Abstract：
:Chromosomal translocations involving the human 12p13 band frequently affect the TEL gene, usually resulting in gene fusion between TEL and genes encoding proteins of various types. The most frequent 12p13 translocation is the t(12;21)(p13;q22), which recombines TEL with the AML1 gene on chromosome 21 and is frequently associated with deletion of the untranslocated TEL allele. Using antisera against different parts of TEL and against the AML1 proteins, we undertook Western blot and immunofluorescence analyses of leukemic samples with and without 12p13 abnormalities. In t(12;21) samples, TEL-AML1 was detected as several protein species in the nuclei, whereas the AML1-TEL protein, was inconsistently expressed. AML1 was found to be expressed but no normal TEL proteins were detected. A survey of the TEL proteins in a panel of human leukemic samples without t(12;21) revealed a variation in the ratio of TEL protein isoforms. We also analysed a leukemic cell line bearing a t(12;22)(p13;q11) that was found to affect the 5' untranslated (UT) region of TEL and to be associated with inactivation of the untranslocated TEL allele. No MN1-TEL fusion could be detected upon RT-PCR analysis, in contrast to the previously investigated t(12;22). Strikingly, extremely low levels of apparently normal TEL proteins, expressed from the translocated allele, were detected by Western blot analysis. These results suggest that the level of TEL expression can be important for leukemogenesis.
journal_name
Oncogenejournal_title
Oncogeneauthors
Poirel H,Lacronique V,Mauchauffé M,Le Coniat M,Raffoux E,Daniel MT,Erickson P,Drabkin H,MacLeod RA,Drexler HG,Ghysdael J,Berger R,Bernard OAdoi
10.1038/sj.onc.1201817subject
Has Abstractpub_date
1998-06-04 00:00:00pages
2895-903issue
22eissn
0950-9232issn
1476-5594journal_volume
16pub_type
杂志文章相关文献
ONCOGENE文献大全abstract：:Chromosome 17 is one of the most frequently altered chromosomes in malignant breast cancer. At least four genes implicated in breast cancer reside on chromosome 17 (p53, 17p13; Her-2/neu/ERBB2, 17q12; BRCA1, 17q21; and nm23, 17q22). In addition, allelic imbalance has been described for at least five regions of chromos...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201073
更新日期：1997-05-15 00:00:00
abstract：:Biomarkers that predict disease progression might assist the development of better therapeutic strategies for aggressive cancers, such as ovarian cancer. Here, we investigated the role of collagen type XI alpha 1 (COL11A1) in cell invasiveness and tumor formation and the prognostic impact of COL11A1 expression in ovar...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2013.307
更新日期：2014-06-26 00:00:00
abstract：:We described previously the characterization of a novel oncogene, cph, activated in primary Syrian hamster embryo fibroblasts by exposure to 3-methylcholanthrene (Velasco et al., Oncogene 9:2065-2069, 1994). The present report describes the participation in the neoplastic conversion of cph-expressing (81C39) hamster f...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-03-02 00:00:00
abstract：:Smad4 is a critical component in transforming growth factor beta (TGF-beta) signaling and frequently mutated in pancreatic and colorectal cancers. Smad4 has two important functional domains, MH1 and MH2, that are involved in different biological processes. The MH1 domain comprises a DNA binding domain and the MH2 doma...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207219
更新日期：2004-02-05 00:00:00
abstract：:In previous studies examining the role of pp60c-src in cellular proliferation, we demonstrated that overexpression of wild type (wt) but not mutated c-src in C3H10T1/2 murine embryo fibroblasts resulted in a 2 to 5 fold enhancement of DNA synthesis in response to epidermal growth factor (EGF). Using phosphotyrosine an...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Previously, we have mimicked human neurofibromatosis type 2 (NF2) in conditional Nf2 mutant (P0Cre;Nf2flox2/flox2) mice. Schwannomas, characteristic for NF2, were found at low frequency in older mice. Here, we report that these mice, upon additional hemizygosity for p53, rapidly develop multiple tumours showing featur...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1207858
更新日期：2004-08-26 00:00:00
abstract：:This study addresses the question of whether loss of p16INK4 expression contributes to the immortalization of human cells. In vitro immortalization usually proceeds through two phases. In the first phase (lifespan extension), cells continue proliferating and their telomeres continue shortening beyond the point at whic...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-09-19 00:00:00
abstract：:Cancer cells lose homeostatic flexibility because of mutations and dysregulated signaling pathways involved in maintaining homeostasis. Tuberous Sclerosis Complex 1 (TSC1) and TSC2 play a fundamental role in cell homeostasis, where signal transduction through TSC1/TSC2 is often compromised in cancer, leading to aberra...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-018-0381-2
更新日期：2018-11-01 00:00:00
abstract：:The cochaperone CDC37 promotes the association of HSP90 with the protein kinase subset of client proteins to maintain their stability and signalling functions. HSP90 inhibitors induce depletion of clients, which include several oncogenic kinases. We hypothesized that the targeting of CDC37 using siRNAs would compromis...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2008.380
更新日期：2009-01-15 00:00:00
abstract：:The mechanisms involved in the p53-dependent control of gene expression following DNA damage have not been completely elucidated. Here, we show that the p53 C terminus associates with factors that are required for the ultraviolet (UV)-induced inhibition of the mRNA 3' cleavage step of the polyadenylation reaction, suc...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2011.29
更新日期：2011-07-07 00:00:00
abstract：:A distinctive subset of renal carcinomas is associated with Xp11. 2 translocations and resulting TFE3 gene fusions (PRCC-TFE3, PSF-TFE3, NONO-TFE3, ASPL-TFE3), encoding related aberrant transcription factors. We report the cloning of a novel clathrin heavy-chain gene (CLTC)-TFE3 gene fusion resulting from a t(X;17)(p1...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206686
更新日期：2003-08-14 00:00:00
abstract：:Triple negative breast cancer (TNBC) refers to tumors that do not express clinically significant levels of estrogen and progesterone receptors, and lack membrane overexpression or gene amplification of ErbB-2/HER2, a receptor tyrosine kinase. Transcriptome and proteome heterogeneity of TNBC poses a major challenge to ...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/s41388-020-01430-9
更新日期：2020-09-01 00:00:00
abstract：:The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator of the increased risk of endometrial hyperplasia and cancer resulting from the use of tamoxifen for the treatment and prevention of breast cancer. ADM has been shown to be induced by tamoxifen in the endometrium and to be a growth factor for...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1205374
更新日期：2002-04-25 00:00:00
abstract：:We recently reported the cloning and sequencing of the mouse A-myb proto-oncogene cDNA and the abundant expression of this mRNA primarily in the testis of adult mice. The A-myb mRNA is detectable by in situ hybridization specifically in the spermatogenic cells, and is downregulated during terminal differentiation. A l...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-09-19 00:00:00
abstract：:BAG-1 is a multifunctional protein that interacts with a wide range of cellular targets including heat-shock proteins and some nuclear hormone receptors. BAG-1 exists as three major isoforms, BAG-1L, BAG-1M and BAG-1S. BAG-1L contains a nuclear localization signal, which is not present in the other isoforms, and is pr...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1206688
更新日期：2003-08-07 00:00:00
abstract：:Hox genes encode DNA-binding proteins that are deployed in overlapping domains along various body axes during embryonic development. This sequential activation of Hox genes in temporal and spatial mode, the Hox code, is critical for the proper positioning of segmented structures along those axes, which include the ver...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/onc.2010.484
更新日期：2011-01-27 00:00:00
abstract：:The oncoprotein c-Myc contains two dimerization motifs- the helix-loop-helix (HLH) and the leucine zipper (LZ) - through which c-Myc specifically dimerizes with Max. We substituted regions of the c-Myc HLH and LZ motifs with the corresponding regions of structurally related proteins that do not interact with Max. Spec...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:The p21WAF1/CIP1/SDI1 gene is an important regulator of crucial cellular processes, including cell cycle control, cellular differentiation, and the response to genotoxic stress. Induction of p21 gene expression upon DNA damage is widely believed to be p53-dependent. In the present study we analysed the expression of p...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1201995
更新日期：1998-08-13 00:00:00
abstract：:Adenovirus E4orf4 protein is a multifunctional viral regulator, which is involved in down regulation of virally-modulated signal transduction, in control of alternative splicing of viral mRNAs, and in induction of apoptosis in transformed cells. It has been previously shown that E4orf4 interacts with protein phosphata...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1203705
更新日期：2000-08-03 00:00:00
abstract：:The maintenance of genomic stability is one of the most important defenses against neoplastic transformation. This objective must be accomplished despite a constant barrage of spontaneous DNA double strand breaks. These dangerous lesions are corrected by two primary pathways of double strand break repair; non homologo...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1204767
更新日期：2001-09-10 00:00:00
abstract：:Intrachromosomal rearrangements involving the RET and the adjacent H4 or ELE1 gene are very frequent events in thyroid cancer of children from Belarus after the Chernobyl reactor accident (Klugbauer et al., 1995). The fusion product between ELE1 and RET (RET/ PTC3) seems to be the prevailing type of rearrangement as s...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1996-09-05 00:00:00
abstract：:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a glycoprotein that is part of the carcinoembryonic antigen and the immunoglobulin superfamilies. We have shown that it functions as a tumor suppressor and that this function depends upon the presence of the longer CEACAM1 cytoplasmic domain. In th...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1209541
更新日期：2006-09-07 00:00:00
abstract：:The ETS transcription factor ERG has been implicated as a major regulator of both normal and aberrant hematopoiesis. In acute myeloid leukemias harboring t(16;21), ERG function is deregulated due to a fusion with FUS/TLS resulting in the expression of a FUS-ERG oncofusion protein. How this oncofusion protein deregulat...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2015.261
更新日期：2016-04-14 00:00:00
abstract：:Signature abnormalities in the cell cycle and apoptotic pathway have been identified in mantle cell lymphoma (MCL), affording the opportunity to develop targeted therapies. In this study, we tested a novel class of kinase inhibitors, styryl sulfones, which differ from prior cell cycle inhibitors in that they are not r...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/sj.onc.1210350
更新日期：2007-08-16 00:00:00
abstract：:A novel protein tyrosine kinase (PTK) substrate, p120, has been previously implicated in ligand-induced signaling through the epidermal growth factor, platelet-derived growth factor and colony-stimulating factor 1 receptors, and in cell transformation by p60v-src. We have isolated a near full-length cDNA encoding muri...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Over the past five decades, a plethora of nonrandom chromosomal abnormalities have been consistently reported in malignant cells facilitating the identification of cancer-associated protein coding oncogenes and tumor suppressors. The genetic dissection of hot spots for chromosomal abnormalities in the age of the seque...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1209910
更新日期：2006-10-09 00:00:00
abstract：:The mitotic spindle is assembled by the coordinated action of centrosomes and kinetochore microtubules. An evolutionally conserved protein family, transforming acidic coiled-coil (TACC), has been shown to be involved in this process. In humans, TACC3 is aberrantly expressed in a variety of human cancers, but its biolo...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2013.382
更新日期：2014-08-14 00:00:00
abstract：:Dysregulation of pleiotropic growth factors, receptors and their downstream signaling pathway components represent a central protumorigenic principle in human hepatocarcinogenesis. Especially the Insulin-like Growth Factor/IGF-1 receptor (IGF/IGF-1R), Hepatocyte Growth Factor (HGF/MET), Wingless (Wnt/beta-catenin/FZD)...
journal_title：Oncogene
pub_type： 杂志文章,评审
doi：10.1038/sj.onc.1209556
更新日期：2006-06-26 00:00:00
abstract：:Dysregulation of cellular signaling pathways can lead to colon cancer. However, research on the key signaling effectors or regulators in colon carcinogenesis is limited. Casein kinase-2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is crucial during adult bone formation and is a promising drug target for osteo...
journal_title：Oncogene
pub_type： 杂志文章
doi：10.1038/onc.2013.340
更新日期：2014-07-10 00:00:00
abstract：:To understand the mechanism for resistance of primary cultures of rat embryo fibroblasts (REFs) to oncogene-induced transformation, we studied the transforming ability of a recombinant retrovirus, ZSV, containing v-src and neo genes in REFs and in the rat cell line F2408. The susceptibility of REFs to p60v-src transfo...
journal_title：Oncogene
pub_type： 杂志文章
doi：
更新日期：1995-07-20 00:00:00
