Abstract:
:The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3-kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.
journal_name
Oncogenejournal_title
Oncogeneauthors
Stebbing J,Lit LC,Zhang H,Darrington RS,Melaiu O,Rudraraju B,Giamas Gdoi
10.1038/onc.2013.80subject
Has Abstractpub_date
2014-02-20 00:00:00pages
939-53issue
8eissn
0950-9232issn
1476-5594pii
onc201380journal_volume
33pub_type
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