Abstract:
:We have previously shown that the PLAG1 gene on chromosome 8q12 is consistently rearranged in pleomorphic adenomas of the salivary glands with t(3;8)(p21;q12) translocations. The t(3;8) results in promoter swapping between the PLAG1 gene, which encodes a novel zinc finger protein, and the constitutively expressed gene for beta-catenin (CTNNB1), a protein with roles in cell-cell adhesion and the WG/WNT signalling pathway. In order to assess the importance of other translocation partner genes of PLAG1, and their possible relationship to CTNNB1, we have characterized a second recurrent translocation, i.e. the t(5;8)(p13;q12). This translocation leads to ectopic expression of a chimeric transcript consisting of sequences from the ubiquitously expressed gene for the leukemia inhibitory factor receptor (LIFR) and PLAG1. As for the t(3;8), the fusions occurred in the 5'-noncoding regions of both genes, exchanging regulatory control elements while preserving the coding sequences. The results of the current as well as previous studies indicate that ectopic expression of PLAG1 under the control of promoters of distinct translocation partner genes is a general pathogenetic mechanism for pleomorphic adenomas with 8q12 aberrations.
journal_name
Oncogenejournal_title
Oncogeneauthors
Voz ML,Aström AK,Kas K,Mark J,Stenman G,Van de Ven WJdoi
10.1038/sj.onc.1201660subject
Has Abstractpub_date
1998-03-01 00:00:00pages
1409-16issue
11eissn
0950-9232issn
1476-5594journal_volume
16pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::BAG-1 is a Hsp70/Hsc70-binding protein that interacts with Bcl-2, Raf-1, steroid hormone receptors, Siah-1, and hepatocyte growth factor (HGF) receptors, implying multiple functions for the BAG-1 protein. Here, we provide evidence that gene transfer-mediated overexpression of BAG-1 markedly enhances the motility of hu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202661
更新日期:1999-05-27 00:00:00
abstract::One-carbon metabolism plays a central role in a broad array of metabolic processes required for the survival and growth of tumor cells. However, the molecular basis of how one-carbon metabolism may influence RNA methylation and tumorigenesis remains largely unknown. Here we show MTHFD2, a mitochondrial enzyme involved...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0869-4
更新日期:2019-08-01 00:00:00
abstract::Glioblastoma is the most common and lethal primary malignant brain tumor in adults. The tumor suppressor gene PTEN is deleted, mutated or hypermethylated in more than 60% of glioblastoma cases resulting in hyperactivation of the phosphoinositide 3-kinase pathway, which leads to sustained PI(3,4,5)P3 signaling, and the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2014.303
更新日期:2015-07-01 00:00:00
abstract::B-cell CLL/lymphoma 6 (BCL6) exerts oncogenic effects in several human hematopoietic malignancies including chronic myeloid leukemia (CML), where BCL6 expression was shown to be essential for CML stem cell survival and self-renewal during imatinib mesylate (IM) treatment. As several lines of evidence suggest that inte...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2017.85
更新日期:2017-08-10 00:00:00
abstract::In contrast to other cell cycle inhibitors, the tumor suppressor p16Ink4a is not detectable or expressed at very low levels in embryonic and adult mouse tissues, and therefore it has often been considered as a specialized checkpoint protein that does not participate in the control of normal cell cycle progression. How...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209437
更新日期:2006-07-06 00:00:00
abstract::DSS1 is an evolutionarily conserved acidic protein that binds to BRCA2. However, study of the function of DSS1 in mammalian cells has been hampered because endogenous DSS1 has not been detectable by Western blotting. Here, we developed a modified Western blotting protocol that detects endogenous DSS1 protein, and used...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209153
更新日期:2006-02-23 00:00:00
abstract::Prostate cancer is the second highest cause of cancer-related deaths of men in the US. Signal transducers and activators of transcription (STATs) proteins are a small family of latent cytoplasmic transcription factors that act downstream of Janus kinase (JAK) activation and mediate intracellular signaling from a wide ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208437
更新日期:2005-03-17 00:00:00
abstract::Wild-type p53 is stabilized and accumulates in the nucleus of DNA damaged cells. The effect of stabilizing p53 is to inhibit cell growth, either through a G1 cell cycle arrest or apoptotic cell death. MDM2 can inhibit p53 activity, in part, by promoting its rapid degradation through the ubiquitin proteolysis pathway. ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203980
更新日期:2000-11-30 00:00:00
abstract::The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or tumor promotional, depending on context. The metastatic regulator, Six1, was recently shown to mediate this switch, providing a novel means to explain this elusive 'TGF-β paradox'. Herein, we identify a mechanism by which Six1 ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.11
更新日期:2012-12-13 00:00:00
abstract::Autophagy is an evolutionarily conserved process regulating cellular homeostasis via digestion of dysfunctional proteins and whole cellular organelles by mechanisms, involving their enclosure into double-membrane vacuoles that are subsequently fused to lysosomes. Glioma stem cells utilize autophagy as a main mechanism...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-018-0395-9
更新日期:2018-11-01 00:00:00
abstract::Soft tissue sarcomas are a heterogeneous group of neoplasms with various histological subtypes. Up to now, no individual causal molecular markers for prognosis and therapeutic success have been identified. A tumorigenic connection between the oncogene product Mdm2 and tumor suppressor p53 is generally accepted, but th...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1201646
更新日期:1998-03-05 00:00:00
abstract::Chromosome end-to-end associations seen at metaphase involve telomeres and are commonly observed in cells derived from individuals with ataxia telangiectasia and most types of human tumors. The associations may arise because of short telomeres and/or alterations of chromatin structure. There is a growing consensus tha...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1996-10-03 00:00:00
abstract::Neuroblastoma is a childhood tumor thought to arise through improper differentiation of neural crest cells. Increased N-Myc expression in neuroblastoma indicates highly malignant disease and poor patient prognosis. N-myc enhances cell growth, insulin-like growth factor type I receptor (IGF-IR) expression, and tumorige...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206362
更新日期:2003-05-01 00:00:00
abstract::Dasatinib, a dual Src family kinase and Abl inhibitor, is being tested clinically for the treatment of prostate cancer bone metastasis. Bidirectional interactions between osteoblasts and prostate cancer cells are critical in the progression of prostate cancer in bone, but the effect of dasatinib on osteoblasts is unkn...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.73
更新日期:2010-06-03 00:00:00
abstract::The high incidence of loss of chromosome 10 alleles in glioblastoma multiforme suggests the presence on this chromosome of a tumor suppressor gene that is important in glioma tumorigenesis and progression. Our initial deletion mapping studies using restriction fragment length polymorphism markers indicated a common de...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract::Chromosomal translocations involving the Mixed-Lineage Leukaemia (MLL) gene underlie many human leukaemias and MLL rearrangements are found in both acute myelogenous and acute lymphoblastic leukaemias. To assess the functionally relevant haematopoietic cell contexts for MLL fusions to be tumorigenic, we have generated...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210818
更新日期:2008-03-20 00:00:00
abstract::The regulatory step in ubiquitin (Ub)-mediated protein degradation involves recognition and selection of the target substrate by an E3 Ub-ligase. E3 Ub-ligases evoke sophisticated mechanisms to regulate their activity temporally and spatially, including multiple post-translational modifications, combinatorial E3 Ub-li...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208614
更新日期:2005-04-18 00:00:00
abstract::The transcription factor PU.1 is essential for terminal myeloid differentiation, B- and T-cell development, erythropoiesis and hematopoietic stem cell maintenance. PU.1 functions as oncogene in Friend virus-induced erythroleukemia and as tumor suppressor in acute myeloid leukemias. Moreover, Friend virus-induced eryth...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1211004
更新日期:2008-05-29 00:00:00
abstract::Apoptosis is essential for normal development and maintenance of homeostasis, and disruption of apoptotic pathways is associated with multiple disease states, including cancer. Although initially identified as central regulators of apoptosis at the level of mitochondria, an important role for BCL-2 proteins at the end...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2008.309
更新日期:2008-10-27 00:00:00
abstract::Fibronectin extracellular matrix plays a critical role in the microenvironment of cells. Loss of this matrix frequently accompanies oncogenic transformation, allowing changes in cell growth, morphology, and tissue organization. The HT1080 human fibrosarcoma cell line is deficient in formation of fibronectin matrix fib...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203626
更新日期:2000-06-29 00:00:00
abstract::Embryonic stem (ES) cells have provided a valid model to understand early events of mammalian lineage specification and differentiation, leading to important insights into the mechanisms that control embryogenesis at the molecular and cellular levels. Furthermore, ES cells have recently evoked great scientific interes...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1208917
更新日期:2005-08-29 00:00:00
abstract::Genetic mutations of oncogenes often underlie deranged cell growth and altered differentiation pathways leading to malignant transformation of B-lymphocytes. However, addiction to oncogenes is not the only drive to lymphoid tumor pathogenesis. Dependence on non-oncogenes, which act by propelling basic mechanisms of ce...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2016.86
更新日期:2016-11-24 00:00:00
abstract::Early Growth Response 1 (EGR1) is a stress response transcription factor with multiple tumour suppressor roles in breast tissue, whose expression is often lost in breast cancers. We have previously shown that the breast cancer oncogene TBX2 (T-BOX2) interacts with EGR1 to co-repress EGR1-target genes including the bre...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0853-z
更新日期:2019-08-01 00:00:00
abstract::Hematopoiesis involves a complex array of growth factors that regulate the survival and proliferation of immature progenitors, influence differentiation commitment, and modulate end-stage cell functions. This mini-review is focused on the role of Stat activation in the development of myeloid cells in response to hemat...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1203477
更新日期:2000-05-15 00:00:00
abstract::We compared the regulation of gamma-glutamyl transferase (gamma GT) and glutathione-S-transferase-P (GST-P) expression in rat liver epithelial cells (228 cells) and a line derived from them (C5 cells) by stable transfection with a metallothionein-activated ras fusion gene (MTrasT24). Earlier studies demonstrated that ...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1989-06-01 00:00:00
abstract::The receptor tyrosine kinase FLT3 is expressed in myeloid and lymphoid progenitor cells. Activating mutations in FLT3 occur in 25-30% of acute myeloid leukaemia (AML) patients. Most common are internal tandem duplications of sequence (ITD) leading to constitutive FLT3-ITD kinase activity with an altered signalling qua...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0757-y
更新日期:2019-06-01 00:00:00
abstract::Myxoid and round-cell liposarcomas share the translocation t(12;16)(q13;p11) creating the TLS-CHOP fusion gene as a common genetic alteration. We previously reported several unique characteristics of genomic sequences around the breakpoints in the TLS and CHOP loci, and among them was the presence of consensus recogni...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203943
更新日期:2000-11-23 00:00:00
abstract::Recent evidence suggests that squamous cell carcinoma of the vulva may have more than one etiology, with only some tumors associated with human papillomavirus (HPV). Cells infected with HPV produce a viral protein (E6) which binds to and causes rapid degradation of p53, possibly contributing to cellular transformation...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
abstract::The p53 family of proteins play instrumental roles in mediating the cellular response to stress. The p53-related gene product, p73, occurs as two distinct protein isoforms, referred to as alpha and beta, which differ in the length of the C-terminal region and arise through alternative splicing of the p73 RNA. Here, we...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202793
更新日期:1999-07-22 00:00:00
abstract::Abundant levels of the hyperactive low molecular weight (LMW) forms of cyclin E contribute to deregulation of Cdk2 in breast tumors, but the mechanism through which they arise is not fully understood. Here, we explored the hypothesis that post-translational processing by a protease generates the LMW forms of cyclin E ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1206166
更新日期:2003-02-06 00:00:00