ATR mediates cisplatin resistance in a p53 genotype-specific manner.

abstract：:SHPTP2 is a ubiquitously-expressed SH2-containing tyrosine phosphatase that is tyrosine phosphorylated in response to activation of various receptor and nonreceptor tyrosine kinases. SHPTP2 associates with the platelet-derived growth factor (PDGF) receptor after ligand stimulation, and binding of SHPTP2 to this recept...

journal_title：Oncogene

authors： Keegan K,Cooper JA

更新日期：1996-04-04 00:00:00

abstract：:Pim kinases are found to be highly expressed in leukemia, lymphoma, prostate and pancreatic cancer. Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc succumb to pre-B-cell lymphoma at a strikingly accelerated speed. Despite that Pim-1/Pim-2 has long been recognized as a strong synergistic partner with c...

journal_title：Oncogene

authors： Zhang Y,Wang Z,Li X,Magnuson NS

更新日期：2008-08-14 00:00:00

abstract：:Germline LKB1 mutations cause Peutz-Jeghers syndrome, a hereditary disorder that predisposes to gastrointestinal hamartomatous polyposis and several types of malignant tumors. Somatic LKB1 alterations are rare in sporadic cancers, however, a few reports showed the presence of somatic alterations in a considerable frac...

journal_title：Oncogene

authors： Matsumoto S,Iwakawa R,Takahashi K,Kohno T,Nakanishi Y,Matsuno Y,Suzuki K,Nakamoto M,Shimizu E,Minna JD,Yokota J

更新日期：2007-08-30 00:00:00

abstract：:We tested the cytotoxic action of 8-hydroxyguanine (8ohG) by observing the viability of several leukemic cell lines (KG-1, U937, Jurkat and K 562) in the presence of 8-hydroxydeoxyguanosine (8ohdG), a nucleoside of 8ohG. It was found that 8ohdG showed cytotoxic action only to KG-1 and that only KG-1 showed a homozygou...

journal_title：Oncogene

authors： Hyun JW,Choi JY,Zeng HH,Lee YS,Kim HS,Yoon SH,Chung MH

更新日期：2000-09-14 00:00:00

abstract：:We have identified sequences in the 5' flanking region of the murine c-myc gene's P1 and P2 transcription initiation sites which form specific complexes with nuclear factors of murine and human origin and are also required for normal P1 and P2 usage. Four nuclear factor binding sites were identified within 400 bp 5' o...

journal_title：Oncogene

authors： Asselin C,Nepveu A,Marcu KB

更新日期：1989-05-01 00:00:00

abstract：:Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a slowly growing tumor with propensity for neuroinvasion and late recurrence, are limited to surgery and radiotherapy. Based on expression analysis performed on clinical specimens of salivary cancers, we identified in ACC expression of the neu...

journal_title：Oncogene

authors： Ivanov SV,Panaccione A,Brown B,Guo Y,Moskaluk CA,Wick MJ,Brown JL,Ivanova AV,Issaeva N,El-Naggar AK,Yarbrough WG

更新日期：2013-08-08 00:00:00

abstract：:Recent studies suggest that the action of platelet-activating factor (PAF), a potent phospholipid modulator of allergic and inflammatory reactions, is diverse and functions as a modulator of a variety of physiological and pathological events in many cell types and tissues. Its role (if any) in modulating the prolifera...

journal_title：Oncogene

authors： Wang H,Chakrabarty S

更新日期：2003-04-10 00:00:00

abstract：:The recent identification of the mouse White spotting and Steel loci as genes encoding the c-kit receptor and its ligand, respectively, has shed light on the importance of this ligand and receptor in embryogenesis, melanogenesis and hematopoiesis. In order to determine if the c-kit proto-oncogene is involved in human ...

journal_title：Oncogene

authors： Vandenbark GR,deCastro CM,Taylor H,Dew-Knight S,Kaufman RE

更新日期：1992-07-01 00:00:00

abstract：:We have previously reported that platelet-derived growth factor (PDGF) induced tyrosine phosphorylation of GTPase-activating protein (GAP) in intact quiescent fibroblasts under conditions in which insulin and basic fibroblast growth factor (bFGF) were ineffective (Molloy et al., 1988). In the present study, we have pr...

journal_title：Oncogene

authors： Heidaran MA,Molloy CJ,Pangelinan M,Choudhury GG,Wang LM,Fleming TP,Sakaguchi AY,Pierce JH

更新日期：1992-01-01 00:00:00

abstract：:Transforming growth factor beta1 (TGF-beta1) belongs to a family of polypeptide factors, whose cytostatic and apoptotic functions help restrain the growth of mammalian cells. Although solid data established the role of TGF-beta's as suppressor factors in tumorigenic processes, in the context of an advanced stage of di...

journal_title：Oncogene

authors： Murillo MM,del Castillo G,Sánchez A,Fernández M,Fabregat I

更新日期：2005-06-30 00:00:00

abstract：:TSC1 and TSC2 are responsible for the tumor suppressor gene syndrome tuberous sclerosis (TSC). Mammalian TSC genes have been shown to be involved in cell cycle regulation. Recently, in Drosophila, these data have been confirmed and TSC genes have further been demonstrated to affect cell size control. Here we provide s...

journal_title：Oncogene

authors： Rosner M,Hofer K,Kubista M,Hengstschläger M

更新日期：2003-07-31 00:00:00

abstract：:The Cancer Genome Atlas consortium brought us terabytes of information about genetic alterations in different types of human tumors. While many cancer-driver genes have been identified through these efforts, interrogating cancer genomes has also shed new light on tumor complexity. Mutations were found to vary tremendo...

journal_title：Oncogene

authors： Janiszewska M

更新日期：2020-03-01 00:00:00

abstract：:Ovarian cancer is the leading cause of death among all gynecological malignancies due to the development of acquired chemoresistance and disease relapse. Although the role of cancer stem cells (CSCs), a subset of tumor cells with the self-renewal and differentiation capabilities, in therapeutic resistance is beginning...

journal_title：Oncogene

authors： Ramadoss S,Sen S,Ramachandran I,Roy S,Chaudhuri G,Farias-Eisner R

更新日期：2017-03-01 00:00:00

abstract：:We reported previously that the v-rel protein (p59v-rel) exists in a high molecular weight complex with at least four other proteins in the cytoplasm of v-rel-transformed chicken pre-B lymphoid cells (Simek, S. & Rice, N.R., J. Virol., 62, 4730-4736, 1989). One of these proteins is the chicken c-rel protein, but the i...

journal_title：Oncogene

authors： Kochel T,Mushinski JF,Rice NR

更新日期：1991-04-01 00:00:00

abstract：:Melanoma dedifferentiation, characterized by the loss of MITF and MITF regulated genes and by upregulation of stemness markers as CD271, is implicated in resistance to chemotherapy, target therapy and immunotherapy. The identification of intrinsic mechanisms fostering melanoma dedifferentiation may provide actionable ...

journal_title：Oncogene

authors： Perotti V,Baldassari P,Molla A,Vegetti C,Bersani I,Maurichi A,Santinami M,Anichini A,Mortarini R

更新日期：2016-06-02 00:00:00

abstract：:Synemin (SYNM) is a type IV intermediate filament that has recently been shown to interact with the LIM domain protein zyxin, thereby possibly modulating cell adhesion and cell motility. Owing to this multiplicity of potential functions relevant to cancer development, we initiated a study to decipher SYNM expression a...

journal_title：Oncogene

authors： Noetzel E,Rose M,Sevinc E,Hilgers RD,Hartmann A,Naami A,Knüchel R,Dahl E

更新日期：2010-08-26 00:00:00

abstract：:Loss of PTEN tumor suppressor enhances metastatic risk in breast cancer, although the underlying mechanisms are poorly defined. We report that homozygous deletion of PTEN in mammary epithelial cells induces tubulin-based microtentacles (McTNs) that facilitate cell reattachment and homotypic aggregation. Treatment with...

journal_title：Oncogene

authors： Vitolo MI,Boggs AE,Whipple RA,Yoon JR,Thompson K,Matrone MA,Cho EH,Balzer EM,Martin SS

更新日期：2013-04-25 00:00:00

abstract：:Cortactin, a p80/85 protein first identified as a src kinase substrate, is thought to be involved in the signaling pathway of mitogenic receptors and adhesion molecules mediating cytoskeletal reorganization. The cortactin gene, EMS1, maps to chromosome 11q13, a region amplified in head and neck squamous cell carcinoma...

journal_title：Oncogene

authors： Patel AS,Schechter GL,Wasilenko WJ,Somers KD

更新日期：1998-06-25 00:00:00

abstract：:Adenovirus E4orf4 protein is a multifunctional viral regulator, which is involved in down regulation of virally-modulated signal transduction, in control of alternative splicing of viral mRNAs, and in induction of apoptosis in transformed cells. It has been previously shown that E4orf4 interacts with protein phosphata...

journal_title：Oncogene

authors： Shtrichman R,Sharf R,Kleinberger T

更新日期：2000-08-03 00:00:00

abstract：:We have examined the possibility that the E7 proteins of the high-risk human papillomavirus (HPV) type 16 and 18 and the oncogenic adenovirus (Ad) type 12 E1A protein share the ability to down-regulate the expression of components of the antigen processing and presentation pathway, as a common strategy in the evasion ...

journal_title：Oncogene

authors： Georgopoulos NT,Proffitt JL,Blair GE

更新日期：2000-10-05 00:00:00

abstract：:This issue attempts to give a 'state of the art' overview of the AP-1 transcription factor family, a fundamental class of transcriptional regulators. The AP-1 family consists of several bZIP (basic region leucine zipper) domain proteins, the Jun, the Fos, and the ATF subfamilies, which all have to dimerize before they...

journal_title：Oncogene

authors： Wagner EF

更新日期：2001-04-30 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by a block in myeloid cell differentiation. As a result of a chromosomal translocation in these patients, the promyelocytic leukemia protein PML is disrupted as are the nuclear bodies it forms. Disruption of PML and PML nuclear bodies in APL is linked to a loss of gr...

journal_title：Oncogene

authors： Topcu Z,Mack DL,Hromas RA,Borden KL

更新日期：1999-11-25 00:00:00

abstract：:Mdm2 is the major negative regulator of p53 tumor-suppressor activity. This oncoprotein is overexpressed in many human tumors that retain the wild-type p53 allele. As such, targeted inhibition of Mdm2 is being considered as a therapeutic anticancer strategy. The N-terminal hydrophobic pocket of Mdm2 binds to p53 and t...

journal_title：Oncogene

authors： Wade M,Li YC,Matani AS,Braun SM,Milanesi F,Rodewald LW,Wahl GM

更新日期：2012-11-08 00:00:00

abstract：:Midkine is a heparin-binding growth factor, originally reported as the product of a retinoic acid-responsive gene during embryogenesis, but currently viewed as a multifaceted factor contributing to both normal tissue homeostasis and disease development. Midkine is abnormally expressed at high levels in various human m...

journal_title：Oncogene

authors： Filippou PS,Karagiannis GS,Constantinidou A

更新日期：2020-03-01 00:00:00

abstract：:Intraductal papillary mucinous neoplasm (IPMN), the most common pancreatic cystic neoplasm, is known to progress to invasive ductal adenocarcinoma. IPMNs commonly harbor activating somatic mutations in GNAS and KRAS, primarily GNAS(R201H) and KRAS(G12D). GNAS encodes the stimulatory G-protein α subunit (Gsα) that medi...

journal_title：Oncogene

authors： Taki K,Ohmuraya M,Tanji E,Komatsu H,Hashimoto D,Semba K,Araki K,Kawaguchi Y,Baba H,Furukawa T

更新日期：2016-05-05 00:00:00

abstract：:Pharmacological inactivation of cancer genes or products is being used as a strategy for therapy in oncology. To investigate the potential role of BCR-ABLp190 cessation in leukaemia development, we generated mice carrying a tetracycline-repressible BCR-ABLp190 transgene. These mice were morphologically normal at birth...

journal_title：Oncogene

authors： Pérez-Caro M,Gutierrez-Cianca N,González-Herrero I,López-Hernández I,Flores T,Orfao A,Sánchez-Martín M,Gutiérrez-Adán A,Pintado B,Sánchez-García I

更新日期：2007-03-15 00:00:00

abstract：:Normal function of the p53 gene is integral to the cellular response to genotoxic stress. One prediction arising from this is that p53 deficiency results in an increased mutation frequency. However, limited evidence has been produced in support of this idea. In order to further investigate the in vivo role of p53 in s...

journal_title：Oncogene

authors： Clarke AR,Howard LA,Harrison DJ,Winton DJ

更新日期：1997-05-01 00:00:00

abstract：:Ovarian cancer (OvCa) is characterized by widespread and rapid metastasis in the peritoneal cavity. Visceral adipocytes promote this process by providing fatty acids (FAs) for tumour growth. However, the exact mechanism of FA transfer from adipocytes to cancer cells remains unknown. This study shows that OvCa cells co...

journal_title：Oncogene

authors： Ladanyi A,Mukherjee A,Kenny HA,Johnson A,Mitra AK,Sundaresan S,Nieman KM,Pascual G,Benitah SA,Montag A,Yamada SD,Abumrad NA,Lengyel E

更新日期：2018-04-01 00:00:00

abstract：:The MET oncogene encodes the receptor for HGF/Scatter Factor, known to control cell motility and invasion in epithelial cells. We report that the Met/HGF receptor, absent in differentiated adult skeletal muscles, is aberrantly expressed in clinical samples and in established cell lines of human rhadbomyosarcomas. In b...

journal_title：Oncogene

authors： Ferracini R,Olivero M,Di Renzo MF,Martano M,De Giovanni C,Nanni P,Basso G,Scotlandi K,Lollini PL,Comoglio PM

更新日期：1996-04-18 00:00:00

abstract：:The cellular and molecular mechanisms of tumor progression following chemotherapy are largely unknown. Here, we demonstrate that cisplatin (CDDP) treatment upregulates VEGF and Flt1 expression leading to the survival and expansion of a highly tumorigenic fraction of side-population (SP) cells in osteosarcoma (HOS), ne...

journal_title：Oncogene

authors： Tsuchida R,Das B,Yeger H,Koren G,Shibuya M,Thorner PS,Baruchel S,Malkin D

更新日期：2008-06-26 00:00:00