Ubiquitination-mediated degradation of SIRT1 by SMURF2 suppresses CRC cell proliferation and tumorigenesis.

abstract：:RRR-alpha-tocopheryl succinate (alpha-vitamin E succinate, VES), one of the vitamin E derivatives, can effectively inhibit the proliferation of human prostate cancer cells. However, little is known about its effect on prostate cancer cell invasive ability. Tumor metastasis is a complex process and the extracellular ma...

journal_title：Oncogene

authors： Zhang M,Altuwaijri S,Yeh S

更新日期：2004-04-15 00:00:00

abstract：:Waldenström macroglobulinemia (WM) is a proliferative disorder of IgM-secreting, lymphoplasmacytoid cells that inhabit the lymph nodes and bone marrow. The disease carries a high prevalence of activating mutations in MyD88 (91%) and CXCR4 (28%). Because signaling through these pathways leads to Bcl-xL induction, we ex...

journal_title：Oncogene

authors： Gaudette BT,Dwivedi B,Chitta KS,Poulain S,Powell D,Vertino P,Leleu X,Lonial S,Chanan-Khan AA,Kowalski J,Boise LH

更新日期：2016-01-28 00:00:00

abstract：:Squamous cell carcinoma (SCC) cells of the head and neck specifically express collagenase-3 (matrix metalloproteinase-13 (MMP-13)), the expression of which correlates with their invasion capacity. Transforming growth factor-beta (TGF-beta) enhances MMP-13 and collagenase-1 (MMP-1) expression and invasion of SCC cells ...

journal_title：Oncogene

authors： Leivonen SK,Ala-Aho R,Koli K,Grénman R,Peltonen J,Kähäri VM

更新日期：2006-04-27 00:00:00

abstract：:The IGF2 gene, which encodes a growth factor, is subject to genomic imprinting. The frequently observed loss of IGF2 imprinting in a variety of tumors has been suggested to contribute to neoplasia. Since these reports have not documented the imprinting status of IGF2 at the cellular level, it cannot be excluded that t...

journal_title：Oncogene

authors： He L,Cui H,Walsh C,Mattsson R,Lin W,Anneren G,Pfeifer-Ohlsson S,Ohlsson R

更新日期：1998-01-08 00:00:00

abstract：:We have previously shown (Smith et al., 1994) that antibodies raised against the growth arrest and DNA damage inducible protein Gadd45 co-precipitate proliferating cell nuclear antigen (PCNA), a protein involved in DNA replication and repair. Here we demonstrate that Gadd45 can directly bind to PCNA using a Far-wester...

journal_title：Oncogene

authors： Chen IT,Smith ML,O'Connor PM,Fornace AJ Jr

更新日期：1995-11-16 00:00:00

abstract：:ETS is a family of transcription factors that contain a highly conserved ETS DNA binding domain. Various members of the ETS family are expressed in cells of hematopoietic lineage. ETS-1, ETS-2 and ERGB/FLI-1 are expressed at high levels in T-lymphocytes. HIV-1 infects T-cells and it has been shown that its LTR contain...

journal_title：Oncogene

authors： Hodge DR,Robinson L,Watson D,Lautenberger J,Zhang XK,Venanzoni M,Seth A

更新日期：1996-01-04 00:00:00

abstract：:In the search for retinoids active against Burkitt's lymphoma (BL), we found that the arotinoid mofarotene (Ro 40-8757) induced strong antiproliferative and apoptotic responses in most established BL cell lines as well as in primary BL cells. Ro 40-8757-induced apoptosis is associated with mitochondrial membrane depol...

journal_title：Oncogene

authors： Cariati R,Zancai P,Righetti E,Rizzo S,De Rossi A,Boiocchi M,Dolcetti R

更新日期：2003-02-13 00:00:00

abstract：:The MYCN gene has been implicated in certain neuronal tumours, such as neuroblastomas and retinoblastomas. These tumours express high levels of mRNA and protein of MYCN as a result of amplification. MYCN encodes a short-lived nuclear phosphoprotein whose function has not yet been elucidated. This study was undertaken ...

journal_title：Oncogene

authors： Hamann U,Wenzel A,Frank R,Schwab M

更新日期：1991-10-01 00:00:00

abstract：:Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase which belongs to the insulin receptor superfamily and is mainly expressed in pre-B lymphocytes and neuronal tissues. Recently, we demonstrated that LTK utilizes Shc and IRS-1 as two major substrates and while both equally activate the Ras pathway, only IRS-...

journal_title：Oncogene

authors： Ueno H,Honda H,Nakamoto T,Yamagata T,Sasaki K,Miyagawa K,Mitani K,Yazaki Y,Hirai H

更新日期：1997-06-26 00:00:00

abstract：:ErbB4, a member of the epidermal growth factor receptor family, plays a role in normal breast and breast cancer development by regulating mammary epithelial cell proliferation, survival and differentiation. In this study, we show that WWP1, a C2-WW-HECT type E3 ubiquitin ligase, binds, ubiquitinates and destructs ErbB...

journal_title：Oncogene

authors： Li Y,Zhou Z,Alimandi M,Chen C

更新日期：2009-08-20 00:00:00

abstract：:Inflammation can act as a crucial mediator of epithelial-to-mesenchymal transition (EMT). In this study, we show that oncostatin M (OSM) is expressed in an autocrine/paracrine fashion in invasive breast carcinoma. OSM stimulation promotes spontaneous lung metastasis of MCF-7 xenografts in nude mice. A conspicuous epig...

journal_title：Oncogene

authors： Guo L,Chen C,Shi M,Wang F,Chen X,Diao D,Hu M,Yu M,Qian L,Guo N

更新日期：2013-11-07 00:00:00

abstract：:Hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue-specific transcription factor known to regulate a large number of genes in hepatocytes and pancreatic beta cells. Although HNF4alpha is highly expressed in some sections of the kidney, little is known about its role in this organ and about HNF4alpha-regulated ge...

journal_title：Oncogene

authors： Lucas B,Grigo K,Erdmann S,Lausen J,Klein-Hitpass L,Ryffel GU

更新日期：2005-09-22 00:00:00

abstract：:To better understand the dual, tumour-suppressive and tumour-promoting function of transforming growth factor-beta (TGFbeta), we analysed mammary epithelial NMuMG cells in response to short and long-term TGFbeta exposure. NMuMG cells became proliferation-arrested and apoptotic after exposure to TGFbeta for 2-5 days, w...

journal_title：Oncogene

authors： Gal A,Sjöblom T,Fedorova L,Imreh S,Beug H,Moustakas A

更新日期：2008-02-21 00:00:00

abstract：:The low-affinity nerve growth factor receptor p75NTR belongs to a membrane receptor superfamily whose members, in certain cell types, are able to transduce an apoptotic signal. To investigate the effect of p75NTR expression in neuroblastoma cells, we transfected the p75NTR cDNA into SK-N-BE cells, a neuroblastoma cell...

journal_title：Oncogene

authors： Bunone G,Mariotti A,Compagni A,Morandi E,Della Valle G

更新日期：1997-03-27 00:00:00

abstract：:The v-erbA oncogene transforms chicken erythrocytic progenitors (T2EC) by blocking their differentiation and freezing them in a state of self-renewal. Transcriptomes of T2EC, expressing either v-erbA or a non-transforming form of v-erbA (S61G), were compared using serial analysis of gene expression and some, but not a...

journal_title：Oncogene

authors： Nguyen-Lefebvre AT,Leprun G,Morin V,Viñuelas J,Couté Y,Madjar JJ,Gandrillon O,Gonin-Giraud S

更新日期：2014-03-20 00:00:00

abstract：:The adenovirus E1A protein has been shown to be involved in the potentiation of apoptosis induced by chemotherapeutic agents, yet the molecular events of E1A-mediated apoptosis are not very clear. A recent report has suggested that deamidation of the Bcl-X(L) protein inhibits its antiapoptotic ability and leads to apo...

journal_title：Oncogene

authors： Chang CY,Lin YM,Lee WP,Hsu HH,Chen EI

更新日期：2006-04-27 00:00:00

abstract：:Retinoic acid receptor-beta (RAR beta) and signal transducer and activator of transcription 1 (STAT1) are important mediators of the antiproliferative and apoptotic actions of retinoids and cytokines/growth factors, respectively. Expression of both RAR beta and STAT1 is lost in most breast cancer cell lines but it can...

journal_title：Oncogene

authors： Shang Y,Baumrucker CR,Green MH

更新日期：1999-11-18 00:00:00

abstract：:Previous work by others has revealed homology between the rel oncogene and the transcription factor NF-kappa B. Further, in vitro-translated v-rel protein and c-rel protein are able to bind to an oligonucleotide containing the kappa B binding site. Unlike the in vitro-translated product, cellular Rel protein exists in...

journal_title：Oncogene

authors： Kochel T,Rice NR

更新日期：1992-03-01 00:00:00

abstract：:The promyelocytic leukemia gene was first identified through its fusion to the gene encoding the retinoic acid receptor alpha (RARalpha) in acute promyelocytic leukemia (APL) patients. The promyelocytic leukemia gene product (PML) becomes conjugated in vivo to the small ubiquitin-like protein SUMO-1, altering its beha...

journal_title：Oncogene

authors： Quimby BB,Yong-Gonzalez V,Anan T,Strunnikov AV,Dasso M

更新日期：2006-05-18 00:00:00

abstract：:Colorectal cancer (CRC) is a heterogeneous disease posing a challenge for accurate classification and treatment of this malignancy. There is no common genetic molecular feature that would allow for the identification of patients at risk for developing recurrences and thus selecting patients who would benefit from more...

journal_title：Oncogene

authors： Fessler E,Jansen M,De Sousa E Melo F,Zhao L,Prasetyanti PR,Rodermond H,Kandimalla R,Linnekamp JF,Franitza M,van Hooff SR,de Jong JH,Oppeneer SC,van Noesel CJ,Dekker E,Stassi G,Wang X,Medema JP,Vermeulen L

更新日期：2016-11-17 00:00:00

abstract：:Superior cervical ganglia 10 (SCG10), as a microtubule (MT) destabilizer, maintains MT homeostasis and has a critical role in neuronal development, but its function in tumorigenesis has not been characterized. In the present study, we demonstrated that p21-activated kinase 4 (PAK4)-mediated SCG10 phosphorylation regul...

journal_title：Oncogene

authors： Guo Q,Su N,Zhang J,Li X,Miao Z,Wang G,Cheng M,Xu H,Cao L,Li F

更新日期：2014-06-19 00:00:00

abstract：:The short isoform of single-minded 2 (SIM2s), a basic helix-loop-helix/PAS (bHLH/PAS) transcription factor, is upregulated in pancreatic and prostate tumours; however, a mechanistic role for SIM2s in these cancers is unknown. Microarray studies in prostate DU145 cells identified the pro-cell death gene, BNIP3 (Bcl-2/a...

journal_title：Oncogene

authors： Farrall AL,Whitelaw ML

更新日期：2009-10-15 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) is involved in diverse processes such as inflammation, carcinogenesis and apoptosis. As COX-2 inhibitors interfere with these processes, inhibition of COX-2 has been suggested as a promising anticancer treatment. However, the role of COX-2 in modulation of apoptosis as well as the death pathwa...

journal_title：Oncogene

authors： Totzke G,Schulze-Osthoff K,Jänicke RU

更新日期：2003-09-11 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease and a major health problem in the United States. While the cytokine TGF-β has been implicated in PDAC development, it can exert both pro-tumorigenic and anti-tumorigenic effects that are highly context dependent and incompletely understood. Using three-dimens...

journal_title：Oncogene

authors： Handler J,Cullis J,Avanzi A,Vucic EA,Bar-Sagi D

更新日期：2018-08-01 00:00:00

abstract：:TSG101 has been identified as a candidate tumor suppressor gene and abnormal transcripts have been identified in a substantial fraction of breast cancers. To determine whether TSG101 expression is commonly altered in other tumors, a series of 15 primary and metastatic prostate cancers were analysed by reverse transcri...

journal_title：Oncogene

authors： Sun Z,Pan J,Bubley G,Balk SP

更新日期：1997-12-18 00:00:00

abstract：:The transcription factor PU.1 is essential for terminal myeloid differentiation, B- and T-cell development, erythropoiesis and hematopoietic stem cell maintenance. PU.1 functions as oncogene in Friend virus-induced erythroleukemia and as tumor suppressor in acute myeloid leukemias. Moreover, Friend virus-induced eryth...

journal_title：Oncogene

authors： Tschan MP,Reddy VA,Ress A,Arvidsson G,Fey MF,Torbett BE

更新日期：2008-05-29 00:00:00

abstract：:Survivin is a member of the inhibitor of apoptosis protein family and has an essential role in mitosis. Survivin is overexpressed in a large variety of human cancers and represents an attractive target for cancer therapy. Epidermal growth factor receptor and Her/neu-transformed human tumors in particular exhibit high ...

journal_title：Oncogene

authors： Berezov A,Cai Z,Freudenberg JA,Zhang H,Cheng X,Thompson T,Murali R,Greene MI,Wang Q

更新日期：2012-04-12 00:00:00

abstract：:Infection by human immunodeficiency virus type 1 (HIV-1) is characterized by progressive loss of various cell types, mainly CD4+ T lymphocytes. While a passive role for the virus in cell destruction is recognized, it does not account for the vast amount of cell death including those of uninfected "bystander' cells. Si...

journal_title：Oncogene

authors： Sastry KJ,Marin MC,Nehete PN,McConnell K,el-Naggar AK,McDonnell TJ

更新日期：1996-08-01 00:00:00

abstract：:The extracellular matrix glycoprotein, fibronectin, influences a variety of cellular functions including adhesion, migration, survival, differentiation, and growth. Fibronectin has also been shown to increase the migration and proliferation of human lung carcinoma cells. However, the role of fibronectin in controlling...

journal_title：Oncogene

authors： Han SW,Roman J

更新日期：2006-07-20 00:00:00

abstract：:The E1a gene of group C adenoviruses is one of the most studied transforming genes of DNA tumor viruses. These transforming genes have been conventionally considered as dominant oncogenes since they transform cells in vitro and many of the resulting transformed cell lines induce tumors in experimental animals. It now ...

journal_title：Oncogene

authors： Chinnadurai G

更新日期：1992-07-01 00:00:00