Retinoic acid receptor alpha suppresses polyomavirus transformation and c-fos expression in rat fibroblasts.

abstract：:A cDNA encoding a complete human c-fos protein was isolated and inserted into two different murine MoMuLV-derived recombinant retroviruses allowing expression of c-fos protein in different cell types. One c-fos-expressing retrovirus, chosen for its ability to express high levels of proteins in fibroblast-like cells, w...

journal_title：Oncogene

authors： Roux P,Verrier B,Klein B,Niccolino M,Marty L,Alexandre C,Piechaczyk M

更新日期：1991-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is generally accompanied by high mortality and low cure rate. CCAAT enhancer-binding proteins (CEBPs) are transcriptional regulators that play a key role in maintaining liver function. Altered expression of C/EBPα and C/EBPβ occurs in many tumours including HCC. saRNAs are small double-s...

journal_title：Oncogene

authors： Zhao X,Reebye V,Hitchen P,Fan J,Jiang H,Sætrom P,Rossi J,Habib NA,Huang KW

更新日期：2019-05-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF alpha) is a proinflammatory cytokine with important roles in regulating inflammatory responses as well as cell cycle proliferation and apoptosis. Although TNFalpha stimulates apoptosis, it also activates the transcription factor NF-kappa B, and studies have shown that inhibition of NF-...

journal_title：Oncogene

authors： Zhou A,Scoggin S,Gaynor RB,Williams NS

更新日期：2003-04-03 00:00:00

abstract：:Syndecan-1 is a heparan sulfate proteoglycan (HSPG) commonly upregulated in AIDS-related B lymphoid malignancies. Tat is the main HIV-1 transactivating factor that has a major role in the pathogenesis of AIDS-related lymphomas (ARL) by engaging heparan sulfate proteoglycans (HSPGs), chemokine receptors and integrins a...

journal_title：Oncogene

authors： Urbinati C,Grillo E,Chiodelli P,Tobia C,Caccuri F,Fiorentini S,David G,Rusnati M

更新日期：2017-05-04 00:00:00

abstract：:Gene expression patterns in normal and v-myc-transformed quail embryo fibroblasts were compared by mRNA differential display. Displaying approximately 2500 mRNA species by reverse transcription/PCR, reamplification of 73 differential cDNA fragments and rescreening by Northern analysis led to the isolation of a clone, ...

journal_title：Oncogene

authors： Oberst C,Weiskirchen R,Hartl M,Bister K

更新日期：1997-03-06 00:00:00

abstract：:In chronic myelogenous leukemia (CML), the oncogene bcr-abl encodes a dysregulated tyrosine kinase that inhibits apoptosis. We showed previously that human erythroleukemia K562 cells are resistant to antineoplastic drug (taxol)-induced apoptosis through the atypical protein kinase C iota isozyme (PKC iota), a kinase d...

journal_title：Oncogene

authors： Lu Y,Jamieson L,Brasier AR,Fields AP

更新日期：2001-08-09 00:00:00

abstract：:An essential mode of acquired resistance to radiotherapy (RT) appears to be promotion of tumor cell motility and invasiveness in various cancer types, including glioblastoma, a process resembling 'evasive resistance'. Hence, a logical advancement of RT would be to identify suitable complementary treatment strategies, ...

journal_title：Oncogene

authors： Weiler M,Pfenning PN,Thiepold AL,Blaes J,Jestaedt L,Gronych J,Dittmann LM,Berger B,Jugold M,Kosch M,Combs SE,von Deimling A,Weller M,Bendszus M,Platten M,Wick W

更新日期：2013-02-28 00:00:00

abstract：:An adenovirus mutant lacking the expression of the large E1B protein (DeltaE1B) has been reported to replicate selectively in cells lacking the expression of functionally wild-type (wt) p53. Based on these results the DeltaE1B or ONYX-015 virus has been proposed to be an oncolytic virus which might be useful to treat ...

journal_title：Oncogene

authors： Steegenga WT,Riteco N,Bos JL

更新日期：1999-09-09 00:00:00

abstract：:CD66a, also known as 'biliary glycoprotein (BGP)', is the human homologue of a cell adhesion molecule (CAM) of the rat (Cell-CAM). CD66a, which belongs to the carcinoembryonic antigen family and the immunoglobulin superfamily, is expressed in cells of myeloid and epithelial origin. The cytoplasmic domain of the major ...

journal_title：Oncogene

authors： Brümmer J,Neumaier M,Göpfert C,Wagener C

更新日期：1995-10-19 00:00:00

abstract：:ERM is a member of the ETS transcription factor family. High levels of the corresponding mRNA are detected in a variety of human breast cancer cell lines, as well as in aggressive human breast tumors. As ERM protein is almost undetectable in these cells, high degradation of this transcription factor has been postulate...

journal_title：Oncogene

authors： Baert JL,Beaudoin C,Monte D,Degerny C,Mauen S,de Launoit Y

更新日期：2007-01-18 00:00:00

abstract：:Oncoprotein C-MYC is overexpressed in human metastatic melanomas and melanoma-derived cells where it is required for the suppression of oncogene-induced senescence (OIS). The genetic events that maintain high levels of C-MYC in melanoma cells and their role in OIS are unknown. Here we report that C-MYC in cells from s...

journal_title：Oncogene

authors： Mannava S,Omilian AR,Wawrzyniak JA,Fink EE,Zhuang D,Miecznikowski JC,Marshall JR,Soengas MS,Sears RC,Morrison CD,Nikiforov MA

更新日期：2012-03-22 00:00:00

abstract：:Uterine leiomyomas or fibroids (UFs) are benign tumors characterized by hyperplastic smooth muscle cells and excessive deposition of extracellular matrix (ECM). Afflicting ~80% of women, and symptomatic in 25%, UFs bring tremendous suffering and are an economic burden worldwide; they cause severe pain and bleeding, an...

journal_title：Oncogene

authors： Cao T,Jiang Y,Wang Z,Zhang N,Al-Hendy A,Mamillapalli R,Kallen AN,Kodaman P,Taylor HS,Li D,Huang Y

更新日期：2019-07-01 00:00:00

abstract：:Herpesvirus saimiri is an oncogenic virus causing rapid T-cell lymphomas in New World primates and rabbits. Deletion analysis of one strain of H saimiri has indicated an open reading frame, StpA, necessary for oncongenicity in monkeys. We have investigated the function of StpA in tumor induction by the generation of t...

journal_title：Oncogene

authors： Kretschmer C,Murphy C,Biesinger B,Beckers J,Fickenscher H,Kirchner T,Fleckenstein B,Rüther U

更新日期：1996-04-18 00:00:00

abstract：:Nerve growth factor induces differentiation and survival of rat PC12 pheochromocytoma cells. The activation of the erk cascade has been implicated in transducing the multitude of signals induced by NGF. In order to explore the role of this signaling cascade in NGF mediated survival, differentiation and proliferation, ...

journal_title：Oncogene

authors： Klesse LJ,Meyers KA,Marshall CJ,Parada LF

更新日期：1999-03-25 00:00:00

abstract：:The forkhead transcription factor FOXO1, a downstream target of phosphatidylinositol-3-kinase/Akt signalling pathway, regulates cyclic differentiation and apoptosis in normal endometrium, but its role in endometrial carcinogenesis is unknown. Screening of endometrial cancer cell lines demonstrated that FOXO1 is expres...

journal_title：Oncogene

authors： Goto T,Takano M,Albergaria A,Briese J,Pomeranz KM,Cloke B,Fusi L,Feroze-Zaidi F,Maywald N,Sajin M,Dina RE,Ishihara O,Takeda S,Lam EW,Bamberger AM,Ghaem-Maghami S,Brosens JJ

更新日期：2008-01-03 00:00:00

abstract：:To clarify the incidence, timing and pathogenetic significance of p53 gene alterations in the progression of small-cell lung carcinoma (SCLC), 17 primary tumors, 13 metastases and nine cell lines from 27 patients were analysed by a polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis. ...

journal_title：Oncogene

authors： Sameshima Y,Matsuno Y,Hirohashi S,Shimosato Y,Mizoguchi H,Sugimura T,Terada M,Yokota J

更新日期：1992-03-01 00:00:00

abstract：:Cytokinesis is the final step of cell division. Increasing evidence suggests failure of cytokinesis might contribute to the development of cancer. Here, we demonstrate that the serologically defined colon cancer antigen-3 (SDCCAG3) forms a complex with PTPN13, a protein tyrosine phosphatase known to be involved in the...

journal_title：Oncogene

authors： Hagemann N,Ackermann N,Christmann J,Brier S,Yu F,Erdmann KS

更新日期：2013-09-26 00:00:00

abstract：:Our previous studies suggested that chromosome 8p deletion is associated with metastasis of hepatocellular carcinoma (HCC), in which some novel metastasis suppressor genes might be harbored. The present study aimed to identify the metastatic suppressor gene(s). A cDNA chip was constructed with the expressed sequence t...

journal_title：Oncogene

authors： Wu X,Jia HL,Wang YF,Ren N,Ye QH,Sun HC,Wang L,Liu YK,Tang ZY,Qin LX

更新日期：2006-03-16 00:00:00

abstract：:Expression of Brca1 in mouse mammary cancer has yet to be analysed. We use a progressive model of neoplasia based on several mouse epithelial cell lines that represent distinct steps toward the fully tumorigenic state. Using RNase protection analysis because acceptable anti-Brca1 antibodies are not available we invest...

journal_title：Oncogene

authors： Mixon M,Kittrell F,Medina D

更新日期：2000-11-02 00:00:00

abstract：:Sp1 is important for the transcription of many genes. Our previous studies have shown that Sp1 is degraded in normal cell, but it is preserved in cancer cells during mitosis and exists a priori in the daughter cells, ready to engage in gene transcription and thereby contributes to the proliferation and survival of can...

journal_title：Oncogene

authors： Chuang JY,Wang SA,Yang WB,Yang HC,Hung CY,Su TP,Chang WC,Hung JJ

更新日期：2012-11-22 00:00:00

abstract：:Ras-genes encode for proteins important for transmitting extracellular signals from the cytoplasm to the nucleus. In this study we investigated the impact of Ras on cell cycle progression after hepatectomy by using adenoviral vectors (adv) expressing beta-galactosidase (beta-gal), a dominant-negative (Ras N17) or a do...

journal_title：Oncogene

authors： Lüdde T,Kubicka S,Plümpe J,Liedtke C,Manns MP,Trautwein C

更新日期：2001-08-30 00:00:00

abstract：:We have found that the differentiation inducer butyric acid causes the synthesis of a cellular protein(s) that mediates a rapid decline in the level of myc RNA in SW837, a cell line derived from a human adenocarcinoma of the rectum. This effect was dose-dependent and was maximal at 1 mM. Among the short chain fatty ac...

journal_title：Oncogene

authors： Herold KM,Rothberg PG

更新日期：1988-10-01 00:00:00

abstract：:The human trk oncogene (originally identified in a colon carcinoma) was activated by a genetic rearrangement which resulted in replacement of the extracellular ligand-binding domain of the proto-trk transmembrane receptor by non-muscle tropomyosin sequences. The product of the trk oncogene, a protein of 70 kDa (p70trk...

journal_title：Oncogene

authors： Mitra G

更新日期：1991-12-01 00:00:00

abstract：:BCL11 genes play crucial roles in lymphopoiesis and have been associated with hematopoietic malignancies. Specifically, disruption of the BCL11B (B-cell chronic lymphocytic leukemia/lymphoma 11B) locus is linked to T-cell acute lymphoblastic leukemia, and the loss of heterozygosity in mice results in T-cell lymphoma. ...

journal_title：Oncogene

authors： Cismasiu VB,Adamo K,Gecewicz J,Duque J,Lin Q,Avram D

更新日期：2005-10-13 00:00:00

abstract：:Experimental studies performed prior to 1990 led to the widely held belief that matrix metalloproteinases (MMPs) produced by cancer cells are of critical importance in tumor invasion and metastasis. Based on this evidence, the pharmaceutical industry produced several well tolerated, orally active MMP inhibitors (MMPIs...

journal_title：Oncogene

authors： Zucker S,Cao J,Chen WT

更新日期：2000-12-27 00:00:00

abstract：:Upstream stimulating factor (USF2) is a basic helix-loop-helix leucine zipper transcription factor, which is found in most tissues. A critical role for USF2 in cellular proliferation has been proposed based on its importance in the regulation of various cyclins and P53 and its capability to antagonize c-myc. In this p...

journal_title：Oncogene

authors： Zhang ZC,Nechushtan H,Jacob-Hirsch J,Avni D,Meyuhas O,Razin E

更新日期：1998-02-12 00:00:00

abstract：:Understanding how disruption of differentiation contributes to the cancer cell phenotype is required to identify alterations essential for malignant transformation and provide experimental basis for their correction. We investigated whether primary quail neuroretina cells, transformed by a conditional v-Src mutant (QN...

journal_title：Oncogene

authors： Mateos S,Amarir S,Laugier D,Marx M,Calothy G

更新日期：2007-05-17 00:00:00

abstract：:The hypoxia-inducible factor 1 (HIF-1) plays a critical role for tumour adaptation to microenvironmental hypoxia, and represents an appealing chemotherapeutic target. Silibinin is a nontoxic flavonoid reported to exhibit anticancer properties. However, the mechanisms by which silibinin inhibits tumour growth are not f...

journal_title：Oncogene

authors： García-Maceira P,Mateo J

更新日期：2009-01-22 00:00:00

abstract：:The heterodimeric nuclear factor (NF) 90/NF45 complex (NF90/NF45) binds nucleic acids and is a multifunctional regulator of gene expression. Here we report that depletion of NF90/NF45 restores the expression of the p53 and p21 proteins in cervical carcinoma cells infected with high-risk human papillomaviruses (HPVs). ...

journal_title：Oncogene

authors： Shamanna RA,Hoque M,Pe'ery T,Mathews MB

更新日期：2013-10-24 00:00:00

abstract：:Earlier we showed that RACK1 regulates growth of human colon cells by suppressing Src activity at G(1) and mitotic checkpoints. Here, we show that RACK1 also induces apoptosis of the cells, partly by inhibiting Src. In the intrinsic pathway, RACK1 inhibits expression of anti-apoptotic Bcl-2 and Bcl-X(L), induces expre...

journal_title：Oncogene

authors： Mamidipudi V,Cartwright CA

更新日期：2009-12-17 00:00:00