Phorbol esters inhibit fibroblast growth factor-2-stimulated fibroblast proliferation by a p38 MAP kinase dependent pathway.

abstract：:TCR-mediated activation of T cell hybridomas induces programmed cell death by a Fas-dependent pathway. We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-ind...

journal_title：Oncogene

authors： Ivanov VN,Lee RK,Podack ER,Malek TR

更新日期：1997-05-22 00:00:00

abstract：:In the published version of this paper the author Shu-Pin Huang's surname was incorrectly given as Hwang instead of Huang. This has now been corrected in the HTML and PDF versions of the paper. ...

journal_title：Oncogene

authors： Pai VC,Hsu CC,Chan TS,Liao WY,Chuu CP,Chen WY,Li CR,Lin CY,Huang SP,Chen LT,Tsai KK

更新日期：2019-02-01 00:00:00

abstract：:Caveolin-1 (Cav1) is an integral membrane, scaffolding protein found in plasma membrane invaginations (caveolae). Cav1 regulates multiple cancer-associated processes. In breast cancer, a tumor suppressive role for Cav1 has been suggested; however, Cav1 is frequently overexpressed in aggressive breast cancer subtypes, ...

journal_title：Oncogene

authors： Rao X,Evans J,Chae H,Pilrose J,Kim S,Yan P,Huang RL,Lai HC,Lin H,Liu Y,Miller D,Rhee JK,Huang YW,Gu F,Gray JW,Huang TM,Nephew KP

更新日期：2013-09-19 00:00:00

abstract：:The alternative nuclear factor-kappaB (NF-κB) -activation pathway proceeds via inducible p100 processing, leading to the activation of RelB-containing dimers. This pathway is aberrantly activated in several types of tumors; however, a direct role for RelB in the control of cell proliferation is still largely unexplore...

journal_title：Oncogene

authors： Jacque E,Billot K,Authier H,Bordereaux D,Baud V

更新日期：2013-05-23 00:00:00

abstract：:Cancer cells show deviant behavior that induces apoptotic signaling. To survive, cancer cells typically acquire changes enabling evasion of death signals. One way they do this is by increasing the expression of anti-apoptotic BCL-2 proteins. Anti-apoptotic BCL-2 family proteins antagonize death signaling by forming he...

journal_title：Oncogene

authors： Ni Chonghaile T,Letai A

更新日期：2008-12-01 00:00:00

abstract：:We have previously shown that nerve growth factor (NGF) induces a rapid and relatively continuous activation of Ras in rat pheochromocytoma PC12 cells while epidermal growth factor (EGF) activates Ras transiently, and that tyrosine kinase activity of the NGF receptor is essential for the activation of Ras (Muroya et a...

journal_title：Oncogene

authors： Hashimoto Y,Matuoka K,Takenawa T,Muroya K,Hattori S,Nakamura S

更新日期：1994-03-01 00:00:00

abstract：:The quail Pax-6 gene is expressed from two promoters named P0 and P1. P0 promoter is under the control of a neuroretina-specific enhancer (EP). This enhancer activates the P0 promoter specifically in neuroretina cells and in a developmental stage-dependent manner. The EP enhancer binds efficiently, as revealed by sout...

journal_title：Oncogene

authors： Plaza S,Aumercier M,Bailly M,Dozier C,Saule S

更新日期：1999-01-28 00:00:00

abstract：:Stimulator of interferon genes (STING) is a cellular sensor that controls cytosolic DNA-activated innate immune signaling. We have previously demonstrated that STING-deficient mice are resistant to carcinogen-induced skin cancer, similar to myeloid differentiation primary response gene 88 (MyD88) deficient mice, since...

journal_title：Oncogene

authors： Ahn J,Konno H,Barber GN

更新日期：2015-10-08 00:00:00

abstract：:Promyelocytic leukemia (PML) nuclear bodies (PML NBs) are discrete subnuclear domains organized by the promyelocytic leukemia protein PML, a tumor suppressor essential for multiple apoptotic pathways. We have recently described a novel family of cellular factors, the THAP proteins, characterized by the presence at the...

journal_title：Oncogene

authors： Roussigne M,Cayrol C,Clouaire T,Amalric F,Girard JP

更新日期：2003-04-24 00:00:00

abstract：:Despite the clonal origin of most tumors, their tremendous heterogeneity suggests that cancer progression springs from the combined forces of both genetic and epigenetic events, which produce variant clonal populations, together with the selective pressures of the microenvironment, which promote growth and, perhaps, d...

journal_title：Oncogene

authors： Macaluso M,Paggi MG,Giordano A

更新日期：2003-09-29 00:00:00

abstract：:Ubiquitin-conjugation targets numerous cellular regulators for proteasome-mediated degradation. Thus, the identification of ubiquitin ligases and their physiological substrates is crucially important, especially for those cases in which aberrant levels of regulatory proteins (e.g., beta-catenin, p27) result from a der...

journal_title：Oncogene

authors： Latres E,Chiaur DS,Pagano M

更新日期：1999-01-28 00:00:00

abstract：:Oncogenes in DNAs from human tumor cell lines have been detected by a new transformation assay. Cellular DNAs are transfected into NIH3T3 murine fibroblasts, and transformed cells are selected by maintaining cell cultures in a defined medium lacking platelet-derived or fibroblast growth factors. DNAs from eight of 17 ...

journal_title：Oncogene

authors： Zhan X,Culpepper A,Reddy M,Loveless J,Goldfarb M

更新日期：1987-01-01 00:00:00

abstract：:Promoter methylation is an important pathway in transcriptional silencing of known and candidate tumor suppressor genes in Head and Neck Squamous Cell Carcinoma (HNSCC). In order to study the association of tumor suppressor gene promoter methylation in HNSCC with patient clinical characteristics, especially alcohol co...

journal_title：Oncogene

authors： Hasegawa M,Nelson HH,Peters E,Ringstrom E,Posner M,Kelsey KT

更新日期：2002-06-20 00:00:00

abstract：:The Cdk inhibitor p21(WAF1/CIP1) is a negative regulator of the cell cycle, although its expression is induced by a number of mitogens that promote cell proliferation. We have found that E2F1 and E2F3, transcription factors that activate genes required for cell cycle progression, are strong activators of the p21 promo...

journal_title：Oncogene

authors： Gartel AL,Goufman E,Tevosian SG,Shih H,Yee AS,Tyner AL

更新日期：1998-12-31 00:00:00

abstract：:The ability of tumour cells to resist apoptosis-inducing signals by cytotoxic T cells may decide the success or failure of tumour elimination. An important effector of apoptosis is the CD95/CD95 ligand system (APO-1/Fas) that mediates perforin-independent cytotoxic T-cell killing of tumour cells. We propose a new stra...

journal_title：Oncogene

authors： Strand S,Vollmer P,van den Abeelen L,Gottfried D,Alla V,Heid H,Kuball J,Theobald M,Galle PR,Strand D

更新日期：2004-04-29 00:00:00

abstract：:Evi5 is a common site of retroviral integration in T-cell lymphomas of AKXD mice. Mapping studies have localized Evi5 to a region approximately 18 kb upstream of another common viral integration site, Gfi1, on mouse chromosome 5 (Liao X, Jenkins NA and Copeland NG, (1995a). J. Virol., 69, 7132-7137). Gfi1 encodes a zi...

journal_title：Oncogene

authors： Liao X,Du Y,Morse HC 3rd,Jenkins NA,Copeland NG

更新日期：1997-03-06 00:00:00

abstract：:The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the ability of avian myeloblastosis virus (AMV) to transform myelomonocytic cells. v-Myb is thought to disrupt the differentiation of myelomonocytic cells by affecting the expression of specific target genes. To identify such...

journal_title：Oncogene

authors： Schlichter U,Burk O,Worpenberg S,Klempnauer KH

更新日期：2001-01-11 00:00:00

abstract：:The metastasis-associated protein 1 (MTA1) is overexpressed in various human cancers and is closely connected with aggressive phenotypes; however, little is known about the transcriptional regulation of the MTA1 gene. This study identified the MTA1 gene as a target of p53-mediated transrepression. The MTA1 promoter co...

journal_title：Oncogene

authors： Lee MH,Na H,Kim EJ,Lee HW,Lee MO

更新日期：2012-12-06 00:00:00

abstract：:Rel/NF-kappaB transcription factors are involved in several physiological processes, including the regulation of apoptosis. These factors were shown to exhibit pro- or anti-apoptotic activities in different cellular models, but at present, the mechanisms underlying these opposite effects are poorly understood. In this...

journal_title：Oncogene

authors： Bernard D,Monte D,Vandenbunder B,Abbadie C

更新日期：2002-06-27 00:00:00

abstract：:The microenvironment of glioblastoma (GBM) contains high levels of inflammatory cytokine interleukin 6 (IL-6), which contributes to promote tumour progression and invasion. The common epidermal growth factor receptor variant III (EGFRvIII) mutation in GBM is associated with significantly higher levels of IL-6. Further...

journal_title：Oncogene

authors： Gurgis FM,Yeung YT,Tang MX,Heng B,Buckland M,Ammit AJ,Haapasalo J,Haapasalo H,Guillemin GJ,Grewal T,Munoz L

更新日期：2015-05-28 00:00:00

abstract：:Glioblastoma multifome is the most common and most aggressive primary brain tumor with no current curative therapy. We found expression of the bZip transcription factor ATF5 in all 29 human glioblastomas and eight human and rat glioma cell lines assessed. ATF5 is not detectably expressed by mature brain neurons and as...

journal_title：Oncogene

authors： Angelastro JM,Canoll PD,Kuo J,Weicker M,Costa A,Bruce JN,Greene LA

更新日期：2006-02-09 00:00:00

abstract：:Proapoptotic nuclear receptor family member Nur77 translocates from the nucleus to the mitochondria, where it interacts with Bcl-2 to trigger apoptosis. Nur77 translocation is induced by certain apoptotic stimuli, including the synthetic retinoid-related 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid...

journal_title：Oncogene

authors： Han YH,Cao X,Lin B,Lin F,Kolluri SK,Stebbins J,Reed JC,Dawson MI,Zhang XK

更新日期：2006-05-18 00:00:00

abstract：:Dysregulation of cellular signaling pathways can lead to colon cancer. However, research on the key signaling effectors or regulators in colon carcinogenesis is limited. Casein kinase-2 interacting protein-1 (CKIP-1; also known as PLEKHO1) is crucial during adult bone formation and is a promising drug target for osteo...

journal_title：Oncogene

authors： Nie J,Liu L,Xing G,Zhang M,Wei R,Guo M,Li X,Xie P,Li L,He F,Han W,Zhang L

更新日期：2014-07-10 00:00:00

abstract：:The c-myc oncogene is the most extensively studied member of the myc gene family which now consists of three characterized members, namely the c-myc, N-myc and L-myc genes. These genes are often found amplified in cell lines from small cell carcinomas of the lung (SCLC). In this study the L-myc gene was examined in a ...

journal_title：Oncogene

authors： Saksela K

更新日期：1987-01-01 00:00:00

abstract：:Three-dimensional explant cultures of muscle tissue were used to characterize secreted proteins regulated by endogenous levels of the angiogenesis modulator thrombospondin (TSP)-1. Explants from TSP1 null mice exhibit enhanced neovascularization associated with increased endothelial outgrowth but decreased outgrowth o...

journal_title：Oncogene

authors： Zhou L,Isenberg JS,Cao Z,Roberts DD

更新日期：2006-01-26 00:00:00

abstract：:Metabolic acid production challenges cellular pH homeostasis in solid cancer tissue, and mechanisms of net acid extrusion represent promising new targets for breast cancer therapy. Here, we used genetically engineered mice to investigate the contribution of the Na+,HCO3--cotransporter NBCn1 (Slc4a7) to intracellular a...

journal_title：Oncogene

authors： Lee S,Axelsen TV,Jessen N,Pedersen SF,Vahl P,Boedtkjer E

更新日期：2018-10-01 00:00:00

abstract：:A hallmark of cancer is the deregulation of cell-cycle machinery, ultimately facilitating aberrant proliferation that fuels tumorigenesis and disease progression. Particularly, in breast cancers, cyclin D1 has a crucial role in the development of disease. Recently, a highly specific inhibitor of CDK4/6 activity (PD-03...

journal_title：Oncogene

authors： Dean JL,Thangavel C,McClendon AK,Reed CA,Knudsen ES

更新日期：2010-07-15 00:00:00

abstract：:Poly(ADP-ribose) polymerase 1 (PARP1) interacts genetically with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to suppress early-onset T-lineage lymphomas in the mouse, but the underlying mechanisms have remained unknown. To address this question, we analyzed a series of lymphomas arising in PARP1(-/-)...

journal_title：Oncogene

authors： Rybanska I,Ishaq O,Chou J,Prakash M,Bakhsheshian J,Huso DL,Franco S

更新日期：2013-04-04 00:00:00

abstract：:The Notch ligand delta-like ligand 4 (DLL4) is an essential component expressed by endothelial tip cells during angiogenic sprouting. We have described a conceptually novel therapeutic strategy for targeting tumor angiogenesis and endothelial tip cells based on DNA vaccination against DLL4. Immunization with DLL4-enco...

journal_title：Oncogene

authors： Haller BK,Bråve A,Wallgard E,Roswall P,Sunkari VG,Mattson U,Hallengärd D,Catrina SB,Hellström M,Pietras K

更新日期：2010-07-29 00:00:00

abstract：:The 120 kD product of the c-cbl oncogene is rapidly tyrosine phosphorylated and recruited to the EGF receptor following ligand binding. Cbl's oncogenic potential is activated by a large carboxy-terminal truncation that generated v-cbl and removes the Ring finger and proline-rich SH3-binding domains. Here we show that ...

journal_title：Oncogene

authors： Thien CB,Langdon WY

更新日期：1997-05-08 00:00:00