Abstract：
:The Dbl oncogene is the putative exchange factor for two small GTP-binding proteins, RhoA and CDC42 which are involved in the polymerization of actin to produce stress fibers and filopodia, respectively. We report here that Dbl oncogene-transformed NIH3T3 cells show actin stress fibers only when cells are plated on fibronectin. Plating of cells on collagen I and IV as well as on poly-D-lysine and gelatin induces polymerization of actin to form filopodia, lamellipodia and membrane ruffles but not stress fibers. The putative collagen receptors, alpha1/beta1 and alpha2/beta1 integrins are expressed at reduced level in Dbl-transformed cells compared to untransformed NIH3T3 fibroblasts. Nevertheless, adhesion to collagens is not altered. Inhibitory monoclonal antibody to mouse integrin beta1 subunit blocked adhesion of both Dbl-transformed and untransformed NIH3T3 cells, demonstrating that adhesion to collagen I and IV is mediated by the beta1 family of integrins. Dbl product rapidly induces the depolymerization of actin stress fibers, rounding up of the cells, and formation of filopodia and lamellipodia when microinjected in NIH3T3 cells plated on gelatin. Thus, Dbl may exert its effect on actin cytoskeleton organization in response to extracellular proteins by altering integrin-mediated signalling pathways.
journal_name
Oncogenejournal_title
Oncogeneauthors
Defilippi P,Olivo C,Tarone G,Mancini P,Torrisi MR,Eva Adoi
10.1038/sj.onc.1201027subject
Has Abstractpub_date
1997-04-24 00:00:00pages
1933-43issue
16eissn
0950-9232issn
1476-5594journal_volume
14pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:To dissect the p53-dependent apoptotic pathway, events following induction of temperature sensitive (ts) p53val138 were studied in a Ewing tumor cell line. Transcriptional deregulation of p53 targets first observable after 1 h at 32 degrees C preceded activation of caspases and the break-down of mitochondrial respirat...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203780
更新日期：2000-08-24 00:00:00
abstract：:The hypoxia-inducible factor 1 (HIF-1) plays a critical role for tumour adaptation to microenvironmental hypoxia, and represents an appealing chemotherapeutic target. Silibinin is a nontoxic flavonoid reported to exhibit anticancer properties. However, the mechanisms by which silibinin inhibits tumour growth are not f...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2008.398
更新日期：2009-01-22 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human cancers, with 5-year patient survival rates of <5%. Activating mutations in KRAS are the predominant oncogenic drivers of PDAC but are accompanied by additional lower frequency genetic alterations. Our group previously identified the guanine ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-019-0985-1
更新日期：2020-01-01 00:00:00
abstract：:Unique hybrids (HINS and CANS lines) between macrophages and a myeloma cell line, NS1 initially expressed myeloma functions but later expressed active macrophage functions together with constitutive expression of c-fos gene. Enhancement of c-fos transcription was also observed in activated mouse peritoneal macrophages...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：:As tumors grow and invade beyond their homeostatic limits, the tumor cells are subjected to insufficient nutrient and oxygen supplies because of excessive demand for nutrition and oxygen, and insufficient vascularization. We therefore hypothesized that tolerance to nutrient deprivation as well as angiogenesis may be c...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205737
更新日期：2002-09-05 00:00:00
abstract：:Transforming growth factor beta1 (TGF-beta1) belongs to a family of polypeptide factors, whose cytostatic and apoptotic functions help restrain the growth of mammalian cells. Although solid data established the role of TGF-beta's as suppressor factors in tumorigenic processes, in the context of an advanced stage of di...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208664
更新日期：2005-06-30 00:00:00
abstract：:The KLF6 gene encodes the Krüppel-like factor 6, a transcription factor that has been individualized as a tumor-suppressor gene involved in the regulation of cell proliferation and differentiation. Recently, high frequency (42%) of KLF6 mutations have been reported in colorectal cancers (CRC) as in prostate cancers, a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208867
更新日期：2005-11-03 00:00:00
abstract：:PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor regulates a variety of cellular processes including cell proliferation, growth, migration and death. This master regulator itself is also under deliberative regulation. Although the evidence for PTEN regulation and its significance in norm...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/onc.2008.242
更新日期：2008-09-18 00:00:00
abstract：:A mutation in codon 122 of the mouse p53 gene resulting in a T to L amino acid substitution (T122-->L) is frequently associated with skin cancer in UV-irradiated mice that are both homozygous mutant for the nucleotide excision repair (NER) gene Xpc (Xpc(-/-)) and hemizygous mutant for the p53 gene. We investigated the...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205779
更新日期：2002-08-22 00:00:00
abstract：:Epigenetic regulation of gene expression is critical in the maintenance of cellular homeostasis. Dysregulation of normal epigenetic transcription occurs in abnormal physiological conditions, such as those seen in cancer cells and cells infected with parasites, making the mechanism underlying abnormal epigenetic transc...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208394
更新日期：2005-03-10 00:00:00
abstract：:The NF-kappa B precursor p100 (lyt-10, p97, p98) generates after proteolytic processing a 52 kDa subunit, which can bind to kappa B-motifs. A deregulated form of the p100 gene, which is structurally altered by a t(10;14) translocation, has a potential oncogenic role in certain human B cell lymphomas. In this study p10...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:To ensure that their mRNAs are translated and that the viral proteins necessary for assembling the next generation of infectious progeny are produced, viruses must effectively seize control of the translational machinery within their host cells. In many cases, the ability to productively engage host translational comp...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1209053
更新日期：2005-11-21 00:00:00
abstract：:The cdk2 gene has been identified as a human cdc2/CDC28-related gene that encodes a protein kinase essential for the G1/S transition in mammalian cells, but not for the G2/M transition, which requires Cdk1, another p34cdc2/CDC28 homolog. Novel potential functions of Cdk2 have been uncovered by using two potent and spe...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203103
更新日期：1999-12-09 00:00:00
abstract：:Ovarian cancer (OvCa) exhibits a specific predilection for metastasis to the omentum. Our earlier studies highlighted the tumour-suppressor effect of secreted protein acidic and rich in cysteine (SPARC) in OvCa through multi-faceted roles inhibiting cancer cell interactions within the peritoneal milieu. The goal of th...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-019-0728-3
更新日期：2019-05-01 00:00:00
abstract：:We have cloned a novel quail cDNA with strong homology to the pim family of proto-oncogenes. The deduced amino acid (aa) sequence of the cDNA, named qpim, is more closely related to Xenopus Pim and to the recently identified rat Pim-3 than to human or rodent Pim-1 or Pim-2. The protein encoded by the qpim cDNA can aut...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203355
更新日期：2000-02-24 00:00:00
abstract：:Targeted therapeutics are potential therapeutic agents because of their selectivity and efficacy against tumors resistant to conventional therapy. The goal of this study was to determine the comparative activity of monovalent, engineered anti-Her2/neu immunotoxins fused to recombinant gelonin (rGel) to the activity of...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2012.612
更新日期：2014-01-23 00:00:00
abstract：:In less than 10 years, the number and importance of non-surgical treatment modalities in patients with colorectal cancer (CRC) have increased dramatically, both in the adjuvant and the advanced settings. However, despite the improvement of cytotoxic therapy in CRC, many patients still develop progressive disease and u...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1210377
更新日期：2007-05-28 00:00:00
abstract：:We have recently identified and cloned the gene for a cytosolic polypeptide, designated oncoprotein 18 (Op18), which is expressed in acute lymphocytic leukemia and some solid tumors including neuroblastoma. Op18 is phosphorylated upon treatment of lymphoid cells with phorbol myristate acetate. We have proposed that un...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
abstract：:Molecular, functional, and clinical analyses strongly suggest that chromosome segment 11p15.5 contains a gene involved in lung cancer pathogenesis. The critical region of allele loss is 310 kb in size. We used our contig of P1-phage artificial chromosome (PAC) clones together with newly identified bacterial artificial...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205027
更新日期：2001-12-06 00:00:00
abstract：:The carboxyl terminus of c-Myb contains a negative regulatory domain that is absent in the v-Myb oncoprotein, but conserved among all the known Myb proteins of animals. This domain inhibits transcriptional activation by c-Myb in animal cells, but not in budding yeast, suggesting that additional protein(s) present in a...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1204048
更新日期：2001-01-04 00:00:00
abstract：:Neoadjuvant and adjuvant chemotherapies provide survival benefits to breast cancer patients, in particular in estrogen receptor negative (ER-) cancers, by reducing rates of recurrences. It is assumed that the benefits of (neo)adjuvant chemotherapy are due to the killing of disseminated, residual cancer cells, however,...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0624-2
更新日期：2019-04-01 00:00:00
abstract：:We examined the biological role of p12(CDK2-AP1) in cisplatin-mediated responses by using murine ES p12(CDK2-AP1) knockout clones generated by a targeted disruption of murine p12(CDK2-AP1). Homozygous knockout clones showed an increased cellular proliferation along with an increase in S and a decrease in G2/M phase po...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1208222
更新日期：2005-01-13 00:00:00
abstract：:We previously showed that the proto-oncogene RON encodes the tyrosine kinase receptor for Macrophage Stimulating Protein (MSP), originally isolated as a chemotactic factor for peritoneal macrophages. To elucidate the biological role of MSP we studied the expression of the Ron receptor in vivo, and the response to the ...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-12-21 00:00:00
abstract：:Urothelial carcinoma (UC) carcinogenesis has been hypothesized to occur through epigenetic repression of tumor-suppressor genes (TSGs). By quantitative real-time polymerase chain reaction array, we found that one potential TSG, angiopoietin-like 4 (ANGPTL4), was expressed at very low levels in all bladder cancer cell ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2017.375
更新日期：2018-02-01 00:00:00
abstract：:Juvenile myelomonocytic leukemia (JMML) is a malignant hematopoietic disorder whose proliferative component is a result of RAS pathway deregulation caused by somatic mutation in the RAS or PTPN11 oncogenes or in patients with underlying neurofibromatosis type 1 (NF-1), by loss of NF1 gene function. To search for poten...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210361
更新日期：2007-08-23 00:00:00
abstract：:Overexpressed or activated hepatocyte growth factor receptor, encoded by the MET proto-oncogene, was found in the majority of colorectal carcinomas (CRCs), whose stepwise progression to malignancy requires transcriptional activation of beta-catenin. We here demonstrate that a functional crosstalk between Met and beta-...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209859
更新日期：2007-02-15 00:00:00
abstract：:We have previously demonstrated the existence of a melanoma tumor suppressor gene(s) on the long arm of chromosome 11 through suppression of tumorigenicity assays. Although loss of heterozygosity studies also support this finding, only a large critical region (44 cM) has been identified to date on 11q22-25. To further...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1202664
更新日期：1999-05-20 00:00:00
abstract：:The von Hippel-Lindau tumor suppressor pVHL regulates the stability of hypoxia-inducible factors (HIF)-1 and -2, oxygen-sensitive basic helix-loop-helix transcription factors, which mediate the hypoxic induction of angiogenic growth factors such as vascular endothelial growth factor. Loss of pVHL function results in c...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2008.160
更新日期：2008-09-11 00:00:00
abstract：:Chemoprevention has been widely explored as a promising strategy for controlling the incidence of lung cancer, the leading cause of cancer-related death. To maximize the benefit of lung cancer chemoprevention, it is important to identify individuals at high risk for the disease. The genetic background has been shown t...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206852
更新日期：2003-10-16 00:00:00
abstract：:Activation of Stat5 by many cytokines implies that it cannot alone insure the specificity of the regulation of its target genes. We have evidenced a physical and functional interaction between members of two unrelated transcription factor families, Ets-1, Ets-2 and Stat5, which could contribute to the proliferative re...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203542
更新日期：2000-04-20 00:00:00
