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From smoking to lung cancer: the CHRNA5/A3/B4 connection.

Abstract：

:Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that modulate key physiological processes ranging from neurotransmission to cancer signaling. These receptors are activated by the neurotransmitter, acetylcholine, and the tobacco alkaloid, nicotine. Recently, the gene cluster encoding the alpha3, alpha5 and beta4 nAChR subunits received heightened interest after a succession of linkage analyses and association studies identified multiple single-nucleotide polymorphisms in these genes that are associated with an increased risk for nicotine dependence and lung cancer. It is not clear whether the risk for lung cancer is direct or an effect of nicotine dependence, as evidence for both scenarios exist. In this study, we summarize the body of work implicating nAChRs in the pathogenesis of lung cancer, with special focus on the clustered nAChR subunits and their emerging role in this disease state.

journal_name

Oncogene

journal_title

Oncogene

authors

Improgo MR,Scofield MD,Tapper AR,Gardner PD

doi

10.1038/onc.2010.256

subject

Has Abstract

pub_date

2010-09-02 00:00:00

pages

4874-84

issue

35

eissn

0950-9232

issn

1476-5594

pii

onc2010256

journal_volume

29

pub_type

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