TRIM24 links glucose metabolism with transformation of human mammary epithelial cells.

abstract：:Targeted expression of transgenes is essential for the accurate representation of human disease in in vivo models. Current approaches to generate conditional transgenic mouse models are cumbersome and not amenable to high-throughput analysis since they require de novo generation and characterization of genetically mod...

journal_title：Oncogene

authors： Shoumariyeh K,Schneider N,Poggio T,Veratti P,Ehrenfeld S,Redhaber DM,Khan R,Pfeifer D,Klingeberg C,Kreutmair S,Rudelius M,Quintanilla-Martinez L,Fend F,Illert AL,Duyster J,Miething C

更新日期：2020-02-01 00:00:00

abstract：:Recently, we identified Insulinoma-Glucagonoma clone 20 (IG20) that can render cells more susceptible to tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis. In addition, it can slow cell proliferation, and enhance drug- and radiation-induced cell death. TNF-related apoptosis-inducing ligand (TRAIL) can selectiv...

journal_title：Oncogene

authors： Ramaswamy M,Efimova EV,Martinez O,Mulherkar NU,Singh SP,Prabhakar BS

更新日期：2004-08-12 00:00:00

abstract：:Undifferentiated cells and embryos express high levels of endogenous non-telomerase reverse transcriptase (RT) of retroposon/retroviral origin. We previously found that RT inhibitors modulate cell growth and differentiation in several cell lines. We have now sought to establish whether high levels of RT activity are d...

journal_title：Oncogene

authors： Sciamanna I,Landriscina M,Pittoggi C,Quirino M,Mearelli C,Beraldi R,Mattei E,Serafino A,Cassano A,Sinibaldi-Vallebona P,Garaci E,Barone C,Spadafora C

更新日期：2005-06-02 00:00:00

abstract：:MEK kinases (MEKKs) are serine-threonine kinases that regulate sequential protein phosphorylation pathways involving mitogen-activated protein kinases (MAPKs), including members of the Jun kinase (JNK) family. MEKK1 is a 196 kDa protein that when cleaved by caspase-3-like proteases generates an active COOH-terminal ki...

journal_title：Oncogene

authors： Widmann C,Johnson NL,Gardner AM,Smith RJ,Johnson GL

更新日期：1997-11-13 00:00:00

abstract：:We analysed the involvement of proteases during taxol-mediated cell death of human A549 non-small-cell lung carcinoma cells using a proteomics approach that specifically targets protein N termini and further detects newly formed N termini that are the result of protein processing. Our analysis revealed 27 protease-med...

journal_title：Oncogene

authors： Impens F,Van Damme P,Demol H,Van Damme J,Vandekerckhove J,Gevaert K

更新日期：2008-07-31 00:00:00

abstract：:The human ret proto-oncogene (proto-ret), encoding a receptor tyrosine kinase, is highly expressed in neuroblastomas, medullary thyroid carcinomas (MTCs) and pheochromocytomas, which are all tumors of cells originating from the neural crest. In studies on the transcription mechanism of proto-ret, we identified the tra...

journal_title：Oncogene

authors： Itoh F,Ishizaka Y,Tahira T,Yamamoto M,Miya A,Imai K,Yachi A,Takai S,Sugimura T,Nagao M

更新日期：1992-06-01 00:00:00

abstract：:LIM domain factors and associated cofactors are important developmental regulators in pattern formation and organogenesis. In addition, overexpression of two LIM-only factors (LMOs) causes acute lymphocytic leukemia. The more recently discovered LMO factor LMO4 is highly expressed in proliferating epithelial cells, an...

journal_title：Oncogene

authors： Wang N,Kudryavtseva E,Ch'en IL,McCormick J,Sugihara TM,Ruiz R,Andersen B

更新日期：2004-02-26 00:00:00

abstract：:Syndecan-1 is a heparan sulfate proteoglycan (HSPG) commonly upregulated in AIDS-related B lymphoid malignancies. Tat is the main HIV-1 transactivating factor that has a major role in the pathogenesis of AIDS-related lymphomas (ARL) by engaging heparan sulfate proteoglycans (HSPGs), chemokine receptors and integrins a...

journal_title：Oncogene

authors： Urbinati C,Grillo E,Chiodelli P,Tobia C,Caccuri F,Fiorentini S,David G,Rusnati M

更新日期：2017-05-04 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) are the predominant excitatory neurotransmitter receptors in the mammalian brain. We found that among the three NMDARs examined (NMDAR1, NMDAR2A, NMDAR2B), only NMDAR2A was silenced in colorectal carcinoma (CRC) cell lines at basal line and reactivated by the demethylating agent...

journal_title：Oncogene

authors： Kim MS,Chang X,Nagpal JK,Yamashita K,Baek JH,Dasgupta S,Wu G,Osada M,Woo JH,Westra WH,Trink B,Ratovitski EA,Moon C,Sidransky D

更新日期：2008-03-27 00:00:00

abstract：:Brn-3a is a transcription factor belonging to the class IV of POU domain transcription factors. It is expressed throughout the peripheral nervous system but especially in postmitotic sensory neurons of dorsal root ganglia. Brn-3a is known to regulate different genes involved in neuronal differentiation and survival. I...

journal_title：Oncogene

authors： Calissano M,Latchman DS

更新日期：2003-08-21 00:00:00

abstract：:An oncogenic mutation (G49A:E17K) in the AKT1 gene has been described recently in human breast, colon, and ovarian cancers. The low frequency of this mutation and perhaps other selective pressures have prevented the isolation of human cancer cell lines that harbor this mutation thereby limiting functional analysis. He...

journal_title：Oncogene

authors： Lauring J,Cosgrove DP,Fontana S,Gustin JP,Konishi H,Abukhdeir AM,Garay JP,Mohseni M,Wang GM,Higgins MJ,Gorkin D,Reis M,Vogelstein B,Polyak K,Cowherd M,Buckhaults PJ,Park BH

更新日期：2010-04-22 00:00:00

abstract：:The Wilms' tumor suppressor gene, WT1, functions as a transcriptional regulator that represses or activates the expression of a variety of putative target genes. However, it is not clear which genes are the biological targets of WT1, nor which cellular pathway(s) is critically altered in tumors as a result of WT1 muta...

journal_title：Oncogene

authors： Udtha M,Lee SJ,Alam R,Coombes K,Huff V

更新日期：2003-06-12 00:00:00

abstract：:We have previously shown (Smith et al., 1994) that antibodies raised against the growth arrest and DNA damage inducible protein Gadd45 co-precipitate proliferating cell nuclear antigen (PCNA), a protein involved in DNA replication and repair. Here we demonstrate that Gadd45 can directly bind to PCNA using a Far-wester...

journal_title：Oncogene

authors： Chen IT,Smith ML,O'Connor PM,Fornace AJ Jr

更新日期：1995-11-16 00:00:00

abstract：:The Dbl oncogene is the putative exchange factor for two small GTP-binding proteins, RhoA and CDC42 which are involved in the polymerization of actin to produce stress fibers and filopodia, respectively. We report here that Dbl oncogene-transformed NIH3T3 cells show actin stress fibers only when cells are plated on fi...

journal_title：Oncogene

authors： Defilippi P,Olivo C,Tarone G,Mancini P,Torrisi MR,Eva A

更新日期：1997-04-24 00:00:00

abstract：:p8 is a stress-induced DNA-binding protein, biochemically related to the architectural chromatin binding HMG protein family and whose function is presently unknown. We obtained fibroblast from mice lacking p8 and found that p8 is involved in cell growth regulation and in apoptosis. p8(-/-) mouse embryonic fibroblasts ...

journal_title：Oncogene

authors： Vasseur S,Hoffmeister A,Garcia-Montero A,Mallo GV,Feil R,Kühbandner S,Dagorn JC,Iovanna JL

更新日期：2002-03-07 00:00:00

abstract：:The C-terminal src kinase (Csk) is responsible for the phosphorylation of the carboxy-terminal tyrosine of several tyrosine kinases of the Src family. This phosphorylation site has a negative regulatory function. Csk is unique among the members of the protein tyrosine kinase family because it lacks the conserved tyros...

journal_title：Oncogene

authors： Bougeret C,Rothhut B,Jullien P,Fischer S,Benarous R

更新日期：1993-05-01 00:00:00

abstract：:The CUB domain-containing protein-1 (CDCP1) is a transmembrane molecule that has recently been implicated in cancer progression. In this study we have established a novel mechanism for initiation of CDCP1-mediated signaling in vivo and demonstrated that specific 135→70-kDa processing of cell-surface CDCP1 by extracell...

journal_title：Oncogene

authors： Casar B,He Y,Iconomou M,Hooper JD,Quigley JP,Deryugina EI

更新日期：2012-08-30 00:00:00

abstract：:Inter-alpha-trypsin inhibitors (ITIs) are protease inhibitors stabilizing the extracellular matrix. ITIs consist of one light (bikunin) and two heavy chains (ITIHs). We have recently characterized ITIH5, a novel member of the ITIH gene family, and showed that its messenger RNA is lost in a high proportion of breast tu...

journal_title：Oncogene

authors： Veeck J,Chorovicer M,Naami A,Breuer E,Zafrakas M,Bektas N,Dürst M,Kristiansen G,Wild PJ,Hartmann A,Knuechel R,Dahl E

更新日期：2008-01-31 00:00:00

abstract：:The integrin linked kinase (ILK) is a cytoplasmic effector of integrin receptors, involved in the regulation of integrin binding properties as well as the activation of cell survival and proliferative pathways, including those involving MAP kinase, PKB/Akt and GSK-3beta. Overexpression of ILK in cultured intestinal an...

journal_title：Oncogene

authors： White DE,Cardiff RD,Dedhar S,Muller WJ

更新日期：2001-10-25 00:00:00

abstract：:Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a com...

journal_title：Oncogene

authors： Liu SK,Berry DM,McGlade CJ

更新日期：2001-10-01 00:00:00

abstract：:Heat shock protein 110 (HSP110) is induced by different stresses and, through its anti-apoptotic and chaperoning properties, helps cells survive these adverse situations. In colon cancers, HSP110 is abnormally abundant. We have recently shown that colorectal cancer patients with microsatellite instability (MSI) had an...

journal_title：Oncogene

authors： Berthenet K,Bokhari A,Lagrange A,Marcion G,Boudesco C,Causse S,De Thonel A,Svrcek M,Goloudina AR,Dumont S,Hammann A,Biard DS,Demidov ON,Seigneuric R,Duval A,Collura A,Jego G,Garrido C

更新日期：2017-04-20 00:00:00

abstract：:Upstream stimulating factor (USF2) is a basic helix-loop-helix leucine zipper transcription factor, which is found in most tissues. A critical role for USF2 in cellular proliferation has been proposed based on its importance in the regulation of various cyclins and P53 and its capability to antagonize c-myc. In this p...

journal_title：Oncogene

authors： Zhang ZC,Nechushtan H,Jacob-Hirsch J,Avni D,Meyuhas O,Razin E

更新日期：1998-02-12 00:00:00

abstract：:Mammalian Mip/LIN-9 is a cell cycle regulatory protein that is negatively regulated by CDK4/cyclin D. It has been demonstrated that Mip/LIN-9 collaborates with B-Myb during S and G(2)/M in the induction of cyclins A and B, and CDK1. The ortholog of Mip/LIN-9 in Drosophila, Mip130, is part of a large multisubunit prote...

journal_title：Oncogene

authors： Pilkinton M,Sandoval R,Colamonici OR

更新日期：2007-11-29 00:00:00

abstract：:Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here we discover that inhibition of antioxidant defenses via glutathione (...

journal_title：Oncogene

authors： Schoeneberger H,Belz K,Schenk B,Fulda S

更新日期：2015-07-30 00:00:00

abstract：:Head and neck squamous carcinomas (HNSCC) present as dense epithelioid three-dimensional (3D) tumor nests that can mediate signals via the human epidermal growth factor receptor (ErbB) tyrosine kinase family to promote intratumoral survival and growth. We examined the role of the tumor microenvironment on ErbB recepto...

journal_title：Oncogene

authors： Humtsoe JO,Pham E,Louie RJ,Chan DA,Kramer RH

更新日期：2016-03-24 00:00:00

abstract：:The specific chromosomal translocation t(9;22)(q22-31;q11-12) has been observed in the myxoid variant of human chondrosarcoma. In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-...

journal_title：Oncogene

authors： Clark J,Benjamin H,Gill S,Sidhar S,Goodwin G,Crew J,Gusterson BA,Shipley J,Cooper CS

更新日期：1996-01-18 00:00:00

abstract：:E mu-bcl-2 transgenic mice bearing the bcl-2 proto-oncogene linked to the immunoglobulin enhancer (E mu) sporadically develop B or T cell lymphomas after a long latent period. To identify genes that play important roles in development of lymphoid malignancies, proviral insertional mutagenesis with Moloney murine leuke...

journal_title：Oncogene

authors： Shinto Y,Morimoto M,Katsumata M,Uchida A,Aozasa K,Okamoto M,Kurosawa T,Ochi T,Greene MI,Tsujimoto Y

更新日期：1995-11-02 00:00:00

abstract：:Mechanisms underlying multidrug resistance (MDR), one of the major causes of cancer treatment failure, are still poorly understood. We selected the osteosarcoma MDR HosDXR150 cell line by culturing Hos cells in the presence of increasing doxorubicin doses and showed that it is crossresistant to vinblastine. Similarly ...

journal_title：Oncogene

authors： La Sala D,Macaluso M,Trimarchi C,Giordano A,Cinti C

更新日期：2003-06-05 00:00:00

abstract：:Guanine nucleotide exchange factors from the Dbl family are proto-oncogenic proteins that activate small GTPases of the Rho family. Here we report the characterization of GEF720, a novel Dbl-like protein related to p115Rho-GEF. GEF720 activated RhoA both in our recently developed Yeast Exchange Assay and in biochemica...

journal_title：Oncogene

authors： De Toledo M,Coulon V,Schmidt S,Fort P,Blangy A

更新日期：2001-11-01 00:00:00

abstract：:Chromosomal translocations involving the human 12p13 band frequently affect the TEL gene, usually resulting in gene fusion between TEL and genes encoding proteins of various types. The most frequent 12p13 translocation is the t(12;21)(p13;q22), which recombines TEL with the AML1 gene on chromosome 21 and is frequently...

journal_title：Oncogene

authors： Poirel H,Lacronique V,Mauchauffé M,Le Coniat M,Raffoux E,Daniel MT,Erickson P,Drabkin H,MacLeod RA,Drexler HG,Ghysdael J,Berger R,Bernard OA

更新日期：1998-06-04 00:00:00