当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Overexpressed miR-200a promotes bladder cancer invasion through direct regulating Dicer/miR-16/JNK2/MMP-2 axis.

Overexpressed miR-200a promotes bladder cancer invasion through direct regulating Dicer/miR-16/JNK2/MMP-2 axis.

Abstract：

:Invasive bladder cancer (BC) is one of the most lethal malignant urological tumors. Although miR-200a has been reported as an onco-miRNA that targets the PTEN gene in endometrioid carcinoma, its biological significance in BC invasion has been poorly explored. In the current study, we found that miR-200a was markedly overexpressed in both human BC tissues and BBN-induced muscle-invasive BC tissues. We further showed that miR-200a overexpression specifically promoted human BC cell invasion, but not migration, via transcriptional upregulation of matrix metalloproteinase (MMP)-2. Mechanistic studies indicated that the increased phosphorylation of c-Jun mediated the increasing levels of MMP-2 mRNA transcription. Further investigation revealed that Dicer was decreased in miR-200a overexpressed BC cells; this resulted in inhibition of miR-16 maturation and consequently led to increased JNK2 protein translation and c-Jun activation. Taken together, the studies here showed that miR-200a overexpression inhibited Dicer expression, in turn, resulted in inhibition of miR-16 maturation, leading to upregulation of JNK2 expression, c-Jun phosphorylation, MMP-2 transcription and, ultimately, BC invasion. Collectively, these results demonstrate that miR-200a is an onco-miRNA that is a positive regulator for BC invasion. This finding could be very useful in the ongoing development of new strategies to treat invasive BC patients.

journal_name

Oncogene

journal_title

Oncogene

authors

Yang R,Xu J,Hua X,Tian Z,Xie Q,Li J,Jiang G,Cohen M,Sun H,Huang C

doi

10.1038/s41388-019-1120-z

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

1983-1996

issue

9

eissn

0950-9232

issn

1476-5594

pii

10.1038/s41388-019-1120-z

journal_volume

39

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Silencing of imprinted CDKN1C gene expression is associated with loss of CpG and histone H3 lysine 9 methylation at DMR-LIT1 in esophageal cancer.

    abstract：:The putative tumor suppressor CDKN1C is an imprinted gene at 11p15.5, a well-known imprinted region often deleted in tumors. The absence of somatic mutations and the frequent diminished expression in tumors would suggest that CDKN1C expression is regulated epigenetically. It has been, however, controversial whether th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207576

    authors： Soejima H,Nakagawachi T,Zhao W,Higashimoto K,Urano T,Matsukura S,Kitajima Y,Takeuchi M,Nakayama M,Oshimura M,Miyazaki K,Joh K,Mukai T

    更新日期：2004-05-27 00:00:00

  • Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes.

    abstract：:Alternative splicing is a widespread process contributing to structural transcript variation and proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both functional and non-functional end-products. Cancer-specific splicing events are known to contribute to disease progression; howev...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2015.318

    authors： Sveen A,Kilpinen S,Ruusulehto A,Lothe RA,Skotheim RI

    更新日期：2016-05-12 00:00:00

  • Bcr-Abl induces autocrine IGF-1 signaling.

    abstract：:Bcr-Abl oncogene is responsible for the initial phase of chronic myelogenous leukemia (CML), which is effectively treated by the Bcr-Abl inhibitor imatinib. Over time patients become resistant to treatment and progress to blast crisis, an event that is driven by additional genetic and epigenetic aberrations. Recently,...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.8

    authors： Lakshmikuttyamma A,Pastural E,Takahashi N,Sawada K,Sheridan DP,DeCoteau JF,Geyer CR

    更新日期：2008-06-19 00:00:00

  • Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase.

    abstract：:There are at least three distinct MAP kinase signaling modules in mammalian cells, distinguished by the family of kinases (Erk, SAPK/JNK, or p38) that is ultimately activated. Many input signals activate multiple MAP kinase cascades, and the mechanisms that control the specificity of signal output are not well underst...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203057

    authors： Kieran MW,Katz S,Vail B,Zon LI,Mayer BJ

    更新日期：1999-11-18 00:00:00

  • Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interaction.

    abstract：:Smad4 is a critical component in transforming growth factor beta (TGF-beta) signaling and frequently mutated in pancreatic and colorectal cancers. Smad4 has two important functional domains, MH1 and MH2, that are involved in different biological processes. The MH1 domain comprises a DNA binding domain and the MH2 doma...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207219

    authors： Kuang C,Chen Y

    更新日期：2004-02-05 00:00:00

  • Mutant p53: an oncogenic transcription factor.

    abstract：:Inactivation of tumor-suppressor genes is one of the key hallmarks of a tumor. Unlike other tumor-suppressor genes, p53 is inactivated by missense mutations in half of all human cancers. It has become increasingly clear that the resulting mutant p53 proteins do not represent only the mere loss of wild-type p53 tumor s...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1210296

    authors： Strano S,Dell'Orso S,Di Agostino S,Fontemaggi G,Sacchi A,Blandino G

    更新日期：2007-04-02 00:00:00

  • FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling.

    abstract：:Human basal-like breast cancer (BLBC) is an enigmatic and aggressive malignancy with a poor prognosis. There is an urgent need to identify therapeutic targets for BLBC, because current treatment modalities are limited and not effective. The forkhead box transcription factor FOXC1 has recently been identified as a crit...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.635

    authors： Wang J,Ray PS,Sim MS,Zhou XZ,Lu KP,Lee AV,Lin X,Bagaria SP,Giuliano AE,Cui X

    更新日期：2012-11-08 00:00:00

  • c-Myc inhibits myogenic differentiation and myoD expression by a mechanism which can be dissociated from cell transformation.

    abstract：:The c-Myc oncoprotein is a basic-helix-loop-helix-leucine zipper (b-HLH-LZ) transcription factor involved in regulating cell proliferation and differentiation. We have used retrovirus-mediated gene transfer to investigate the effect of ectopic c-Myc expression on the spontaneous differentiation of primary quail myobla...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： La Rocca SA,Crouch DH,Gillespie DA

    更新日期：1994-12-01 00:00:00

  • Dinucleotide repeats negatively modulate the promoter activity of Cyr61 and is unstable in hepatocellular carcinoma patients.

    abstract：:Cyr61 is a secreted, cysteine-rich, heparin-binding protein that mediates diverse functions including extracellular matrix formation, differentiation, cell proliferation, adhesion, migration, survival, as well as angiogenesis and tumorigenesis. In this study, we found that Cyr61 gene expression is significantly downre...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208550

    authors： Wang B,Ren J,Ooi LL,Chong SS,Lee CG

    更新日期：2005-06-02 00:00:00

  • Overexpression of the wild-type p53 gene inhibits NF-kappaB activity and synergizes with aspirin to induce apoptosis in human colon cancer cells.

    abstract：:The tumor suppressor gene p53 is a potent transcriptional regulator of genes which are involved in many cellular activities including cell cycle arrest, apoptosis, and angiogenesis. Recent studies have demonstrated that the activation of the transcriptional factor nuclear factor kappaB (NF-kappaB) plays an essential r...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203383

    authors： Shao J,Fujiwara T,Kadowaki Y,Fukazawa T,Waku T,Itoshima T,Yamatsuji T,Nishizaki M,Roth JA,Tanaka N

    更新日期：2000-02-10 00:00:00

  • Mitochondrial DNA mutations in human cancer.

    abstract：:Somatic mitochondrial DNA (mtDNA) mutations have been increasingly observed in primary human cancers. As each cell contains many mitochondria with multiple copies of mtDNA, it is possible that wild-type and mutant mtDNA can co-exist in a state called heteroplasmy. During cell division, mitochondria are randomly distri...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1209604

    authors： Chatterjee A,Mambo E,Sidransky D

    更新日期：2006-08-07 00:00:00

  • The role of immunoglobulin kappa elements in c-myc activation.

    abstract：:Burkitt's lymphoma cells are characterized by chromosomal translocations involving the proto-oncogene c-myc on chromosome 8 and one of the immunoglobulin gene loci on chromosome 2, 14 or 22. The translocated c-myc allele is transcriptionally activated, shows a preferential usage of promoter P1 over P2 (promoter shift)...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Hörtnagel K,Mautner J,Strobl LJ,Wolf DA,Christoph B,Geltinger C,Polack A

    更新日期：1995-04-06 00:00:00

  • Loss of Mel-18 induces tumor angiogenesis through enhancing the activity and expression of HIF-1α mediated by the PTEN/PI3K/Akt pathway.

    abstract：:Mel-18 has been implicated in several processes in tumor progression, in which the Akt pathway is involved as an important key molecular event. However, the function of Mel-18 in human cancers has not been fully established yet. Here, we examined the effect of Mel-18 on tumor angiogenesis in human breast cancer, and f...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.174

    authors： Park JH,Lee JY,Shin DH,Jang KS,Kim HJ,Kong G

    更新日期：2011-11-10 00:00:00

  • Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.

    abstract：:Aneuploidy is frequently detected in solid tumors but the mechanisms regulating the generation of aneuploidy and their relevance in cancer initiation remain under debate and are incompletely characterized. Spatial and temporal regulation of integrin traffic is critical for cell migration and cytokinesis. Impaired inte...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.527

    authors： Högnäs G,Tuomi S,Veltel S,Mattila E,Murumägi A,Edgren H,Kallioniemi O,Ivaska J

    更新日期：2012-08-02 00:00:00

  • The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine-induced, but not v-Src induced JAK-STAT activation.

    abstract：:Recently, constitutive activation of JAK kinases (JAKs) and/or signal transducers and activators of transcription (STATs) has been reported in growing numbers of human cancer cells as well as oncogene-transformed cells. JAB/SOCS-1 has been shown to be an intrinsic JAK tyrosine kinase inhibitor and to suppress the cyto...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203829

    authors： Iwamoto T,Senga T,Naito Y,Matsuda S,Miyake Y,Yoshimura A,Hamaguchi M

    更新日期：2000-09-28 00:00:00

  • Wilms' tumor 1 splice variants have opposite effects on the tumorigenicity of adenovirus-transformed baby-rat kidney cells.

    abstract：:The Wilms' Tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family. As a result of alternative RNA splicing, the gene can be expressed as four polypeptides which differ in the presence or absence of two stretches of amino acids: one of 17 residues (17aa) just N-terminal of the four zinc-fingers and...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Menke AL,Riteco N,van Ham RC,de Bruyne C,Rauscher FJ 3rd,van der Eb AJ,Jochemsen AG

    更新日期：1996-02-01 00:00:00

  • Cell density mediated pericellular hypoxia leads to induction of HIF-1alpha via nitric oxide and Ras/MAP kinase mediated signaling pathways.

    abstract：:Environmental signals in the cellular milieu such as hypoxia, growth factors, extracellular matrix (ECM), or cell-surface molecules on adjacent cells can activate signaling pathways that communicate the state of the environment to the nucleus. Several groups have evaluated gene expression or signaling pathways in resp...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204972

    authors： Sheta EA,Trout H,Gildea JJ,Harding MA,Theodorescu D

    更新日期：2001-11-15 00:00:00

  • Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency.

    abstract：:Genetically defined mouse models offer an important tool to identify critical secondary genetic alterations with relevance to human cancer pathogenesis. We used newly generated MMTV-Cre105Ayn mice to inactivate p53 and/or Rb strictly in the mammary epithelium, and to determine recurrent genomic changes associated with...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.300

    authors： Cheng L,Zhou Z,Flesken-Nikitin A,Toshkov IA,Wang W,Camps J,Ried T,Nikitin AY

    更新日期：2010-10-21 00:00:00

  • Promoter specificity and stability control of the p53-related protein p73.

    abstract：:The p53 family of proteins play instrumental roles in mediating the cellular response to stress. The p53-related gene product, p73, occurs as two distinct protein isoforms, referred to as alpha and beta, which differ in the length of the C-terminal region and arise through alternative splicing of the p73 RNA. Here, we...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202793

    authors： Lee CW,La Thangue NB

    更新日期：1999-07-22 00:00:00

  • Histone deacetylases and the immunological network: implications in cancer and inflammation.

    abstract：:The initiation, magnitude and duration of an immune response against antigens are a tightly regulated process involving a dynamic, orchestrated balance of pro- and anti-inflammatory pathways in immune cells. Such a delicate balance is critical for allowing efficient immune response against foreign antigens while preve...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2009.334

    authors： Villagra A,Sotomayor EM,Seto E

    更新日期：2010-01-14 00:00:00

  • Silencing of the Tropomyosin-1 gene by DNA methylation alters tumor suppressor function of TGF-beta.

    abstract：:Loss of actin stress fibers has been associated with cell transformation and metastasis. TGF-beta induction of stress fibers in epithelial cells requires high molecular weight tropomyosins encoded by TPM1 and TPM2 genes. Here, we investigated the mechanism underlying the failure of TGF-beta to induce stress fibers and...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208688

    authors： Varga AE,Stourman NV,Zheng Q,Safina AF,Quan L,Li X,Sossey-Alaoui K,Bakin AV

    更新日期：2005-07-28 00:00:00

  • Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells.

    abstract：:Sp1 is important for the transcription of many genes. Our previous studies have shown that Sp1 is degraded in normal cell, but it is preserved in cancer cells during mitosis and exists a priori in the daughter cells, ready to engage in gene transcription and thereby contributes to the proliferation and survival of can...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.649

    authors： Chuang JY,Wang SA,Yang WB,Yang HC,Hung CY,Su TP,Chang WC,Hung JJ

    更新日期：2012-11-22 00:00:00

  • Induction of apoptosis by p75 neurotrophin receptor in human neuroblastoma cells.

    abstract：:The low-affinity nerve growth factor receptor p75NTR belongs to a membrane receptor superfamily whose members, in certain cell types, are able to transduce an apoptotic signal. To investigate the effect of p75NTR expression in neuroblastoma cells, we transfected the p75NTR cDNA into SK-N-BE cells, a neuroblastoma cell...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1200972

    authors： Bunone G,Mariotti A,Compagni A,Morandi E,Della Valle G

    更新日期：1997-03-27 00:00:00

  • Epigenetic patterns of the retinoic acid receptor beta2 promoter in retinoic acid-resistant thyroid cancer cells.

    abstract：:Treatment with retinoic acid (RA) is effective to restore radioactive iodine uptake in metastases of a small fraction of thyroid cancer patients. In order to find predictive markers of response, we took advantage of two thyroid cancer cell lines, FTC133 and FTC238, with low RA-receptor (RAR)beta expression but differi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210178

    authors： Cras A,Darsin-Bettinger D,Balitrand N,Cassinat B,Soulié A,Toubert ME,Delva L,Chomienne C

    更新日期：2007-06-07 00:00:00

  • Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.

    abstract：:Tumor suppressor TP53 is frequently mutated in colorectal cancer (CRC), and most mutations are missense type. Although gain-of-functions by mutant p53 have been demonstrated experimentally, the precise mechanism for malignant progression in in vivo tumors remains unsolved. We generated ApcΔ716 Trp53LSL•R270H villin-Cr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2017.194

    authors： Nakayama M,Sakai E,Echizen K,Yamada Y,Oshima H,Han TS,Ohki R,Fujii S,Ochiai A,Robine S,Voon DC,Tanaka T,Taketo MM,Oshima M

    更新日期：2017-10-19 00:00:00

  • Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway.

    abstract：:Hypoxic microenvironment supports cancer stem cell survival, causes poor response to anticancer therapy and tumor recurrence. Inhibition of Notch-1 signaling in adenocarcinoma of the lung (ACL) cells causes apoptosis specifically under hypoxia. Here, we found that Akt-1 activation is a key mediator of Notch-1 pro-surv...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.7

    authors： Eliasz S,Liang S,Chen Y,De Marco MA,Machek O,Skucha S,Miele L,Bocchetta M

    更新日期：2010-04-29 00:00:00

  • Phosphorylation of Ets1 regulates the complementation of a CSF-1 receptor impaired in mitogenesis.

    abstract：:Ets1, the founder member of the Ets transcription factor family, is involved in a variety of developmental and cellular processes. Previous studies have shown that serine phosphorylation of Ets1 inhibits its DNA binding activity, suggesting that phosphorylation is important in the regulation of Ets1 function. To furth...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Rabault B,Roussel MF,Quang CT,Ghysdael J

    更新日期：1996-08-15 00:00:00

  • O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.

    abstract：:Cancer cells are known to adopt aerobic glycolysis in order to fuel tumor growth, but the molecular basis of this metabolic shift remains largely undefined. O-GlcNAcase (OGA) is an enzyme harboring O-linked β-N-acetylglucosamine (O-GlcNAc) hydrolase and cryptic lysine acetyltransferase activities. Here, we report that...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0975-3

    authors： Singh JP,Qian K,Lee JS,Zhou J,Han X,Zhang B,Ong Q,Ni W,Jiang M,Ruan HB,Li MD,Zhang K,Ding Z,Lee P,Singh K,Wu J,Herzog RI,Kaech S,Wendel HG,Yates JR 3rd,Han W,Sherwin RS,Nie Y,Yang X

    更新日期：2020-01-01 00:00:00

  • A Herpes saimiri oncogene causing peripheral T-cell lymphoma in transgenic mice.

    abstract：:Herpesvirus saimiri is an oncogenic virus causing rapid T-cell lymphomas in New World primates and rabbits. Deletion analysis of one strain of H saimiri has indicated an open reading frame, StpA, necessary for oncongenicity in monkeys. We have investigated the function of StpA in tumor induction by the generation of t...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Kretschmer C,Murphy C,Biesinger B,Beckers J,Fickenscher H,Kirchner T,Fleckenstein B,Rüther U

    更新日期：1996-04-18 00:00:00

  • Both the helix-loop-helix and the leucine zipper motifs of c-Myc contribute to its dimerization specificity with Max.

    abstract：:The oncoprotein c-Myc contains two dimerization motifs- the helix-loop-helix (HLH) and the leucine zipper (LZ) - through which c-Myc specifically dimerizes with Max. We substituted regions of the c-Myc HLH and LZ motifs with the corresponding regions of structurally related proteins that do not interact with Max. Spec...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Davis LJ,Halazonetis TD

    更新日期：1993-01-01 00:00:00