Abstract：
:Mutations in the c-KIT receptor occur somatically in many sporadic Gastrointestinal Stromal Tumors (GIST), and similar mutations have been identified at the germline level in kindreds with multiple GISTs. These mutations activate the tyrosine kinase activity of c-KIT and induce constitutive signaling. To investigate the function of activated c-KIT in GIST, we established a human GIST cell line, GIST882, which expresses an activating KIT mutation (K642E) in the first part of the cytoplasmic split tyrosine kinase domain. Notably, the K642E substitution is encoded by a homozygous exon 13 missense mutation, and, therefore, GIST882 cells do not express native KIT. GIST882 c-KIT protein is constitutively tyrosine phosphorylated, but tyrosine phosphorylation was rapidly and completely abolished after incubating the cells with the selective tyrosine kinase inhibitor STI571. Furthermore, GIST882 cells evidenced decreased proliferation and the onset of apoptotic cell death after prolonged incubation with STI571. Similar results were obtained after administering STI571 to a primary GIST cell culture that expressed a c-KIT exon 11 juxtamembrane mutation (K558NP). These cell-culture-based studies support an important role for c-KIT signaling in GIST and suggest therapeutic potential for STI571 in patients afflicted by this chemoresistant tumor.
journal_name
Oncogenejournal_title
Oncogeneauthors
Tuveson DA,Willis NA,Jacks T,Griffin JD,Singer S,Fletcher CD,Fletcher JA,Demetri GDdoi
10.1038/sj.onc.1204704subject
Has Abstractpub_date
2001-08-16 00:00:00pages
5054-8issue
36eissn
0950-9232issn
1476-5594journal_volume
20pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:We have previously shown that transactivation by tumor suppressor protein p53 can be inhibited in vivo at elevated protein concentrations. In this study we characterize the structural requirements of this function. We show that oligomerization domain of p53 is involved in loss of transactivation at high protein concen...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201749
更新日期：1998-05-07 00:00:00
abstract：:The skin represents a physical and chemical barrier against invading pathogens, which is additionally supported by restriction factors that provide intrinsic cellular immunity. These factors detect viruses to block their replication cycle. Here, we uncover the Myb-related transcription factor, partner of profilin (MYP...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0398-6
更新日期：2018-11-01 00:00:00
abstract：:Persistent infection with hepatitis B virus (HBV) is one of the primary risk factors for human hepatocellular carcinoma (HCC). In a human ecological study, we have shown that, in addition to HBV, animal food consumption also significantly contributes to the variance of HCC. To test the interacting effect of HBV and an...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201444
更新日期：1997-12-04 00:00:00
abstract：:Delta(9)-Tetrahydrocannabinol (THC) is the primary cannabinoid of marijuana and has been shown to either potentiate or inhibit tumor growth, depending on the type of cancer and its pathogenesis. Little is known about the activity of cannabinoids like THC on epidermal growth factor receptor-overexpressing lung cancers,...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210641
更新日期：2008-01-10 00:00:00
abstract：:Previously, we cloned two gene fragments encoding novel protein tyrosine phosphatases, termed PTP-U1 and PTP-U2. Here, we report the full-length sequence, expression, and chromosomal localization of the PTP-U2 gene. The cDNA for PTP-U2, which was obtained from a human normal kidney library, predicts a protein of 1216 ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-05-04 00:00:00
abstract：:Different diagnostic and prognostic groups of colorectal carcinoma (CRC) have been defined. However, accurate diagnosis and prediction of survival are sometimes difficult. Gene expression profiling might improve these classifications and bring new insights into underlying molecular mechanisms. We profiled 50 cancerous...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207262
更新日期：2004-02-19 00:00:00
abstract：:Snail is a zinc finger transcription factor that triggers the epithelial-mesenchymal transition (EMT) by directly repressing E-cadherin expression. Snail is required for mesoderm and neural crest formation during embryonic development and has recently been implicated in the EMT associated with tumour progression. In a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205416
更新日期：2002-05-09 00:00:00
abstract：:Steroid receptor co-activator-3 (SRC-3/AIB1) is an oncogene that is amplified and overexpressed in many human cancers. However, the molecular mechanisms that regulate 'activated SRC-3 oncoprotein' turnover during tumorigenesis remain to be elucidated. Here, we report that speckle-type POZ protein (SPOP), a cullin 3 (C...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.151
更新日期：2011-10-20 00:00:00
abstract：:The carboxyl terminus of c-Myb contains a negative regulatory domain that is absent in the v-Myb oncoprotein, but conserved among all the known Myb proteins of animals. This domain inhibits transcriptional activation by c-Myb in animal cells, but not in budding yeast, suggesting that additional protein(s) present in a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204048
更新日期：2001-01-04 00:00:00
abstract：:Resistance to detachment-induced apoptosis, a process commonly referred as anoikis, is emerging as a hallmark of metastatic malignancies, mainly because it can ensure anchorage-independent growth and survival during organ colonization. Besides, a sustained oxidative stress has been associated with several steps of car...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2009.77
更新日期：2009-05-21 00:00:00
abstract：:The molecular interactions implicated in the mammalian G1/S cell cycle phase transition comprise a highly nonlinear network which can produce seemingly paradoxical results and make intuitive interpretations unreliable. A new approach to this problem is presented, consisting of (1) a convention of unambiguous reaction ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201608
更新日期：1998-02-26 00:00:00
abstract：:Heregulins (neuregulins) are a family of proteins known to interact and activate the receptor tyrosine kinases ErbB2 in association with ErbB3 or ErbB4. Using immunofluorescence microscopy, electron microscopy autoradiography, and SDS-PAGE analysis of nuclear fractions, we show that the heregulin-beta1(1-244) isoform ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-06-06 00:00:00
abstract：:Many components of the Wnt/β-catenin signaling pathway have critical functions in mammary gland development and tumor formation, yet the contribution of glycogen synthase kinase-3 (GSK-3α and GSK-3β) to mammopoiesis and oncogenesis is unclear. Here, we report that WAP-Cre-mediated deletion of GSK-3 in the mammary epit...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2014.279
更新日期：2015-07-01 00:00:00
abstract：:Activation of the Met tyrosine kinase growth factor receptor by its ligand HGF/SF has been shown to increase in vitro invasiveness in epithelial cell lines. To study the effect of Met-HGF/SF signaling in breast cancer cells, we transfected met, hgf/sf and dominant negative (DN) forms of met into the poorly differentia...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203557
更新日期：2000-05-11 00:00:00
abstract：:EDD (E3 isolated by differential display), located at chromosome 8q22.3, is the human orthologue of the Drosophila melanogaster tumour suppressor gene 'hyperplastic discs' and encodes a HECT domain E3 ubiquitin protein-ligase. To investigate the possible involvement of EDD in human cancer, several cancers from diverse...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206775
更新日期：2003-08-07 00:00:00
abstract：:Tumor-derived DNA from a non-Hodgkin's (T cell) lymphoma patient, assayed by NIH3T3 transfection followed by inoculation of cells into nude mice, was found to contain an activated N-ras proto-oncogene. The mode of activation was determined by hybridization with N-ras-specific oligonucleotide probes detecting mutations...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:We have characterized a chromosomal translocation in a cell line (SU-DUL5) established from a patient with lymphoblastic lymphoma in which the c-myc gene on chromosome 8 was juxtaposed to a t(14;18). Cytogenetic analysis of this cell line showed 14q+, 18q-, and 8p+q+ marker chromosomes in the absence of t(14;18). Geno...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-12-01 00:00:00
abstract：:TCR-mediated activation of T cell hybridomas induces programmed cell death by a Fas-dependent pathway. We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-ind...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201088
更新日期：1997-05-22 00:00:00
abstract：:MOZ and MLL, encoding a histone acetyltransferase (HAT) and a histone methyltransferase, respectively, are targets for recurrent chromosomal translocations found in acute myeloblastic or lymphoblastic leukemia. In MOZ (MOnocytic leukemia Zinc-finger protein)/CBP- or mixed lineage leukemia (MLL)-rearranged leukemias, a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2010.254
更新日期：2010-09-09 00:00:00
abstract：:We recently reported the cloning and overexpression of full-length forms of human fibroblast growth factor (FGF) receptors, bek and flg. These receptors contain three immunoglobulin (Ig)-like domains and an unusual acidic motif in the extracellular region, a single transmembrane segment and a protein tyrosine kinase c...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1991-12-01 00:00:00
abstract：:Expression of viral proteins may result in susceptibility of cells to the cytotoxic effect of Tumor Necrosis Factor Alpha (TNF). While murine C127 cells containing the bovine papillomavirus type 1 (BPV-1) genome were reported to exhibit increased TNF sensitivity, the gene(s) responsible was not identified. The BPV-1 E...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202373
更新日期：1999-01-21 00:00:00
abstract：:The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pe...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2017.214
更新日期：2017-11-02 00:00:00
abstract：:We previously reported cloning the rLot1 gene, and its human homolog (hLOT1), through analysis of differential gene expression in normal and malignant rat ovarian surface epithelial cells. Both human and rat ovarian carcinoma cell lines exhibited lost or decreased expression of this gene. Interestingly, the LOT1 gene ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203067
更新日期：1999-11-11 00:00:00
abstract：:Receptor crosstalk is an emerging and recurrent theme in cytokine and growth factor signaling; however, insight into the mechanism(s) underlying these interactions remains limited. Recently, we reported that crosstalk occurs between ErbB3 and the interferon alpha (IFN-alpha) signaling complex in the myeloma cell line ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207203
更新日期：2004-02-12 00:00:00
abstract：:Several small GTPases of the Ras superfamily have been shown to antagonize TGFbeta signaling in human tumor cell lines. Some of these GTPases are post-translationally modified by farnesylation, a lipid modification catalyzed by farnesyltransferase and required for the proteins to attach to membranes and to function. I...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203920
更新日期：2000-11-16 00:00:00
abstract：:Activation of cellular transcriptional responses, mediated by hypoxia-inducible factor (HIF), is common in many types of cancer, and generally confers a poor prognosis. Known to induce many hundreds of protein-coding genes, HIF has also recently been shown to be a key regulator of the non-coding transcriptional respon...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2014.378
更新日期：2015-08-20 00:00:00
abstract：:Oxygen is the ultimate source of oxidizing power for disulfide bond formation, suggesting that under limiting oxygen proper protein folding might be compromised. We show that secretion of vascular endothelial growth factor (VEGF), a protein with multiple disulfide bonds, was indeed impeded under hypoxia and was partia...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208325
更新日期：2005-02-03 00:00:00
abstract：:The RCAS retroviral vector was used to express chicken and mouse cellular Jun proteins in chicken embryo fibroblasts. Both mouse and chicken proteins induced foci of transformed cells with low to moderate efficiency compared with viral Jun, but were as effective as the viral protein in promoting anchorage-independent ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:A key hallmark of many cancers, particularly the most aggressive, is the capacity to metabolize glucose at an elevated rate, a phenotype detected clinically using positron emission tomography (PET). This phenotype provides cancer cells, including those that participate in metastasis, a distinct competitive edge over n...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1209603
更新日期：2006-08-07 00:00:00
abstract：:Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia. Here, we found that leukemic stem cells (LSCs) were highly differentiated, and leukemia progression was severely impaire...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-020-01547-x
更新日期：2021-01-01 00:00:00
