quintanilla MI,Orengo CC,Gagne TA,Bundman DS,Longley MA,Fisher C,Roop DR

更新日期：1993-08-01 00:00:00

abstract：:The c-Myb transcriptional regulator is crucial to the development and functioning of haemopoietic cells, so much so that mouse embryos homozygous for an inactivated c-myb allele die from anaemia at about day 15 of gestation. By analysing c-myb(-/-) chimaeras we show that no mature cells of any lymphoid or myeloid line...

journal_title：Oncogene

authors： Sumner R,Crawford A,Mucenski M,Frampton J

更新日期：2000-07-13 00:00:00

abstract：:Thymidine kinase (TK) is a nucleotide salvage pathway enzyme whose activity is highly dependent on the growth state and cell cycle phase of a cell. Cells in the resting or quiescent (G0) phase express very low levels of TK mRNA and protein. When quiescent cells are stimulated to enter the cell cycle by the addition of...

journal_title：Oncogene

authors： Kauffman MG,Rose PA,Kelly TJ

更新日期：1991-08-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) is an important multifunctional cytokine whose gene expression is regulated mainly at the transcriptional level. Previous studies using transgenic mice as well as in vitro analyses showed that a potential regulatory element(s) exists between -260 to -230 bp in the upstream region of the ...

journal_title：Oncogene

authors： Jiang JG,Gao B,Zarnegar R

更新日期：2000-05-25 00:00:00

abstract：:The cloning and characterization of the common fragile site (CFS) FRA6E (6q26) identified Parkin, the gene involved in the pathogenesis of many cases of juvenile, early-onset and, rarely, late-onset Parkinson's disease, as the third large gene to be localized within a large CFS. Initial analyses of Parkin indicated th...

journal_title：Oncogene

authors： Denison SR,Wang F,Becker NA,Schüle B,Kock N,Phillips LA,Klein C,Smith DI

更新日期：2003-11-13 00:00:00

abstract：:We previously reported cloning the rLot1 gene, and its human homolog (hLOT1), through analysis of differential gene expression in normal and malignant rat ovarian surface epithelial cells. Both human and rat ovarian carcinoma cell lines exhibited lost or decreased expression of this gene. Interestingly, the LOT1 gene ...

journal_title：Oncogene

authors： Abdollahi A,Bao R,Hamilton TC

更新日期：1999-11-11 00:00:00

abstract：:Chromosome 8 loss of heterozygosity (LOH) in cancer of the urinary bladder is associated with high tumour grade and stage. We have screened 193 cases of transitional cell carcinoma (TCC) of the bladder using 30 microsatellite polymorphisms on chromosome 8. Forty three cases (22%) showed LOH on 8p, the majority of whic...

journal_title：Oncogene

authors： Takle LA,Knowles MA

更新日期：1996-03-07 00:00:00

abstract：:The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Although Stat5 is the best-characterized mediator of PRL signals, PRL also activates multiple other signals, whose roles in normal and pathologic pro...

journal_title：Oncogene

authors： Gutzman JH,Rugowski DE,Nikolai SE,Schuler LA

更新日期：2007-09-20 00:00:00

abstract：:An early event of cell migration is characterized as the rapid reorganization of the actin cytoskeleton. Recently, we have demonstrated that rapamycin inhibits tumor cell motility. To understand the underlying mechanism, this study was set to determine whether rapamycin inhibition of cell motility is related to its pr...

journal_title：Oncogene

authors： Liu L,Chen L,Chung J,Huang S

更新日期：2008-08-28 00:00:00

abstract：:BTG2, a p53-inducible antiproliferative gene, is stimulated in breast cancer cells by activation of nuclear factor kappa B (NF-kappaB). In rat mammary glands, BTG2 is expressed in epithelial cells and levels decreased during pregnancy and lactation but recovered during involution. Estrogen and progestin suppress BTG2 ...

journal_title：Oncogene

authors： Kawakubo H,Carey JL,Brachtel E,Gupta V,Green JE,Walden PD,Maheswaran S

更新日期：2004-10-28 00:00:00

abstract：:The signal transduction pathways, orchestrating the differentiation of hematopoietic stem and progenitor cells in response to cytokine stimulation, are strictly controlled by networks of feedback loops, highly selective protein interactions and finely tuned on/off switches. In hematological malignancies, the aberrant ...

journal_title：Oncogene

authors： Gery S,Koeffler HP

更新日期：2013-06-27 00:00:00