EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors.

abstract：:Lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are extracellular lipid mediators that signal through distinct members of the Edg/LP subfamily of G protein-coupled receptors (GPCRs). LPA and S1P receptors are expressed in almost every cell type and can couple to multiple G proteins (G(i), G(q) and G(12/1...

journal_title：Oncogene

authors： Kranenburg O,Moolenaar WH

更新日期：2001-03-26 00:00:00

abstract：:Pim kinases are found to be highly expressed in leukemia, lymphoma, prostate and pancreatic cancer. Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc succumb to pre-B-cell lymphoma at a strikingly accelerated speed. Despite that Pim-1/Pim-2 has long been recognized as a strong synergistic partner with c...

journal_title：Oncogene

authors： Zhang Y,Wang Z,Li X,Magnuson NS

更新日期：2008-08-14 00:00:00

abstract：:We identified IFIX as a new member of the hematopoietic interferon (IFN)-inducible nuclear protein with the 200-amino-acid repeat (HIN-200) family. Six different alternatively spliced forms of mRNA are transcribed from the IFIX gene, which are predicted to encode six different isoforms of IFIX proteins (IFIXalpha1, al...

journal_title：Oncogene

authors： Ding Y,Wang L,Su LK,Frey JA,Shao R,Hunt KK,Yan DH

更新日期：2004-06-03 00:00:00

abstract：:The maintenance of genome stability is essential for the cell as the integrity of genomic information guaranties reproduction of a whole organism. DNA damage occurring in response to different natural and nonnatural stimuli (errors in DNA replication, UV radiation, chemical agents, etc.) is normally detected by specia...

journal_title：Oncogene

authors： Prokhorova EA,Egorshina AY,Zhivotovsky B,Kopeina GS

更新日期：2020-01-01 00:00:00

abstract：:Primary neonatal Balb/c keratinocyte (NEK) cultures grown, using 3T3 feeder cell support in high calcium, serum supplemented medium, were transfected with EJ-Ha-ras or v-fos DNA sequences and pSV2 neo. Several neo resistant clones were isolated and several established cell lines expressing the transfected gene product...

journal_title：Oncogene

authors： Appleby MW,Greenfield IM,Crook T,Parkinson EK,Stanley MA

更新日期：1989-11-01 00:00:00

abstract：:Recently the rat and mouse Growth Factor Independence (Gfi-1) genes have been cloned (Gilks et al., 1993; Zoring et al; 1996). This gene allows cells in culture to overcome the depletion of growth factors in the culture medium and maintain their proliferative potential. As part of a cloning strategy to isolated genes ...

journal_title：Oncogene

authors： Roberts T,Cowell JK

更新日期：1997-02-27 00:00:00

abstract：:Ovarian cancer is the leading cause of death among all gynecological malignancies due to the development of acquired chemoresistance and disease relapse. Although the role of cancer stem cells (CSCs), a subset of tumor cells with the self-renewal and differentiation capabilities, in therapeutic resistance is beginning...

journal_title：Oncogene

authors： Ramadoss S,Sen S,Ramachandran I,Roy S,Chaudhuri G,Farias-Eisner R

更新日期：2017-03-01 00:00:00

abstract：:The transcription factor nuclear factor kappa B (NF-κB) and the long non-coding RNA (lncRNA) HOTAIR (HOX transcript antisense RNA) have diverse functional roles in cancer. In this study, we show that upregulation of HOTAIR induced platinum resistance in ovarian cancer, and increased HOTAIR levels were observed in recu...

journal_title：Oncogene

authors： Özeş AR,Miller DF,Özeş ON,Fang F,Liu Y,Matei D,Huang T,Nephew KP

更新日期：2016-10-13 00:00:00

abstract：:Upstream stimulating factor (USF2) is a basic helix-loop-helix leucine zipper transcription factor, which is found in most tissues. A critical role for USF2 in cellular proliferation has been proposed based on its importance in the regulation of various cyclins and P53 and its capability to antagonize c-myc. In this p...

journal_title：Oncogene

authors： Zhang ZC,Nechushtan H,Jacob-Hirsch J,Avni D,Meyuhas O,Razin E

更新日期：1998-02-12 00:00:00

abstract：:The p53 tumor suppressor protein activates transcription and induces cell death. A close homologue of p53, termed p73, is expressed in transactivating (TA) forms that induce growth arrest and apoptosis much like p53. However, the p73 gene contains a second promoter, giving rise to the expression of p73 Delta N, a spec...

journal_title：Oncogene

authors： Kartasheva NN,Contente A,Lenz-Stöppler C,Roth J,Dobbelstein M

更新日期：2002-07-18 00:00:00

abstract：:Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a slowly growing tumor with propensity for neuroinvasion and late recurrence, are limited to surgery and radiotherapy. Based on expression analysis performed on clinical specimens of salivary cancers, we identified in ACC expression of the neu...

journal_title：Oncogene

authors： Ivanov SV,Panaccione A,Brown B,Guo Y,Moskaluk CA,Wick MJ,Brown JL,Ivanova AV,Issaeva N,El-Naggar AK,Yarbrough WG

更新日期：2013-08-08 00:00:00

abstract：:We have cloned and sequenced the nov gene (novH) which is the homolog of the chicken nov proto-oncogene overexpressed in avian nephroblastomas. The novH gene is highly conserved and encodes a putative IGF-binding protein similar to that of chicken. We report that relative to autologous normal kidney expression of novH...

journal_title：Oncogene

authors： Martinerie C,Huff V,Joubert I,Badzioch M,Saunders G,Strong L,Perbal B

更新日期：1994-09-01 00:00:00

abstract：:We have recently isolated the erythroleukemic cell line, HB60-5, that proliferates in the presence of erythropoietin (Epo) and stem cell factor (SCF), but undergoes terminal differentiation in the presence of Epo alone. Ectopic expression of the ets related transcription factor Fli-1 in these cells resulted in the est...

journal_title：Oncogene

authors： Zochodne B,Truong AH,Stetler K,Higgins RR,Howard J,Dumont D,Berger SA,Ben-David Y

更新日期：2000-05-04 00:00:00

abstract：:In this issue of Oncogene, Mollinedo and co-workers present promising evidence that cholesterol-sensitive signaling pathways involving lipid rafts can be therapeutically targeted in multiple myeloma. Because the pathways considered in their study are used by other types of tumor cells, one implication of this report i...

journal_title：Oncogene

authors： Freeman MR,Di Vizio D,Solomon KR

更新日期：2010-07-01 00:00:00

abstract：:Germline BAP1 mutations predispose to several cancers, in particular malignant mesothelioma. Mesothelioma is an aggressive malignancy generally associated with professional exposure to asbestos. However, to date, we found that none of the mesothelioma patients carrying germline BAP1 mutations were professionally expos...

journal_title：Oncogene

authors： Napolitano A,Pellegrini L,Dey A,Larson D,Tanji M,Flores EG,Kendrick B,Lapid D,Powers A,Kanodia S,Pastorino S,Pass HI,Dixit V,Yang H,Carbone M

更新日期：2016-04-14 00:00:00

abstract：:The effect of p53-dependent cell-cycle arrest and senescence on Emu-myc-induced B-cell lymphoma development remains controversial. To address this question, we crossed Emu-myc mice with the p53(515C) mutant mouse, encoding the mutant p53R172P protein that retains the ability to activate the cell-cycle inhibitor and se...

journal_title：Oncogene

authors： Post SM,Quintás-Cardama A,Terzian T,Smith C,Eischen CM,Lozano G

更新日期：2010-03-04 00:00:00

abstract：:Cytosolic proteins containing SH2 and SH3 domains, such as Crk and Crk-like (CrkL), are broadly expressed adapters that interact with a variety of proteins to fulfill key roles in signal transduction pathways triggered by activation of receptor and non-receptor tyrosine kinases. Crk and CrkL are similar to each other ...

journal_title：Oncogene

authors： Park TJ,Curran T

更新日期：2014-10-23 00:00:00

abstract：:LNCaP cells are human prostatic cancer cells that have a frame-shift mutation of the tumor suppressor gene PTEN and do not express the insulin receptor substrate-1 (IRS-1), a major substrate of the type 1 insulin-like growth factor receptor (IGF-IR). Ectopic expression of IRS-1 in LNCaP cells increases cell adhesion a...

journal_title：Oncogene

authors： Reiss K,Wang JY,Romano G,Tu X,Peruzzi F,Baserga R

更新日期：2001-01-25 00:00:00

abstract：:BTK is a cytoplasmic protein-tyrosine kinase, whose corresponding gene was isolated in the early 1990s. BTK was initially identified by positional cloning of the gene causing X-linked agammaglobulinemia and independently in a search for new kinases. Given the phenotype of affected patients, namely lack of B-lymphocyte...

journal_title：Oncogene

authors： Smith CI

更新日期：2017-04-01 00:00:00

abstract：:Esophageal cancer is one of the most lethal cancers worldwide with poor survival and limited therapeutic options. The discovery of microRNAs created a new milestone in cancer research. miR-377 is located in chromosome region 14q32, which is frequently deleted in esophageal squamous cell carcinoma (ESCC), but the biolo...

journal_title：Oncogene

authors： Li B,Xu WW,Han L,Chan KT,Tsao SW,Lee NPY,Law S,Xu LY,Li EM,Chan KW,Qin YR,Guan XY,He QY,Cheung ALM

更新日期：2017-07-13 00:00:00

abstract：:Colony-stimulating factors and other cytokines signal via their cognate receptors to regulate hematopoiesis. In many developmental systems, inductive signalling determines cell fate and, by analogy with this, it has been postulated that cytokines, signalling via their cognate receptors, may play an instructive role in...

journal_title：Oncogene

authors： Robb L

更新日期：2007-10-15 00:00:00

abstract：:Identifying novel and known genes that are differentially expressed in breast cancer has important implications in understanding the biology of breast tumorigenesis and developing new diagnostic and therapeutic agents. In this study we have combined two powerful technologies, PCR-based cDNA subtraction and cDNA microa...

journal_title：Oncogene

authors： Jiang Y,Harlocker SL,Molesh DA,Dillon DC,Stolk JA,Houghton RL,Repasky EA,Badaro R,Reed SG,Xu J

更新日期：2002-03-28 00:00:00

abstract：:To date, constitutively activating point mutations reported in hematopoietic growth factor receptors in patients with acute myeloid leukemia (AML) have been restricted to receptors with intrinsic tyrosine kinase activity such as c-kit and FLT3. We describe here a Thr617Asn mutation in the transmembrane domain of the n...

journal_title：Oncogene

authors： Forbes LV,Gale RE,Pizzey A,Pouwels K,Nathwani A,Linch DC

更新日期：2002-09-05 00:00:00

abstract：:We have previously reported that platelet-derived growth factor (PDGF) induced tyrosine phosphorylation of GTPase-activating protein (GAP) in intact quiescent fibroblasts under conditions in which insulin and basic fibroblast growth factor (bFGF) were ineffective (Molloy et al., 1988). In the present study, we have pr...

journal_title：Oncogene

authors： Heidaran MA,Molloy CJ,Pangelinan M,Choudhury GG,Wang LM,Fleming TP,Sakaguchi AY,Pierce JH

更新日期：1992-01-01 00:00:00

abstract：:Amplification of the N-myc gene is a significant adverse prognostic factor in neuroblastoma, a common childhood tumor. In non-transformed cells, myc expression is controlled through an autoregulatory circuit, through which elevated Myc protein levels lead to down-regulation of myc transcription. The precise mechanism ...

journal_title：Oncogene

authors： Sivak LE,Tai KF,Smith RS,Dillon PA,Brodeur GM,Carroll WL

更新日期：1997-10-16 00:00:00

abstract：:Small cell lung cancer (SCLC) is a disease characterized by aggressive clinical behavior and lack of effective therapy. Owing to its tendency for early dissemination, only a third of patients have limited-stage disease at the time of diagnosis. SCLC is thought to derive from pulmonary neuroendocrine cells. Although se...

journal_title：Oncogene

authors： Kalari S,Jung M,Kernstine KH,Takahashi T,Pfeifer GP

更新日期：2013-07-25 00:00:00

abstract：:Bcl-2 or Bcl-X(L) confers resistance to chemotherapy in multiple myeloma (MM). Here we characterized the effects of ABT-737, a potent small-molecule inhibitor of antiapoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w with markedly higher affinity than previously reported compounds, on human MM cells. ABT-737 induces apoptos...

journal_title：Oncogene

authors： Chauhan D,Velankar M,Brahmandam M,Hideshima T,Podar K,Richardson P,Schlossman R,Ghobrial I,Raje N,Munshi N,Anderson KC

更新日期：2007-04-05 00:00:00

abstract：:The p53-regulated GADD45 gene is one of the important players in cellular response to DNA damage, and probably involved in the control of cell cycle checkpoint, apoptosis and DNA repair. There are both the p53-dependent and -independent pathways that regulate GADD45 induction. Following ionizing radiation, induction o...

journal_title：Oncogene

authors： Jin S,Fan F,Fan W,Zhao H,Tong T,Blanck P,Alomo I,Rajasekaran B,Zhan Q

更新日期：2001-05-10 00:00:00

abstract：:FLT3 tyrosine kinase domain (TKD) mutations are detected in approximately 7% of acute myeloid leukemia patients, and suggested to correlate with poor prognosis and confer resistance to FLT3 inhibitors. To explore activation mechanism of FLT3 TKD mutation, we analysed critical tyrosine residues for the constitutive act...

journal_title：Oncogene

authors： Ishiko J,Mizuki M,Matsumura I,Shibayama H,Sugahara H,Scholz G,Serve H,Kanakura Y

更新日期：2005-12-08 00:00:00

abstract：:Jun : Fos and Jun : ATF complexes represent two classes of AP-1 dimers that (1) preferentially bind to either heptameric or octameric AP-1 binding sites, and (2) are differently regulated by cellular signaling pathways and oncogene products. To discriminate between the functions of Jun : Fos, Jun : ATF and Jun : Jun, ...

journal_title：Oncogene

authors： van Dam H,Castellazzi M

更新日期：2001-04-30 00:00:00