Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition.

abstract：:Approximately 80% of breast cancers express the estrogen receptor-alpha (ERalpha) and are treated with anti-estrogens. Resistance to these agents is a major cause of mortality. We have shown that estrogen inhibits Notch, whereas anti-estrogens or estrogen withdrawal activate Notch signaling. Combined inhibition of Not...

journal_title：Oncogene

authors： Hao L,Rizzo P,Osipo C,Pannuti A,Wyatt D,Cheung LW,Sonenshein G,Osborne BA,Miele L

更新日期：2010-01-14 00:00:00

abstract：:The membrane-anchored MMP-regulator RECK is down regulated in many solid tumors; the extent of RECK down regulation correlates with poor prognosis. Forced expression of RECK in tumor cells results in suppression of angiogenesis, invasion, and metastasis. Studies on the roles and the mechanisms of regulation of the REC...

journal_title：Oncogene

authors： Echizenya M,Kondo S,Takahashi R,Oh J,Kawashima S,Kitayama H,Takahashi C,Noda M

更新日期：2005-09-01 00:00:00

abstract：:Gene expression patterns in normal and v-myc-transformed quail embryo fibroblasts were compared by mRNA differential display. Displaying approximately 2500 mRNA species by reverse transcription/PCR, reamplification of 73 differential cDNA fragments and rescreening by Northern analysis led to the isolation of a clone, ...

journal_title：Oncogene

authors： Oberst C,Weiskirchen R,Hartl M,Bister K

更新日期：1997-03-06 00:00:00

abstract：:NF-kappaB is known to exert a cytoprotective action against TNF-alpha-induced apoptosis. To study the role of NF-kappaB in various TNF-alpha-treated epithelial cell lines, we generated stable transfectants overexpressing a mutated unresponsive form of the IkappaBalpha inhibitor (MT cells). As NF-kappaB prevented TNF-a...

journal_title：Oncogene

authors： Delhalle S,Deregowski V,Benoit V,Merville MP,Bours V

更新日期：2002-05-30 00:00:00

abstract：:Alterations affecting the epidermal growth factor (EGF)/transforming growth factor alpha (TGF alpha)-responsive mitogenic pathway are frequently detected in malignancies. In particular, the EGF-receptor (EGFR) molecule has been found overexpressed in a number of human tumors, and TGF alpha is produced by a large array...

journal_title：Oncogene

authors： Di Marco E,Pierce JH,Fleming TP,Kraus MH,Molloy CJ,Aaronson SA,Di Fiore PP

更新日期：1989-07-01 00:00:00

abstract：:Talins are adaptor proteins that regulate focal adhesion signaling by conjugating integrins to the cytoskeleton. Talins directly bind integrins and are essential for integrin activation. We previously showed that β1 integrins are activated in metastatic prostate cancer (PCa) cells, increasing PCa metastasis to lymph n...

journal_title：Oncogene

authors： Jin JK,Tien PC,Cheng CJ,Song JH,Huang C,Lin SH,Gallick GE

更新日期：2015-04-02 00:00:00

abstract：:Several small GTPases of the Ras superfamily have been shown to antagonize TGFbeta signaling in human tumor cell lines. Some of these GTPases are post-translationally modified by farnesylation, a lipid modification catalyzed by farnesyltransferase and required for the proteins to attach to membranes and to function. I...

journal_title：Oncogene

authors： Adnane J,Bizouarn FA,Chen Z,Ohkanda J,Hamilton AD,Munoz-Antonia T,Sebti SM

更新日期：2000-11-16 00:00:00

abstract：:ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis. Here, we have described iASPP, a ...

journal_title：Oncogene

authors： Slee EA,Gillotin S,Bergamaschi D,Royer C,Llanos S,Ali S,Jin B,Trigiante G,Lu X

更新日期：2004-12-02 00:00:00

abstract：:The NF-kappaB signaling pathway has particular relevance to several liver diseases including hepatitis (liver infection by Helicobacter, viral hepatitis induced by HBV and HCV), liver fibrosis and cirrhosis and hepatocellular carcinoma. Furthermore, the NF-kappaB signaling pathway is a potential target for development...

journal_title：Oncogene

authors： Sun B,Karin M

更新日期：2008-10-20 00:00:00

abstract：:Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived...

journal_title：Oncogene

authors： Qiao Y,Zhang C,Li A,Wang D,Luo Z,Ping Y,Zhou B,Liu S,Li H,Yue D,Zhang Z,Chen X,Shen Z,Lian J,Li Y,Wang S,Li F,Huang L,Wang L,Zhang B,Yu J,Qin Z,Zhang Y

更新日期：2018-02-15 00:00:00

abstract：:Initiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs only once in the cell cycle. Expression of all mammalian genes of the MCM family is induced by growth stimulation, unlike yeast, and the mRNA levels peak at G1/S boundary. In this study, ...

journal_title：Oncogene

authors： Ohtani K,Iwanaga R,Nakamura M,Ikeda M,Yabuta N,Tsuruga H,Nojima H

更新日期：1999-04-08 00:00:00

abstract：:The tumor suppressor protein, p53, plays a critical role as a transcriptional activator of downstream target genes involved in the cellular response to DNA damaging agents. We examined the cell cycle checkpoint response of human mammary epithelial cells (HMEC) and their isogenic fibroblast counterparts to ionizing (IR...

journal_title：Oncogene

authors： Meyer KM,Hess SM,Tlsty TD,Leadon SA

更新日期：1999-10-14 00:00:00

abstract：:The maintenance of genome stability is essential for the cell as the integrity of genomic information guaranties reproduction of a whole organism. DNA damage occurring in response to different natural and nonnatural stimuli (errors in DNA replication, UV radiation, chemical agents, etc.) is normally detected by specia...

journal_title：Oncogene

authors： Prokhorova EA,Egorshina AY,Zhivotovsky B,Kopeina GS

更新日期：2020-01-01 00:00:00

abstract：:The activities of E2F transcription factors are inhibited by interactions with members of the retinoblastoma (RB) tumor suppressor family, p105RB, p107 and p130. In cycling cells p107 and p130 also interact with heterodimers comprised of Cdk2 and either A or E cyclins. We characterized E2F complexes present in C2C12 a...

journal_title：Oncogene

authors： Corbeil HB,Whyte P,Branton PE

更新日期：1995-09-07 00:00:00

abstract：:Deregulation of mitotic microtubule (MT) dynamics results in defective spindle assembly and chromosome missegregation, leading further to chromosome instability, a hallmark of tumor cells. RBP-J interacting and tubulin-associated protein (RITA) has been identified as a negative regulator of the Notch signaling pathway...

journal_title：Oncogene

authors： Steinhäuser K,Klöble P,Kreis NN,Ritter A,Friemel A,Roth S,Reichel JM,Michaelis J,Rieger MA,Louwen F,Oswald F,Yuan J

更新日期：2017-04-01 00:00:00

abstract：:Cancer cells acquire several traits that allow for their survival and progression, including the ability to evade the host immune response. However, the mechanisms by which cancer cells evade host immune responses remain largely elusive. Here we study the phenomena of immune evasion in malignant melanoma cells. We fin...

journal_title：Oncogene

authors： Dong Y,Richards JA,Gupta R,Aung PP,Emley A,Kluger Y,Dogra SK,Mahalingam M,Wajapeyee N

更新日期：2014-09-18 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) production by stromal fibroblasts plays an important role in tumor angiogenesis. However, VEGF is also expressed by normal tissue fibroblasts, raising the question of how the VEGF activity of fibroblasts is regulated. Here we report that the latent VEGF angiogenic activity of ...

journal_title：Oncogene

authors： Ito TK,Ishii G,Chiba H,Ochiai A

更新日期：2007-11-08 00:00:00

abstract：:Previously, we cloned two gene fragments encoding novel protein tyrosine phosphatases, termed PTP-U1 and PTP-U2. Here, we report the full-length sequence, expression, and chromosomal localization of the PTP-U2 gene. The cDNA for PTP-U2, which was obtained from a human normal kidney library, predicts a protein of 1216 ...

journal_title：Oncogene

authors： Seimiya H,Sawabe T,Inazawa J,Tsuruo T

更新日期：1995-05-04 00:00:00

abstract：:To appreciate the involvement of known or potential susceptibility genes in sporadic breast tumors, we have searched for chromosomal deletions by studying loss of heterozygosity (LOH) at 43 microsatellite (CA)n markers from human chromosomes 10, 11 and 17, in 115 unselected consecutive samples of breast carcinoma with...

journal_title：Oncogene

authors： Kerangueven F,Eisinger F,Noguchi T,Allione F,Wargniez V,Eng C,Padberg G,Theillet C,Jacquemier J,Longy M,Sobol H,Birnbaum D

更新日期：1997-01-23 00:00:00

abstract：:The Myc-deregulating chromosomal T(12;15)(Igh-Myc) translocation, the hallmark mutation of inflammation- and interleukin 6-dependent mouse plasmacytoma (PCT), is the premier model of cancer-associated chromosomal translocations because it is the only translocation in mice that occurs spontaneously (B lymphocyte lineag...

journal_title：Oncogene

authors： Takizawa M,Kim JS,Tessarollo L,McNeil N,Waldschmidt TJ,Casellas R,Ried T,Janz S

更新日期：2010-07-15 00:00:00

abstract：:We have previously shown (Smith et al., 1994) that antibodies raised against the growth arrest and DNA damage inducible protein Gadd45 co-precipitate proliferating cell nuclear antigen (PCNA), a protein involved in DNA replication and repair. Here we demonstrate that Gadd45 can directly bind to PCNA using a Far-wester...

journal_title：Oncogene

authors： Chen IT,Smith ML,O'Connor PM,Fornace AJ Jr

更新日期：1995-11-16 00:00:00

abstract：:Tripartite motif 24 protein (TRIM24) is a plant homeodomain/bromodomain histone reader, recently associated with poor overall survival of breast-cancer patients. At a molecular level, TRIM24 is a negative regulator of p53 levels and a co-activator of estrogen receptor. However, the role of TRIM24 in breast tumorigenes...

journal_title：Oncogene

authors： Pathiraja TN,Thakkar KN,Jiang S,Stratton S,Liu Z,Gagea M,Shi X,Shah PK,Phan L,Lee MH,Andersen J,Stampfer M,Barton MC

更新日期：2015-05-28 00:00:00

abstract：:The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that tran...

journal_title：Oncogene

authors： Matsuoka M,Jeang KT

更新日期：2011-03-24 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease and a major health problem in the United States. While the cytokine TGF-β has been implicated in PDAC development, it can exert both pro-tumorigenic and anti-tumorigenic effects that are highly context dependent and incompletely understood. Using three-dimens...

journal_title：Oncogene

authors： Handler J,Cullis J,Avanzi A,Vucic EA,Bar-Sagi D

更新日期：2018-08-01 00:00:00

abstract：:To understand the mechanism of interferon (IFN)-mediated suppression of cell cycle progression, we have earlier shown that IFN-alpha enhances the expression of underphosphorylated retinoblastoma protein by inhibiting the cyclin-dependent kinase-2 (CDK-2) activity (Kumar and Atlas, Proc. Natl. Acad. Sci. 89, 6599-6603,...

journal_title：Oncogene

authors： Mandal M,Bandyopadhyay D,Goepfert TM,Kumar R

更新日期：1998-01-15 00:00:00

abstract：:The most frequent genetic alterations described in neuroblastoma (NB) are amplification of MYCN oncogene and deletion of chromosome 1p, although somatic deletions have been demonstrated at other chromosomal intervals. Since loss of heterozygosity (LOH) at distal 4p has been observed in about 20-29% of neuroblastomas, ...

journal_title：Oncogene

authors： Perri P,Longo L,Cusano R,McConville CM,Rees SA,Devoto M,Conte M,Ferrara GB,Seri M,Romeo G,Tonini GP

更新日期：2002-11-28 00:00:00

abstract：:Amplification and overexpression of the E2F3 gene at 6p22 in human bladder cancer is associated with increased tumour stage, grade and proliferation index, and in prostate cancer E2F3 overexpression is linked to tumour aggressiveness. We first used small interfering RNA technology to confirm the potential importance o...

journal_title：Oncogene

authors： Olsson AY,Feber A,Edwards S,Te Poele R,Giddings I,Merson S,Cooper CS

更新日期：2007-02-15 00:00:00

abstract：:Tumor-derived DNA from a non-Hodgkin's (T cell) lymphoma patient, assayed by NIH3T3 transfection followed by inoculation of cells into nude mice, was found to contain an activated N-ras proto-oncogene. The mode of activation was determined by hybridization with N-ras-specific oligonucleotide probes detecting mutations...

journal_title：Oncogene

authors： Wodnar-Filipowicz A,Senn HP,Jiricny J,Signer E,Moroni C

更新日期：1987-01-01 00:00:00

abstract：:We have previously demonstrated that the expression of FGFR3 is frequently downregulated in colorectal carcinoma cells. Here we have shown that FGFR1 is overexpressed in colorectal carcinoma cells and the gene expressions between FGFR1 and FGFR3 are mutually exclusive. Moreover, we have also shown that the disruption ...

journal_title：Oncogene

authors： Jang JH

更新日期：2005-01-27 00:00:00

abstract：:Members of the polo subfamily of protein kinases play crucial roles in cell proliferation. To study the function of this family in more detail, we isolated the cDNA of human Fnk (FGF-inducible kinase) which codes for a serine/threonine kinase of 646 aa. Despite the homology to the proliferation-associated polo-like ki...

journal_title：Oncogene

authors： Holtrich U,Wolf G,Yuan J,Bereiter-Hahn J,Karn T,Weiler M,Kauselmann G,Rehli M,Andreesen R,Kaufmann M,Kuhl D,Strebhardt K

更新日期：2000-10-05 00:00:00