Sp1 expression regulates lung tumor progression.

abstract：:Serine 62 (Ser62) phosphorylation affects the c-Myc protein stability in cancer cells. However, the mechanism for dephosphorylating c-Myc is not well understood. In this study, we identified carboxyl-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (SCP1) as a novel phosphatase specifically dephosph...

journal_title：Oncogene

authors： Wang W,Liao P,Shen M,Chen T,Chen Y,Li Y,Lin X,Ge X,Wang P

更新日期：2016-01-28 00:00:00

abstract：:Constitutive activation of the phosphoinositide 3-kinase (PI3K)-AKT pathway is observed in up to 70% of acute myelogenous leukemia. To investigate the relevance of an intrinsic PI3K-AKT pathway activation in hematopoietic malignancies, we analysed the effect of point mutations in the catalytic (p110alpha) and regulato...

journal_title：Oncogene

authors： Horn S,Bergholz U,Jücker M,McCubrey JA,Trümper L,Stocking C,Bäsecke J

更新日期：2008-07-03 00:00:00

abstract：:During normal tumor growth and in response to some therapies, tumor cells experience acute or chronic deprivation of nutrients and oxygen and induce tumor vascularization. While this occurs predominately through sprouting angiogenesis, tumor cells have also been shown to directly contribute to vessel formation through...

journal_title：Oncogene

authors： Langer EM,Kendsersky ND,Daniel CJ,Kuziel GM,Pelz C,Murphy KM,Capecchi MR,Sears RC

更新日期：2018-02-22 00:00:00

abstract：:A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell transformation by p60v-src. We have isolated a near full-length cDNA encoding muri...

journal_title：Oncogene

authors： Reynolds AB,Herbert L,Cleveland JL,Berg ST,Gaut JR

更新日期：1992-12-01 00:00:00

abstract：:We studied the role of the mitogen-activated protein kinase (MAPK) pathway in the regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in breast tumor MCF-7 cells. We found that addition of a protein kinase C (PKC) activator to MCF-7 cultures prevented TRAIL-induced apoptosi...

journal_title：Oncogene

authors： Sarker M,Ruiz-Ruiz C,Robledo G,López-Rivas A

更新日期：2002-06-20 00:00:00

abstract：:The Ov/Br septin gene, which is also a fusion partner of MLL in acute myeloid leukaemia, is a member of a family of novel GTP binding proteins that have been implicated in cytokinesis and exocytosis. In this study, we describe the genomic and transcriptional organization of this gene, detailing seventeen exons distrib...

journal_title：Oncogene

authors： McIlhatton MA,Burrows JF,Donaghy PG,Chanduloy S,Johnston PG,Russell SE

更新日期：2001-09-13 00:00:00

abstract：:Cell cycle modulation of cyclin A expression is due to the periodic relief of a transcriptional repression mediated by a bipartite negative DNA regulatory region. The 5' element (Cell Cycle Responsive Element: CCRE; cell Cycle Dependent Element: CDE) is clearly occupied in a cyclic manner in vivo, whereas the 3' eleme...

journal_title：Oncogene

authors： Philips A,Chambeyron S,Lamb N,Vié A,Blanchard JM

更新日期：1999-11-04 00:00:00

abstract：:Recent analyses have revealed that RUNX family members play important roles in both normal developmental processes and carcinogenesis. Of the three known RUNX family members, RUNX3 has been shown to be involved in neurogenesis of the dorsal root ganglia, T-cell differentiation and tumorigenesis of gastric epithelium. ...

journal_title：Oncogene

authors： Bae SC,Choi JK

更新日期：2004-05-24 00:00:00

abstract：:Cyclooxygenase (COX)-2 is upregulated in hepatocellular carcinoma (HCC). However, the direct causative effect of COX-2 in spontaneous HCC formation remains unknown. We thus investigate the role and molecular pathogenesis of COX-2 in HCC by using liver-specific COX-2 transgenic (TG) mice. We found spontaneous HCC forma...

journal_title：Oncogene

authors： Chen H,Cai W,Chu ESH,Tang J,Wong CC,Wong SH,Sun W,Liang Q,Fang J,Sun Z,Yu J

更新日期：2017-08-01 00:00:00

abstract：:Although increasing evidence indicated that the deregulation of microRNAs (miRNAs) contributes to tumorigenesis and invasion, little is known about the role of miR-637 in human gliomas. In the present study, we found that the expression level of miR-637 was significantly reduced in clinical glioma tissues compared wit...

journal_title：Oncogene

authors： Que T,Song Y,Liu Z,Zheng S,Long H,Li Z,Liu Y,Wang G,Liu Y,Zhou J,Zhang X,Fang W,Qi S

更新日期：2015-09-17 00:00:00

abstract：:FGFR1 (fibroblast growth factor receptor 1) regulates many key cellular responses including proliferation, migration and differentiation through activation of signaling pathways. Irregularities in FGFR1 signaling have been implicated in several pathological conditions, including human cancer. In order to discover nove...

journal_title：Oncogene

authors： Nadratowska-Wesolowska B,Haugsten EM,Zakrzewska M,Jakimowicz P,Zhen Y,Pajdzik D,Wesche J,Wiedlocha A

更新日期：2014-10-02 00:00:00

abstract：:The products of two cellular proto-oncogenes c-fos and c-jun form a heterodimeric complex that contribute to the DNA-binding activity referred to as AP-1 (activator protein-1). Two domains have been proposed to be required for heterodimer formation and protein-DNA complex formation. The leucine zipper domain mediated ...

journal_title：Oncogene

authors： Cohen DR,Curran T

更新日期：1990-06-01 00:00:00

abstract：:Despite extensive characterization of the role of the EWS-ETS fusions, little is known about secondary genetic alterations and their clinical contribution to Ewing sarcoma (ES). It has been demonstrated that the molecular structure of EWS-ETS lacks prognostic value. Moreover, CDKN2A deletion and TP53 mutation, despite...

journal_title：Oncogene

authors： Mackintosh C,Ordóñez JL,García-Domínguez DJ,Sevillano V,Llombart-Bosch A,Szuhai K,Scotlandi K,Alberghini M,Sciot R,Sinnaeve F,Hogendoorn PC,Picci P,Knuutila S,Dirksen U,Debiec-Rychter M,Schaefer KL,de Álava E

更新日期：2012-03-08 00:00:00

abstract：:The degree of DNA methylation in the c-fos gene and its vicinity in liver, brain and spleen of mice of different ages was examined using methylation-sensitive restriction endonucleases. The gene had an invariable unmethylated domain from 1.8kb upstream of the cap site to the first intron. The domain was flanked on bot...

journal_title：Oncogene

authors： Uehara Y,Ono T,Kurishita A,Kokuryu H,Okada S

更新日期：1989-08-01 00:00:00

abstract：:The most common genetic alteration identified in transitional cell carcinoma (TCC) of the bladder is loss of heterozygosity (LOH) on chromosome 9. However, localization of tumor suppressor genes on 9q has been hampered by the low frequency of subchromosomal deletions. We have analysed 139 primary, initial low stage TC...

journal_title：Oncogene

authors： Simoneau M,Aboulkassim TO,LaRue H,Rousseau F,Fradet Y

更新日期：1999-01-07 00:00:00

abstract：:Expression of polyomavirus middle-T antigen (middle-T) is involved in the formation of various tumors in vivo, e.g. hemangiomas and mammary gland tumors. Several genes have been shown to be activated in middle-T-expressing cells, but the underlying mechanisms have only been partially elucidated. Among the genes regula...

journal_title：Oncogene

authors： Besser D,Urich M,Sakaue M,Messerschmitt A,Ballmer-Hofer K,Nagamine Y

更新日期：1995-12-07 00:00:00

abstract：:MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression post-transcriptionally, are involved in many complex cellular processes. Several miRNAs are differentially expressed in hematopoietic tissues and play important roles in normal differentiation, but, when aberrantly regulated, contribute to the abn...

journal_title：Oncogene

authors： Pelosi A,Careccia S,Lulli V,Romania P,Marziali G,Testa U,Lavorgna S,Lo-Coco F,Petti MC,Calabretta B,Levrero M,Piaggio G,Rizzo MG

更新日期：2013-08-01 00:00:00

abstract：:Individuals with germline mutations in the tumour-suppressor gene CYLD are at high risk of developing disfiguring cutaneous appendageal tumours, the defining tumour being the highly organised cylindroma. Here, we analysed CYLD mutant tumour genomes by array comparative genomic hybridisation and gene expression microar...

journal_title：Oncogene

authors： Rajan N,Elliott R,Clewes O,Mackay A,Reis-Filho JS,Burn J,Langtry J,Sieber-Blum M,Lord CJ,Ashworth A

更新日期：2011-10-13 00:00:00

abstract：:A locus in feline DNA, termed flvi-1, has been identified as harboring retroviral integrations commonly found in natural feline lymphomas induced by infection with feline leukemia virus (FeLV). Southern blot analysis of human and murine DNA using restriction fragments representing flvi-1 demonstrates its phylogenetic ...

journal_title：Oncogene

authors： Levesque KS,Mattei MG,Levy LS

更新日期：1991-08-01 00:00:00

abstract：:The tumor-stroma crosstalk is a dynamic process fundamental in tumor development. In hepatocellular carcinoma (HCC), the progression of malignant hepatocytes frequently depends on transforming growth factor (TGF)-beta provided by stromal cells. TGF-beta induces an epithelial to mesenchymal transition (EMT) of oncogeni...

journal_title：Oncogene

authors： van Zijl F,Mair M,Csiszar A,Schneller D,Zulehner G,Huber H,Eferl R,Beug H,Dolznig H,Mikulits W

更新日期：2009-11-12 00:00:00

abstract：:MicroRNAs (miRNAs) make up a novel class of gene regulators; they function as oncogenes or tumor suppressors by targeting tumor-suppressor genes or oncogenes. A recent study that analysed a large number of human cancer cell lines showed that miR-330 is a potential tumor-suppressor gene. However, the function and molec...

journal_title：Oncogene

authors： Lee KH,Chen YL,Yeh SD,Hsiao M,Lin JT,Goan YG,Lu PJ

更新日期：2009-09-24 00:00:00

abstract：:Heregulins are a group of growth factors that play diverse and critical roles in the signaling network of the human epidermal growth factor receptor (HER or EGFR) superfamily. Our earlier studies have shown that recombinant heregulinbeta1 (HRG) induces apoptosis in SKBr3 breast cancer cells that overexpress HER2. Here...

journal_title：Oncogene

authors： Le XF,Marcelli M,McWatters A,Nan B,Mills GB,O'Brian CA,Bast RC Jr

更新日期：2001-12-13 00:00:00

abstract：:The adenomatous polyposis coli (APC) tumor suppressor gene is mutationally inactivated in both familial and sporadic forms of colorectal cancers. In addition, hypermethylation of CpG islands in the upstream portion of APC, a potential alternative mechanism of tumor suppressor gene inactivation, has been described in c...

journal_title：Oncogene

authors： Tsuchiya T,Tamura G,Sato K,Endoh Y,Sakata K,Jin Z,Motoyama T,Usuba O,Kimura W,Nishizuka S,Wilson KT,James SP,Yin J,Fleisher AS,Zou T,Silverberg SG,Kong D,Meltzer SJ

更新日期：2000-07-27 00:00:00

abstract：:Retinoids have been shown to inhibit the growth of a number of human tumor cells, including several ovarian adenocarcinoma cell lines. All-trans retinoic acid (RA) is an effective growth suppressor of CA-OV3 cells but not SK-OV3 cells. Since the effects of RA are known to be mediated via the nuclear receptors (RARs an...

journal_title：Oncogene

authors： Wu S,Zhang D,Zhang ZP,Soprano DR,Soprano KJ

更新日期：1998-12-03 00:00:00

abstract：:The Wilms' Tumor 1 gene (WT1) encodes a transcription factor of the zinc-finger family. As a result of alternative RNA splicing, the gene can be expressed as four polypeptides which differ in the presence or absence of two stretches of amino acids: one of 17 residues (17aa) just N-terminal of the four zinc-fingers and...

journal_title：Oncogene

authors： Menke AL,Riteco N,van Ham RC,de Bruyne C,Rauscher FJ 3rd,van der Eb AJ,Jochemsen AG

更新日期：1996-02-01 00:00:00

abstract：:To explore the mechanism of estrogen-induced growth of normal endometrium, the transactivation system of the cyclin D1 gene was analysed using cultured normal endometrial glandular cells. Estradiol (E2) treatment of cultured normal endometrial glandular cells induced upregulation of c-Jun, and then cyclin D1 proteins,...

journal_title：Oncogene

authors： Shiozawa T,Miyamoto T,Kashima H,Nakayama K,Nikaido T,Konishi I

更新日期：2004-11-11 00:00:00

abstract：:We have previously shown that the PLAG1 gene on chromosome 8q12 is consistently rearranged in pleomorphic adenomas of the salivary glands with t(3;8)(p21;q12) translocations. The t(3;8) results in promoter swapping between the PLAG1 gene, which encodes a novel zinc finger protein, and the constitutively expressed gene...

journal_title：Oncogene

authors： Voz ML,Aström AK,Kas K,Mark J,Stenman G,Van de Ven WJ

更新日期：1998-03-01 00:00:00

abstract：:Although there is indirect genetic evidence that MEN1, the gene for multiple endocrine neoplasia type 1, is a tumor suppressor gene, little is known about the MEN1-encoded protein, menin. Menin was stably overexpressed in a well-characterized murine tumor cell line, (valine-12)-RAS-transformed NIH3T3 cells. Menin over...

journal_title：Oncogene

authors： Kim YS,Burns AL,Goldsmith PK,Heppner C,Park SY,Chandrasekharappa SC,Collins FS,Spiegel AM,Marx SJ

更新日期：1999-10-21 00:00:00

abstract：:The role of the hepatitis B virus protein HBx in liver cell proliferation and apoptosis remains controversial. Using a transgenic mouse model, we have recently shown that HBx stimulates the apoptotic turnover of hepatocytes, independently of p53. In this paper, we tested whether the proapoptotic function of HBx can in...

journal_title：Oncogene

authors： Terradillos O,de La Coste A,Pollicino T,Neuveut C,Sitterlin D,Lecoeur H,Gougeon ML,Kahn A,Buendia MA

更新日期：2002-01-17 00:00:00

abstract：:Most cases of breast cancer (BrCa) mortality are due to vascular metastasis. BrCa cells must intravasate through endothelial cells (ECs) to enter a blood vessel in the primary tumor and then adhere to ECs and extravasate at the metastatic site. In this study we demonstrate that inhibition of hypoxia-inducible factor (...

journal_title：Oncogene

authors： Zhang H,Wong CC,Wei H,Gilkes DM,Korangath P,Chaturvedi P,Schito L,Chen J,Krishnamachary B,Winnard PT Jr,Raman V,Zhen L,Mitzner WA,Sukumar S,Semenza GL

更新日期：2012-04-05 00:00:00