PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity.

abstract：:Vascular endothelial (VE)-cadherin is exclusively expressed at interendothelial junctions of normal and tumour vessels. In this report, we characterized the transcriptional activity of the human VE-cadherin promoter. Transient transfection assays revealed that sequences at positions --1135/-744 and -166/-5 base pairs ...

journal_title：Oncogene

authors： Prandini MH,Dreher I,Bouillot S,Benkerri S,Moll T,Huber P

更新日期：2005-04-21 00:00:00

abstract：:Tumor metastasis, but not primary overgrowth, is the leading cause of mortality for cancer patients. During the past decade, Drosophila melanogaster has been well-accepted as an excellent model to address the intrinsic mechanism of different aspects of cancer progression, ranging from tumor initiation to metastasis. I...

journal_title：Oncogene

authors： Ma X,Huang J,Tian Y,Chen Y,Yang Y,Zhang X,Zhang F,Xue L

更新日期：2017-06-01 00:00:00

abstract：:Graft versus host disease (GvHD), which is the primary complication of allogeneic bone marrow transplantation, can alter the intestinal barrier targeted by activated donor T-cells. Chemical inhibition of the stress protein HSP90 was demonstrated in vitro to inhibit T-cell activation and to modulate endoplasmic reticul...

journal_title：Oncogene

authors： Joly AL,Deepti A,Seignez A,Goloudina A,Hebrard S,Schmitt E,Richaud S,Fourmaux E,Hammann A,Collura A,Svrcek M,Jego G,Robinet E,Solary E,Demidov O,Kohli E,Garrido C

更新日期：2016-06-02 00:00:00

abstract：:Cellular senescence functions as a tumor suppressor that protects against cancer progression. α-Catulin, an α-catenin-related protein, is reported to have tumorigenic potential because it regulates the nuclear factor-κB (NF-κB) pathway, but little is known about its clinical relevance and the mechanism through which i...

journal_title：Oncogene

authors： Fan LC,Chiang WF,Liang CH,Tsai YT,Wong TY,Chen KC,Hong TM,Chen YL

更新日期：2011-06-09 00:00:00

abstract：:Cytokinesis is the final step of cell division. Increasing evidence suggests failure of cytokinesis might contribute to the development of cancer. Here, we demonstrate that the serologically defined colon cancer antigen-3 (SDCCAG3) forms a complex with PTPN13, a protein tyrosine phosphatase known to be involved in the...

journal_title：Oncogene

authors： Hagemann N,Ackermann N,Christmann J,Brier S,Yu F,Erdmann KS

更新日期：2013-09-26 00:00:00

abstract：:Mutations of the retinoblastoma tumor-suppressor gene (RB1) or components regulating the CDK-RB-E2F pathway have been identified in nearly every human malignancy. Re-establishing cell cycle control through cyclin-dependent kinase (CDK) inhibition has therefore emerged as an attractive option in the development of targ...

journal_title：Oncogene

authors： Johnson J,Thijssen B,McDermott U,Garnett M,Wessels LF,Bernards R

更新日期：2016-09-15 00:00:00

abstract：:The breast cancer susceptibility gene 1 (BRCA1) is mutated in approximately 50% of hereditary breast cancers, and its expression is decreased in 30-40% of sporadic breast cancers, suggesting a general role in breast cancer development. BRCA1 physically and functionally interacts with estrogen receptor-alpha (ERalpha) ...

journal_title：Oncogene

authors： Wen J,Li R,Lu Y,Shupnik MA

更新日期：2009-01-29 00:00:00

abstract：:Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos. However, to date, we found that none of the mesothelioma patients carrying germline BAP1 mutations were professionally expos...

journal_title：Oncogene

authors： Napolitano A,Pellegrini L,Dey A,Larson D,Tanji M,Flores EG,Kendrick B,Lapid D,Powers A,Kanodia S,Pastorino S,Pass HI,Dixit V,Yang H,Carbone M

更新日期：2016-04-14 00:00:00

abstract：:The rel oncogene from the avian reticuloendotheliosis virus strain T is a 59 kd phosphoprotein localized primarily to the cytoplasm of transformed cells. Recently, the v-rel protein was shown to associate with several cellular proteins with molecular weights of 124 kd, 115 kd, and 36 kd. We have analysed the subcellul...

journal_title：Oncogene

authors： Morrison LE,Kabrun N,Mudri S,Hayman MJ,Enrietto PJ

更新日期：1989-06-01 00:00:00

abstract：:L-ascorbate (L-ascorbic acid, vitamin C) clearly has an inhibitory effect on cancer cells. However, the mechanism underlying differential sensitivity of cancer cells from same tissue to L-ascorbate is yet to be clarified. Here, we demonstrate that L-ascorbate has a selective killing effect, which is influenced by sodi...

journal_title：Oncogene

authors： Hong SW,Lee SH,Moon JH,Hwang JJ,Kim DE,Ko E,Kim HS,Cho IJ,Kang JS,Kim DJ,Kim JE,Shin JS,Jung DJ,Jeong YJ,Cho BJ,Kim TW,Lee JS,Kang JS,Hwang YI,Noh DY,Jin DH,Lee WJ

更新日期：2013-03-21 00:00:00

abstract：:Transcription factors of the Maf proto-oncogene family have been shown to participate in the regulation of several differentiation specific genes. We previously reported that a member(s) of this family is involved in the regulation of the neuroretina specific gene, QR1, through a promoter region, designated the A box,...

journal_title：Oncogene

authors： Benkhelifa S,Provot S,Lecoq O,Pouponnot C,Calothy G,Felder-Schmittbuhl MP

更新日期：1998-07-16 00:00:00

abstract：:Transcription factor PAX8 expression is upregulated in several types of cancers. However, little is known about the function of PAX8 in the progression of hepatoma and its regulatory mechanisms. Here, we show that PAX8 silencing inhibits the proliferation and clonogenicity of hepatoma cells and its growth in vivo. The...

journal_title：Oncogene

authors： Wang J,Li N,Huang ZB,Fu S,Yu SM,Fu YM,Zhou PC,Chen RC,Zhou RR,Huang Y,Hu XW,Fan XG

更新日期：2019-10-01 00:00:00

abstract：:The structure and expression of 14-3-3 sigma(sigma) was analysed in squamous carcinomas (SCC) of the vulva and in the vulval pre-malignant lesion vulval intraepithelial neoplasia (VIN). Sequence analysis of the sigma coding region did not detect mutations in any case of SCC or VIN III and loss of heterozygosity (LOH) ...

journal_title：Oncogene

authors： Gasco M,Sullivan A,Repellin C,Brooks L,Farrell PJ,Tidy JA,Dunne B,Gusterson B,Evans DJ,Crook T

更新日期：2002-03-14 00:00:00

abstract：:Previous reports have demonstrated that E7 is the major transforming gene of HPV-16 and that continued expression of the gene is required to maintain the transformed phenotype of primary baby rat kidney cells transformed by HPV-16 E7 and EJ-ras. To investigate the point of action of E7 in the cell cycle we have utilis...

journal_title：Oncogene

authors： Banks L,Barnett SC,Crook T

更新日期：1990-06-01 00:00:00

abstract：:The viability of rat embryo cells immortalized by thermosensitive mutants of SV40 or polyoma Large T antigen is impaired at the non-permissive temperature thus demonstrating that the immortal phenotype is dominantly maintained by Large T antigens. We have observed that exposing these cells to the restrictive temperatu...

journal_title：Oncogene

authors： Zheng DQ,Vayssière JL,Petit PX,LeCoeur H,Spatz A,Mignotte B,Feunteun J

更新日期：1994-11-01 00:00:00

abstract：:A minimal transcription activation domain of the v-Myb oncoprotein was initially mapped to a central cluster of charged residues using GAL4-Myb fusion proteins. This region has been proposed to interact directly with the CBP co-activator in animal cells. Regions flanking this central domain of v-Myb are required for t...

journal_title：Oncogene

authors： Wang DM,Lipsick JS

更新日期：2002-02-28 00:00:00

abstract：:Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the cytoplasm, whereas the other family members rem...

journal_title：Oncogene

authors： Longworth MS,Laimins LA

更新日期：2006-07-27 00:00:00

abstract：:Infection by human immunodeficiency virus type 1 (HIV-1) is characterized by progressive loss of various cell types, mainly CD4+ T lymphocytes. While a passive role for the virus in cell destruction is recognized, it does not account for the vast amount of cell death including those of uninfected "bystander' cells. Si...

journal_title：Oncogene

authors： Sastry KJ,Marin MC,Nehete PN,McConnell K,el-Naggar AK,McDonnell TJ

更新日期：1996-08-01 00:00:00

abstract：:Receptor tyrosine kinases of the Eph family are upregulated in several different types of cancer. One family member in particular, the EphA2 receptor, has been linked to breast, prostate, lung and colon cancer, as well as melanoma. However, mechanisms by which EphA2 contributes to tumor progression are far from clear....

journal_title：Oncogene

authors： Fang WB,Brantley-Sieders DM,Parker MA,Reith AD,Chen J

更新日期：2005-11-24 00:00:00

abstract：:Src family kinases are prototypical modular signaling proteins. Their conserved domain organization includes a myristoylated N-terminal segment followed by SH3, SH2, and tyrosine kinase domains, and a short C-terminal tail. Structural dissection of Src kinases has elucidated the canonical mechanisms of phosphotyrosine...

journal_title：Oncogene

authors： Boggon TJ,Eck MJ

更新日期：2004-10-18 00:00:00

abstract：:The molecular basis for the resistance of tumor cells to cell-mediated cytotoxicity remains poorly understood and thus poses a major challenge for cancer immunotherapy. The present study was designed to determine whether the WNT1-inducible signaling pathway protein 2 (WISP2, also referred to as CCN5), a key regulator ...

journal_title：Oncogene

authors： Akalay I,Tan TZ,Kumar P,Janji B,Mami-Chouaib F,Charpy C,Vielh P,Larsen AK,Thiery JP,Sabbah M,Chouaib S

更新日期：2015-04-23 00:00:00

abstract：:To investigate the mechanisms by which p53 suppresses cell transformation, we used the simian virus 40 (SV40) large T antigen (LTag), the adenovirus E1a proteins, and an activated ras protein (EJ-ras), to examine different pathways of transformation for their susceptibility to suppression by p53: While p53 can suppres...

journal_title：Oncogene

authors： Hansen R,Reddel R,Braithwaite A

更新日期：1995-12-21 00:00:00

abstract：:We reported previously that the v-rel protein (p59v-rel) exists in a high molecular weight complex with at least four other proteins in the cytoplasm of v-rel-transformed chicken pre-B lymphoid cells (Simek, S. & Rice, N.R., J. Virol., 62, 4730-4736, 1989). One of these proteins is the chicken c-rel protein, but the i...

journal_title：Oncogene

authors： Kochel T,Mushinski JF,Rice NR

更新日期：1991-04-01 00:00:00

abstract：:The human ETS2 gene is a member of the ets gene family (ETS1, ETS2, ERG, ELK1 and ELK2) with amino acid similarity to the v-ets oncogene of the avian leukemia virus, E26. The ETS2 gene is composed of 10 exons, nine of which contribute to the open reading frame encoding 469 amino acids. The ETS2 gene directs the synthe...

journal_title：Oncogene

authors： Watson DK,Mavrothalassitis GJ,Jorcyk CL,Smyth FE,Papas TS

更新日期：1990-10-01 00:00:00

abstract：:The E2F1 transcription factor plays a pivotal role in driving cells out of a quiescent state and into the S phase of the cell cycle, in part by transactivating genes needed for DNA replication including DHFR, thymidine kinase, and DNA Polymerase alpha. E2F1 has also been implicated in regulating an S phase checkpoint,...

journal_title：Oncogene

authors： Stubbs MC,Hall DJ

更新日期：2002-05-23 00:00:00

abstract：:Type I interferon (IFN) enhances the transcription of the tumor suppressor gene p53. To elucidate the molecular mechanism mediating IFN-induced apoptosis, we analysed programmed cell death in response to type I (IFNalpha) or type II (IFNgamma) treatment in relation to p53 status. In two cell lines (MCF-7, SKNSH), IFNa...

journal_title：Oncogene

authors： Porta C,Hadj-Slimane R,Nejmeddine M,Pampin M,Tovey MG,Espert L,Alvarez S,Chelbi-Alix MK

更新日期：2005-01-20 00:00:00

abstract：:Primary cilia are microtubule-based, dynamic organelles characterized by continuous assembly and disassembly. The intraflagellar transport (IFT) machinery, including IFT88 in cilia, is involved in the maintenance of bidirectional motility along the axonemes, which is required for ciliogenesis and functional competence...

journal_title：Oncogene

authors： Lee J,Yi S,Won M,Song YS,Yi HS,Park YJ,Park KC,Kim JT,Chang JY,Lee MJ,Sul HJ,Choi JE,Kim KS,Kero J,Kim J,Shong M

更新日期：2018-08-01 00:00:00

abstract：:In this study, we show that the ETS transcription factor ER81 directly binds to and activates the promoter of the matrix metalloproteinase gene, MMP-1. Further, the oncoprotein HER2/Neu synergizes with ER81 to stimulate MMP-1 transcription. The activation of ER81 by HER2/Neu is mediated by MAP kinases, which phosphory...

journal_title：Oncogene

authors： Bosc DG,Goueli BS,Janknecht R

更新日期：2001-09-27 00:00:00

abstract：:Constitutive activation of the signal transducer and activator of transcription 3 (Stat3) and mutation of the p53 are both commonly detected in human prostate cancer cells. We sought to investigate whether there is functional regulation of Stat3 by wild-type (wt) p53. Our results demonstrate that expression of wt p53 ...

journal_title：Oncogene

authors： Lin J,Tang H,Jin X,Jia G,Hsieh JT

更新日期：2002-05-02 00:00:00

abstract：:Approximately a third of all drugs act by binding directly to cell surface receptors coupled to G proteins. Other drugs act indirectly on these same pathways, for example, by inhibiting neurotransmitter reuptake or by blocking the inactivation of intracellular second messengers. These drugs have revolutionized the tre...

journal_title：Oncogene

authors： Hao N,Behar M,Elston TC,Dohlman HG

更新日期：2007-05-14 00:00:00