Abstract:
:Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the cytoplasm, whereas the other family members remain in the nucleus. Histone deacetylase 3 often forms complexes with corepressor proteins that do not associate with the other Class I HDACs, and its phosphorylation correlates with increased enzymatic activity. Here we show that HDAC3 also localizes to the plasma membrane in multiple cell types. Furthermore, c-Src is shown to form a complex with HDAC3 at the plasma membrane and to use HDAC3 as a substrate for phosphorylation. Our results describe a novel localization and binding partner for the HDAC3 protein, as well as implicate c-Src in HDAC3 regulation.
journal_name
Oncogenejournal_title
Oncogeneauthors
Longworth MS,Laimins LAdoi
10.1038/sj.onc.1209473subject
Has Abstractpub_date
2006-07-27 00:00:00pages
4495-500issue
32eissn
0950-9232issn
1476-5594pii
1209473journal_volume
25pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::A selective switch from expression of Shc1 gene to Shc3 occurs with maturation of neuronal precursors into postmitotic neurons. Previous studies showed that in the embryo, Shc1 is maximally expressed in dividing CNS stem cells while it is silenced in mature neurons, where it is replaced by Shc3. Under normal condition...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208708
更新日期:2005-08-04 00:00:00
abstract::Raf-1 is a serine-threonine protein kinase that functions as a central component of the mitogen-activated protein kinase signal transduction pathway. Raf-1 activity is currently assayed in vitro by either measuring 32P incorporation into MEK, Raf-1's only characterized substrate, or by using the phosphorylated MEK to ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203862
更新日期:2000-10-12 00:00:00
abstract::p53 is involved in several DNA repair pathways. Some of these require the specific transactivation of p53-dependent genes and others involve direct interactions between the p53 protein and DNA repair associated proteins. Previously, we have shown that p53 acts directly in Base Excision Repair (BER) when assayed under ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204120
更新日期:2001-02-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF), an important angiogenic factor, regulates cell proliferation, differentiation, and apoptosis through activation of its tyrosine-kinase receptors, such as Flt-1 and Flk-1/Kdr. Human malignant mesothelioma cells (HMC), which have wild-type p53, express VEGF and exhibit cell gro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205382
更新日期:2002-04-25 00:00:00
abstract::Transforming growth factor alpha (TGFalpha) is widely expressed in malignant as well as normal cells and is involved in regulating cell growth and differentiation. Although processing of TGFalpha has been extensively studied in normal cells, there is little information regarding TGFalpha cleavage in malignant cells. T...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203513
更新日期:2000-04-06 00:00:00
abstract::Histone deacetylases (HDACs) catalyse the removal of acetyl groups from the N-terminal tails of histones. All known HDACs can be categorized into one of four classes (I-IV). The class III HDAC or silencing information regulator 2 (Sir2) family exhibits characteristics consistent with a distinctive role in regulation o...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210617
更新日期:2007-08-13 00:00:00
abstract::The phosphatidylinositol 3'-kinase (PI3K) pathway is dysregulated in multiple myeloma (MM); we therefore tested a highly selective class I PI3K inhibitor, GDC-0941, for anti-myeloma activity. Functional and mechanistic studies were first performed in MM cell lines, then extended to primary MM patient samples cultured ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.594
更新日期:2014-01-16 00:00:00
abstract::It is now well established that the immune system can control neoplastic development and growth in a process termed immunosurveillance. A link between host immunosurveillance and neoplastic progression is revealed in cases where the immune response becomes compromised due to genetic or other pathological conditions, r...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2008.268
更新日期:2008-10-06 00:00:00
abstract::The human cellular homolog of v-rel, the transforming gene of reticuloendotheliosis virus, strain T, was previously localized to 2 cent-2p13 by a combination of somatic cell hybrid and in situ hybridization analyses. In this study, we use translocation chromosome analysis to refine c-rel's genetic assignment to 2p12-2...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
abstract::Somatic alterations of fibroblast growth factor receptors (FGFRs) have been described in a wide range of malignancies. A number of anti-FGFR therapies are currently under investigation in clinical trials for subjects with FGFR gene amplifications, mutations and translocations. Here, we develop cell line models of acqu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.161
更新日期:2015-04-23 00:00:00
abstract::Previous studies have shown that the cell cycle-regulated B-myb promoter contains a conserved E2F binding site that is critical for repressing transcription in quiescent cells. To investigate its significance for permanent promoter silencing, we have inactivated this binding site in the mouse genome. Mice homozygous f...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210087
更新日期:2007-04-26 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is associated with an increased risk for lung cancer and an aberrant microbiota of the lung. Microbial colonization contributes to chronic neutrophilic inflammation in COPD. Nontypeable Haemophilus influenzae (NTHi) is frequently found in lungs of stable COPD patients and i...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.28
更新日期:2017-07-20 00:00:00
abstract::In an effort to understand the mechanisms governing the regulation of the mouse Ron receptor gene, a mouse genomic library was screened and overlapping clones coding for the Ron gene and flanking DNA were identified. Continuous DNA sequence was obtained for approximately 16.4 kilobases. The gene, from the initiator me...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201508
更新日期:1998-01-08 00:00:00
abstract::Most colorectal carcinomas harbor genetic alterations that result in stabilization of beta-catenin. A colorectal carcinoma cell line, HCT116, which has both mutated and wild-type beta-catenin genes, was engineered by homologous recombination to investigate the significance of beta-catenin gene mutation. As expected, t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205756
更新日期:2002-08-29 00:00:00
abstract::A cDNA encoding a complete human c-fos protein was isolated and inserted into two different murine MoMuLV-derived recombinant retroviruses allowing expression of c-fos protein in different cell types. One c-fos-expressing retrovirus, chosen for its ability to express high levels of proteins in fibroblast-like cells, w...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract::Clinical and epidemiological data support a role for human papilloma virus (HPV) type 16 in the pathogenesis of cervical carcinoma. The W12 cell line contains HPV16 sequences, predominantly as a high copy number episome, and is immortalised in vitro, but non-tumourigenic. A morphologically distinct sub-line of the par...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-04-01 00:00:00
abstract::The disabled homolog 2 (DAB2) gene was recently identified as a tumor suppressor gene with its expression downregulated in multiple cancer types. The role of DAB2 in lung tumorigenesis, however, is not fully characterized, and the mechanisms of DAB2 dysregulation in lung cancer are not defined. Here we show that low D...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.381
更新日期:2014-08-21 00:00:00
abstract::Viruses have been engineered to replicate selectively in cancer cells, based on a number of innovative principles. Several of these viruses have entered clinical trials and have proven relatively safe, and have shown evidence of efficacy. However, further research is required to enable these agents to function systemi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209064
更新日期:2005-11-21 00:00:00
abstract::SCC-S2/GG2-1/NDED is a recently discovered antiapoptotic molecule induced by the activation of the transcription factor NF-kappaB. Here we have examined a role of SCC-S2 in cell growth regulation in vitro and in vivo. Western blotting using an antipeptide antibody revealed endogenous SCC-S2 as a approximately 21 kDa c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207123
更新日期:2004-01-15 00:00:00
abstract::The most frequent targets of genetic alterations in human lymphoid leukemias are transcription factor genes with essential functions in blood cell development. TAL1, LYL1, HOX11 and other transcription factors essential for normal hematopoiesis are often misexpressed in the thymus in T-cell acute lymphoblastic leukemi...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1210766
更新日期:2007-10-15 00:00:00
abstract::For many years the precise genetic etiology of the majority of Wilms' tumors has remained unexplained. Recently, the WTX gene, mapped to chromosome Xq11.1, has been reported to be lost or mutated in approximately one-third of Wilms' tumors. Moreover, in female cases, the somatically inactivated alleles were found to i...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.93
更新日期:2008-07-31 00:00:00
abstract::Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the synthesis of prostaglandins, promotes the development of colorectal cancer, and is a key molecular target of non-steroidal anti-inflammatory drugs, compounds that reduce the relative risk of developing colon cancer. In this study, we showed that interferon gamm...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210015
更新日期:2007-03-29 00:00:00
abstract::High Mobility Group AT-hook 2 (HMGA2) is a chromatin modifier and its overexpression has been found in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Level of Hmga2 expression is fine-tuned by Lin28b-Let-7 axis and Polycomb Repressive Complex 2, in which deletion of Ezh2 leads to activa...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-020-01629-w
更新日期:2021-01-15 00:00:00
abstract::In spite of relentless efforts to devise new treatment strategies, primary glioblastomas invariably recur as aggressive, therapy-resistant relapses and patients rapidly succumb to these tumors. Many therapeutic agents are first tested in clinical trials involving recurrent glioblastomas. Remarkably, however, fundament...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.85
更新日期:2016-11-10 00:00:00
abstract::We studied the role of the mitogen-activated protein kinase (MAPK) pathway in the regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in breast tumor MCF-7 cells. We found that addition of a protein kinase C (PKC) activator to MCF-7 cultures prevented TRAIL-induced apoptosi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205523
更新日期:2002-06-20 00:00:00
abstract::Colon carcinogenesis is a multiple-step process involving the accumulation of a series of genetic and epigenetic alterations. The most commonly initiating event of intestinal carcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/β-catenin pathway. Olfactomedin 4 ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2016.58
更新日期:2016-10-06 00:00:00
abstract::Genetic lesions found in tumors are often targeted to the negative growth regulatory tumor suppressor genes. Much of our understanding of tumor suppressor gene function is derived from experimental manipulations in cultured cells. Recently, however, the generation of mice with germ line tumor suppressor gene mutations...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1202573
更新日期:1998-12-24 00:00:00
abstract::Human papillomaviruses (HPVs) are involved in the pathogenesis of cancer of the cervix (CaCx). MicroRNA (miRNA) expression analysis using Ambion (Austin, TX, USA) arrays showed that three miRNAs were overexpressed and 24 underexpressed in cervical cell lines containing integrated HPV-16 DNA compared to the normal cerv...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210919
更新日期:2008-04-17 00:00:00
abstract::Mammalian systems respond to environmental stress by either adapting or undergoing programmed cell death. While there is general agreement that the caspase family of proteases serve as the effectors of the apoptotic death response, the signaling apparatus involved in the decision to activate the caspase system is less...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1202570
更新日期:1998-12-24 00:00:00
abstract::The Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) has a significant role in initiating EBV-associated lymphoproliferative disease and EBV-related malignancies. In view of clinical features related to the type of EBV latency, LMP1 may influence invasiveness of EBV associated tumors categorized as ty...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203502
更新日期:2000-03-30 00:00:00