Abstract:
:The RASSF8 gene, which maps close to the KRAS2 gene, contains a RAS-associated domain and encodes a protein that is evolutionarily conserved from fish to humans. Analysis of the RASSF8 transcript revealed a complex expression pattern of 5'-UTR mRNA isoforms in normal lung and in lung adenocarcinomas (ADCAs), with no apparent differences. However, RASSF8 gene transcript levels were approximately seven-fold-lower in lung ADCAs as compared to normal lung tissue. Expression of RASSF8 protein by transfected lung cancer cells led to inhibition of anchorage-independent growth in soft agar in A549 cells and reduction of clonogenic activity in NCI-H520 cells. These results raise the possibility protein encoded by RASSF8 is a novel tumor suppressor for lung cancer.
journal_name
Oncogenejournal_title
Oncogeneauthors
Falvella FS,Manenti G,Spinola M,Pignatiello C,Conti B,Pastorino U,Dragani TAdoi
10.1038/sj.onc.1209422subject
Has Abstractpub_date
2006-06-29 00:00:00pages
3934-8issue
28eissn
0950-9232issn
1476-5594pii
1209422journal_volume
25pub_type
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