当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma.

Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma.

Abstract：

:The proto-oncogene BMI1 and its product, Bmi1, is overexpressed in various types of tumors, particularly in aggressive tumors and tumors resistant to conventional chemotherapy. BMI1/Bmi1 is also crucially involved in cancer-initiating cell maintenance, and is recurrently upregulated in mantle cell lymphoma (MCL), especially aggressive variants. Recently, side population (SP) cells were shown to exhibit tumor-initiating characteristics in various types of tumors. In this study, we show that recurrent MCL cases significantly exhibit upregulation of BMI1/Bmi1. We further demonstrate that clonogenic MCL SP shows such tumor-initiating characteristics as high tumorigenicity and self-renewal capability, and that BMI1 was upregulated in the SP from recurrent MCL cases and MCL cell lines. On screening for upstream regulators of BMI1, we found that expression of microRNA-16 (miR-16) was downregulated in MCL SP cells by regulating Bmi1 in the SPs, leading to reductions in tumor size following lymphoma xenografts. Moreover, to investigate downstream targets of BMI1 in MCL, we performed cross-linking/chromatin immunoprecipitation assay against MCL cell lines and demonstrated that Bmi1 directly regulated pro-apoptotic genes such as BCL2L11/Bim and PMAIP1/Noxa, leading to enhance anti-apoptotic potential of MCL. Finally, we found that a proteasome inhibitor bortezomib, which has been recently used for relapsed MCL, effectively induced apoptosis among MCL cells while reducing expression of Bmi1 and increasing miR-16 in MCL SP. These results suggest that upregulation of BMI1 and downregulation of miR-16 in MCL SP has a key role in the disease's progression by reducing MCL cell apoptosis. Our results provide important new insight into the pathogenesis of MCL and strongly suggest that targeting BMI1/Bmi1 might be an effective approach to treating MCL, particularly refractory and recurrent cases.

journal_name

Oncogene

journal_title

Oncogene

authors

Teshima K,Nara M,Watanabe A,Ito M,Ikeda S,Hatano Y,Oshima K,Seto M,Sawada K,Tagawa H

doi

10.1038/onc.2013.177

subject

Has Abstract

pub_date

2014-04-24 00:00:00

pages

2191-203

issue

17

eissn

0950-9232

issn

1476-5594

pii

onc2013177

journal_volume

33

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Cyclin D3 action in androgen receptor regulation and prostate cancer.

    abstract：:Prostate cancer (PCa) cell proliferation is dependent on activation of the androgen receptor (AR), a ligand-dependent transcription factor. AR activation controls G1-S phase progression through fostering enhanced translation of the D-type cyclins, which promote cell cycle progression through activation of CDK4/6. Howe...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210981

    authors： Olshavsky NA,Groh EM,Comstock CE,Morey LM,Wang Y,Revelo MP,Burd C,Meller J,Knudsen KE

    更新日期：2008-05-15 00:00:00

  • Nuclear FGF-2 facilitates cell survival in vitro and during establishment of metastases.

    abstract：:Nuclear-targeted high molecular weight 24 kDa fibroblast growth factor 2 (FGF-2) may induce specific cell functions through intracrine mechanisms. The role of nuclear FGF-2 on the metastatic potential of carcinoma cells was examined by conditional FGF-2 expression, which demonstrated that spontaneous metastasis in nud...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207638

    authors： Thomas-Mudge RJ,Okada-Ban M,Vandenbroucke F,Vincent-Salomon A,Girault JM,Thiery JP,Jouanneau J

    更新日期：2004-06-10 00:00:00

  • The role of Gads in hematopoietic cell signalling.

    abstract：:Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is expressed specifically in hematopoietic cells and functions in the coordination of tyrosine kinase mediated signal transduction. Gads plays a critical role in signalling from the T cell receptor by promoting the formation of a com...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1204771

    authors： Liu SK,Berry DM,McGlade CJ

    更新日期：2001-10-01 00:00:00

  • Physical interaction of estrogen receptor with MnSOD: implication in mitochondrial O2.- upregulation and mTORC2 potentiation in estrogen-responsive breast cancer cells.

    abstract：:Augmented reactive oxygen species levels consequential to functional alteration of key mitochondrial attributes contribute to carcinogenesis, either directly via oxidative DNA damage infliction or indirectly via activation of oncogenic signaling cascades. We previously reported activation of a key oncogenic signaling ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.346

    authors： Lone MU,Baghel KS,Kanchan RK,Shrivastava R,Malik SA,Tewari BN,Tripathi C,Negi MP,Garg VK,Sharma M,Bhatt ML,Bhadauria S

    更新日期：2017-03-30 00:00:00

  • Hormonal modulation of ESR1 mutant metastasis.

    abstract：:Estrogen receptor alpha gene (ESR1) mutations occur frequently in ER-positive metastatic breast cancer, and confer clinical resistance to aromatase inhibitors. Expression of the ESR1 Y537S mutation induced an epithelial-mesenchymal transition (EMT) with cells exhibiting enhanced migration and invasion potential in vit...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-020-01563-x

    authors： Gu G,Tian L,Herzog SK,Rechoum Y,Gelsomino L,Gao M,Du L,Kim JA,Dustin D,Lo HC,Beyer AR,Edwards DG,Gonzalez T,Tsimelzon A,Huang HJ,Fernandez NM,Grimm SL,Hilsenbeck SG,Liu D,Xu J,Alaniz A,Li S,Mills GB,Janku F

    更新日期：2020-12-15 00:00:00

  • Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27.

    abstract：:Many lines of evidence indicate that connexin genes expressing gap junction (GJ) proteins inhibit tumor cell proliferation. However, the precise molecular mechanisms remain unclear. In this study, we show that overexpression of connexin43 (Cx43) suppressed proliferation of human osteosarcoma U2OS cells through inhibit...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204563

    authors： Zhang YW,Morita I,Ikeda M,Ma KW,Murota S

    更新日期：2001-07-12 00:00:00

  • Beta-catenin inhibits cell growth of a malignant mesothelioma cell line, NCI-H28, with a 3p21.3 homozygous deletion.

    abstract：:We have found that a malignant mesothelioma cell line, NCI-H28, had a chromosome 3p21.3 homozygous deletion containing the beta-catenin gene (CTNNB1), which suggested that the deletion of beta-catenin might have a growth advantage in the development of this tumor. To determine whether beta-catenin has a growth-inhibit...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206533

    authors： Usami N,Sekido Y,Maeda O,Yamamoto K,Minna JD,Hasegawa Y,Yoshioka H,Imaizumi M,Ueda Y,Takahashi M,Shimokata K

    更新日期：2003-09-11 00:00:00

  • Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition.

    abstract：:Epithelial-mesenchymal transition (EMT) has pivotal roles during embryonic development and carcinoma progression. Members of the Snai1 family of zinc finger transcription factors are central mediators of EMT and induce EMT in part by directly repressing epithelial markers such as E-cadherin, a gatekeeper of the epithe...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.234

    authors： Lin T,Ponn A,Hu X,Law BK,Lu J

    更新日期：2010-09-02 00:00:00

  • DNA binding and selective gene induction by different forms of the p53 protein.

    abstract：:P53 is a tumor suppressor gene that plays a crucial role in suppressing tumorigenesis by inducing either cell cycle arrest or apoptosis in cells with DNA damage. In more than 50% of tumors p53 is inactivated by gene mutations. However, there have also been reports of tumor cells in which p53 remains wild type and is p...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210110

    authors： Mayelzadeh F,Martinez JD

    更新日期：2007-05-10 00:00:00

  • Regulation of fibronectin matrix assembly by activated Ras in transformed cells.

    abstract：:Fibronectin extracellular matrix plays a critical role in the microenvironment of cells. Loss of this matrix frequently accompanies oncogenic transformation, allowing changes in cell growth, morphology, and tissue organization. The HT1080 human fibrosarcoma cell line is deficient in formation of fibronectin matrix fib...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203626

    authors： Brenner KA,Corbett SA,Schwarzbauer JE

    更新日期：2000-06-29 00:00:00

  • Vital functions for lethal caspases.

    abstract：:Caspases are a family of cysteine proteases expressed as inactive zymogens in virtually all animal cells. These enzymes play a central role in most cell death pathways leading to apoptosis but growing evidences implicate caspases also in nonapoptotic functions. Several of these enzymes, activated in molecular platform...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1208524

    authors： Launay S,Hermine O,Fontenay M,Kroemer G,Solary E,Garrido C

    更新日期：2005-08-04 00:00:00

  • The Gag-Myb-Ets fusion oncogene alters the apoptotic response and growth factor dependence of interleukin-3 dependent murine cells.

    abstract：:Expression of the avian E26-derived Gag-Myb-Ets fusion oncogene in interleukin-3(IL3)-dependent murine hematopoietic cell lines results in a pattern of cell line dependent changes in growth factor-induced proliferation and apoptosis. A drug-selectable retrovirus expressing p135Gag-Myb-Ets induced an erythropoietin(Epo...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Athanasiou M,Mavrothalassitis GJ,Yuan CC,Blair DG

    更新日期：1996-01-18 00:00:00

  • Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.

    abstract：:Adhesion to the extracellular matrix (ECM) is critical for epithelial tissue homeostasis and function. ECM detachment induces metabolic stress and programmed cell death via anoikis. ECM-detached mammary epithelial cells are able to rapidly activate autophagy allowing for survival and an opportunity for re-attachment. ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2012.512

    authors： Avivar-Valderas A,Bobrovnikova-Marjon E,Alan Diehl J,Bardeesy N,Debnath J,Aguirre-Ghiso JA

    更新日期：2013-10-10 00:00:00

  • OTX1 expression in breast cancer is regulated by p53.

    abstract：:The p53 transcription factor has a critical role in cell stress response and in tumor suppression. Wild-type p53 protein is a growth modulator and its inactivation is a critical event in malignant transformation. It has been recently demonstrated that wild-type p53 has developmental and differentiation functions. Inde...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.31

    authors： Terrinoni A,Pagani IS,Zucchi I,Chiaravalli AM,Serra V,Rovera F,Sirchia S,Dionigi G,Miozzo M,Frattini A,Ferrari A,Capella C,Pasquali F,Curto FL,Albertini A,Melino G,Porta G

    更新日期：2011-07-07 00:00:00

  • Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer.

    abstract：:Acquired therapeutic resistance is the major drawback to effective systemic therapies for cancers. Aggressive triple-negative breast cancers (TNBC) develop resistance to chemotherapies rapidly, whereas the underlying mechanisms are not completely understood. Here we show that genotoxic treatments significantly increas...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2015.189

    authors： Niu J,Xue A,Chi Y,Xue J,Wang W,Zhao Z,Fan M,Yang CH,Shao ZM,Pfeffer LM,Wu J,Wu ZH

    更新日期：2016-03-10 00:00:00

  • Myostatin inhibits rhabdomyosarcoma cell proliferation through an Rb-independent pathway.

    abstract：:Rhabdomyosarcoma (RMS) tumors are the most common soft-tissue sarcomas in childhood. In this investigation, we show that myostatin, a skeletal muscle-specific inhibitor of growth and differentiation is expressed and translated in the cultured RMS cell line, RD. The addition of exogenous recombinant myostatin inhibits ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207144

    authors： Langley B,Thomas M,McFarlane C,Gilmour S,Sharma M,Kambadur R

    更新日期：2004-01-15 00:00:00

  • Characterization of a major colon cancer susceptibility locus (Ccs3) on mouse chromosome 3.

    abstract：:Treatment of mice with the carcinogen azoxymethane (AOM) induces a number of lesions in the colon, including hyperplastic lesions, as well adenomas and carcinomas in situ. Inbred strains of mice show different responses to AOM-induced carcinogenesis. A/J mice are highly susceptible and develop a greater number of hype...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2009.369

    authors： Meunier C,Cai J,Fortin A,Kwan T,Marquis JF,Turbide C,Van Der Kraak L,Jothy S,Beauchemin N,Gros P

    更新日期：2010-02-04 00:00:00

  • Regulation of TRAIL-induced apoptosis by XIAP in pancreatic carcinoma cells.

    abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a promising candidate for cancer therapy because of its relative tumor selectivity. However, many cancers including pancreatic cancer remain resistant towards TRAIL. To develop TRAIL for cancer therapy of pancreatic carcinoma, it will therefore b...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209776

    authors： Vogler M,Dürr K,Jovanovic M,Debatin KM,Fulda S

    更新日期：2007-01-11 00:00:00

  • Latent infection with Kaposi's sarcoma-associated herpesvirus enhances retrotransposition of long interspersed element-1.

    abstract：:Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), a gamma-2 herpesvirus, is the causative agent of KS, primary effusion lymphoma (PEL), and a plasma cell variant of multicentric Castleman's disease. Although KSHV latency is detected in KS-related tumors, oncogenic pathways activated by KSHV latent infection are not...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0726-5

    authors： Nakayama R,Ueno Y,Ueda K,Honda T

    更新日期：2019-05-01 00:00:00

  • Tyrosine kinase gene expression in the mouse small intestine.

    abstract：:To identify tyrosine kinases that may regulate regeneration of the mammalian intestinal epithelium, we amplified portions of the catalytic domains of protein kinases expressed in intestinal crypt cells, using the polymerase chain reaction technique with primers directed against two invariant amino acid sequence motifs...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Siyanova EY,Serfas MS,Mazo IA,Tyner AL

    更新日期：1994-07-01 00:00:00

  • p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer.

    abstract：:The role of p53 in genotoxic therapy-induced metabolic shift in cancers is not yet known. In this study, we investigated the role of p53 in the glycolytic shift in head and neck squamous cell carcinoma cell lines following irradiation. Isogenic p53-null radioresistant cancer cells established through cumulative irradi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0697-6

    authors： Chang HW,Kim MR,Lee HJ,Lee HM,Kim GC,Lee YS,Nam HY,Lee M,Jang HJ,Lee KE,Lee JC,Byun Y,Kim SW,Kim SY

    更新日期：2019-05-01 00:00:00

  • Importin-β/karyopherin-β1 modulates mitotic microtubule function and taxane sensitivity in cancer cells via its nucleoporin-binding region.

    abstract：:The nuclear transport receptor importin-β/karyopherin-β1 is overexpressed in cancers that display genomic instability. It is regarded as a promising cancer target and inhibitors are being developed. In addition to its role in nucleo-cytoplasmic transport, importin-β regulates mitosis, but the programmes and pathways i...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0989-x

    authors： Verrico A,Rovella P,Di Francesco L,Damizia M,Staid DS,Le Pera L,Schininà ME,Lavia P

    更新日期：2020-01-01 00:00:00

  • Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.

    abstract：:Proapoptotic nuclear receptor family member Nur77 translocates from the nucleus to the mitochondria, where it interacts with Bcl-2 to trigger apoptosis. Nur77 translocation is induced by certain apoptotic stimuli, including the synthetic retinoid-related 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209358

    authors： Han YH,Cao X,Lin B,Lin F,Kolluri SK,Stebbins J,Reed JC,Dawson MI,Zhang XK

    更新日期：2006-05-18 00:00:00

  • JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress.

    abstract：:Ferritin is the major intracellular iron storage protein that sequesters excess free iron to minimize generation of iron-catalysed reactive oxygen species. We previously demonstrated that expression of ferritin heavy chain (ferritin H) was induced by pro-oxidants, which is a part of cellular antioxidant response to pr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208901

    authors： Tsuji Y

    更新日期：2005-11-17 00:00:00

  • The regulation of translation by the 5' untranslated region of Xenopus c-myc I mRNA during early development.

    abstract：:The translational efficiency of chloramphenicol acetyltransferase (CAT) mRNA containing 5' untranslated region (UTR) sequences of Xenopus c-myc I mRNA was examined in the Xenopus oocyte and early embryo. In contrast to their reduced translation in the oocyte, CAT mRNAs containing 5' UTR sequences located between the c...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Lazarus P

    更新日期：1992-05-01 00:00:00

  • Imbalance of Clara cell-mediated homeostatic inflammation is involved in lung metastasis.

    abstract：:We have previously shown that tumor necrosis factor (TNF)α produced from primary tumor-induced expression of two endogenous Toll-like receptor 4 (TLR4) ligands, S100A8 and serum amyloid A3 (SAA3), in pre-metastatic lungs. However, mechanistic details of the signaling network and relevance to pulmonary physiology are p...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.53

    authors： Tomita T,Sakurai Y,Ishibashi S,Maru Y

    更新日期：2011-08-04 00:00:00

  • Transcriptional activation of the hepatocyte growth factor receptor (c-met) gene by its ligand (hepatocyte growth factor) is mediated through AP-1.

    abstract：:Hepatocyte Growth Factor (HGF) exerts its biological effects via binding and activating a transmembrane protein tyrosine kinase receptor known as c-Met. Previous studies from our laboratory demonstrated that c-met gene expression is inducible by its own ligand (HGF). However, the molecular mechanism(s) involved in thi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203404

    authors： Seol DW,Chen Q,Zarnegar R

    更新日期：2000-02-24 00:00:00

  • Biochemical and mutagenic analysis of the melanoma tumor suppressor gene product/p16.

    abstract：:P16 was originally discovered by its ability to interact with CDK4 and to specifically inhibit the catalytic activity of the CDK4/D1 kinase. Increased attention has focused on the p16 gene because of its location on chromosome 9p21, a region involved in chromosomal rearrangements in a large number of tumor types. The ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Wick ST,Dubay MM,Imanil I,Brizuela L

    更新日期：1995-11-16 00:00:00

  • The neural guidance receptor Plexin C1 delays melanoma progression.

    abstract：:Plexin C1 is a type I transmembrane receptor with intrinsic R-Ras GTPase activity, which regulates cytoskeletal remodeling and adhesion in normal human melanocytes. Melanocytes are pigment-producing cells of the epidermis, precursors for melanoma, and express high levels of Plexin C1, which is lost in melanoma in vitr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2012.511

    authors： Chen Y,Soong J,Mohanty S,Xu L,Scott G

    更新日期：2013-10-10 00:00:00

  • Cytotoxic drug-induced, p53-mediated upregulation of caspase-8 in tumor cells.

    abstract：:Apoptosis resistance is crucially involved in cancer development and progression, represents the leading cause for failure of anticancer therapy and is caused, for example, by downregulation of proapoptotic intracellular signaling molecules such as caspase-8. We found that the cytotoxic drugs methotrexate (MTX) and 5-...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210666

    authors： Ehrhardt H,Häcker S,Wittmann S,Maurer M,Borkhardt A,Toloczko A,Debatin KM,Fulda S,Jeremias I

    更新日期：2008-01-31 00:00:00