Defective cleavage of membrane bound TGFalpha leads to enhanced activation of the EGF receptor in malignant cells.

abstract：:High-risk papillomavirus type 18 (HPV18) is one of the less represented HPV types in low-grade lesions of the anogenital tract, whereas it occupies the second place in cervical cancer, where it can be found in 16% of the cases worldwide, after HPV16 present in 54% of them. These epidemiological data indicate that HPV1...

journal_title：Oncogene

authors： Teissier S,Pang CL,Thierry F

更新日期：2010-09-09 00:00:00

abstract：:p73 is a member of the p53 family. Recent studies have shown that DNA damage can stabilize p73 protein and enhance p73-mediated apoptosis in a c-Abl dependent manner. To determine what regulates p73 transcriptionally, we analysed the expression of p73 in several cell lines following genotoxic stresses. We found that p...

journal_title：Oncogene

authors： Chen X,Zheng Y,Zhu J,Jiang J,Wang J

更新日期：2001-02-08 00:00:00

abstract：:CD97, a member of the adhesion family of G-protein-coupled receptors (GPCRs), complexes with and potentiates lysophosphatidic acid (LPA) receptor signaling to the downstream effector RHOA. We show here that CD97 was expressed in a majority of thyroid cancers but not normal thyroid epithelium and that the level of CD97...

journal_title：Oncogene

authors： Ward Y,Lake R,Martin PL,Killian K,Salerno P,Wang T,Meltzer P,Merino M,Cheng SY,Santoro M,Garcia-Rostan G,Kelly K

更新日期：2013-05-30 00:00:00

abstract：:Previously, we showed that the BRCA1 protein interacts directly and functionally with estrogen receptor-alpha (ER-alpha), resulting in the inhibition of estradiol (E2)-stimulated ER-alpha transcriptional activity. The interaction sites were mapped to the N-terminus of BRCA1 (within amino acids (aa) 1-302) and the liga...

journal_title：Oncogene

authors： Ma YX,Tomita Y,Fan S,Wu K,Tong Y,Zhao Z,Song LN,Goldberg ID,Rosen EM

更新日期：2005-03-10 00:00:00

abstract：:We have recently described the N-terminal RAS association domain family of genes, RASSF7-10. Previously, we cloned the N-terminal RASSF10 gene and demonstrated frequent methylation of the associated 5'-CpG island in acute lymphoblastic leukemia. To characterize RASSF10 gene expression, we demonstrate that in developin...

journal_title：Oncogene

authors： Hill VK,Underhill-Day N,Krex D,Robel K,Sangan CB,Summersgill HR,Morris M,Gentle D,Chalmers AD,Maher ER,Latif F

更新日期：2011-02-24 00:00:00

abstract：:The protein kinase encoded by the ataxia telangiectasia and Rad3-related (ATR) gene is activated by DNA-damaging agents that are frequently used as anticancer therapeutics. Inhibition of ATR expression in cultured cancer cells has been demonstrated to increase sensitivity to chemotherapeutic drugs, including the DNA-c...

journal_title：Oncogene

authors： Sangster-Guity N,Conrad BH,Papadopoulos N,Bunz F

更新日期：2011-06-02 00:00:00

abstract：:We screened cdc2 kinase inhibitors from cultured mediums of micro organisms using purified mouse cyclin B-cdc2 kinase and a specific substrate peptide for cdc2 kinase. A selective inhibitor of cdc2 kinase was isolated from the cultured medium of Aspergillus species F-25799, and identified as butyrolactone I. Butyrolac...

journal_title：Oncogene

authors： Kitagawa M,Okabe T,Ogino H,Matsumoto H,Suzuki-Takahashi I,Kokubo T,Higashi H,Saitoh S,Taya Y,Yasuda H

更新日期：1993-09-01 00:00:00

abstract：:The 2;13 chromosomal translocation occurs in most cases of the cancer alveolar rhabdomyosarcoma (ARMS), and juxtaposes the genes encoding the PAX3 and FKHR transcription factors. The resulting chimeric protein PAX3-FKHR is a potent transcriptional activator, and is hypothesized to function as a dominant acting oncogen...

journal_title：Oncogene

authors： Xia SJ,Barr FG

更新日期：2004-09-09 00:00:00

abstract：:In this study, alterations in gene expression patterns have been examined in v-Rel-transformed avian bone marrow cells. Using a conditional v-Rel estrogen receptor chimera (v-RelER) which transforms cells in an estrogen-dependent manner, we constructed subtraction cDNA libraries from v-RelER-transformed bone marrow ce...

journal_title：Oncogene

authors： Petrenko O,Ischenko I,Enrietto PJ

更新日期：1997-10-02 00:00:00

abstract：:The gfi-1 gene encodes a zinc finger containing protein that is specifically expressed in T-lymphocytes and is a frequent target of proviral insertion in T-cell lymphoma provoked by infection with MoMuLV--a non acute transforming retrovirus. Expression of a gfi-1 transgene targeted to T-cells by the lck proximal promo...

journal_title：Oncogene

authors： Schmidt T,Karsunky H,Gau E,Zevnik B,Elsässer HP,Möröy T

更新日期：1998-11-19 00:00:00

abstract：:The hepatitis B virus (HBV) X protein (pX) stimulates transcription regulated by cis-acting elements that control many viral and cellular genes, including the c-myc and the c-fos proto-oncogenes. Using several c-fos promoter deletion mutants, we found the serum-responsive element (SRE) located at -315, the modified TP...

journal_title：Oncogene

authors： Avantaggiati ML,Natoli G,Balsano C,Chirillo P,Artini M,De Marzio E,Collepardo D,Levrero M

更新日期：1993-06-01 00:00:00

abstract：:Treatment of many cancers relies on the combined action of several genotoxins, but the detrimental effect of these drugs on normal cells can cause severe side effects. One major challenge in anticancer therapy is therefore to increase the selectivity of current treatments toward cancer cells in order to spare normal c...

journal_title：Oncogene

authors： Michod D,Yang JY,Chen J,Bonny C,Widmann C

更新日期：2004-11-25 00:00:00

abstract：:The cochaperone CDC37 promotes the association of HSP90 with the protein kinase subset of client proteins to maintain their stability and signalling functions. HSP90 inhibitors induce depletion of clients, which include several oncogenic kinases. We hypothesized that the targeting of CDC37 using siRNAs would compromis...

journal_title：Oncogene

authors： Smith JR,Clarke PA,de Billy E,Workman P

更新日期：2009-01-15 00:00:00

abstract：:The Myc-deregulating chromosomal T(12;15)(Igh-Myc) translocation, the hallmark mutation of inflammation- and interleukin 6-dependent mouse plasmacytoma (PCT), is the premier model of cancer-associated chromosomal translocations because it is the only translocation in mice that occurs spontaneously (B lymphocyte lineag...

journal_title：Oncogene

authors： Takizawa M,Kim JS,Tessarollo L,McNeil N,Waldschmidt TJ,Casellas R,Ried T,Janz S

更新日期：2010-07-15 00:00:00

abstract：:Replacement of leucine 301 in the human colony stimulating factor 1 receptor (CSF-1R) by serine, threonine, glutamic acid, or proline induced ligand-independent transforming activity in mouse NIH3T3 cells, whereas substitution by phenylalanine, methionine, cysteine, or lysine did not. Serine, glutamic acid, and prolin...

journal_title：Oncogene

authors： Roussel MF,Downing JR,Sherr CJ

更新日期：1990-01-01 00:00:00

abstract：:The current histoclinical breast cancer classification is simple but imprecise. Several molecular classifications of breast cancers based on expression profiling have been proposed as alternatives. However, their reliability and clinical utility have been repeatedly questioned, notably because most of them were derive...

journal_title：Oncogene

authors： Guedj M,Marisa L,de Reynies A,Orsetti B,Schiappa R,Bibeau F,MacGrogan G,Lerebours F,Finetti P,Longy M,Bertheau P,Bertrand F,Bonnet F,Martin AL,Feugeas JP,Bièche I,Lehmann-Che J,Lidereau R,Birnbaum D,Bertucci F,de

更新日期：2012-03-01 00:00:00

abstract：:Targeting altered cancer cell metabolism with the glycolysis inhibitor, 2-deoxyglucose (2DG), is a viable therapeutic strategy, but the effects of 2DG on lymphoma cells and the mechanism of action are unknown. Five T-cell lymphoma lines and two B-cell lymphoma lines were shown to be highly sensitive to 2DG. Examinatio...

journal_title：Oncogene

authors： Zagorodna O,Martin SM,Rutkowski DT,Kuwana T,Spitz DR,Knudson CM

更新日期：2012-05-31 00:00:00

abstract：:Transforming Growth Factor-beta1 (TGF-beta1) inhibits the proliferation of most cells, but stimulates some mesenchymal cell types, including murine NIH3T3 fibroblasts. We show here that TGF-beta1 growth stimulation of NIH3T3 fibroblasts is reversed when these cells are transformed by SV40 or are transfected with a pla...

journal_title：Oncogene

authors： Dkhissi F,Raynal S,Jullien P,Lawrence DA

更新日期：1999-01-21 00:00:00

abstract：:To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease proc...

journal_title：Oncogene

authors： Peng WX,Koirala P,Mo YY

更新日期：2017-10-12 00:00:00

abstract：:Checkpoint protein Chk1 has been identified as an Hsp90 client. Treatment with 100 nM geldanamycin (GM) for 24 h markedly reduced the Chk1 amount in Jurkat and ML-1 leukemia cell lines. Because Chk1 plays a central role in G2 checkpoint, we added GM to G2-arrested Jurkat and HL-60 cells pretreated with 50 nM doxorubic...

journal_title：Oncogene

authors： Sugimoto K,Sasaki M,Isobe Y,Tsutsui M,Suto H,Ando J,Tamayose K,Ando M,Oshimi K

更新日期：2008-05-15 00:00:00

abstract：:Genomic imprinting at 11p15 is suggested to play a role in certain pediatric tumors such as Wilms' tumor, based on the findings of selective maternal loss of this chromosomal region. Although the allele loss at 11p15 is also frequent in a number of cancers of adults including lung, breast, and bladder cancers, possibl...

journal_title：Oncogene

authors： Kondo M,Matsuoka S,Uchida K,Osada H,Nagatake M,Takagi K,Harper JW,Takahashi T,Elledge SJ,Takahashi T

更新日期：1996-03-21 00:00:00

abstract：:Targeting Bruton tyrosine kinase (BTK) by ibrutinib is an effective treatment for patients with relapsed/refractory mantle cell lymphoma (MCL). However, both primary and acquired resistance to ibrutinib have developed in a significant number of these patients. A combinatory strategy targeting multiple oncogenic pathwa...

journal_title：Oncogene

authors： Li Y,Bouchlaka MN,Wolff J,Grindle KM,Lu L,Qian S,Zhong X,Pflum N,Jobin P,Kahl BS,Eickhoff JC,Wuerzberger-Davis SM,Miyamoto S,Thomas CJ,Yang DT,Capitini CM,Rui L

更新日期：2016-12-01 00:00:00

abstract：:EDD (E3 isolated by differential display), located at chromosome 8q22.3, is the human orthologue of the Drosophila melanogaster tumour suppressor gene 'hyperplastic discs' and encodes a HECT domain E3 ubiquitin protein-ligase. To investigate the possible involvement of EDD in human cancer, several cancers from diverse...

journal_title：Oncogene

authors： Clancy JL,Henderson MJ,Russell AJ,Anderson DW,Bova RJ,Campbell IG,Choong DY,Macdonald GA,Mann GJ,Nolan T,Brady G,Olopade OI,Woollatt E,Davies MJ,Segara D,Hacker NF,Henshall SM,Sutherland RL,Watts CK

更新日期：2003-08-07 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP1-36 hormone is processed by matrix metalloproteinases to yield a stable product, PTHrP1-17. PTHrP1-17 retains the ability to signal through PTH1R...

journal_title：Oncogene

authors： Frieling JS,Shay G,Izumi V,Aherne ST,Saul RG,Budzevich M,Koomen J,Lynch CC

更新日期：2017-08-01 00:00:00

abstract：:A protein of 300 kDa (p300) associates with the adenovirus E1A proteins and has been implicated in the control of cell cycle progression. In mammalian cells, p300 is actively phosphorylated in both quiescent and proliferating cells and its level of phosphorylation increases as it travels from late G1 into M phase. E1A...

journal_title：Oncogene

authors： Banerjee AC,Recupero AJ,Mal A,Piotrkowski AM,Wang DM,Harter ML

更新日期：1994-06-01 00:00:00

abstract：:Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however,...

journal_title：Oncogene

authors： Lan Q,Peyvandi S,Duffey N,Huang YT,Barras D,Held W,Richard F,Delorenzi M,Sotiriou C,Desmedt C,Lorusso G,Rüegg C

更新日期：2019-04-01 00:00:00

abstract：:Although transforming ras oncogenes have been implicated as causative factors in liver cell transformation, the exact function and phenotypic alterations generated by the expression of such transforming genes in liver epithelial cells has yet to be defined. We have utilized a retroviral vector system to deliver an ind...

journal_title：Oncogene

authors： Huber BE,Cordingley MG

更新日期：1988-09-01 00:00:00

abstract：:Melanoma dedifferentiation, characterized by the loss of MITF and MITF regulated genes and by upregulation of stemness markers as CD271, is implicated in resistance to chemotherapy, target therapy and immunotherapy. The identification of intrinsic mechanisms fostering melanoma dedifferentiation may provide actionable ...

journal_title：Oncogene

authors： Perotti V,Baldassari P,Molla A,Vegetti C,Bersani I,Maurichi A,Santinami M,Anichini A,Mortarini R

更新日期：2016-06-02 00:00:00

abstract：:Clinical and experimental evidence is consistent with a key role for transforming human papilloma viruses (HPVs) in the aetiology of anogenital carcinoma. Cervical carcinoma does, however, occasionally occur in the absence of HPV sequences (Riou et al., 1990). We have used a direct cDNA/PCR sequencing protocol to anal...

journal_title：Oncogene

authors： Crook T,Wrede D,Vousden KH

更新日期：1991-05-01 00:00:00

abstract：:Terminal differentiation of skeletal myoblasts is accompanied by down-regulation of vimentin and beta-, gamma-actins and up-regulation of desmin and sarcomeric alpha-actin(s). To investigate whether the normal decline in expression of vimentin and beta-, gamma-actins was coupled to withdrawal of proliferating myoblast...

journal_title：Oncogene

authors： Olson EN,Capetanaki YG

更新日期：1989-07-01 00:00:00