当前位置： SCI文献检索 > ONCOGENE期刊下所有文献 > Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX.

Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX.

Abstract：

:MSH2 and MLH1 have a central role in correcting mismatches in DNA occurring during DNA replication and have been implicated in the engagement of apoptosis induced by a number of cytotoxic anticancer agents. The function of MLH1 is not clearly defined, although it is required for mismatch repair (MMR) and engagement of apoptosis after certain types of DNA damage. In order to identify other partners of MLH1 that may be involved in signalling MMR or apoptosis, we used human MLH1 in yeast two-hybrid screens of normal human breast and ovarian cDNA libraries. As well as known partners of MLH1 such as PMS1, MLH3 and MBD4, we identified the carboxy terminus of the human c-MYC proto-oncogene as an interacting sequence. We demonstrate, both in vitro by yeast two-hybrid and GST-fusion pull-down experiments, as well as in vivo by coimmunoprecipitation from human tumour cell extracts, that MLH1 interacts with the c-MYC protein. We further demonstrate that the heterodimeric partner of c-MYC, MAX, interacts with a different MMR protein, MSH2, both in vitro and in vivo. Using an inducible c-MYC-ER fusion gene, we show that elevated c-MYC expression leads to an increased HGPRT mutation rate of Rat1 cells and an increase in the number of frameshift mutants at the HGPRT locus. The effect on HGPRT mutation rate is small (2-3-fold), but is consistent with deregulated c-MYC expression partially inhibiting MMR activity.

journal_name

Oncogene

journal_title

Oncogene

authors

Mac Partlin M,Homer E,Robinson H,McCormick CJ,Crouch DH,Durant ST,Matheson EC,Hall AG,Gillespie DA,Brown R

doi

10.1038/sj.onc.1206252

subject

Has Abstract

pub_date

2003-02-13 00:00:00

pages

819-25

issue

6

eissn

0950-9232

issn

1476-5594

pii

1206252

journal_volume

22

pub_type

杂志文章

相关文献

ONCOGENE文献大全
  • Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues.

    abstract：:The HER-2/neu proto-oncogene is homologous with, but distinct from, the epidermal growth factor receptor. Current evidence indicates that this gene is frequently amplified and/or overexpressed in some human breast and ovarian cancers and that these alterations may be clinically important; however, little is known abou...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Press MF,Cordon-Cardo C,Slamon DJ

    更新日期：1990-07-01 00:00:00

  • Combined effects of the two reciprocal t(4;11) fusion proteins MLL.AF4 and AF4.MLL confer resistance to apoptosis, cell cycling capacity and growth transformation.

    abstract：:The reciprocal chromosomal translocation t(4;11) is correlated with infant, childhood, adult and therapy-related high-risk acute leukemia. Here, we investigated the biological effects of MLL.AF4, AF4.MLL or the combination of both reciprocal fusion proteins in a conditional in vitro cell culture model system. Several ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210125

    authors： Gaussmann A,Wenger T,Eberle I,Bursen A,Bracharz S,Herr I,Dingermann T,Marschalek R

    更新日期：2007-05-17 00:00:00

  • MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways.

    abstract：:MicroRNAs (miRNAs) as modulators of gene expression have been described to display both tumor-promoting and tumor-suppressive functions. Although their role has been studied in different tumor types, little is known about how they regulate nuclear factor κB (NF-κB) signaling in breast cancer. Here, we performed an unb...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2011.571

    authors： Keklikoglou I,Koerner C,Schmidt C,Zhang JD,Heckmann D,Shavinskaya A,Allgayer H,Gückel B,Fehm T,Schneeweiss A,Sahin O,Wiemann S,Tschulena U

    更新日期：2012-09-13 00:00:00

  • MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation.

    abstract：:MicroRNAs (miRNAs) make up a novel class of gene regulators; they function as oncogenes or tumor suppressors by targeting tumor-suppressor genes or oncogenes. A recent study that analysed a large number of human cancer cell lines showed that miR-330 is a potential tumor-suppressor gene. However, the function and molec...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2009.192

    authors： Lee KH,Chen YL,Yeh SD,Hsiao M,Lin JT,Goan YG,Lu PJ

    更新日期：2009-09-24 00:00:00

  • Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells.

    abstract：:Human T-cell leukemia virus type 1 (HTLV-1) Tax transforms normal T-cells in the presence of interleukin (IL)-2 in vitro. STAT is a family of transcription factors that play a pivotal role in cytokine-induced functions of a various type of cells. We investigated the involvement of STATs in the transformation of T-cell...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202608

    authors： Nakamura N,Fujii M,Tsukahara T,Arai M,Ohashi T,Wakao H,Kannagi M,Yamamoto N

    更新日期：1999-04-29 00:00:00

  • Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site.

    abstract：:Ufo/Axl belongs to a new family of receptor tyrosine kinases with an extracellular structure similar to that of neural cell adhesion molecules. In order to elucidate intracellular signaling, the cytoplasmic moiety of Ufo/Axl was used to screen an expression library according to the CORT (cloning of receptor targets) m...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201123

    authors： Braunger J,Schleithoff L,Schulz AS,Kessler H,Lammers R,Ullrich A,Bartram CR,Janssen JW

    更新日期：1997-06-05 00:00:00

  • The retinoblastoma gene family in differentiation and development.

    abstract：:The retinoblastoma (Rb) tumor suppressor gene and its close relatives p107 and p130 are best known for their function in the control of cell cycle progression. In recent years, however, a new role for these proteins has been emerging as they have been linked with regulation of terminal differentiation of many tissues ...

    journal_title：Oncogene

    pub_type： 杂志文章,评审

    doi：10.1038/sj.onc.1203244

    authors： Lipinski MM,Jacks T

    更新日期：1999-12-20 00:00:00

  • Overlapping gene expression profiles of cell migration and tumor invasion in human bladder cancer identify metallothionein 1E and nicotinamide N-methyltransferase as novel regulators of cell migration.

    abstract：:Cell migration is essential to cancer invasion and metastasis and is spatially and temporally integrated through transcriptionally dependent and independent mechanisms. As cell migration is studied in vitro, it is important to identify genes that both drive cell migration and are biologically relevant in promoting inv...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.264

    authors： Wu Y,Siadaty MS,Berens ME,Hampton GM,Theodorescu D

    更新日期：2008-11-06 00:00:00

  • STAT activation by the PDGF receptor requires juxtamembrane phosphorylation sites but not Src tyrosine kinase activation.

    abstract：:Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202694

    authors： Sachsenmaier C,Sadowski HB,Cooper JA

    更新日期：1999-06-17 00:00:00

  • MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene.

    abstract：:MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively control expression of target genes in animals and plants. The microRNA-21 gene (mir-21) has been identified as the only miRNA commonly overexpressed in solid tumors of the lung, breast, stomach, prostate, colon, brain, head and neck, esophagus and pa...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2008.72

    authors： Lu Z,Liu M,Stribinskis V,Klinge CM,Ramos KS,Colburn NH,Li Y

    更新日期：2008-07-17 00:00:00

  • Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters.

    abstract：:Resistance and relapse are still primary causes that result in poor effectiveness of chemotherapy in malignant gliomas. Therefore, development of new therapeutic strategies requires the identification of key molecular pathways regulating chemoresistance. We previously found that abnormal high expression of the Tie2 re...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2009.103

    authors： Martin V,Xu J,Pabbisetty SK,Alonso MM,Liu D,Lee OH,Gumin J,Bhat KP,Colman H,Lang FF,Fueyo J,Gomez-Manzano C

    更新日期：2009-06-18 00:00:00

  • Two transient increases in c-myc gene expression during neuroectodermal differentiation of mouse embryonal carcinoma cells.

    abstract：:Mouse embryonal carcinoma (EC) cells of the P19 line can be induced to differentiate into neurons, astrocytes and fibroblasts by exposure to retinoic acid (RA), whereas treatment of the EC cells with dimethyl sulfoxide (DMSO) leads to differentiation into mesodermal tissues, including cardiac and skeletal muscle. In R...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： St-Arnaud R,Nepveu A,Marcu KB,McBurney MW

    更新日期：1988-11-01 00:00:00

  • Differential expression of Myc1 and Myc2 isoforms in cells transformed by eIF4E: evidence for internal ribosome repositioning in the human c-myc 5'UTR.

    abstract：:eIF4E is essential for translation initiation, but its overexpression causes malignant transformation. Recent work demonstrated that eIF4E/F participates in exposing and locating alternate translation start codons during scanning. Translation initiation of several important protooncogenes and growth-regulators, such a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202890

    authors： Carter PS,Jarquin-Pardo M,De Benedetti A

    更新日期：1999-07-29 00:00:00

  • Endoreplication in megakaryoblastic cell lines is accompanied by sustained expression of G1/S cyclins and downregulation of cdc25C.

    abstract：:In most eukaryotic cells, a link between S and M phases of the cell cycle must be assured in order to maintain the ploidy of newly divided cells. However, in some cell l/pes, e.g. the precursors of platelets megakaryocytes, extra S-phases can occur in the absence of concomitant mitoses, resulting in polyploidy. We hav...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： García P,Calés C

    更新日期：1996-08-15 00:00:00

  • Leukaemia lineage specification caused by cell-specific Mll-Enl translocations.

    abstract：:Chromosomal translocations involving the Mixed-Lineage Leukaemia (MLL) gene underlie many human leukaemias and MLL rearrangements are found in both acute myelogenous and acute lymphoblastic leukaemias. To assess the functionally relevant haematopoietic cell contexts for MLL fusions to be tumorigenic, we have generated...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1210818

    authors： Cano F,Drynan LF,Pannell R,Rabbitts TH

    更新日期：2008-03-20 00:00:00

  • Molecular mechanisms of constitutive NF-kappaB/Rel activation in Hodgkin/Reed-Sternberg cells.

    abstract：:A common characteristic of malignant cells derived from patients with Hodgkin's disease (HD) is a high level of constitutive nuclear NF-kappaB/Rel activity, which stimulates proliferation and confers resistance to apoptosis. We have analysed the mechanisms that account for NF-kappaB activation in a panel of Hodgkin/Re...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202351

    authors： Krappmann D,Emmerich F,Kordes U,Scharschmidt E,Dörken B,Scheidereit C

    更新日期：1999-01-28 00:00:00

  • Localization of chromosome 8p regions involved in early tumorigenesis of oral and laryngeal squamous carcinoma.

    abstract：:We analysed 30 primary invasive oral and laryngeal squamous carcinomas (SC), with concurrent dysplastic lesions, for genetic alterations at 15 microsatellite loci on the short arm of chromosome 8. Overall, loss of heterozygosity (LOH) was observed, in at least one informative locus, in 27% of the dysplastic lesions an...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1201808

    authors： El-Naggar AK,Coombes MM,Batsakis JG,Hong WK,Goepfert H,Kagan J

    更新日期：1998-06-11 00:00:00

  • Adrenomedullin promotes formation of xenografted endometrial tumors by stimulation of autocrine growth and angiogenesis.

    abstract：:The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator of the increased risk of endometrial hyperplasia and cancer resulting from the use of tamoxifen for the treatment and prevention of breast cancer. ADM has been shown to be induced by tamoxifen in the endometrium and to be a growth factor for...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205374

    authors： Oehler MK,Hague S,Rees MC,Bicknell R

    更新日期：2002-04-25 00:00:00

  • Radiation-induced transgenerational alterations in genome stability and DNA damage.

    abstract：:Mutation induction in directly exposed cells is currently regarded as the main component of the genetic risk of ionizing radiation for humans. However, recent data on the transgenerational increases in mutation rates in the offspring of irradiated parents indicate that the genetic risk could be greater than predicted ...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209723

    authors： Barber RC,Hickenbotham P,Hatch T,Kelly D,Topchiy N,Almeida GM,Jones GD,Johnson GE,Parry JM,Rothkamm K,Dubrova YE

    更新日期：2006-11-30 00:00:00

  • Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1).

    abstract：:PGP9.5 (UCH-L1) is a member of the ubiquitin C-terminal hydrolase (UCH) family of proteins that is expressed in neuronal tissues. Our previous studies have shown that PGP9.5 was highly expressed in primary lung cancers and lung cancer cell lines. Additionally, the frequency of PGP9.5 over expression increases with tum...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205390

    authors： Caballero OL,Resto V,Patturajan M,Meerzaman D,Guo MZ,Engles J,Yochem R,Ratovitski E,Sidransky D,Jen J

    更新日期：2002-05-02 00:00:00

  • Identification of candidate target genes for EVI-1, a zinc finger oncoprotein, using a novel selection strategy.

    abstract：:We have sought to identify and isolate target genes for the zinc finger protein, EVI-1, which has been implicated in the genesis of myelogenous leukemia both in mouse and human. We have approached this with a two-step selection: we first selected for genomic fragments of mouse DNA that bind to the protein with high af...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1202331

    authors： Kim JH,Hui P,Yue D,Aycock J,Leclerc C,Bjoring AR,Perkins AS

    更新日期：1998-09-24 00:00:00

  • Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways.

    abstract：:Interstitial fluid flow in and around the tumor tissue is a physiologically relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor. Yet, the effects of interstitial flow and associated fluid shear stress on the tumor cell function have been largely overlooked. Using in vitro bi...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2014.397

    authors： Wang P,Chen SH,Hung WC,Paul C,Zhu F,Guan PP,Huso DL,Kontrogianni-Konstantopoulos A,Konstantopoulos K

    更新日期：2015-08-27 00:00:00

  • Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition.

    abstract：:The expression of the monocyte-chemoattractant-protein-1 (MCP-1) is closely linked with a non-tumorigenic phenotype in somatic cell hybrids made between the human papillomavirus type 18 (HPV 18) positive cervical carcinoma cell line HeLa and normal human fibroblasts. In contrast, MCP-1 transcription is absent in tumor...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1203643

    authors： Finzer P,Soto U,Delius H,Patzelt A,Coy JF,Poustka A,zur Hausen H,Rösl F

    更新日期：2000-07-06 00:00:00

  • The amino-terminus of the E2F-1 transcription factor inhibits DNA replication of autonomously replicating plasmids in mammalian cells.

    abstract：:The E2F1 transcription factor plays a pivotal role in driving cells out of a quiescent state and into the S phase of the cell cycle, in part by transactivating genes needed for DNA replication including DHFR, thymidine kinase, and DNA Polymerase alpha. E2F1 has also been implicated in regulating an S phase checkpoint,...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1205473

    authors： Stubbs MC,Hall DJ

    更新日期：2002-05-23 00:00:00

  • A functional analysis of PCNA-binding peptides derived from protein sequence, interaction screening and rational design.

    abstract：:Proliferating cell nuclear antigen (PCNA) has no intrinsic enzymatic function, but functions as a sliding platform to mediate protein interactions with the DNA strand. Many proteins interact with PCNA through a small conserved motif with consensus QxxLxxFF. This work uses Schizosaccharomyces pombe and human cells to a...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1209320

    authors： Warbrick E

    更新日期：2006-05-11 00:00:00

  • ROS release by PPARβ/δ-null fibroblasts reduces tumor load through epithelial antioxidant response.

    abstract：:Tumor stroma has an active role in the initiation, growth, and propagation of many tumor types by secreting growth factors and modulating redox status of the microenvironment. Although PPARβ/δ in fibroblasts was shown to modulate oxidative stress in the wound microenvironment, there has been no evidence of a similar e...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-017-0109-8

    authors： Tan EHP,Sng MK,How ISB,Chan JSK,Chen J,Tan CK,Wahli W,Tan NS

    更新日期：2018-04-01 00:00:00

  • Lack of CD45 in FLT3-ITD mice results in a myeloproliferative phenotype, cortical porosity, and ectopic bone formation.

    abstract：:The receptor tyrosine kinase FLT3 is expressed in myeloid and lymphoid progenitor cells. Activating mutations in FLT3 occur in 25-30% of acute myeloid leukaemia (AML) patients. Most common are internal tandem duplications of sequence (ITD) leading to constitutive FLT3-ITD kinase activity with an altered signalling qua...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/s41388-019-0757-y

    authors： Kresinsky A,Schnöder TM,Jacobsen ID,Rauner M,Hofbauer LC,Ast V,König R,Hoffmann B,Svensson CM,Figge MT,Hilger I,Heidel FH,Böhmer FD,Müller JP

    更新日期：2019-06-01 00:00:00

  • Expression of antisense osteopontin RNA inhibits tumor promoter-induced neoplastic transformation of mouse JB6 epidermal cells.

    abstract：:Elevated expression of osteopontin (OPN), a secreted adhesive phosphoglycoprotein, is frequently associated with many transformed cell lines of epithelial and stromal origin. Moreover, several clonal lines of preneoplastic JB6 cells derived from Balb/c mouse epidermal cultures (Colburn et al., 1978, 1979), upon treatm...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：

    authors： Su L,Mukherjee AB,Mukherjee BB

    更新日期：1995-06-01 00:00:00

  • Androgen receptor promotes melanoma metastasis via altering the miRNA-539-3p/USP13/MITF/AXL signals.

    abstract：:Early studies demonstrated that male melanoma patients have worse survival than female patients, yet the detailed mechanisms for this gender difference remain unclear. We analyzed around 100 cases of human melanoma and found that androgen receptor (AR) positive melanoma patients have worse survival outcomes compared w...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/onc.2016.330

    authors： Wang Y,Ou Z,Sun Y,Yeh S,Wang X,Long J,Chang C

    更新日期：2017-03-23 00:00:00

  • Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.

    abstract：:Exogenous expression of the catalytic subunit of telomerase, hTERT, in a normal human foreskin fibroblast cell strain resulted in telomerase activity and an extended proliferative lifespan prior to a period of crisis. Three immortalized cell lines with stably maintained telomere lengths were established from cells tha...

    journal_title：Oncogene

    pub_type： 杂志文章

    doi：10.1038/sj.onc.1207440

    authors： Noble JR,Zhong ZH,Neumann AA,Melki JR,Clark SJ,Reddel RR

    更新日期：2004-04-15 00:00:00