Glycine-cysteine substitution at codon 13 of the N-ras proto-oncogene in a human T cell non-Hodgkin's lymphoma.

abstract：:All mature blood cells originate from a small population of self-renewing pluripotent hematopoietic stem cells (HSCs). The capacity to self-renew characterizes all stem cells, whether normal or neoplastic. Interestingly, recent studies suggest that self-renewal is essential for tumor cell maintenance, implicating that...

journal_title：Oncogene

authors： Lessard J,Faubert A,Sauvageau G

更新日期：2004-09-20 00:00:00

abstract：:ERM is a member of the ETS transcription factor family. High levels of the corresponding mRNA are detected in a variety of human breast cancer cell lines, as well as in aggressive human breast tumors. As ERM protein is almost undetectable in these cells, high degradation of this transcription factor has been postulate...

journal_title：Oncogene

authors： Baert JL,Beaudoin C,Monte D,Degerny C,Mauen S,de Launoit Y

更新日期：2007-01-18 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a highly conserved serine-threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling pathway in diverse human cancers, this kinase is a key therapeutic target. Redd1 is a negative regulator of mTOR, mediati...

journal_title：Oncogene

authors： Jin HO,Seo SK,Kim YS,Woo SH,Lee KH,Yi JY,Lee SJ,Choe TB,Lee JH,An S,Hong SI,Park IC

更新日期：2011-09-01 00:00:00

abstract：:Maf b-Zip transcription factors are involved in both terminal differentiation and oncogenesis. To investigate this apparent contradiction, we used two different primary cell types and performed an extensive analysis of transformation parameters induced by Maf proteins. We show that MafA and c-Maf are potent oncogenes ...

journal_title：Oncogene

authors： Pouponnot C,Sii-Felice K,Hmitou I,Rocques N,Lecoin L,Druillennec S,Felder-Schmittbuhl MP,Eychène A

更新日期：2006-03-02 00:00:00

abstract：:Colorectal cancer is a major cause of cancer deaths in Western countries, but epidemiological data suggest that dietary modification might reduce these by as much as 90%. Cyclo-oxygenase 2 (COX2), an inducible isoform of prostaglandin H synthase, which mediates prostaglandin synthesis during inflammation, and which is...

journal_title：Oncogene

authors： Plummer SM,Holloway KA,Manson MM,Munks RJ,Kaptein A,Farrow S,Howells L

更新日期：1999-10-28 00:00:00

abstract：:The E3 ligase S-phase kinase-associated protein 2(Skp2) is overexpressed in human cancers and correlated with poor prognosis, but its contributions to tumorigenesis and chemoresistance in nasopharyngeal carcinoma (NPC) are not evident. Herein we show that Skp2 is highly expressed in NPC tumor tissues and cell lines. K...

journal_title：Oncogene

authors： Yu X,Wang R,Zhang Y,Zhou L,Wang W,Liu H,Li W

更新日期：2019-12-01 00:00:00

abstract：:MCF2/DBL is an X-linked proto-oncogene encoding a protein with a yet undetermined function. It can be activated in vitro by loss of 5' sequences in NIH3T3 bioassays; in vivo, deletion of the gene has been found in some hemophilia B patients. PCR analysis of its expression in mouse tissues shows a restriction to the go...

journal_title：Oncogene

authors： Galland F,Pirisi V,de Lapeyriere O,Birnbaum D

更新日期：1991-05-01 00:00:00

abstract：:Structural rearrangements involving chromosome 13 are frequently seen in B-cell chronic lymphocytic leukaemia. The presence of reciprocal translocations involving 13q14 in 10-15% of cases pinpoints the location of a gene important in leukaemogenesis. In order to characterise the exact location of the 13q14 breakpoint,...

journal_title：Oncogene

authors： Hawthorn LA,Chapman R,Oscier D,Cowell JK

更新日期：1993-06-01 00:00:00

abstract：:We have previously reported the isolation of several temperature-sensitive (ts) mutants of F9 cells. Further investigations showed that some mutants were induced to differentiate at non-permissive temperature of cell growth, accompanied by changes in the expression of various genes, whereas others were not. During the...

journal_title：Oncogene

authors： Kosaka M,Iwai SA,Nishina Y,Sumi T,Nishimune Y

更新日期：1992-12-01 00:00:00

abstract：:The majority (75%) of human breast cancers express estrogen receptor (ER). Although ER-positive tumors usually respond to antiestrogen therapies, 30% of them do not. It is not known what controls the ER status of breast cancers or their responsiveness to antihormone interventions. In this report, we document that tran...

journal_title：Oncogene

authors： Zhang X,Podsypanina K,Huang S,Mohsin SK,Chamness GC,Hatsell S,Cowin P,Schiff R,Li Y

更新日期：2005-06-16 00:00:00

abstract：:Oncostatin M (OM) is a polypeptide cytokine that induces autocrine and paracrine effects on AIDS-Kaposi's sarcoma (KS) cells (Nair et al., Science, 255, 1430-1432, 1992; Miles et al., Science, 255, 1432-1434, 1992). The signalling pathways underlying this activation are largely unknown. We have found that OM binding t...

journal_title：Oncogene

authors： Soldi R,Graziani A,Benelli R,Ghigo D,Bosia A,Albini A,Bussolino F

更新日期：1994-08-01 00:00:00

abstract：:The p53 tumor suppressor is regulated by the MDM2 oncoprotein. Overexpression of MDM2 maintains p53 at low levels and contributes to the functional inactivation of p53 in a subset of tumors. We found that treatment with roscovitine and olomoucin, which were originally developed as cyclin-dependent kinase (CDK) inhibit...

journal_title：Oncogene

authors： Lu W,Chen L,Peng Y,Chen J

更新日期：2001-05-31 00:00:00

abstract：:Procollagen lysyl hydroxylase 1 (PLOD1) is highly expressed in malignant tumors such as esophageal squamous cell carcinoma, gastric cancer, and colorectal cancer. Bioinformatics analysis revealed that PLOD1 is associated with the progression of GBM, particularly the most malignant mesenchymal subtype (MES). Moreover, ...

journal_title：Oncogene

authors： Wang Z,Shi Y,Ying C,Jiang Y,Hu J

更新日期：2021-01-08 00:00:00

abstract：:Diminished expression of the metastasis suppressor protein RKIP was previously reported in a number of cancers. The underlying mechanism remains unknown. Here, we show that the expression of RKIP negatively correlates with that of Snail zinc-transcriptional repressor, a key modulator of normal and neoplastic epithelia...

journal_title：Oncogene

authors： Beach S,Tang H,Park S,Dhillon AS,Keller ET,Kolch W,Yeung KC

更新日期：2008-04-03 00:00:00

abstract：:In search of human homologues of the anti-apoptotic protein Nr-13, we have characterized a human EST clone that potentially encodes a protein, which is the closest homologue of Nr-13 among the Bcl-2 family members, to date known, in humans. Phylogenetic analyses suggest Human nrh, Mouse diva/boo and Quail nr-13 to be ...

journal_title：Oncogene

authors： Aouacheria A,Arnaud E,Venet S,Lalle P,Gouy M,Rigal D,Gillet G

更新日期：2001-09-13 00:00:00

abstract：:Mutant p53 proteins were shown to exert complex DNA-interactions in vitro, like binding to MAR-DNA, but so far it is unknown whether such interactions also occur in vivo. Therefore we analysed the binding of mutant (mut) p53 (Gly245-->Ser) in Onda 11 glioma cells to cellular DNA in vivo, using p53-specific chromatin i...

journal_title：Oncogene

authors： Koga H,Deppert W

更新日期：2000-08-24 00:00:00

abstract：:The development of hepatocellular carcinomas (HCC) depends on their local microenvironment and the induction of neovascularization is a decisive step in tumor progression, since the growth of solid tumors is limited by nutrient and oxygen supply. Hypoxia is the critical factor that induces transcription of the hypoxia...

journal_title：Oncogene

authors： Wen Y,Zhou X,Lu M,He M,Tian Y,Liu L,Wang M,Tan W,Deng Y,Yang X,Mayer MP,Zou F,Chen X

更新日期：2019-03-01 00:00:00

abstract：:Activator protein one (AP1) (jun/fos) factors comprise a family of transcriptional regulators (c-jun, junB, junD, c-fos, FosB, Fra-1 and Fra-2) that are key controllers of epidermal keratinocyte survival and differentiation, and are important drivers of cancer development. Understanding the role of these factors in ep...

journal_title：Oncogene

authors： Rorke EA,Adhikary G,Jans R,Crish JF,Eckert RL

更新日期：2010-11-04 00:00:00

abstract：:As tumors grow and invade beyond their homeostatic limits, the tumor cells are subjected to insufficient nutrient and oxygen supplies because of excessive demand for nutrition and oxygen, and insufficient vascularization. We therefore hypothesized that tolerance to nutrient deprivation as well as angiogenesis may be c...

journal_title：Oncogene

authors： Kato K,Ogura T,Kishimoto A,Minegishi Y,Nakajima N,Miyazaki M,Esumi H

更新日期：2002-09-05 00:00:00

abstract：:Ewing sarcoma is a pediatric bone tumor characterized in 85% of cases by the fusion between EWS and FLI1 genes that results in the expression of the EWS-FLI1 aberrant transcription factor. Histologically, the Ewing tumor expresses high levels of the CD99 membrane glycoprotein. It has been recently described that CD99 ...

journal_title：Oncogene

authors： Franzetti GA,Laud-Duval K,Bellanger D,Stern MH,Sastre-Garau X,Delattre O

更新日期：2013-08-15 00:00:00

abstract：:Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the cytoplasm, whereas the other family members rem...

journal_title：Oncogene

authors： Longworth MS,Laimins LA

更新日期：2006-07-27 00:00:00

abstract：:Augmented reactive oxygen species levels consequential to functional alteration of key mitochondrial attributes contribute to carcinogenesis, either directly via oxidative DNA damage infliction or indirectly via activation of oncogenic signaling cascades. We previously reported activation of a key oncogenic signaling ...

journal_title：Oncogene

authors： Lone MU,Baghel KS,Kanchan RK,Shrivastava R,Malik SA,Tewari BN,Tripathi C,Negi MP,Garg VK,Sharma M,Bhatt ML,Bhadauria S

更新日期：2017-03-30 00:00:00

abstract：:We have identified sequences in the 5' flanking region of the murine c-myc gene's P1 and P2 transcription initiation sites which form specific complexes with nuclear factors of murine and human origin and are also required for normal P1 and P2 usage. Four nuclear factor binding sites were identified within 400 bp 5' o...

journal_title：Oncogene

authors： Asselin C,Nepveu A,Marcu KB

更新日期：1989-05-01 00:00:00

abstract：:Degradation of chromosomal DNA into nucleosome-sized fragments is one of the characteristics of apoptotic cell death. Here, we examined whether caspase-activated DNase (CAD) is responsible for the DNA fragmentation that occurs upon exposure to various apoptotic stimuli. When human Jurkat cells were exposed to etoposid...

journal_title：Oncogene

authors： McIlroy D,Sakahira H,Talanian RV,Nagata S

更新日期：1999-08-05 00:00:00

abstract：:The low-affinity nerve growth factor receptor p75NTR belongs to a membrane receptor superfamily whose members, in certain cell types, are able to transduce an apoptotic signal. To investigate the effect of p75NTR expression in neuroblastoma cells, we transfected the p75NTR cDNA into SK-N-BE cells, a neuroblastoma cell...

journal_title：Oncogene

authors： Bunone G,Mariotti A,Compagni A,Morandi E,Della Valle G

更新日期：1997-03-27 00:00:00

abstract：:The p53 oncosuppressor is strictly maintained in an inactive form under normal conditions, while it is post-translationally activated by a variety of stresses, enacting different protective biological functions. Since one critical issue in cancer gene therapy is tumor specificity, we asked whether the tight p53 regula...

journal_title：Oncogene

authors： Bossi G,Mazzaro G,Porrello A,Crescenzi M,Soddu S,Sacchi A

更新日期：2004-01-15 00:00:00

abstract：:The current model for colorectal tumorigenesis defines four specific mutations (activation of a ras proto-oncogene and inactivation of the APC, p53 and DCC tumor-suppressor genes) that accumulate in a colonic epithelial cell as it progresses towards a carcinoma. However, further mutations must be needed for progressio...

journal_title：Oncogene

authors： Young J,Leggett B,Ward M,Thomas L,Buttenshaw R,Searle J,Chenevix-Trench G

更新日期：1993-03-01 00:00:00

abstract：:We constructed a lung cancer-specific database housing expression data and clinical data from over 6700 patients in 56 studies. Expression data from 23 genome-wide platforms were carefully processed and quality controlled, whereas clinical data were standardized and rigorously curated. Empowered by this lung cancer da...

journal_title：Oncogene

authors： Cai L,Lin S,Girard L,Zhou Y,Yang L,Ci B,Zhou Q,Luo D,Yao B,Tang H,Allen J,Huffman K,Gazdar A,Heymach J,Wistuba I,Xiao G,Minna J,Xie Y

更新日期：2019-04-01 00:00:00

abstract：:The cbl oncogene was first identified as part of a transforming retrovirus which arose in a mouse pre-B cell lymphoma. Its protein product, p120cbl, is cytoplasmic and has several distinctive domains including a highly basic region, a RING finger motif and a large proline-rich domain. A mutation to cbl in the 70Z/3 pr...

journal_title：Oncogene

authors： Bowtell DD,Langdon WY

更新日期：1995-10-19 00:00:00

abstract：:Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects occurring in both the irradiated and nonirradiated cells in the population. This phenomenon, termed the 'bystander response', has been shown to occur both in vi...

journal_title：Oncogene

authors： Azzam EI,de Toledo SM,Little JB

更新日期：2003-10-13 00:00:00