Abstract:
:Over the past five decades, a plethora of nonrandom chromosomal abnormalities have been consistently reported in malignant cells facilitating the identification of cancer-associated protein coding oncogenes and tumor suppressors. The genetic dissection of hot spots for chromosomal abnormalities in the age of the sequenced human genome resulted in the discovery that microRNA (miRNA) genes, encoding for a class of small noncoding RNAs, frequently resides in such genomic regions. The combination of nonrandom chromosomal abnormalities and other types of genetic alterations or epigenetic events contribute to downregulation or overexpression of miRNAs. The consequent abnormal expression of miRNAs affect cell cycle, survival and differentiation programs and selective targeting of these noncoding genes could provide novel therapeutic options for killing the malignant cells.
journal_name
Oncogenejournal_title
Oncogeneauthors
Calin GA,Croce CMdoi
10.1038/sj.onc.1209910subject
Has Abstractpub_date
2006-10-09 00:00:00pages
6202-10issue
46eissn
0950-9232issn
1476-5594pii
1209910journal_volume
25pub_type
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