The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis.

abstract：:The cyclin-dependent kinase inhibitor p27 is a key regulator of cell-cycle progression. Its expression and localization are altered in several types of malignancies, which has prognostic significance in cancers such as renal cell carcinoma (RCC). S-phase kinase-associated protein 2 (SKP-2) is an F-box protein that is ...

journal_title：Oncogene

authors： Shanmugasundaram K,Block K,Nayak BK,Livi CB,Venkatachalam MA,Sudarshan S

更新日期：2013-04-18 00:00:00

abstract：:The t(2;5) chromosomal translocation occurs in anaplastic large-cell lymphoma arising from activated T lymphocytes. This genomic rearrangement generates the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) oncoprotein that is a chimeric protein consisting of parts of the nuclear protein NPM and ALK receptor protei...

journal_title：Oncogene

authors： Chikamori M,Fujimoto J,Tokai-Nishizumi N,Yamamoto T

更新日期：2007-05-03 00:00:00

abstract：:We previously showed that the proto-oncogene RON encodes the tyrosine kinase receptor for Macrophage Stimulating Protein (MSP), originally isolated as a chemotactic factor for peritoneal macrophages. To elucidate the biological role of MSP we studied the expression of the Ron receptor in vivo, and the response to the ...

journal_title：Oncogene

authors： Gaudino G,Avantaggiato V,Follenzi A,Acampora D,Simeone A,Comoglio PM

更新日期：1995-12-21 00:00:00

abstract：:We reported previously that the v-rel protein (p59v-rel) exists in a high molecular weight complex with at least four other proteins in the cytoplasm of v-rel-transformed chicken pre-B lymphoid cells (Simek, S. & Rice, N.R., J. Virol., 62, 4730-4736, 1989). One of these proteins is the chicken c-rel protein, but the i...

journal_title：Oncogene

authors： Kochel T,Mushinski JF,Rice NR

更新日期：1991-04-01 00:00:00

abstract：:Dysregulated microRNA (miRNA) mediate malignant phenotypes, including metabolic reprogramming. By performing an integrative analysis of miRNA and metabolome data for the NCI-60 cell line panel, we identified an miRNA cluster strongly associated with both c-Myc expression and global metabolic variation. Within this clu...

journal_title：Oncogene

authors： Koufaris C,Valbuena GN,Pomyen Y,Tredwell GD,Nevedomskaya E,Lau CH,Yang T,Benito A,Ellis JK,Keun HC

更新日期：2016-05-01 00:00:00

abstract：:The genetic instability driving tumorigenesis is fueled by DNA damage and by errors made by the DNA replication. Upon DNA damage the cell organizes an integrated response not only by the classical DNA repair mechanisms but also involving mechanisms of replication, transcription, chromatin structure dynamics, cell cycl...

journal_title：Oncogene

authors： Ceruti JM,Scassa ME,Fló JM,Varone CL,Cánepa ET

更新日期：2005-06-09 00:00:00

abstract：:The Cbl family proteins Cbl, Cbl-b, and Cbl-c/Cbl-3 are thought to regulate signaling through protein-tyrosine kinases, positively as scaffold proteins and negatively as ubiquitin ligases. However, the precise signaling pathways and target proteins for each Cbl family member are not well understood. Here we show that ...

journal_title：Oncogene

authors： Kim M,Tezuka T,Tanaka K,Yamamoto T

更新日期：2004-03-04 00:00:00

abstract：:BRAF mutations occur in ~10% of colorectal cancer (CRC) and are associated with poor prognosis. Inhibitors selective for the BRAFV600E oncoprotein, the most common BRAF mutant, elicit only poor response rates in BRAF-mutant CRC as single agents. This unresponsiveness was mechanistically attributed to the loss of negat...

journal_title：Oncogene

authors： Herr R,Halbach S,Heizmann M,Busch H,Boerries M,Brummer T

更新日期：2018-03-01 00:00:00

abstract：:We have used two different, but complementary assays to characterize functions of SV40 T antigen that are necessary for its ability to immortalize rat embryo fibroblasts. In accordance with previous work, we found that several functions were required. These include activities that map to the p53 binding domain and the...

journal_title：Oncogene

authors： Powell AJ,Darmon AJ,Gonos ES,Lam EW,Peden KW,Jat PS

更新日期：1999-12-02 00:00:00

abstract：:Activation of the Akt/PKB protein kinase family triggers increases in cell size, metabolism and survival. Akt coordinately regulates these fundamental cellular processes through phosphorylation-dependent inactivation of tumor suppressors and activation of trophic signaling. Akt signaling stimulates transport and metab...

journal_title：Oncogene

authors： Plas DR,Thompson CB

更新日期：2005-11-14 00:00:00

abstract：:This study examines whether the serine/threonine protein kinase, Akt, is involved in the crosstalk between the ErbB2 and estrogen receptor-alpha (ER-alpha) pathways. Treatment of MCF-7 cells with 10(-9) M heregulin-beta1 (HRG-beta1) resulted in a rapid phosphorylation of Akt and a 15-fold increase in Akt activity. Akt...

journal_title：Oncogene

authors： Stoica GE,Franke TF,Wellstein A,Morgan E,Czubayko F,List HJ,Reiter R,Martin MB,Stoica A

更新日期：2003-04-10 00:00:00

abstract：:The MT-2 cell-line, which had been established through in vitro cell to cell transmission of human T-cell leukemia virus type I (HTLV-I) among human primary lymphocytes, was shown to possess multiple copies of integrated proviruses, including defective proviral genomes. By analysing a genomic clone, we identified the ...

journal_title：Oncogene

authors： Kubota S,Siomi H,Hatanaka M,Pomerantz RJ

更新日期：1996-04-04 00:00:00

abstract：:Chronic inflammation has been associated with a variety of human cancers including prostate cancer. Interleukin-17 (IL-17) is a critical pro-inflammatory cytokine, which has been demonstrated to promote development of prostate cancer, colon cancer, skin cancer, breast cancer, lung cancer and pancreas cancer. IL-17 pro...

journal_title：Oncogene

authors： Zhang Q,Liu S,Parajuli KR,Zhang W,Zhang K,Mo Z,Liu J,Chen Z,Yang S,Wang AR,Myers L,You Z

更新日期：2017-02-02 00:00:00

abstract：:Although established cell lines can be transformed with oncogenic ras, primary epithelial cells cannot, but require the coexpression of an immortalizing oncogene, such as the E1A region of adenovirus. We have previously shown that immortalization of primary epithelial cells by E1A 12S requires the expression of five r...

journal_title：Oncogene

authors： Gopalakrishnan S,Fischer RS,Quinlan MP

更新日期：1996-12-19 00:00:00

abstract：:Treatment of cells with insulin and protein tyrosine phosphatase inhibitors such as vanadate and pervanadate resulted in the tyrosine phosphorylation of Grb10, a Src homology 2 (SH2) and pleckstrin homology domain-containing adaptor protein which binds to a number of receptor tyrosine kinases including the insulin rec...

journal_title：Oncogene

authors： Langlais P,Dong LQ,Hu D,Liu F

更新日期：2000-06-08 00:00:00

abstract：:Lysyl oxidase (LOX) is a multifunctional protein required for normal collagen and elastin biosynthesis and maturation. In addition, LOX has complex roles in cancer in which the lysyl oxidase propeptide (LOX-PP) domain of secreted pro-LOX has tumor-suppressor activity, while the active enzyme promotes metastasis. In pr...

journal_title：Oncogene

authors： Bais MV,Ozdener GB,Sonenshein GE,Trackman PC

更新日期：2015-04-09 00:00:00

abstract：:Centromeric instability is characterized by dynamic formation of centromeric breaks, deletions, isochromosomes and translocations, which are commonly observed in cancer. So far, however, the mechanisms of centromeric instability in cancer cells are still poorly understood. In this study, we tested the hypothesis that ...

journal_title：Oncogene

authors： Deng W,Tsao SW,Mak GW,Tsang CM,Ching YP,Guan XY,Huen MS,Cheung AL

更新日期：2011-03-17 00:00:00

abstract：:TRAIL (TNF-related apoptosis-inducing ligand) induces apoptosis in susceptible cells by binding to death receptors 4 (DR4) and 5 (DR5). TRAIL preferentially induces apoptosis in transformed cells and the identification of mechanisms by which TRAIL-induced apoptosis can be enhanced may lead to novel cancer chemotherape...

journal_title：Oncogene

authors： Clarke P,Meintzer SM,Spalding AC,Johnson GL,Tyler KL

更新日期：2001-10-18 00:00:00

abstract：:Oncogenesis results from changes in kinetics or in abundance of proteins in signal transduction networks. Recently, it was shown that control of signalling cannot reside in a single gene product, and might well be dispersed over many components. Which of the reactions in these complex networks are most important, and ...

journal_title：Oncogene

authors： Hornberg JJ,Binder B,Bruggeman FJ,Schoeberl B,Heinrich R,Westerhoff HV

更新日期：2005-08-25 00:00:00

abstract：:Structural rearrangements involving chromosome 13 are frequently seen in B-cell chronic lymphocytic leukaemia. The presence of reciprocal translocations involving 13q14 in 10-15% of cases pinpoints the location of a gene important in leukaemogenesis. In order to characterise the exact location of the 13q14 breakpoint,...

journal_title：Oncogene

authors： Hawthorn LA,Chapman R,Oscier D,Cowell JK

更新日期：1993-06-01 00:00:00

abstract：:Castration-resistant prostate cancer (CRPC) continues to be a major clinical problem and the mechanisms behind it remain unclear. Thioredoxin domain-containing protein 5 (TXNDC5) is involved in protein folding and chaperone activity, and its overexpression has been reported in multiple malignancies. In the current stu...

journal_title：Oncogene

authors： Wang L,Song G,Chang X,Tan W,Pan J,Zhu X,Liu Z,Qi M,Yu J,Han B

更新日期：2015-09-03 00:00:00

abstract：:Caveolin-1 is an essential structural constituent of caveolae that has been implicated in mitogenic signaling and oncogenesis. Caveolin-1 is down-regulated in oncogene-transformed and tumor-derived cells. Antisense suppression of caveolin-1 or expression of a dominant negative form are sufficient for inducing cellular...

journal_title：Oncogene

authors： Fiucci G,Ravid D,Reich R,Liscovitch M

更新日期：2002-04-04 00:00:00

abstract：:Although loss of sensitivity to transforming growth factor beta (TGF beta) may be a key step in the escape of epithelial tumours from normal growth control, the intracellular signals determining responsiveness remain controversial, particularly the role of p53. We have investigated this question using thyroid epitheli...

journal_title：Oncogene

authors： Blaydes JP,Schlumberger M,Wynford-Thomas D,Wyllie FS

更新日期：1995-01-19 00:00:00

abstract：:RNA polymerase (pol) III synthesizes a range of essential products, including tRNA, 5S rRNA and 7SL RNA, which are required for protein synthesis and trafficking. High rates of pol III transcription are necessary for cells to sustain growth. A wide range of transformed and tumour cell types have been shown to express ...

journal_title：Oncogene

authors： White RJ

更新日期：2004-04-19 00:00:00

abstract：:The TrkA receptor protein tyrosine kinase is involved in signalling PC12 cell differentiation and cessation of cell division in response to nerve growth factor (NGF). To assess the importance of adaptor proteins and Ras in NGF control of phosphoinositide 3-OH kinase (PI 3-kinase), specific receptor mutations in Trk ha...

journal_title：Oncogene

authors： Hallberg B,Ashcroft M,Loeb DM,Kaplan DR,Downward J

更新日期：1998-08-13 00:00:00

abstract：:The adenomatous polyposis coli (APC) tumor suppressor gene is mutationally inactivated in both familial and sporadic forms of colorectal cancers. In addition, hypermethylation of CpG islands in the upstream portion of APC, a potential alternative mechanism of tumor suppressor gene inactivation, has been described in c...

journal_title：Oncogene

authors： Tsuchiya T,Tamura G,Sato K,Endoh Y,Sakata K,Jin Z,Motoyama T,Usuba O,Kimura W,Nishizuka S,Wilson KT,James SP,Yin J,Fleisher AS,Zou T,Silverberg SG,Kong D,Meltzer SJ

更新日期：2000-07-27 00:00:00

abstract：:SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes that includes HACS1. HACS1 encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and has...

journal_title：Oncogene

authors： Claudio JO,Zhu YX,Benn SJ,Shukla AH,McGlade CJ,Falcioni N,Stewart AK

更新日期：2001-08-30 00:00:00

abstract：:Jun : Fos and Jun : ATF complexes represent two classes of AP-1 dimers that (1) preferentially bind to either heptameric or octameric AP-1 binding sites, and (2) are differently regulated by cellular signaling pathways and oncogene products. To discriminate between the functions of Jun : Fos, Jun : ATF and Jun : Jun, ...

journal_title：Oncogene

authors： van Dam H,Castellazzi M

更新日期：2001-04-30 00:00:00

abstract：:FGFR1 (fibroblast growth factor receptor 1) regulates many key cellular responses including proliferation, migration and differentiation through activation of signaling pathways. Irregularities in FGFR1 signaling have been implicated in several pathological conditions, including human cancer. In order to discover nove...

journal_title：Oncogene

authors： Nadratowska-Wesolowska B,Haugsten EM,Zakrzewska M,Jakimowicz P,Zhen Y,Pajdzik D,Wesche J,Wiedlocha A

更新日期：2014-10-02 00:00:00

abstract：:The introduction of highly active antiretroviral therapy (HAART) has changed dramatically the landscape of HIV disease. Deaths from AIDS-related diseases have been reduced by 75% since protease inhibitor therapy and combination antiretroviral therapy came into use in late 1995. While KS is declining, the situation for...

journal_title：Oncogene

authors： Berretta M,Cinelli R,Martellotta F,Spina M,Vaccher E,Tirelli U

更新日期：2003-09-29 00:00:00