Abstract:
:MEMO1 (mediator of ErbB2-driven cell motility 1) regulates HER2-dependent cell migration. Increased MEMO1 expression is associated with cancer aggressiveness. Here, we found that MEMO1 is also involved in breast carcinogenesis via regulating insulin-like growth factor-I receptor-dependent signaling events. We showed that MEMO1 binds to insulin receptor substrate 1, activates the downstream PI3K/Akt signaling pathway, leads to upregulation of Snail1 and thereby triggers the epithelial-mesenchymal transition (EMT) program. In addition, MEMO1 overexpression is accompanied by growth factor-independent proliferation, anchorage-independent growth in soft agar, and enhanced metastatic potential. Together, these findings suggest that MEMO1 acts as an oncogene and is a potential therapeutic target for cancer treatment.
journal_name
Oncogenejournal_title
Oncogeneauthors
Sorokin AV,Chen Jdoi
10.1038/onc.2012.327subject
Has Abstractpub_date
2013-06-27 00:00:00pages
3130-8issue
26eissn
0950-9232issn
1476-5594pii
onc2012327journal_volume
32pub_type
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