Targeting an E2F site in the mouse genome prevents promoter silencing in quiescent and post-mitotic cells.

abstract：:Cells from patients with the human genetic disorder ataxia-telangiectasia (A-T) are defective in the activation of cell cycle checkpoints in response to ionizing radiation damage. In order to understand the role of ATM in checkpoint control we investigated whether Schizosaccaromyces pombe chk1, a protein kinase implic...

journal_title：Oncogene

authors： Chen P,Gatei M,O'Connell MJ,Khanna KK,Bugg SJ,Hogg A,Scott SP,Hobson K,Lavin MF

更新日期：1999-01-07 00:00:00

abstract：:Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) and mutation of the p53 are both commonly detected in human prostate cancer cells. We sought to investigate whether there is functional regulation of Stat3 by wild-type (wt) p53. Our results demonstrate that expression of wt p53 ...

journal_title：Oncogene

authors： Lin J,Tang H,Jin X,Jia G,Hsieh JT

更新日期：2002-05-02 00:00:00

abstract：:Rad54 and Mus81 mammalian proteins physically interact and are important for the homologous recombination DNA repair pathway; however, their functional interactions in vivo are poorly defined. Here, we show that combinatorial loss of Rad54 and Mus81 results in hypersensitivity to DNA-damaging agents, defects on both t...

journal_title：Oncogene

authors： Ghamrasni SE,Cardoso R,Li L,Guturi KK,Bjerregaard VA,Liu Y,Venkatesan S,Hande MP,Henderson JT,Sanchez O,Hickson ID,Hakem A,Hakem R

更新日期：2016-09-15 00:00:00

abstract：:Loss of von Hippel Lindau (VHL) protein function is a key driver of VHL diseases, including sporadic and inherited clear cell renal cell carcinoma. Modulation of the proteostasis of VHL, especially missense point-mutated VHL, is a promising approach to augmenting VHL levels and function. VHL proteostasis is regulated ...

journal_title：Oncogene

authors： German P,Bai S,Liu XD,Sun M,Zhou L,Kalra S,Zhang X,Minelli R,Scott KL,Mills GB,Jonasch E,Ding Z

更新日期：2016-09-22 00:00:00

abstract：:The hepatitis B virus (HBV) X protein (pX) stimulates transcription regulated by cis-acting elements that control many viral and cellular genes, including the c-myc and the c-fos proto-oncogenes. Using several c-fos promoter deletion mutants, we found the serum-responsive element (SRE) located at -315, the modified TP...

journal_title：Oncogene

authors： Avantaggiati ML,Natoli G,Balsano C,Chirillo P,Artini M,De Marzio E,Collepardo D,Levrero M

更新日期：1993-06-01 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) is a transmembrane receptor tyrosine kinase in the insulin receptor superfamily. We recently demonstrated that the growth factors pleiotrophin (PTN) and midkine (MK) are ligands for ALK and that upon ALK activation, insulin receptor substrate-1 (IRS-1) and other substrates are phosphor...

journal_title：Oncogene

authors： Kuo AH,Stoica GE,Riegel AT,Wellstein A

更新日期：2007-02-08 00:00:00

abstract：:Differentiation inducible leukemic as well as normal myeloid precursors treated with physiological myeloid differentiation inducer have been used to explore the immediate early genetic response of cells to terminal differentiation and growth arrest stimuli. cDNA clones of 12 distinct genes, referred to as MyD genes, w...

journal_title：Oncogene

authors： Lord KA,Hoffman-Liebermann B,Liebermann DA

更新日期：1990-03-01 00:00:00

abstract：:We have previously reported on the identification of a cDNA (placenta growth factor, PlGF) coding for a novel angiogenic factor expressed in placental tissue that is similar to vascular permeability factor/vascular endothelial growth factor (VPF/VEGF). Biochemical and functional characterization of PlGF derived from t...

journal_title：Oncogene

authors： Maglione D,Guerriero V,Viglietto G,Ferraro MG,Aprelikova O,Alitalo K,Del Vecchio S,Lei KJ,Chou JY,Persico MG

更新日期：1993-04-01 00:00:00

abstract：:Upregulated gene 19 (U19)/ELL-associated factor 2 (Eaf2) is a potential human tumor suppressor that exhibits frequent allelic loss and downregulation in high-grade prostate cancer. U19/Eaf2, along with its homolog Eaf1, has been reported to regulate transcriptional elongation via interaction with the eleven-nineteen l...

journal_title：Oncogene

authors： Xiao W,Zhang Q,Habermacher G,Yang X,Zhang AY,Cai X,Hahn J,Liu J,Pins M,Doglio L,Dhir R,Gingrich J,Wang Z

更新日期：2008-03-06 00:00:00

abstract：:Alterations in expression of c-myb can have profound effects on the growth and differentiation of hematopoietic cells. Thus, it is important to understand the mechanisms by which c-myb is regulated during hematopoietic cell differentiation. Previous studies pertaining to the regulation of c-myb have been carried out w...

journal_title：Oncogene

authors： Boise LH,Gorse KM,Westin EH

更新日期：1992-09-01 00:00:00

abstract：:Histone modifications such as acetylation, methylation and phosphorylation have been implicated in fundamental cellular processes such as epigenetic regulation of gene expression, organization of chromatin structure, chromosome segregation, DNA replication and DNA repair. Males absent on the first (MOF) is responsible...

journal_title：Oncogene

authors： Rea S,Xouri G,Akhtar A

更新日期：2007-08-13 00:00:00

abstract：:Immunopurified mouse p53 proteins were used to gain experimental access to the mechanisms underlying nonprimate p53 directed suppression of SV40 origin directed DNA replication in vivo. In replication competent HeLa cell extracts containing exogenous T antigen, mouse p53 blocks T antigen dependent DNA synthesis as in ...

journal_title：Oncogene

authors： Stürzbecher HW,Brain R,Maimets T,Addison C,Rudge K,Jenkins JR

更新日期：1988-10-01 00:00:00

abstract：:To understand the mechanism of interferon (IFN)-mediated suppression of cell cycle progression, we have earlier shown that IFN-alpha enhances the expression of underphosphorylated retinoblastoma protein by inhibiting the cyclin-dependent kinase-2 (CDK-2) activity (Kumar and Atlas, Proc. Natl. Acad. Sci. 89, 6599-6603,...

journal_title：Oncogene

authors： Mandal M,Bandyopadhyay D,Goepfert TM,Kumar R

更新日期：1998-01-15 00:00:00

abstract：:Invadopodia are cell protrusions that mediate cancer cell extravasation but the microenvironmental cues and signaling factors that induce invadopodia formation during extravasation remain unclear. Using intravital imaging and loss of function experiments, we determined invadopodia contain receptors involved in chemota...

journal_title：Oncogene

authors： Williams KC,Cepeda MA,Javed S,Searle K,Parkins KM,Makela AV,Hamilton AM,Soukhtehzari S,Kim Y,Tuck AB,Ronald JA,Foster PJ,Chambers AF,Leong HS

更新日期：2019-05-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) are a kind of adult stem cells that can be isolated easily from bone marrow, adipose tissue, umbilical cord and many other tissues. MSCs have been shown to specifically migrate to inflammatory sites, including tumors, and hold great promise as tumor-specific vectors to deliver antitumor a...

journal_title：Oncogene

authors： Xu C,Lin L,Cao G,Chen Q,Shou P,Huang Y,Han Y,Wang Y,Shi Y

更新日期：2014-10-16 00:00:00

abstract：:The recent years have seen a significant shift in the expectations for the therapeutic management of disseminated melanoma. The clinical success of BRAF targeted therapy suggests that long-term disease control may one day be a reality for genetically defined subgroups of melanoma patients. Despite this progress, few a...

journal_title：Oncogene

authors： Fedorenko IV,Gibney GT,Smalley KS

更新日期：2013-06-20 00:00:00

abstract：:One of the hallmarks of malignancy is the polarization of tumor-associated macrophages (TAMs) from a pro-immune (M1-like) phenotype to an immune-suppressive (M2-like) phenotype. However, the molecular basis of the process is still unclear. MicroRNA (miRNA) comprises a group of small, non-coding RNAs that are broadly e...

journal_title：Oncogene

authors： Yang J,Zhang Z,Chen C,Liu Y,Si Q,Chuang TH,Li N,Gomez-Cabrero A,Reisfeld RA,Xiang R,Luo Y

更新日期：2014-06-05 00:00:00

abstract：:The Ste20-like kinase, SLK, is involved in the control of cell motility through its effects on actin reorganization and focal adhesion turnover. Here we investigated the role of SLK in chemotaxis downstream of the tyrosine kinase receptor, HER2/ErbB2/Neu, which is frequently overexpressed in human breast cancers. Our ...

journal_title：Oncogene

authors： Roovers K,Wagner S,Storbeck CJ,O'Reilly P,Lo V,Northey JJ,Chmielecki J,Muller WJ,Siegel PM,Sabourin LA

更新日期：2009-08-06 00:00:00

abstract：:We isolated three related cDNA clones from a mouse cerebellar library; the type I cDNA was identical to the gene encoding the apoptosis-associated tyrosine kinase (AATYK), whose expression in myeloid precursor cells is increased during growth arrest or apoptosis. Low levels of AATYK mRNA expression were seen in adult ...

journal_title：Oncogene

authors： Tomomura M,Fernandez-Gonzales A,Yano R,Yuzaki M

更新日期：2001-03-01 00:00:00

abstract：:Here we describe the identification of a novel vertebrate-specific centrosome/spindle pole-associated protein (CSPP) involved in cell-cycle regulation. The protein is predicted to have a tripartite domain structure, where the N- and C-terminal domains are linked through a coiled-coil mid-domain. Experimental analysis ...

journal_title：Oncogene

authors： Patzke S,Hauge H,Sioud M,Finne EF,Sivertsen EA,Delabie J,Stokke T,Aasheim HC

更新日期：2005-02-10 00:00:00

abstract：:The tumor suppressor p53 has been found to be the most commonly mutated gene in human cancers; however, the frequency of p53 mutations varies from 10 to 70% across different cancer types. This variability can partly be explained by inactivating mechanisms aside from direct genomic polymorphisms. The p53 gene encodes 1...

journal_title：Oncogene

authors： Takahashi R,Giannini C,Sarkaria JN,Schroeder M,Rogers J,Mastroeni D,Scrable H

更新日期：2013-06-27 00:00:00

abstract：:Initiation of DNA replication requires the function of MCM gene products, which participate in ensuring that DNA replication occurs only once in the cell cycle. Expression of all mammalian genes of the MCM family is induced by growth stimulation, unlike yeast, and the mRNA levels peak at G1/S boundary. In this study, ...

journal_title：Oncogene

authors： Ohtani K,Iwanaga R,Nakamura M,Ikeda M,Yabuta N,Tsuruga H,Nojima H

更新日期：1999-04-08 00:00:00

abstract：:Many anticancer drugs exert their cytotoxicity through DNA damage and induction of apoptosis. Small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC) have different sensitivity to treatment with radiation and chemotherapeutic agents with SCLC being more sensitive than NSCLC both in vitro and in vivo...

journal_title：Oncogene

authors： Joseph B,Ekedahl J,Lewensohn R,Marchetti P,Formstecher P,Zhivotovsky B

更新日期：2001-05-24 00:00:00

abstract：:Genetic mutations in BRCA1, which is crucial for the process of DNA repair and maintenance of genomic integrity, are known to increase markedly the risk of breast and ovarian cancers. Clinical genetic testing has been used to identify new BRCA1 variants; however, functional assessment and determination of their pathog...

journal_title：Oncogene

authors： Kweon J,Jang AH,Shin HR,See JE,Lee W,Lee JW,Chang S,Kim K,Kim Y

更新日期：2020-01-01 00:00:00

abstract：:Matrilysin (MMP-7) is thought to contribute to invasive growth and metastasis of colon carcinoma and many other human cancers. The present study demonstrates that treatment of human colon carcinoma cells with active matrilysin induces cell aggregation in vitro and promotes liver metastasis in nude mice. When two kinds...

journal_title：Oncogene

authors： Kioi M,Yamamoto K,Higashi S,Koshikawa N,Fujita K,Miyazaki K

更新日期：2003-11-27 00:00:00

abstract：:Cancer cells acquire several traits that allow for their survival and progression, including the ability to evade the host immune response. However, the mechanisms by which cancer cells evade host immune responses remain largely elusive. Here we study the phenomena of immune evasion in malignant melanoma cells. We fin...

journal_title：Oncogene

authors： Dong Y,Richards JA,Gupta R,Aung PP,Emley A,Kluger Y,Dogra SK,Mahalingam M,Wajapeyee N

更新日期：2014-09-18 00:00:00

abstract：:PTEN, encoding a lipid phosphatase, is a tumor suppressor gene and is mutated in various types of cancers. It is reported to regulate G1 to S phase transition of the cell cycle by influencing the expression, protein stability and subcellular location of cyclin D1. Here, we provide evidence that PTEN modulates the tran...

journal_title：Oncogene

authors： Huang W,Chang HY,Fei T,Wu H,Chen YG

更新日期：2007-04-12 00:00:00

abstract：:Resistance and relapse are still primary causes that result in poor effectiveness of chemotherapy in malignant gliomas. Therefore, development of new therapeutic strategies requires the identification of key molecular pathways regulating chemoresistance. We previously found that abnormal high expression of the Tie2 re...

journal_title：Oncogene

authors： Martin V,Xu J,Pabbisetty SK,Alonso MM,Liu D,Lee OH,Gumin J,Bhat KP,Colman H,Lang FF,Fueyo J,Gomez-Manzano C

更新日期：2009-06-18 00:00:00

abstract：:SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes that includes HACS1. HACS1 encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and has...

journal_title：Oncogene

authors： Claudio JO,Zhu YX,Benn SJ,Shukla AH,McGlade CJ,Falcioni N,Stewart AK

更新日期：2001-08-30 00:00:00

abstract：:Experimental studies performed prior to 1990 led to the widely held belief that matrix metalloproteinases (MMPs) produced by cancer cells are of critical importance in tumor invasion and metastasis. Based on this evidence, the pharmaceutical industry produced several well tolerated, orally active MMP inhibitors (MMPIs...

journal_title：Oncogene

authors： Zucker S,Cao J,Chen WT

更新日期：2000-12-27 00:00:00