PU.1 binding to the p53 family of tumor suppressors impairs their transcriptional activity.


:The transcription factor PU.1 is essential for terminal myeloid differentiation, B- and T-cell development, erythropoiesis and hematopoietic stem cell maintenance. PU.1 functions as oncogene in Friend virus-induced erythroleukemia and as tumor suppressor in acute myeloid leukemias. Moreover, Friend virus-induced erythroleukemia requires maintenance of PU.1 expression and the disruption of p53 function greatly accelerates disease progression. It has been hypothesized that p53-mediated expression of the p21(Cip1) cell cycle inhibitor during differentiation of pre-erythroleukemia cells promotes selection against p53 function. In addition to the blockage of erythroblast differentiation provided by increased levels of PU.1, we propose that PU.1 alters p53 function. We demonstrate that PU.1 reduces the transcriptional activity of the p53 tumor suppressor family and thus inhibits activation of genes important for cell cycle regulation and apoptosis. Inhibition is mediated through binding of PU.1 to the DNA-binding and/or oligomerization domains of p53/p73 proteins. Lastly, knocking down endogenous PU.1 in p53 wild-type REH B-cell precursor leukemia cells leads to increased expression of the p53 target p21(Cip1).






Tschan MP,Reddy VA,Ress A,Arvidsson G,Fey MF,Torbett BE




Has Abstract


2008-05-29 00:00:00
















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    authors: Zhang JS,Gong A,Young CY

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    abstract::We reconstituted a three-dimensional gastric carcinoma model similar to invasive gastric carcinoma tissue. This model consists of a human gastric carcinoma cell line, GCTM-1, a human fibroblast cell line, TIG-1-20, and transforming growth factor-beta (TGF-beta)-containing type I collagen gel. Using this model, we were...


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    authors: Kuga H,Morisaki T,Nakamura K,Onishi H,Noshiro H,Uchiyama A,Tanaka M,Katano M

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  • RB and cell cycle progression.

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    pub_type: 杂志文章,评审


    authors: Giacinti C,Giordano A

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    authors: Feki A,Jefford CE,Berardi P,Wu JY,Cartier L,Krause KH,Irminger-Finger I

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  • Hypoxia-induced TUFT1 promotes the growth and metastasis of hepatocellular carcinoma by activating the Ca2+/PI3K/AKT pathway.

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    authors: Brümmer J,Neumaier M,Göpfert C,Wagener C

    更新日期:1995-10-19 00:00:00

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    authors: Harjes U,Bridges E,Gharpure KM,Roxanis I,Sheldon H,Miranda F,Mangala LS,Pradeep S,Lopez-Berestein G,Ahmed A,Fielding B,Sood AK,Harris AL

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  • DNA: leukemia's secret weapon of bone mass destruction.

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    pub_type: 评论,杂志文章


    authors: Tait S

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    authors: Iida S,Seto M,Yamamoto K,Komatsu H,Tojo A,Asano S,Kamada N,Ariyoshi Y,Takahashi T,Ueda R

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    authors: Bauer M,Su G,Casper C,He R,Rehrauer W,Friedl A

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    authors: Lan Q,Peyvandi S,Duffey N,Huang YT,Barras D,Held W,Richard F,Delorenzi M,Sotiriou C,Desmedt C,Lorusso G,Rüegg C

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    pub_type: 杂志文章,评审


    authors: Mikels AJ,Nusse R

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    authors: Carlson H,Ota S,Song Y,Chen Y,Hurlin PJ

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    pub_type: 杂志文章


    authors: Kabsch K,Alonso A

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    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Hailat N,Strahler J,Melhem R,Zhu XX,Brodeur G,Seeger RC,Reynolds CP,Hanash S

    更新日期:1990-11-01 00:00:00

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    pub_type: 杂志文章


    authors: Senchenko V,Liu J,Braga E,Mazurenko N,Loginov W,Seryogin Y,Bazov I,Protopopov A,Kisseljov FL,Kashuba V,Lerman MI,Klein G,Zabarovsky ER

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    pub_type: 杂志文章


    authors: Watson DK,Mavrothalassitis GJ,Jorcyk CL,Smyth FE,Papas TS

    更新日期:1990-10-01 00:00:00