Abstract:
:We studied the role of the mitogen-activated protein kinase (MAPK) pathway in the regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in breast tumor MCF-7 cells. We found that addition of a protein kinase C (PKC) activator to MCF-7 cultures prevented TRAIL-induced apoptosis, by inhibiting a step downstream of both caspase-8 activation and BID cleavage. TRAIL-induced translocation of Bax from cytosol to mitochondria, release of cytochrome c from mitochondria and activation of caspase-9 were all inhibited by PKC activation. PKC-mediated prevention of mitochondrial apoptotic events and apoptosis was found to be dependent on the MAPK pathway. Since TRAIL is a ligand of potential use in antineoplastic clinical trials, our findings may provide relevant information in cancer therapy.
journal_name
Oncogenejournal_title
Oncogeneauthors
Sarker M,Ruiz-Ruiz C,Robledo G,López-Rivas Adoi
10.1038/sj.onc.1205523subject
Has Abstractpub_date
2002-06-20 00:00:00pages
4323-7issue
27eissn
0950-9232issn
1476-5594journal_volume
21pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Despite emergence of new systemic therapies, metastatic melanoma remains a challenging and often fatal form of skin cancer. The renin-angiotensin system (RAS) is a major physiological regulatory pathway controlling salt-water equilibrium, intravascular volume and blood pressure. Biological effects of the RAS are media...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0563-y
更新日期:2019-03-01 00:00:00
abstract::Stimulation of resting W53 cells (lymphoid murine cells expressing prolactin (PRL) receptor) by PRL induced expression of growth-related immediate-early genes (IEG), and proliferation through activation of the Src kinases. Since IEG are essential for cell cycle progression, we have studied how PRL controls expression ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208002
更新日期:2004-09-23 00:00:00
abstract::Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and comprises two major histological subtypes: alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS). Seventy-five percent of ARMS harbor reciprocal chromosomal translocations leading to fusion genes of the forkhead transcriptio...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.368
更新日期:2010-12-02 00:00:00
abstract::Genetic mutations in BRCA1, which is crucial for the process of DNA repair and maintenance of genomic integrity, are known to increase markedly the risk of breast and ovarian cancers. Clinical genetic testing has been used to identify new BRCA1 variants; however, functional assessment and determination of their pathog...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0968-2
更新日期:2020-01-01 00:00:00
abstract::Trichostatin A (TSA), a histone deacetylase inhibitor, strongly increases acetylation of the N-terminal tails of histone H3. Many studies have correlated the function of TSA with the hyperacetylation of histone. Although histone H3 is known to be phosphorylated, the effect of acetylation on phosphorylation is not know...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206507
更新日期:2003-08-14 00:00:00
abstract::Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects occurring in both the irradiated and nonirradiated cells in the population. This phenomenon, termed the 'bystander response', has been shown to occur both in vi...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1206961
更新日期:2003-10-13 00:00:00
abstract::Identification of prostate cancers at high risk of progression is difficult and a better understanding of how peptide growth factors influence cellular function might be useful. Fibroblast growth factors (FGFs) have been implicated in prostate cancer development. FGF8 was identified in the Shionogi mouse mammary carci...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202624
更新日期:1999-04-29 00:00:00
abstract::Scirrhous carcinoma of the stomach is characterized by rapid growth with a vast fibrous stroma, high invasiveness, and substantially a poor prognosis. Little is known of the molecular pathogenesis of this disease. Members of the emerging family of the CCN gene (for connective tissue growth factor, cysteine-rich 61, ne...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204723
更新日期:2001-09-06 00:00:00
abstract::Genetic mutations of oncogenes often underlie deranged cell growth and altered differentiation pathways leading to malignant transformation of B-lymphocytes. However, addiction to oncogenes is not the only drive to lymphoid tumor pathogenesis. Dependence on non-oncogenes, which act by propelling basic mechanisms of ce...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.86
更新日期:2016-11-24 00:00:00
abstract::p53 is known to play a role in iron homeostasis and is required for FDXR-mediated iron metabolism via iron regulatory protein 2 (IRP2). Interestingly, p53 is frequently mutated in tumors wherein iron is often accumulated, suggesting that mutant p53 may exert its gain of function by altering iron metabolism. In this st...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0876-5
更新日期:2019-08-01 00:00:00
abstract::Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumor-associated vascular endothelium, which functions as an accessory co...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1206813
更新日期:2003-09-29 00:00:00
abstract::SEMA3B, a member of class 3 semaphorins, is a tumor suppressor. Competition with vascular endothelial growth factor (VEGF)165 explains a portion of the activity, whereas the VEGF-independent mechanism was not elucidated. We employed a microarray and screened for the genes whose expression was increased by SEMA3B in NC...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2008.263
更新日期:2008-11-20 00:00:00
abstract::The C3H/HeJ (C3H), A/J and BALB/cByJ (BALB) mouse strains are respectively resistant, sensitive and intermediate regarding the induction of lung tumors by urethane. The phenotypic difference between C3H and A/J is largely determined by the Pas1 (Pulmonary adenoma susceptibility 1) gene on chromosome 6, the A/J allele ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201357
更新日期:1997-10-09 00:00:00
abstract::Invasive bladder cancer (BC) is one of the most lethal malignant urological tumors. Although miR-200a has been reported as an onco-miRNA that targets the PTEN gene in endometrioid carcinoma, its biological significance in BC invasion has been poorly explored. In the current study, we found that miR-200a was markedly o...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-1120-z
更新日期:2020-02-01 00:00:00
abstract::Identification and characterization of genes expressed in normal cells and decreased in their malignant counterparts is an important method for detecting candidate tumor suppressors. Using differential display of mRNAs from nontumorigenic infinite life span human fibroblast cell strain MSU-1.1 and an isogenic fibrosar...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202290
更新日期:1999-01-14 00:00:00
abstract::Overexpression of members of the myc family of oncogenes contributes to the development of many vertebrate malignancies. Although several functions for myc gene products have been proposed, the targets for Myc activity during oncogenesis or normal development remain to be identified. Oocytes of Xenopus laevis, which a...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract::Latent membrane protein 1 (LMP1), an oncoprotein encoded by Epstein-Barr virus (EBV), is an integral membrane protein, which acts like a constitutively active receptor. LMP1 is critical for some facet of EBV's induction and maintenance of proliferation of infected B cells. It, in part, mimics signaling by the CD40 rec...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208367
更新日期:2005-03-03 00:00:00
abstract::The human c-rel gene (REL), encoding an NF-kappaB transcription factor, is amplified or mutated in several human B-cell lymphomas and can transform chicken lymphoid cells in vitro. We have previously shown that certain deletions of C-terminal transactivation sequences enhance REL's transforming ability in chicken sple...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208902
更新日期:2005-11-10 00:00:00
abstract::The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but not by SUMO2/3 at multiple sites. We show that FOXM1 SUMOylation...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.546
更新日期:2014-08-21 00:00:00
abstract::We described previously the characterization of a novel oncogene, cph, activated in primary Syrian hamster embryo fibroblasts by exposure to 3-methylcholanthrene (Velasco et al., Oncogene 9:2065-2069, 1994). The present report describes the participation in the neoplastic conversion of cph-expressing (81C39) hamster f...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-03-02 00:00:00
abstract::Several cytokines, growth factors and the HIV transactivator Tat were shown to be involved in the pathogenesis of Kaposi's sarcoma. BKV/tat transgenic mice develop Kaposi's sarcoma-like lesions, and spindle-shaped cells (TTB) have been derived from these lesions. Here we show that TTB cells co-express hepatocyte growt...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-09-05 00:00:00
abstract::We have recently identified and cloned the gene for a cytosolic polypeptide, designated oncoprotein 18 (Op18), which is expressed in acute lymphocytic leukemia and some solid tumors including neuroblastoma. Op18 is phosphorylated upon treatment of lymphoid cells with phorbol myristate acetate. We have proposed that un...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::SCC-S2/GG2-1/NDED is a recently discovered antiapoptotic molecule induced by the activation of the transcription factor NF-kappaB. Here we have examined a role of SCC-S2 in cell growth regulation in vitro and in vivo. Western blotting using an antipeptide antibody revealed endogenous SCC-S2 as a approximately 21 kDa c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207123
更新日期:2004-01-15 00:00:00
abstract::In previous studies we changed five conserved amino acid residues in the catalytic domain of the yeast Ras-specific guanine nucleotide exchange factor CDC25GEF (Park et al., 1994). One of the substitutions (R1489E) resulted in a molecule which could bind Ras but was catalytically inactive. These observations suggested...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1200893
更新日期:1997-02-20 00:00:00
abstract::The transcription factor hypoxia inducible factor 1 (HIF1), an HIF1alpha-aryl hydrocarbon receptor nuclear translocator (ARNT) dimeric factor, is essential to the cellular response to hypoxia. We described a t(1;12)(q21;p13) chromosomal translocation in human acute myeloblastic leukemia that involves the translocated ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209503
更新日期:2006-08-10 00:00:00
abstract::Caspase-8 is a key effector of death-receptor-triggered apoptosis. In a previous study, we demonstrated, however, that caspase-8 can also be activated in a death receptor-independent manner via the mitochondrial apoptosis pathway, downstream of caspase-3. Here, we show that caspases-3 and -8 mediate a mitochondrial am...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206280
更新日期:2003-04-17 00:00:00
abstract::Human basal cell cancer (BCC) has unique growth characteristics with virtual inability to metastasize. We investigated clonality and genetic progression using p53 mutations as marker. Sampling was done through microdissection of frozen immunohistochemically stained 16 microm slices of tumors. From 11 BCC tumors 78 sam...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201435
更新日期:1997-08-28 00:00:00
abstract::L-ascorbate (L-ascorbic acid, vitamin C) clearly has an inhibitory effect on cancer cells. However, the mechanism underlying differential sensitivity of cancer cells from same tissue to L-ascorbate is yet to be clarified. Here, we demonstrate that L-ascorbate has a selective killing effect, which is influenced by sodi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.176
更新日期:2013-03-21 00:00:00
abstract::Excessive adiposity has long been associated with increased incidence of breast cancer in post-menopausal women, and with increased mortality from breast cancer, regardless of the menopausal status. Although adipose tissue-derived estrogen contributes to obesity-associated risk for estrogen receptor (ER)-positive brea...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.130
更新日期:2009-07-30 00:00:00
abstract::To identify genes that are differentially over-expressed in Small Cell Lung Carcinoma (SCLC) we have used a combination of suppression subtractive hybridization and cDNA microarray to analyse the expression profiles of 2400 cDNAs clones. Genes that are over-expressed in SCLC were identified using 32 pairs of fluoresce...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205480
更新日期:2002-05-23 00:00:00