Abstract:
:The cbl oncogene was first identified as part of a transforming retrovirus which arose in a mouse pre-B cell lymphoma. Its protein product, p120cbl, is cytoplasmic and has several distinctive domains including a highly basic region, a RING finger motif and a large proline-rich domain. A mutation to cbl in the 70Z/3 pre-B cell lymphoma produces an oncogenic protein which exhibits a marked enhancement of tyrosine phosphorylation. Parallel studies have demonstrated that p120cbl is a substrate of protein tyrosine kinases activated by engagement of the T cell antigen receptor and that cbl is phosphorylated by oncogenic forms of the Abl tyrosine kinase. A genetic analysis of the Caenorhabditis elegans cbl homologue, sli-1, demonstrates that sli-1 negatively regulates the LET-23 tyrosine kinase receptor. Here we show that p120cbl is rapidly phosphorylated on tyrosine residues following EGF stimulation and that it forms an inducible complex with the receptor. Our results also show that the oncogenic 70Z/3 form of cbl has enhanced binding to the EGF receptor and that peptides spanning the proline-rich region bind a range SH3 domains. These findings are consistent with a conserved role for cbl/sli-1 proteins in mammals and nematodes.
journal_name
Oncogenejournal_title
Oncogeneauthors
Bowtell DD,Langdon WYsubject
Has Abstractpub_date
1995-10-19 00:00:00pages
1561-7issue
8eissn
0950-9232issn
1476-5594journal_volume
11pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Despite the recent success of MAPK signaling-targeted drugs in melanoma, the majority of patients with metastatic melanoma still undergo disease progression after initial tumor shrinkage indicating gradually developing therapy resistance. This review will give an overview on currently suggested concepts of resistance ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2014.249
更新日期:2015-06-04 00:00:00
abstract::Localized, nonindolent prostate cancer (PCa) is characterized by large-scale genomic rearrangements, aneuploidy, chromothripsis, and other forms of chromosomal instability (CIN), yet how this occurs remains unclear. A well-established mechanism of CIN is the overproduction of centrosomes, which promotes tumorigenesis ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0995-z
更新日期:2020-01-01 00:00:00
abstract::Triple-negative breast cancers (TNBCs) are characterized by a poor prognosis and lack of targeted treatments, and thus, new therapeutic strategies are urgently needed. Inhibitors against programmed death-1 (PD-1)/PD-1 ligand (PD-L1) have shown significant efficacy in various solid cancers, but their activity against T...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0700-2
更新日期:2019-05-01 00:00:00
abstract::Mutations in the c-KIT receptor occur somatically in many sporadic Gastrointestinal Stromal Tumors (GIST), and similar mutations have been identified at the germline level in kindreds with multiple GISTs. These mutations activate the tyrosine kinase activity of c-KIT and induce constitutive signaling. To investigate t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204704
更新日期:2001-08-16 00:00:00
abstract::The myb family of genes encodes highly homologous nuclear transcription factors that play distinct roles in the development of breast, germ cells and hematoid organs. While the mechanisms associated with the regulation of these genes remain unknown, the transactivation of c-Myb was previously shown to be upregulated b...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207537
更新日期:2004-05-20 00:00:00
abstract::Caspase-8 is a key effector of death-receptor-triggered apoptosis. In a previous study, we demonstrated, however, that caspase-8 can also be activated in a death receptor-independent manner via the mitochondrial apoptosis pathway, downstream of caspase-3. Here, we show that caspases-3 and -8 mediate a mitochondrial am...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206280
更新日期:2003-04-17 00:00:00
abstract::The mechanism by which the p53 family of proteins coordinately regulates select target genes after various types of cell stress is not well understood. To further define factors that dictate regulation of target genes, we examined the binding of p53, DeltaNp63alpha and RNA polymerase II (pol II) to the regulatory regi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210441
更新日期:2007-09-13 00:00:00
abstract::The NAD-dependent deacetylase sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, plays a pivotal role in deacetylating histone and nonhistone proteins. Recently, it has been reported that SIRT1 is upregulated in various kinds of tumors and is associated with cell growth and metastasis. However, the factors a...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-1298-0
更新日期:2020-05-01 00:00:00
abstract::Somatic RET mutations have been identified in a variable proportion (about 30-70%) of sporadic Medullary Thyroid Carcinoma (MTC) cases. They are represented by the Met918Thr substitution (exon 16) typical of Multiple Endocrine Neoplasia type 2B (MEN2B) and, to a lesser extent, by nucleotide changes occurring at one of...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201079
更新日期:1997-05-29 00:00:00
abstract::The tumour suppressor p53 is a transcription factor with high affinity for specific DNA target sequences. Wild type p53 has a very short half life in normal cells but the protein shows transient accumulation in response to DNA damage, accompanied by up-regulation of target genes such as p21 and induction of growth arr...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-05-04 00:00:00
abstract::We have previously shown that the PLAG1 gene on chromosome 8q12 is consistently rearranged in pleomorphic adenomas of the salivary glands with t(3;8)(p21;q12) translocations. The t(3;8) results in promoter swapping between the PLAG1 gene, which encodes a novel zinc finger protein, and the constitutively expressed gene...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201660
更新日期:1998-03-01 00:00:00
abstract::The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of v...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.80
更新日期:2014-02-20 00:00:00
abstract::Transforming Growth Factor-beta1 (TGF-beta1) inhibits the proliferation of most cells, but stimulates some mesenchymal cell types, including murine NIH3T3 fibroblasts. We show here that TGF-beta1 growth stimulation of NIH3T3 fibroblasts is reversed when these cells are transformed by SV40 or are transfected with a pla...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202341
更新日期:1999-01-21 00:00:00
abstract::Amplification of the N-myc gene is a significant adverse prognostic factor in neuroblastoma, a common childhood tumor. In non-transformed cells, myc expression is controlled through an autoregulatory circuit, through which elevated Myc protein levels lead to down-regulation of myc transcription. The precise mechanism ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201363
更新日期:1997-10-16 00:00:00
abstract::Cell cycle checkpoints ensure genome integrity and are frequently compromised in human cancers. A therapeutic strategy being explored takes advantage of checkpoint defects in p53-deficient tumors in order to sensitize them to DNA-damaging agents by eliminating Chk1-mediated checkpoint responses. Using mouse models, we...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.84
更新日期:2013-01-31 00:00:00
abstract::High-throughput, human cell-based applications of RNA-mediated interference (RNAi) have emerged in recent years as perhaps the most powerful of a 'second wave' of functional genomics technologies. The available reagents and methodologies for RNAi screening studies now enable a wide range of different scopes and scales...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208072
更新日期:2004-11-01 00:00:00
abstract::Heat shock protein 90 (Hsp90) is a survival signaling chaperone and a cancer chemotherapeutic target. However, we have found that inhibitors of Hsp90 diminished the apoptotic response induced in leukemic cells by the antitumor alkyl-lysophospholipid analog edelfosine, which acts through lipid raft reorganization. Edel...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210816
更新日期:2008-03-13 00:00:00
abstract::The von Hippel-Lindau tumor suppressor pVHL regulates the stability of hypoxia-inducible factors (HIF)-1 and -2, oxygen-sensitive basic helix-loop-helix transcription factors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial growth factor. Loss of pVHL function results in c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.160
更新日期:2008-09-11 00:00:00
abstract::Uterine leiomyomas or fibroids (UFs) are benign tumors characterized by hyperplastic smooth muscle cells and excessive deposition of extracellular matrix (ECM). Afflicting ~80% of women, and symptomatic in 25%, UFs bring tremendous suffering and are an economic burden worldwide; they cause severe pain and bleeding, an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0808-4
更新日期:2019-07-01 00:00:00
abstract::The transcription factor Ets-1 regulates the expression of several angiogenic and extracellular matrix remodeling factors, and might be implicated in disease progression of breast cancer. In the present study, the prognostic value of Ets-1 expression was assessed by quantitative real-time fluorescence RT-PCR in 123 sp...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206040
更新日期:2002-12-05 00:00:00
abstract::Structural rearrangements involving chromosome 13 are frequently seen in B-cell chronic lymphocytic leukaemia. The presence of reciprocal translocations involving 13q14 in 10-15% of cases pinpoints the location of a gene important in leukaemogenesis. In order to characterise the exact location of the 13q14 breakpoint,...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-06-01 00:00:00
abstract::Radiation therapy (RT) is useful for selectively killing cancer cells. However, because high levels of ionizing radiation (IR) are toxic to normal cells, RT cannot be applied repeatedly to cancer patients. Therefore, novel chemicals that enhance the efficacy of chemoradiotherapy (CRT) would be valuable. Here, we repor...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2015.47
更新日期:2015-12-03 00:00:00
abstract::Like other types of pre-malignant lesions and carcinoma, angiogenesis is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular endothelial cell growth factor (VEGF) is known to be one of the most important inducers of angiogenesis and is upregulated in carcinoma of ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203817
更新日期:2000-09-21 00:00:00
abstract::The progression and negative outcome of a variety of human carcinomas are intimately associated with aberrant activity of the c-Met oncogene. The underlying cause of this dysregulation, however, remains a subject of discussion, as the majority of cancer patients do not present with activating mutations in c-Met recept...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.586
更新日期:2011-04-28 00:00:00
abstract::Epigenetic regulations play crucial roles in leukemogenesis and leukemia progression. SUV39H1 is the dominant H3K9 methyltransferase in the hematopoietic system, and its expression declines with aging. However, the role of SUV39H1 via its-mediated repressive modification H3K9me3 in leukemogenesis/leukemia progression ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01495-6
更新日期:2020-12-01 00:00:00
abstract::The human ret proto-oncogene (proto-ret), encoding a receptor tyrosine kinase, is highly expressed in neuroblastomas, medullary thyroid carcinomas (MTCs) and pheochromocytomas, which are all tumors of cells originating from the neural crest. In studies on the transcription mechanism of proto-ret, we identified the tra...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the ability of avian myeloblastosis virus (AMV) to transform myelomonocytic cells. v-Myb is thought to disrupt the differentiation of myelomonocytic cells by affecting the expression of specific target genes. To identify such...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204071
更新日期:2001-01-11 00:00:00
abstract::Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR) overexpression has been implicated in MPNST formation, but its precise role and relevant signaling pathways remain unknown. We found that EGFR overexpression pro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.579
更新日期:2014-01-09 00:00:00
abstract::An improved understanding of the biochemical alterations that accompany tumor progression and metastasis is necessary to inform the next generation of diagnostic tools and targeted therapies. Metabolic reprogramming is known to occur during the epithelial-mesenchymal transition (EMT), a process that promotes metastasi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0885-4
更新日期:2020-04-01 00:00:00
abstract::CD66a, also known as 'biliary glycoprotein (BGP)', is the human homologue of a cell adhesion molecule (CAM) of the rat (Cell-CAM). CD66a, which belongs to the carcinoembryonic antigen family and the immunoglobulin superfamily, is expressed in cells of myeloid and epithelial origin. The cytoplasmic domain of the major ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-10-19 00:00:00