Abstract:
:MCF2/DBL is an X-linked proto-oncogene encoding a protein with a yet undetermined function. It can be activated in vitro by loss of 5' sequences in NIH3T3 bioassays; in vivo, deletion of the gene has been found in some hemophilia B patients. PCR analysis of its expression in mouse tissues shows a restriction to the gonads and tissues of neuroectodermal origin. It also identifies an exon encoding 42 amino acids that is alternatively spliced in murine, but not human testis.
journal_name
Oncogenejournal_title
Oncogeneauthors
Galland F,Pirisi V,de Lapeyriere O,Birnbaum Dsubject
Has Abstractpub_date
1991-05-01 00:00:00pages
833-9issue
5eissn
0950-9232issn
1476-5594journal_volume
6pub_type
杂志文章相关文献
ONCOGENE文献大全abstract::Inhibitor of apoptosis (IAP) proteins are a family comprised of a total of eight mammalian members that were initially described to act as endogenous inhibitors of caspases. In addition, extensive evidence has been accumulated over the last years showing that IAP proteins can regulate various signal transduction pathw...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.63
更新日期:2014-02-06 00:00:00
abstract::RNF8 is a ubiquitin ligase with a FHA domain near its N terminus, and a RING-finger domain at its C terminus, through which it recruits several ubiquitin-conjugating enzymes. In metazoans, only the mitotic checkpoint regulator CHFR shares this domain architecture. Here we show that RNF8 is a nuclear protein that follo...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210782
更新日期:2008-02-28 00:00:00
abstract::Ovarian endometrioid adenocarcinomas (OEAs) frequently exhibit constitutive activation of canonical WNT signaling, usually as a result of oncogenic mutations that stabilize and dysregulate the β-catenin protein. In previous work, we used microarray-based methods to compare gene expression in OEAs with and without dysr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2011.123
更新日期:2011-10-06 00:00:00
abstract::The ability of tumour cells to resist apoptosis-inducing signals by cytotoxic T cells may decide the success or failure of tumour elimination. An important effector of apoptosis is the CD95/CD95 ligand system (APO-1/Fas) that mediates perforin-independent cytotoxic T-cell killing of tumour cells. We propose a new stra...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207387
更新日期:2004-04-29 00:00:00
abstract::The p53-regulated GADD45 gene is one of the important players in cellular response to DNA damage, and probably involved in the control of cell cycle checkpoint, apoptosis and DNA repair. There are both the p53-dependent and -independent pathways that regulate GADD45 induction. Following ionizing radiation, induction o...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204390
更新日期:2001-05-10 00:00:00
abstract::Bone morphogenetic proteins (BMPs) are known to play an important role in melanoma development and progression. However, the downstream targets of BMPs have not been investigated thus far. Therefore, we treated melanoma cell lines with the Smad-specific BMP inhibitor Dorsomorphin and performed a cDNA microarray. We id...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.115
更新日期:2013-02-14 00:00:00
abstract::Hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma (HCC). HBV encodes the potentially oncogenic HBx protein, which mainly functions as a transcriptional co-activator involving in multiple gene deregulations. However, mechanisms underlying HBx-mediated oncogenicity remain unc...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204481
更新日期:2001-06-21 00:00:00
abstract::Several lines of evidence suggest that gastrin and the CCK-2 receptor (CCK2R) could contribute to pancreatic carcinogenesis by modulating processes such as proliferation, cell adhesion or migration. In the current study, we used a 'cancer gene array' and identified beta1-integrin subunit as a new gastrin-regulated gen...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209484
更新日期:2006-07-27 00:00:00
abstract::Blockade of the mitogen-activated protein (MAP) kinase pathway suppresses growth of colon cancer in vivo. Here we demonstrate a direct link between the extracellular signal-regulated kinase ERK2 and the growth-promoting cell adhesion molecule, integrin alphavbeta6, in colon cancer cells. Down-regulation of beta6 integ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205286
更新日期:2002-02-21 00:00:00
abstract::Human carcinomas frequently express high levels of receptors in the EGF receptor family, and overexpression of at least two of these receptors, the EGF receptor (EGFr) and closely related ErbB2, has been associated with a more aggressive clinical behavior. Further, transfection or activation of high levels of these tw...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204082
更新日期:2000-12-27 00:00:00
abstract::We have previously shown (Smith et al., 1994) that antibodies raised against the growth arrest and DNA damage inducible protein Gadd45 co-precipitate proliferating cell nuclear antigen (PCNA), a protein involved in DNA replication and repair. Here we demonstrate that Gadd45 can directly bind to PCNA using a Far-wester...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-11-16 00:00:00
abstract::Prolonged activation of protein kinase Cs (PKCs) by long-term treatment of cells with phorbol ester tumor promoters down-regulates the expression of many PKCs. To investigate the molecular mechanisms involved in the down-regulation of PKC eta, we expressed the novel PKCs eta and θ and various mutant forms in bab...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203779
更新日期:2000-08-31 00:00:00
abstract::The human papillomavirus (HPV) E6 protein is one of three oncoproteins encoded by the virus. It has long been recognized as a potent oncogene and is intimately associated with the events that result in the malignant conversion of virally infected cells. In order to understand the mechanisms by which E6 contributes to ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/sj.onc.1204869
更新日期:2001-11-26 00:00:00
abstract::Neuroblastoma is the second most common pediatric malignancy, characterized by a high rate of unexplained spontaneous remissions. Much progress has been made in understanding neuroblastoma differentiation triggered by certain agents such as retinoic acid. However, little is known about the signalling pathways that lea...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1208494
更新日期:2005-05-05 00:00:00
abstract::T-cell lymphoproliferative diseases are often associated with recurrent chromosomal translocations involving T cell receptor genes (TCR) and genes that are thought to play a role in the pathogenesis of these diseases. Whereas numerous such genes have already been identified in acute T cell leukemias, no candidate gene...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::The Notch ligand delta-like ligand 4 (DLL4) is an essential component expressed by endothelial tip cells during angiogenic sprouting. We have described a conceptually novel therapeutic strategy for targeting tumor angiogenesis and endothelial tip cells based on DNA vaccination against DLL4. Immunization with DLL4-enco...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2010.176
更新日期:2010-07-29 00:00:00
abstract::Like other types of pre-malignant lesions and carcinoma, angiogenesis is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular endothelial cell growth factor (VEGF) is known to be one of the most important inducers of angiogenesis and is upregulated in carcinoma of ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1203817
更新日期:2000-09-21 00:00:00
abstract::Accumulating evidences indicate that p120 catenin, a member of the E-cadherin (E-CD)/catenin adhesion complex, plays a role in tumor invasion. To establish the expression pattern of p120 in breast cancer, we analysed 326 breast tissue biopsies by tissue microarray. Most of the lobular tumors (88%) showed exclusive cyt...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1207439
更新日期:2004-04-22 00:00:00
abstract::Alternative splicing has critical roles in normal development and can promote growth and survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific mRNA transcripts, can lead to loss-of-function in tumor suppressors or activation of oncogenes and cancer pathways. Emerging data suggest th...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.570
更新日期:2015-01-02 00:00:00
abstract::Castration-resistant prostate cancer (CRPC) continues to pose a significant clinical challenge with new generation second-line hormonal therapies affording limited improvement in disease outcome. As the androgen receptor (AR) remains a critical driver in CRPC, understanding the determinants of its transcriptional acti...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.508
更新日期:2014-12-11 00:00:00
abstract::Although activating mutations of fibroblast growth factor receptor 3 (FGFR3) are frequent in bladder tumors, little information is available on their specific effects in urothelial cells or the basis for the observed mutation spectrum. We investigated the phenotypic and signaling consequences of three FGFR3 mutations ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2009.280
更新日期:2009-12-03 00:00:00
abstract::The growth and progression of prostate cancer are dependent on androgens and androgen receptor (AR), which act by modulating gene expression. Utilizing a gene microarray approach, we have identified the alpha1-subunit gene of soluble guanylyl cyclase (sGC) as a novel androgen-regulated gene. A heterodimeric cytoplasmi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1209956
更新日期:2007-03-08 00:00:00
abstract::SH3 and SAM domains are protein interaction motifs that are predominantly seen in signaling molecules, adaptors, and scaffold proteins. We have identified a novel family of putative adaptor genes that includes HACS1. HACS1 encodes a 441 amino acid protein that is differentially expressed in hematopoietic cells and has...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1204698
更新日期:2001-08-30 00:00:00
abstract::Tumor suppressor p53 is a nuclear transcription factor that blocks cell cycle progression and induces apoptosis. We have previously shown that the MCF7 resistance to the cytotoxic action of TNF correlates with p53 mutations. In the present study, we used a recombinant adenovirus carrying a wild-type p53 gene (Adwtp53)...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1202919
更新日期:1999-09-23 00:00:00
abstract::Stimulation of the c-Kit receptor tyrosine kinase has a critical role in the development and migration of melanocytes, and oncogenic c-Kit mutants contribute to the progression of some melanomas. c-Kit signalling activates the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.562
更新日期:2014-01-09 00:00:00
abstract::Upregulated gene 19 (U19)/ELL-associated factor 2 (Eaf2) is a potential human tumor suppressor that exhibits frequent allelic loss and downregulation in high-grade prostate cancer. U19/Eaf2, along with its homolog Eaf1, has been reported to regulate transcriptional elongation via interaction with the eleven-nineteen l...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1210786
更新日期:2008-03-06 00:00:00
abstract::Genetic analysis of beta-catenin-induced oncogenic transformation in chicken embryo fibroblasts (CEF) revealed the following prerequisites for oncogenicity: (1) removal of the N terminal phosphorylation sites targeted by glycogen synthase kinase 3beta (GSK3beta), (2) retention of the N terminal transactivation domain,...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/sj.onc.1205796
更新日期:2002-10-10 00:00:00
abstract::Polyomavirus infection of adolescent athymic female mice causes a high incidence of mammary adenocarcinomas. We have examined the role of ovarian hormones, age and mammary gland developmental stage at infection on subsequent tumor induction, viral replication and gene expression. Ovariectomy (OVX) of adolescent mice 1...
journal_title:Oncogene
pub_type: 杂志文章
doi:
更新日期:1995-11-02 00:00:00
abstract::Bone metastatic prostate cancer provokes extensive osteogenesis by driving the recruitment and osteoblastic differentiation of mesenchymal stromal cells (MSCs). The resulting lesions greatly contribute to patient morbidity and mortality, underscoring the need for defining how prostate metastases subvert the MSC-osteob...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/s41388-019-0913-4
更新日期:2019-10-01 00:00:00
abstract::Melanoma progression is typically depicted as a linear and stepwise process in which metastasis occurs relatively late in disease progression. Significant evidence suggests that in a subset of melanomas, progression is much more complex and less linear in nature. Epidemiologic and experimental observations in melanoma...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2013.194
更新日期:2014-05-08 00:00:00