High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice.

abstract：:The Li-Fraumeni Syndrome (LFS) is a rare, dominantly inherited syndrome that features high risk of cancers in childhood and early adulthood. Affected families tend to develop bone and soft tissue sarcomas, breast cancers, brain tumors, leukemias, and adrenocortical carcinomas. In some kindreds, the genetic abnormality...

journal_title：Oncogene

authors： Quesnel S,Verselis S,Portwine C,Garber J,White M,Feunteun J,Malkin D,Li FP

更新日期：1999-07-08 00:00:00

abstract：:The mouse pancreatic amylase Amy-2.2 gene was fused to the structural gene for SV40 T antigen, and 51 independent transgenic founder mice carrying the fusion gene were generated. The majority of the founders and 100% of their offspring in the derived transgenic lines developed pancreatic acinar cell carcinomas and sto...

journal_title：Oncogene

authors： Ceci JD,Kovatch RM,Swing DA,Jones JM,Snow CM,Rosenberg MP,Jenkins NA,Copeland NG,Meisler MH

更新日期：1991-02-01 00:00:00

abstract：:MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression post-transcriptionally, are involved in many complex cellular processes. Several miRNAs are differentially expressed in hematopoietic tissues and play important roles in normal differentiation, but, when aberrantly regulated, contribute to the abn...

journal_title：Oncogene

authors： Pelosi A,Careccia S,Lulli V,Romania P,Marziali G,Testa U,Lavorgna S,Lo-Coco F,Petti MC,Calabretta B,Levrero M,Piaggio G,Rizzo MG

更新日期：2013-08-01 00:00:00

abstract：:Common fragile sites are specific genomic loci that form constrictions and gaps on metaphase chromosomes under conditions that slow, but do not arrest, DNA replication. These sites have been shown to have a role in various chromosomal rearrangements in tumors. Different DNA damage response proteins were shown to regul...

journal_title：Oncogene

authors： Ozeri-Galai E,Schwartz M,Rahat A,Kerem B

更新日期：2008-04-03 00:00:00

abstract：:Dlk/ZIP kinase is a newly discovered serine/threonine kinase which, due to its homology to DAP kinase, was named DAP like kinase, Dlk. This kinase is tightly associated with nuclear structures, it undergoes extensive autophosphorylation and phosphorylates myosin light chain and core histones H3, H2A and H4 in vitro. M...

journal_title：Oncogene

authors： Page G,Kögel D,Rangnekar V,Scheidtmann KH

更新日期：1999-12-02 00:00:00

abstract：:Ki-1 lymphoma is a subtype of human malignant lymphoma characterized by the expression of CD30 (Ki-1) and a peculiar morphology. It is occasionally accompanied by a unique reciprocal chromosomal translocation t(2;5)(p23;q35). A Ki-1 lymphoma cell line, AMS3, was established by maintaining biopsied tumor cells in SCID ...

journal_title：Oncogene

authors： Shiota M,Fujimoto J,Semba T,Satoh H,Yamamoto T,Mori S

更新日期：1994-06-01 00:00:00

abstract：:Protein kinase D2 (PKD2) is a serine/threonine kinase that belongs to the PKD family of calcium-calmodulin kinases, which comprises three isoforms: PKD1, PKD2, and PKD3. PKD2 is activated by many stimuli including growth factors, phorbol esters, and G-protein-coupled receptor agonists. PKD2 participation to uncontroll...

journal_title：Oncogene

authors： Azoitei N,Cobbaut M,Becher A,Van Lint J,Seufferlein T

更新日期：2018-03-01 00:00:00

abstract：:Helicobacter pylori induces a strong motogenic response in infected gastric epithelial host cells, which is enhanced by translocation of the pathogenic factor cytotoxin-associated gene A (CagA) into host cells via a specialized type IV secretion system. Once injected into the cytosol CagA is rapidly tyrosine phosphory...

journal_title：Oncogene

authors： Poppe M,Feller SM,Römer G,Wessler S

更新日期：2007-05-24 00:00:00

abstract：:Alternative splicing is a widespread process contributing to structural transcript variation and proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both functional and non-functional end-products. Cancer-specific splicing events are known to contribute to disease progression; howev...

journal_title：Oncogene

authors： Sveen A,Kilpinen S,Ruusulehto A,Lothe RA,Skotheim RI

更新日期：2016-05-12 00:00:00

abstract：:To study the interplay of steroid hormones and oncogenes in the control of endometrial cell proliferation and differentiation we have generated cell lines derived from rat endometrium by expressing the immortalizing oncogenes adeno E1A or SV40 large T antigen. These lines are positive for mesenchymal markers and conta...

journal_title：Oncogene

authors： Helftenbein G,Alvarez CV,Tuohimaa P,Beato M

更新日期：1993-08-01 00:00:00

abstract：:Colitis-associated colorectal cancers are an etiologically distinct subgroup of colon cancers that occur in individuals suffering from inflammatory bowel disease and arise as a consequence of persistent exposure of hyperproliferative epithelial stem cells to an inflammatory microenvironment. An intrinsic defect in the...

journal_title：Oncogene

authors： Kosa P,Szabo R,Molinolo AA,Bugge TH

更新日期：2012-08-09 00:00:00

abstract：:Mutations in p53 change the sensitivity to cancer chemotherapeutic drugs. Whereas many drugs, including the vinca alkaloids, often become less effective when p53 is transcriptionally inactivated, several, most notably paclitaxel, may become more effective. In studying the underlying mechanism(s), we found that increas...

journal_title：Oncogene

authors： Zhang CC,Yang JM,White E,Murphy M,Levine A,Hait WN

更新日期：1998-03-26 00:00:00

abstract：:Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed that a clique of self-regulated core TFs control cell identity and cell state. These core TFs form interconnected feed-forward trans...

journal_title：Oncogene

authors： Chen Y,Xu L,Lin RY,Müschen M,Koeffler HP

更新日期：2020-10-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the synthesis of prostaglandins, promotes the development of colorectal cancer, and is a key molecular target of non-steroidal anti-inflammatory drugs, compounds that reduce the relative risk of developing colon cancer. In this study, we showed that interferon gamm...

journal_title：Oncogene

authors： Klampfer L,Huang J,Kaler P,Sasazuki T,Shirasawa S,Augenlicht L

更新日期：2007-03-29 00:00:00

abstract：:The p53 gene has been implicated as a tumor suppressor gene with mutations found in common human cancers. We examined 51 early stage, primary, resected non-small cell lung cancer specimens using an RNAase protection assay and cDNA sequencing. Mutations changing the p53 coding sequence were found in 23/51 (45%) tumor s...

journal_title：Oncogene

authors： Chiba I,Takahashi T,Nau MM,D'Amico D,Curiel DT,Mitsudomi T,Buchhagen DL,Carbone D,Piantadosi S,Koga H

更新日期：1990-10-01 00:00:00

abstract：:The E3 region of adenovirus induces down-regulation of epidermal growth factor receptor (EGFR) through endocytosis. Here we report that an EGFR-related protein, the HER-2/c-erbB-2 gene product, p185, is also down-regulated by adenovirus, but via a different mechanism. We found that the adenovirus E1a gene is responsib...

journal_title：Oncogene

authors： Yan DH,Chang LS,Hung MC

更新日期：1991-02-01 00:00:00

abstract：:Despite the progress made in targeted anticancer therapies in recent years, challenges remain. The identification of new potential targets will ensure that the arsenal of cancer therapies continues to expand. FAM83B was recently discovered in a forward genetic screen for novel oncogenes that drive human mammary epithe...

journal_title：Oncogene

authors： Cipriano R,Bryson BL,Miskimen KL,Bartel CA,Hernandez-Sanchez W,Bruntz RC,Scott SA,Lindsley CW,Brown HA,Jackson MW

更新日期：2014-06-19 00:00:00

abstract：:Identification of prostate cancers at high risk of progression is difficult and a better understanding of how peptide growth factors influence cellular function might be useful. Fibroblast growth factors (FGFs) have been implicated in prostate cancer development. FGF8 was identified in the Shionogi mouse mammary carci...

journal_title：Oncogene

authors： Dorkin TJ,Robinson MC,Marsh C,Bjartell A,Neal DE,Leung HY

更新日期：1999-04-29 00:00:00

abstract：:The epidermal growth factor receptor (EGFR) is activated by a variety of ligands including EGF and transforming growth factor-alpha (TGFalpha), whereas no ligand for the homologous ErbB2 oncoprotein has yet been identified. Here we use both an ErbB2 phosphoantibody (aPY1222) and an activation-specific EGFR antibody to...

journal_title：Oncogene

authors： Gulliford TJ,Huang GC,Ouyang X,Epstein RJ

更新日期：1997-10-01 00:00:00

abstract：:The 5' untranslated region of the proto-oncogene c-myc contains an internal ribosome entry segment (IRES) (Nanbru et al., 1997; Stoneley et al., 1998) and thus c-myc protein synthesis can be initiated by a cap-independent as well as a cap-dependent mechanism (Stoneley et al., 2000). In cell lines derived from patients...

journal_title：Oncogene

authors： Chappell SA,LeQuesne JP,Paulin FE,deSchoolmeester ML,Stoneley M,Soutar RL,Ralston SH,Helfrich MH,Willis AE

更新日期：2000-09-07 00:00:00

abstract：:The temperature-sensitive mutant tsp53val135 accumulates in the cytoplasm of cells kept at the non-permissive temperature (39 degrees C), but is rapidly transported into the cell nucleus at the permissive temperature (30 degrees C). tsp53 thus may serve as a model for analysing cellular parameters influencing the subc...

journal_title：Oncogene

authors： Klotzsche O,Etzrodt D,Hohenberg H,Bohn W,Deppert W

更新日期：1998-07-02 00:00:00

abstract：:Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that frequently arise in patients with neurofibromatosis type 1 (NF1). Most of these tumors are unresectable at diagnosis and minimally responsive to conventional treatment, lending urgency to the identification of new pathway dependencies and ...

journal_title：Oncogene

authors： Ki DH,Oppel F,Durbin AD,Look AT

更新日期：2019-09-01 00:00:00

abstract：:Beta-catenin and plakoglobin are closely related armadillo family proteins with shared and distinct properties; Both are associated with cadherins in actin-containing adherens junctions. Plakoglobin is also found in desmosomes where it anchors intermediate filaments to the desmosomal plaques. Beta-catenin, on the othe...

journal_title：Oncogene

authors： Sadot E,Simcha I,Iwai K,Ciechanover A,Geiger B,Ben-Ze'ev A

更新日期：2000-04-13 00:00:00

abstract：:The human MSH2/6 complex is essential for mismatch recognition during the repair of replication errors. Although mismatch repair components have been implicated in DNA homologous recombination repair, the exact function of hMSH2/6 in this pathway is unclear. Here, we show that the recombinant hMSH2/6 protein complex s...

journal_title：Oncogene

authors： Yang Q,Zhang R,Wang XW,Linke SP,Sengupta S,Hickson ID,Pedrazzi G,Perrera C,Stagljar I,Littman SJ,Modrich P,Harris CC

更新日期：2004-05-06 00:00:00

abstract：:Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) is noted for its transforming potential. Yet, it also acts as a cytostatic and growth-relenting factor in Burkitt's lymphoma (BL) cells. The underlying molecular mechanisms of the growth inhibitory property of LMP1 have remained largely unknown. In this...

journal_title：Oncogene

authors： Anastasiadou E,Boccellato F,Vincenti S,Rosato P,Bozzoni I,Frati L,Faggioni A,Presutti C,Trivedi P

更新日期：2010-03-04 00:00:00

abstract：:The essential role of prolactin (PRL) in normal mammary gland growth and differentiation has implicated this hormone in the development and progression of breast cancer. Although Stat5 is the best-characterized mediator of PRL signals, PRL also activates multiple other signals, whose roles in normal and pathologic pro...

journal_title：Oncogene

authors： Gutzman JH,Rugowski DE,Nikolai SE,Schuler LA

更新日期：2007-09-20 00:00:00

abstract：:Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived...

journal_title：Oncogene

authors： Qiao Y,Zhang C,Li A,Wang D,Luo Z,Ping Y,Zhou B,Liu S,Li H,Yue D,Zhang Z,Chen X,Shen Z,Lian J,Li Y,Wang S,Li F,Huang L,Wang L,Zhang B,Yu J,Qin Z,Zhang Y

更新日期：2018-02-15 00:00:00

abstract：:Prostate cancer (PCa) is the most commonly diagnosed non-cutaneous cancer in men in the western world. Mutations in tumor suppressor genes and in oncogenes are important for PCa progression, whereas the role of stem cell proteins in prostate carcinogenesis is insufficiently examined. This study investigates the role o...

journal_title：Oncogene

authors： Queisser A,Hagedorn S,Wang H,Schaefer T,Konantz M,Alavi S,Deng M,Vogel W,von Mässenhausen A,Kristiansen G,Duensing S,Kirfel J,Lengerke C,Perner S

更新日期：2017-03-01 00:00:00

abstract：:Gastrin and its precursors promote proliferation in different gastrointestinal cells. Since mature, amidated gastrin (G-17) can induce cyclin D1, we determined whether G-17-mediated induction of cyclin D1 transcription involved Wnt signaling and CRE-binding protein (CREB) pathways. Our studies indicate that G-17 induc...

journal_title：Oncogene

authors： Pradeep A,Sharma C,Sathyanarayana P,Albanese C,Fleming JV,Wang TC,Wolfe MM,Baker KM,Pestell RG,Rana B

更新日期：2004-04-29 00:00:00

abstract：:Amplification of the N-myc gene is a significant adverse prognostic factor in neuroblastoma, a common childhood tumor. In non-transformed cells, myc expression is controlled through an autoregulatory circuit, through which elevated Myc protein levels lead to down-regulation of myc transcription. The precise mechanism ...

journal_title：Oncogene

authors： Sivak LE,Tai KF,Smith RS,Dillon PA,Brodeur GM,Carroll WL

更新日期：1997-10-16 00:00:00