Tumor heterogeneity and plasticity as elusive drivers for resistance to MAPK pathway inhibition in melanoma.

abstract：:The mitochondrial apoptosis pathway mediates cell death through the release of various pro-apoptotic factors including cytochrome c and Smac, the second mitochondrial activator of caspases, into the cytosol. Smac was shown previously to inhibit IAP proteins and to facilitate initiation of the caspase cascade upon cyto...

journal_title：Oncogene

authors： Hasenjäger A,Gillissen B,Müller A,Normand G,Hemmati PG,Schuler M,Dörken B,Daniel PT

更新日期：2004-06-03 00:00:00

abstract：:Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts, can lead to loss-of-function in tumor suppressors or activation of oncogenes and cancer pathways. Emerging data suggest th...

journal_title：Oncogene

authors： Chen J,Weiss WA

更新日期：2015-01-02 00:00:00

abstract：:Familial adenomatous polyposis (FAP) is caused by germline mutations in the adenomatous polyposis coli (APC) gene. Two promoters, 1A and 1B, have been recognized in APC, and 1B is thought to have a minor role in the regulation of the gene. We have identified a novel deletion encompassing half of this promoter in the l...

journal_title：Oncogene

authors： Rohlin A,Engwall Y,Fritzell K,Göransson K,Bergsten A,Einbeigi Z,Nilbert M,Karlsson P,Björk J,Nordling M

更新日期：2011-12-15 00:00:00

abstract：:Overexpression of the nuclear phosphoprotein p53 has been detected in many different transformed human cell lines and primary adult tumors. Elevated steady-state levels of p53 appear to be the result of an increase in the stability of the protein and, in adult cancers, high levels of the protein are associated with mu...

journal_title：Oncogene

authors： Davidoff AM,Pence JC,Shorter NA,Iglehart JD,Marks JR

更新日期：1992-01-01 00:00:00

abstract：:A single heat shock factor (HSF), mediating the heat shock response, exists from yeast to Drosophila, whereas several related HSFs have been found in mammals. This raises the question of the specific or redundant functions of the different members of the HSF family and in particular of HSF1 and HSF2, which are both ub...

journal_title：Oncogene

authors： Lecomte S,Desmots F,Le Masson F,Le Goff P,Michel D,Christians ES,Le Dréan Y

更新日期：2010-07-22 00:00:00

abstract：:Triple-negative breast cancers (TNBCs) are characterized by a poor prognosis and lack of targeted treatments, and thus, new therapeutic strategies are urgently needed. Inhibitors against programmed death-1 (PD-1)/PD-1 ligand (PD-L1) have shown significant efficacy in various solid cancers, but their activity against T...

journal_title：Oncogene

authors： Castagnoli L,Cancila V,Cordoba-Romero SL,Faraci S,Talarico G,Belmonte B,Iorio MV,Milani M,Volpari T,Chiodoni C,Hidalgo-Miranda A,Tagliabue E,Tripodo C,Sangaletti S,Di Nicola M,Pupa SM

更新日期：2019-05-01 00:00:00

abstract：:MEMO1 (mediator of ErbB2-driven cell motility 1) regulates HER2-dependent cell migration. Increased MEMO1 expression is associated with cancer aggressiveness. Here, we found that MEMO1 is also involved in breast carcinogenesis via regulating insulin-like growth factor-I receptor-dependent signaling events. We showed t...

journal_title：Oncogene

authors： Sorokin AV,Chen J

更新日期：2013-06-27 00:00:00

abstract：:Despite the fact that objective response rates to 5-FU are as low as 20%, 5-FU remains the most commonly used drug for the treatment of colorectal cancer. The lack of understanding of resistance to 5-FU, therefore, remains a significant impediment in maximizing its efficacy. We used intestinal epithelial cells with an...

journal_title：Oncogene

authors： Klampfer L,Swaby LA,Huang J,Sasazuki T,Shirasawa S,Augenlicht L

更新日期：2005-06-02 00:00:00

abstract：:Tuftelin1 (TUFT1), an acidic protein constituent of developing and mineralizing tooth tissues, is regulated by hypoxia and the Hedgehog signaling pathway. We investigated the role of TUFT1 in hepatocellular carcinoma (HCC). qRT-PCR, immunohistochemistry and western blot were employed to evaluate TUFT1 level in HCC. MT...

journal_title：Oncogene

authors： Dou C,Zhou Z,Xu Q,Liu Z,Zeng Y,Wang Y,Li Q,Wang L,Yang W,Liu Q,Tu K

更新日期：2019-02-01 00:00:00

abstract：:Cancer therapy drugs, such as diamminedichloroplatinum (cisplatin), mitomycin C, etoposide and a number of other compounds, as well as energy-rich radiation, are known to act on cellular DNA. These agents are shown to induce nuclear accumulation of the so-called tumor-suppressor protein p53 in fibroblastoid cells, as ...

journal_title：Oncogene

authors： Fritsche M,Haessler C,Brandner G

更新日期：1993-02-01 00:00:00

abstract：:Metastasis is the process through which the primary cancer cells spread beyond the primary tumor and disseminate to other organs. Most cancer patients die of metastatic disease. EMT is proposed to be the initial event associated with cancer metastasis and how it occurred is still a mystery. CtBP is known as a co-repre...

journal_title：Oncogene

authors： Zhao Z,Hao D,Wang L,Li J,Meng Y,Li P,Wang Y,Zhang C,Zhou H,Gardner K,Di LJ

更新日期：2019-03-01 00:00:00

abstract：:To explore the mechanism of estrogen-induced growth of normal endometrium, the transactivation system of the cyclin D1 gene was analysed using cultured normal endometrial glandular cells. Estradiol (E2) treatment of cultured normal endometrial glandular cells induced upregulation of c-Jun, and then cyclin D1 proteins,...

journal_title：Oncogene

authors： Shiozawa T,Miyamoto T,Kashima H,Nakayama K,Nikaido T,Konishi I

更新日期：2004-11-11 00:00:00

abstract：:Prostate cancer is the second highest cause of cancer-related deaths of men in the US. Signal transducers and activators of transcription (STATs) proteins are a small family of latent cytoplasmic transcription factors that act downstream of Janus kinase (JAK) activation and mediate intracellular signaling from a wide ...

journal_title：Oncogene

authors： Flowers LO,Subramaniam PS,Johnson HM

更新日期：2005-03-17 00:00:00

abstract：:Unique transcriptional transactivation by the human immunodeficiency virus type 1 (HIV-1) Tat protein of long terminal repeat (LTR)-driven RNA expression, in the absence of the transactivator responsive element (TAR), was previously demonstrated in central nervous system (CNS)-derived astrocytic cell-lines, including ...

journal_title：Oncogene

authors： Niikura M,Dornadula G,Zhang H,Mukhtar M,Lingxun D,Khalili K,Bagasra O,Pomerantz RJ

更新日期：1996-07-18 00:00:00

abstract：:The integrin linked kinase (ILK) is a cytoplasmic effector of integrin receptors, involved in the regulation of integrin binding properties as well as the activation of cell survival and proliferative pathways, including those involving MAP kinase, PKB/Akt and GSK-3beta. Overexpression of ILK in cultured intestinal an...

journal_title：Oncogene

authors： White DE,Cardiff RD,Dedhar S,Muller WJ

更新日期：2001-10-25 00:00:00

abstract：:Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas af...

journal_title：Oncogene

authors： Wang Y,Sugiyama H,Axelson H,Panda CK,Babonits M,Ma A,Steinberg JM,Alt FW,Klein G,Wiener F

更新日期：1992-06-01 00:00:00

abstract：:Lineage-restricted transcription factors (TFs) are frequently mutated or overexpressed in cancer and contribute toward malignant behaviors; however, the molecular bases of their oncogenic properties are largely unknown. As TF activities are difficult to inhibit directly with small molecules, the genes and pathways the...

journal_title：Oncogene

authors： Sulahian R,Casey F,Shen J,Qian ZR,Shin H,Ogino S,Weir BA,Vazquez F,Liu XS,Hahn WC,Bass AJ,Chan V,Shivdasani RA

更新日期：2014-12-04 00:00:00

abstract：:The c-myc proto-oncogene has been shown to cause blockages to differentiation in many cell lineages. Although the mechanism by which c-Myc affects this process remains unknown, it is considered that it might result indirectly as an outcome of the continued cell-cycle progression invoked by c-Myc in cells which must gr...

journal_title：Oncogene

authors： Ryan KM,Birnie GD

更新日期：1997-06-12 00:00:00

abstract：:The transcription factor NF-kappa-B is normally sequestered in the cytoplasm by its inhibitory subunit IkappaB. Most extracellular signals activate NF-kappa-B through a mechanism involving the phosphorylation and proteasome-dependent degradation of IkappaB. EGF activates NF-kappaB in A-431 carcinoma cells, which overe...

journal_title：Oncogene

authors： Sun L,Carpenter G

更新日期：1998-04-23 00:00:00

abstract：:Prothymosin alpha (PT-alpha) is a nuclear protein involved in cell proliferation. Transcription of PT-alpha has been reported to be regulated by the c-myc gene in vitro. We identified PT-alpha as being overexpressed in a human colon cancer minus normal mucosa subtraction cDNA library. Northern blot (messenger RNA) ana...

journal_title：Oncogene

authors： Mori M,Barnard GF,Staniunas RJ,Jessup JM,Steele GD Jr,Chen LB

更新日期：1993-10-01 00:00:00

abstract：:Myogenic transcription is repressed in myoblasts by serum-activated cyclin-dependent kinases, such as cdk2 and cdk4. Serum withdrawal promotes muscle-specific gene expression at least in part by down-regulating the activity of these cdks. Unlike the other cdks, cdk9 is not serum- or cell cycle-regulated and is instead...

journal_title：Oncogene

authors： Simone C,Stiegler P,Bagella L,Pucci B,Bellan C,De Falco G,De Luca A,Guanti G,Puri PL,Giordano A

更新日期：2002-06-13 00:00:00

abstract：:Previous reports have demonstrated that E7 is the major transforming gene of HPV-16 and that continued expression of the gene is required to maintain the transformed phenotype of primary baby rat kidney cells transformed by HPV-16 E7 and EJ-ras. To investigate the point of action of E7 in the cell cycle we have utilis...

journal_title：Oncogene

authors： Banks L,Barnett SC,Crook T

更新日期：1990-06-01 00:00:00

abstract：:Uncontrolled growth and diffused invasion are major causes of mortality in patients with malignant gliomas. Nodal has been shown to have a central role in the tumorigenic signaling pathways of malignant melanoma. In this study, we show that grade IV human glioma cell lines expressed different levels of Nodal, parallel...

journal_title：Oncogene

authors： Lee CC,Jan HJ,Lai JH,Ma HI,Hueng DY,Lee YC,Cheng YY,Liu LW,Wei HW,Lee HM

更新日期：2010-05-27 00:00:00

abstract：:Temozolomide was recognized as the first-line therapy for glioblastoma to prolong the survival of patients noticeably, while recent clinical studies found that some patients were not sensitive to temozolomide treatment. The possible mechanisms seemed to be methylguanine-DNA-methyltransferase (MGMT), mismatch repair, P...

journal_title：Oncogene

authors： Nie E,Miao F,Jin X,Wu W,Zhou X,Zeng A,Yu T,Zhi T,Shi Z,Wang Y,Zhang J,Liu N,You Y

更新日期：2019-04-01 00:00:00

abstract：:Recently, we identified Insulinoma-Glucagonoma clone 20 (IG20) that can render cells more susceptible to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. In addition, it can slow cell proliferation, and enhance drug- and radiation-induced cell death. TNF-related apoptosis-inducing ligand (TRAIL) can selectiv...

journal_title：Oncogene

authors： Ramaswamy M,Efimova EV,Martinez O,Mulherkar NU,Singh SP,Prabhakar BS

更新日期：2004-08-12 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP1-36 hormone is processed by matrix metalloproteinases to yield a stable product, PTHrP1-17. PTHrP1-17 retains the ability to signal through PTH1R...

journal_title：Oncogene

authors： Frieling JS,Shay G,Izumi V,Aherne ST,Saul RG,Budzevich M,Koomen J,Lynch CC

更新日期：2017-08-01 00:00:00

abstract：:Prostate carcinoma (PCA) is the most frequently diagnosed malignancy in American men. PCA at advanced stages can both proliferate abnormally and resist apoptosis. Among the many known signal transduction pathways, phosphatidylinositide-3'OH kinase (PI3-kinase) has been shown to play an important role in cell survival ...

journal_title：Oncogene

authors： Xue LY,Qiu Y,He J,Kung HJ,Oleinick NL

更新日期：1999-06-03 00:00:00

abstract：:The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Although Stat5 is the best-characterized mediator of PRL signals, PRL also activates multiple other signals, whose roles in normal and pathologic pro...

journal_title：Oncogene

authors： Gutzman JH,Rugowski DE,Nikolai SE,Schuler LA

更新日期：2007-09-20 00:00:00

abstract：:Differentiation inducible leukemic as well as normal myeloid precursors treated with physiological myeloid differentiation inducer have been used to explore the immediate early genetic response of cells to terminal differentiation and growth arrest stimuli. cDNA clones of 12 distinct genes, referred to as MyD genes, w...

journal_title：Oncogene

authors： Lord KA,Hoffman-Liebermann B,Liebermann DA

更新日期：1990-03-01 00:00:00

abstract：:Histone deacetylases (HDACs) negatively regulate gene expression by removing acetyl groups from lysine residues present in histones and other proteins. Histone deacetylase 3 is unique among the Class I family of HDACs, as it is able to shuttle between the nucleus and the cytoplasm, whereas the other family members rem...

journal_title：Oncogene

authors： Longworth MS,Laimins LA

更新日期：2006-07-27 00:00:00