当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Latent infection with Kaposi's sarcoma-associated herpesvirus enhances retrotransposition of long interspersed element-1.

Latent infection with Kaposi's sarcoma-associated herpesvirus enhances retrotransposition of long interspersed element-1.

Abstract：

:Kaposi's sarcoma (KS)-associated herpesvirus (KSHV), a gamma-2 herpesvirus, is the causative agent of KS, primary effusion lymphoma (PEL), and a plasma cell variant of multicentric Castleman's disease. Although KSHV latency is detected in KS-related tumors, oncogenic pathways activated by KSHV latent infection are not fully understood. Here, we found that retrotransposition of long interspersed element-1 (L1), a retrotransposon in the human genome, was enhanced in PEL cells. Among the KSHV latent genes, viral FLICE-inhibitory protein (vFLIP) enhanced L1 retrotransposition in an NF-κB-dependent manner. Intracellular cell adhesion molecule-1 (ICAM-1), an NF-κB target, regulated the vFLIP-mediated enhancement of L1 retrotransposition. Furthermore, ICAM-1 downregulated the expression of Moloney leukemia virus 10 (MOV10), an L1 restriction factor. Knockdown of ICAM-1 or overexpression of MOV10 relieved the vFLIP-mediated enhancement of L1 retrotransposition. Collectively, during KSHV latency, vFLIP upregulates ICAM-1 in an NF-κB-dependent manner, which, in turn, downregulates MOV10 expression and thereby enhances L1 retrotransposition. Because active L1 retrotransposition can lead to genomic instability, which is commonly found in KS and PEL, activation of L1 retrotransposition during KSHV latency may accelerate oncogenic processes through enhancing genomic instability. Our results suggest that L1 retrotransposition may be a novel target for impeding tumor development in KSHV-infected patients.

journal_name

Oncogene

journal_title

Oncogene

authors

Nakayama R,Ueno Y,Ueda K,Honda T

doi

10.1038/s41388-019-0726-5

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

4340-4351

issue

22

eissn

0950-9232

issn

1476-5594

pii

10.1038/s41388-019-0726-5

journal_volume

38

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • miR-34a functions as a tumor suppressor modulating EGFR in glioblastoma multiforme.

    abstract：:Chromosome 1p36.23 is frequently deleted in glioblastoma multiforme (GBM). miR-34a localizes in this region. Our experiments found that miR-34a was often deleted and epidermal growth factor receptor (EGFR) was frequently amplified in genomic DNA of 55 GBMs using single-nucleotide polymorphism DNA microarray. Notably, ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2012.132

    authors： Yin D,Ogawa S,Kawamata N,Leiter A,Ham M,Li D,Doan NB,Said JW,Black KL,Phillip Koeffler H

    更新日期：2013-02-28 00:00:00

  • Loss of the tumor suppressor, Tp53, enhances the androgen receptor-mediated oncogenic transformation and tumor development in the mouse prostate.

    abstract：:Recent genome analysis of human prostate cancers demonstrated that both AR gene amplification and TP53 mutation are among the most frequently observed alterations in advanced prostate cancer. However, the biological role of these dual genetic alterations in prostate tumorigenesis is largely unknown. In addition, there...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0901-8

    authors： He Y,Johnson DT,Yang JS,Wu H,You S,Yoon J,Lee DH,Kim WK,Aldahl J,Le V,Hooker E,Yu EJ,Geradts J,Cardiff RD,Sun Z

    更新日期：2019-09-01 00:00:00

  • Downregulation of c-fos gene transcription in cells transformed by E1A and cHa-ras oncogenes: a role of sustained activation of MAP/ERK kinase cascade and of inactive chromatin structure at c-fos promoter.

    abstract：:REF cells transformed by oncogenes E1A and cHa-ras reveal high and constitutive DNA-binding activity of AP-1 factor lacking in c-Fos protein. Consistently, the transcription of c-fos gene has been found to be downregulated. To elucidate the mechanisms of c-fos downregulation in E1A+cHa-ras transformants, we studied th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205118

    authors： Kukushkin AN,Abramova MV,Svetlikova SB,Darieva ZA,Pospelova TV,Pospelov VA

    更新日期：2002-01-24 00:00:00

  • Identifying LRRC16B as an oncofetal gene with transforming enhancing capability using a combined bioinformatics and experimental approach.

    abstract：:Oncofetal genes are expressed in embryos or fetuses, are downregulated or undetectable in adult tissues, and then re-expressed in tumors. Known oncofetal genes, such as AFP, GCB, FGF18, IMP-1 and SOX1, often have important clinical applications or pivotal biological functions. To find new oncofetal-like genes, we used...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2010.451

    authors： Hsu CC,Chiang CW,Cheng HC,Chang WT,Chou CY,Tsai HW,Lee CT,Wu ZH,Lee TY,Chao A,Chow NH,Ho CL

    更新日期：2011-02-10 00:00:00

  • Arsenite blocks growth factor induced activation of the MAP kinase cascade, upstream of Ras and downstream of Grb2-Sos.

    abstract：:Pretreatment of cells with 0.5 mM sodium arsenite (but not other activators of stress-activated MAP kinase cascades) prevents the activation of p21Ras and strongly suppresses the activation of c-Raf and the MAP kinase cascade by a variety of growth factors. Arsenite appears to exert its effect by preventing the guanin...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202168

    authors： Doza YN,Hall-Jackson CA,Cohen P

    更新日期：1998-07-09 00:00:00

  • A peptide that inhibits function of Myristoylated Alanine-Rich C Kinase Substrate (MARCKS) reduces lung cancer metastasis.

    abstract：:Myristoylated Alanine-Rich C Kinase Substrate (MARCKS), a substrate of protein kinase C, is a key regulatory molecule controlling mucus granule secretion by airway epithelial cells as well as directed migration of leukocytes, stem cells and fibroblasts. Phosphorylation of MARKCS may be involved in these responses. How...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2013.336

    authors： Chen CH,Thai P,Yoneda K,Adler KB,Yang PC,Wu R

    更新日期：2014-07-10 00:00:00

  • The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells.

    abstract：:Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is transcriptionally inactivated, several, most notably paclitaxel, may become more effective. In studying the underlying mechanism(s), we found that increas...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201658

    authors： Zhang CC,Yang JM,White E,Murphy M,Levine A,Hait WN

    更新日期：1998-03-26 00:00:00

  • Artemis is a negative regulator of p53 in response to oxidative stress.

    abstract：:Artemis is a multifunctional phospho-protein with roles in V(D)J recombination, repair of double-strand breaks by nonhomologous end-joining and regulation of cell-cycle checkpoints after DNA damage. Here, we describe a new function of Artemis as a negative regulator of p53 in response to oxidative stress in both prima...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2009.100

    authors： Zhang X,Zhu Y,Geng L,Wang H,Legerski RJ

    更新日期：2009-06-04 00:00:00

  • The v-rel and c-rel proteins exist in high molecular weight complexes in avian and murine cells.

    abstract：:We reported previously that the v-rel protein (p59v-rel) exists in a high molecular weight complex with at least four other proteins in the cytoplasm of v-rel-transformed chicken pre-B lymphoid cells (Simek, S. & Rice, N.R., J. Virol., 62, 4730-4736, 1989). One of these proteins is the chicken c-rel protein, but the i...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Kochel T,Mushinski JF,Rice NR

    更新日期：1991-04-01 00:00:00

  • Mechanistic insight into taxol-induced cell death.

    abstract：:We analysed the involvement of proteases during taxol-mediated cell death of human A549 non-small-cell lung carcinoma cells using a proteomics approach that specifically targets protein N termini and further detects newly formed N termini that are the result of protein processing. Our analysis revealed 27 protease-med...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.96

    authors： Impens F,Van Damme P,Demol H,Van Damme J,Vandekerckhove J,Gevaert K

    更新日期：2008-07-31 00:00:00

  • PCNA: structure, functions and interactions.

    abstract：:Proliferating cell nuclear antigen (PCNA) plays an essential role in nucleic acid metabolism as a component of the replication and repair machinery. This toroidal-shaped protein encircles DNA and can slide bidirectionally along the duplex. One of the well-established functions for PCNA is its role as the processivity ...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1200886

    authors： Kelman Z

    更新日期：1997-02-13 00:00:00

  • Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells.

    abstract：:Ret is a receptor tyrosine kinase predominantly expressed in tissue derived from the neuroectoderm and is involved in multiple endocrine neoplasia type 2A and 2B, familiar medullary thyroid carcinoma, and Hirschsprung's disease. The ligand for the receptor is still unknown. Previously, using a human epidermal growth f...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： van Weering DH,Medema JP,van Puijenbroek A,Burgering BM,Baas PD,Bos JL

    更新日期：1995-12-07 00:00:00

  • F-prostanoid receptor alters adhesion, morphology and migration of endometrial adenocarcinoma cells.

    abstract：:Cellular adhesion to extracellular matrix is a central phenomenon for the maintenance of tissue integrity and cellular movement. Collectively, these processes are regulated by a fine-tuned balance between the formation and loosening of adhesive contacts, a process involving integrins, and the elevation and diminution ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210883

    authors： Sales KJ,Boddy SC,Jabbour HN

    更新日期：2008-04-10 00:00:00

  • The human ETS1 gene: genomic structure, promoter characterization and alternative splicing.

    abstract：:Genomic clones encompassing the human ETS1 gene were isolated and utilized to define its molecular organization. This gene consists of eight exons spanning over 60 kb. The 5' end of the human ETS1 gene was subcloned and characterized. S1 nuclease, primer extension and RNAase protection analyses of human mRNAs showed m...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Jorcyk CL,Watson DK,Mavrothalassitis GJ,Papas TS

    更新日期：1991-04-01 00:00:00

  • The lncRNA BORG facilitates the survival and chemoresistance of triple-negative breast cancers.

    abstract：:Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNB...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0586-4

    authors： Gooding AJ,Zhang B,Gunawardane L,Beard A,Valadkhan S,Schiemann WP

    更新日期：2019-03-01 00:00:00

  • AHNP-streptavidin: a tetrameric bacterially produced antibody surrogate fusion protein against p185her2/neu.

    abstract：:The anti-p185(her2/neu) peptidomimetic (AHNP) is a small exo-cyclic peptide derived from the anti-p185(her2/neu) rhumAb 4D5 (h4D5). AHNP mimics many but not all of the antitumor characteristics exhibited by h4D5. However, the pharmacokinetic profiles of AHNP are less than optimal for therapeutic or diagnostic purposes...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209745

    authors： Masuda K,Richter M,Song X,Berezov A,Masuda K,Murali R,Greene MI,Zhang H

    更新日期：2006-12-14 00:00:00

  • The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control.

    abstract：:Acute promyelocytic leukemia (APL) is characterized by a block in myeloid cell differentiation. As a result of a chromosomal translocation in these patients, the promyelocytic leukemia protein PML is disrupted as are the nuclear bodies it forms. Disruption of PML and PML nuclear bodies in APL is linked to a loss of gr...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203201

    authors： Topcu Z,Mack DL,Hromas RA,Borden KL

    更新日期：1999-11-25 00:00:00

  • Fstl1/DIP2A/MGMT signaling pathway plays important roles in temozolomide resistance in glioblastoma.

    abstract：:Temozolomide was recognized as the first-line therapy for glioblastoma to prolong the survival of patients noticeably, while recent clinical studies found that some patients were not sensitive to temozolomide treatment. The possible mechanisms seemed to be methylguanine-DNA-methyltransferase (MGMT), mismatch repair, P...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0596-2

    authors： Nie E,Miao F,Jin X,Wu W,Zhou X,Zeng A,Yu T,Zhi T,Shi Z,Wang Y,Zhang J,Liu N,You Y

    更新日期：2019-04-01 00:00:00

  • Pim1 cooperates with E2a-Pbx1 to facilitate the progression of thymic lymphomas in transgenic mice.

    abstract：:Mice transgenic for the leukemia oncogene E2A-PBX1 invariably develop lethal, high-grade T-cell lymphomas by 5 months of age. In this study, retroviral insertional mutagenesis was employed to identify oncogenes that cooperate with the E2A-PBX1 transgene in lymphomagenesis. Neonatal retroviral infection substantially r...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201670

    authors： Feldman BJ,Reid TR,Cleary ML

    更新日期：1997-11-27 00:00:00

  • Stimulation by hydrogen peroxide of DNA synthesis, competence family gene expression and phosphorylation of a specific protein in quiescent Balb/3T3 cells.

    abstract：:Treatment of quiescent Balb/3T3 clone A31-1-1 cells with 0.1-0.2 mM H2O2 in the presence of 1 microM insulin induced DNA synthesis 20-24 h later at almost the same level as that in cells treated with 10% serum. Treatment with 0.1-0.2 mM H2O2 alone did not induce DNA synthesis and was not toxic to the cells. Cell cycle...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Shibanuma M,Kuroki T,Nose K

    更新日期：1990-07-01 00:00:00

  • Polyomavirus large T-antigen protects mouse cells from Fas-, TNF-alpha- and taxol-induced apoptosis.

    abstract：:Polyomavirus large T-antigen (PyLT-Ag), a nucleophosphoprotein essential for regulating viral gene expression, modulates the cell cycle by binding to the Rb tumor suppressor gene product. PyLT-Ag/Rb binding is essential for in vitro immortalization. However, the effect of PyLT-Ag on apoptosis has not been extensively ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1204015

    authors： Rodier F,Bertrand R,Bossolasco M,Mes-Masson AM

    更新日期：2000-12-14 00:00:00

  • The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells.

    abstract：:Small cell lung cancer (SCLC) is a disease characterized by aggressive clinical behavior and lack of effective therapy. Owing to its tendency for early dissemination, only a third of patients have limited-stage disease at the time of diagnosis. SCLC is thought to derive from pulmonary neuroendocrine cells. Although se...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2012.362

    authors： Kalari S,Jung M,Kernstine KH,Takahashi T,Pfeifer GP

    更新日期：2013-07-25 00:00:00

  • v-Myb represses the transcription of Ets-2.

    abstract：:The v-Myb oncogene causes monoblastic leukemia and transforms only myelomonocytic cells in culture. The v-Myb protein is nuclear and binds to specific DNA sequences. To identify genes regulated by v-Myb, we utilized primary cells transformed by a retrovirus encoding a v-Myb-estrogen receptor (ER) fusion protein. The E...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209868

    authors： Wang DM,Sevcikova S,Wen H,Roberts S,Lipsick JS

    更新日期：2007-02-22 00:00:00

  • A study of stabilisation of p53 protein versus point mutation in colorectal carcinoma.

    abstract：:Abnormalities of the p53 tumour suppressor gene occur in many types of cancer including approximately 60% of colorectal carcinomas. This study investigates in 47 colorectal carcinomas the relationship between stabilised p53 protein detected by immunocytochemistry (ICC), and p53 mutation. 27 cases stained positively wi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Cripps KJ,Purdie CA,Carder PJ,White S,Komine K,Bird CC,Wyllie AH

    更新日期：1994-09-01 00:00:00

  • The erythropoietin-receptor pathway modulates survival of cancer cells.

    abstract：:Anemia in cancer patients is associated with reduced quality of life and local failure after radiation treatment. However, the use of erythropoietin to correct cancer anemia and to improve radiation efficacy was disappointing. Erythropoietin-receptor signaling mainly acts via activation of STAT 5, but also crossactiva...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1208140

    authors： Pajonk F,Weil A,Sommer A,Suwinski R,Henke M

    更新日期：2004-11-25 00:00:00

  • Adrenomedullin antagonist suppresses in vivo growth of human pancreatic cancer cells in SCID mice by suppressing angiogenesis.

    abstract：:Since it is reported that adrenomedullin (AM) upregulated by hypoxia inhibits hypoxic cell death, we examined the effects of AM antagonist (AM C-terminal fragment; AM(22-52)) on the growth of pancreatic cancer cells. We, for the first time, demonstrated that AM antagonist significantly reduced the in vivo growth of th...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1206207

    authors： Ishikawa T,Chen J,Wang J,Okada F,Sugiyama T,Kobayashi T,Shindo M,Higashino F,Katoh H,Asaka M,Kondo T,Hosokawa M,Kobayashi M

    更新日期：2003-02-27 00:00:00

  • 5-aza-2'-deoxycytidine upregulates caspase-9 expression cooperating with p53-induced apoptosis in human lung cancer cells.

    abstract：:Treating lung cancer cell lines using low-dose 5-aza-2'-deoxycytidine (DAC) caused an accumulation of procaspase-9 through mRNA upregulation, but the cells did not undergo apoptosis. However, when cells were treated with DAC and infected with a low dose of a recombinant wild-type p53 adenovirus vector (Ad-p53), a syne...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207381

    authors： Gomyo Y,Sasaki J,Branch C,Roth JA,Mukhopadhyay T

    更新日期：2004-09-02 00:00:00

  • Bone morphogenetic protein 3B silencing in non-small-cell lung cancer.

    abstract：:Bone morphogenetic protein 3B (BMP3B) is a member of the TGF-beta superfamily. The BMP3B promoter sequence was previously identified as a target for aberrant DNA methylation in non-small-cell lung cancer (NSCLC). Aberrant DNA hypermethylation in the BMP3B promoter is associated with downregulation of BMP3B transcripti...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207441

    authors： Dai Z,Popkie AP,Zhu WG,Timmers CD,Raval A,Tannehill-Gregg S,Morrison CD,Auer H,Kratzke RA,Niehans G,Amatschek S,Sommergruber W,Leone GW,Rosol T,Otterson GA,Plass C

    更新日期：2004-04-29 00:00:00

  • Kinase drug discovery approaches in chronic myeloproliferative disorders.

    abstract：:Myeloproliferative disorders (MPDs) are clonal malignancies that arise from hematopoietic progenitors and characterized by overproduction of mature, functional blood cells. These disorders can be broadly characterized into Philadelphia chromosome-positive (Ph(+)) or negative (Ph(-)) genetic groupings. Chronic myeloid ...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/onc.2009.107

    authors： Kumar C,Purandare AV,Lee FY,Lorenzi MV

    更新日期：2009-06-18 00:00:00

  • Autocrine activation of JAK2 by IL-11 promotes platinum drug resistance.

    abstract：:Antineoplastic platinum agents are used in first-line treatment of ovarian cancer, but treatment failure frequently results from platinum drug resistance. Emerging observations suggest a role of reactive oxygen species (ROS) in the resistance of cancer drugs including platinum drugs. However, the molecular link betwee...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-018-0238-8

    authors： Zhou W,Sun W,Yung MMH,Dai S,Cai Y,Chen CW,Meng Y,Lee JB,Braisted JC,Xu Y,Southall NT,Shinn P,Huang X,Song Z,Chen X,Kai Y,Cai X,Li Z,Hao Q,Cheung ANY,Ngan HYS,Liu SS,Barak S,Hao J,Dai Z,Tzatsos A,Peng W

    更新日期：2018-07-01 00:00:00