Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression.

abstract：:Activation of the platelet-derived growth factor (PDGF) receptor tyrosine kinase induces tyrosine phosphorylation of Signal Transducer and Activator of Transcription (STAT) proteins. Since the PDGF receptor also activates the Src tyrosine kinase, it is possible that Src mediates tyrosine phosphorylation of STATs in PD...

journal_title：Oncogene

authors： Sachsenmaier C,Sadowski HB,Cooper JA

更新日期：1999-06-17 00:00:00

abstract：:Histone acetyltransferases (HATs) have a central role in the modification of chromatin as well as in the pathogenesis of a broad set of diseases including cancers. Gcn5 is the first identified transcription-related HAT that has been implicated in the regulation of diverse cellular functions. However, how Gcn5 proteins...

journal_title：Oncogene

authors： Li Y,Jaramillo-Lambert AN,Yang Y,Williams R,Lee NH,Zhu W

更新日期：2012-02-02 00:00:00

abstract：:Here we show that pemetrexed-treated mesothelioma cells undergo accelerated senescence. This is characterized by the secretion of proinflammatory and mitogenic cytokines, reminiscent of an SASP (senescence-associated secretory phenotype). Conditioned media from senescent MPM (malignant pleural mesothelioma) cells trig...

journal_title：Oncogene

authors： Canino C,Mori F,Cambria A,Diamantini A,Germoni S,Alessandrini G,Borsellino G,Galati R,Battistini L,Blandino R,Facciolo F,Citro G,Strano S,Muti P,Blandino G,Cioce M

更新日期：2012-06-28 00:00:00

abstract：:Stimulation of the c-Kit receptor tyrosine kinase has a critical role in the development and migration of melanocytes, and oncogenic c-Kit mutants contribute to the progression of some melanomas. c-Kit signalling activates the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways an...

journal_title：Oncogene

authors： Todd JR,Scurr LL,Becker TM,Kefford RF,Rizos H

更新日期：2014-01-09 00:00:00

abstract：:Resistance and relapse are still primary causes that result in poor effectiveness of chemotherapy in malignant gliomas. Therefore, development of new therapeutic strategies requires the identification of key molecular pathways regulating chemoresistance. We previously found that abnormal high expression of the Tie2 re...

journal_title：Oncogene

authors： Martin V,Xu J,Pabbisetty SK,Alonso MM,Liu D,Lee OH,Gumin J,Bhat KP,Colman H,Lang FF,Fueyo J,Gomez-Manzano C

更新日期：2009-06-18 00:00:00

abstract：:MicroRNAs (miRNAs) as modulators of gene expression have been described to display both tumor-promoting and tumor-suppressive functions. Although their role has been studied in different tumor types, little is known about how they regulate nuclear factor κB (NF-κB) signaling in breast cancer. Here, we performed an unb...

journal_title：Oncogene

authors： Keklikoglou I,Koerner C,Schmidt C,Zhang JD,Heckmann D,Shavinskaya A,Allgayer H,Gückel B,Fehm T,Schneeweiss A,Sahin O,Wiemann S,Tschulena U

更新日期：2012-09-13 00:00:00

abstract：:Altered expression of regulatory RNA-binding proteins (RBPs) in cancer leads to abnormal expression of mRNAs encoding many factors involved in cancer hallmarks. While conventional anticancer therapies usually target one pathway at a time, targeting key RBP would affect multiple genes and thus overcome drug resistance....

journal_title：Oncogene

authors： Rataj F,Planel S,Denis J,Roelants C,Filhol O,Guyon L,Feige JJ,Cherradi N

更新日期：2019-06-01 00:00:00

abstract：:Bloom's syndrome (BS) is an autosomal recessive disorder associated with an elevated incidence of cancers. The gene mutated in BS, BLM, encodes a RecQ helicase family member. BS cells exhibit genomic instability, including excessive homologous recombination and chromosomal aberrations. We reported previously that BS c...

journal_title：Oncogene

authors： Rassool FV,North PS,Mufti GJ,Hickson ID

更新日期：2003-11-27 00:00:00

abstract：:Activating mutations of the ALK receptor occur in a subset of neuroblastoma tumors. We previously demonstrated that Alk mutations cooperate with MYCN overexpression to induce neuroblastoma in mice and identified Ret as being strongly upregulated in MYCN/Alkmut tumors. By a genetic approach in vivo, we now document an ...

journal_title：Oncogene

authors： Lopez-Delisle L,Pierre-Eugène C,Louis-Brennetot C,Surdez D,Raynal V,Baulande S,Boeva V,Grossetête-Lalami S,Combaret V,Peuchmaur M,Delattre O,Janoueix-Lerosey I

更新日期：2018-03-01 00:00:00

abstract：:Transcription factor PAX8 expression is upregulated in several types of cancers. However, little is known about the function of PAX8 in the progression of hepatoma and its regulatory mechanisms. Here, we show that PAX8 silencing inhibits the proliferation and clonogenicity of hepatoma cells and its growth in vivo. The...

journal_title：Oncogene

authors： Wang J,Li N,Huang ZB,Fu S,Yu SM,Fu YM,Zhou PC,Chen RC,Zhou RR,Huang Y,Hu XW,Fan XG

更新日期：2019-10-01 00:00:00

abstract：:Like other types of pre-malignant lesions and carcinoma, angiogenesis is associated with high-grade cervical dysplasia and with invasive squamous carcinoma of the cervix. Vascular endothelial cell growth factor (VEGF) is known to be one of the most important inducers of angiogenesis and is upregulated in carcinoma of ...

journal_title：Oncogene

authors： López-Ocejo O,Viloria-Petit A,Bequet-Romero M,Mukhopadhyay D,Rak J,Kerbel RS

更新日期：2000-09-21 00:00:00

abstract：:Upregulated gene 19 (U19)/ELL-associated factor 2 (Eaf2) is a potential human tumor suppressor that exhibits frequent allelic loss and downregulation in high-grade prostate cancer. U19/Eaf2, along with its homolog Eaf1, has been reported to regulate transcriptional elongation via interaction with the eleven-nineteen l...

journal_title：Oncogene

authors： Xiao W,Zhang Q,Habermacher G,Yang X,Zhang AY,Cai X,Hahn J,Liu J,Pins M,Doglio L,Dhir R,Gingrich J,Wang Z

更新日期：2008-03-06 00:00:00

abstract：:Diminished expression of the metastasis suppressor protein RKIP was previously reported in a number of cancers. The underlying mechanism remains unknown. Here, we show that the expression of RKIP negatively correlates with that of Snail zinc-transcriptional repressor, a key modulator of normal and neoplastic epithelia...

journal_title：Oncogene

authors： Beach S,Tang H,Park S,Dhillon AS,Keller ET,Kolch W,Yeung KC

更新日期：2008-04-03 00:00:00

abstract：:Fallopian tube carcinoma (FTC) is a rare, poorly studied and aggressive cancer, associated with poor survival. Since tumorigenesis is related to the acquisition of genetic changes, we used genome-wide array comparative genomic hybridization to analyse copy number aberrations occurring in FTC in order to obtain a bette...

journal_title：Oncogene

authors： Snijders AM,Nowee ME,Fridlyand J,Piek JM,Dorsman JC,Jain AN,Pinkel D,van Diest PJ,Verheijen RH,Albertson DG

更新日期：2003-07-03 00:00:00

abstract：:Growing evidence demonstrates that hepatitis B virus (HBV) integration and resulting insertional mutagenesis play an important role in cell growth or maintenance in hepatocellular carcinomas (HCCs). To determine if HBV integration occurs and affects cellular genes at such a stage of infection, we analysed viral-host j...

journal_title：Oncogene

authors： Minami M,Daimon Y,Mori K,Takashima H,Nakajima T,Itoh Y,Okanoue T

更新日期：2005-06-23 00:00:00

abstract：:Mdm2 is the major negative regulator of p53 tumor-suppressor activity. This oncoprotein is overexpressed in many human tumors that retain the wild-type p53 allele. As such, targeted inhibition of Mdm2 is being considered as a therapeutic anticancer strategy. The N-terminal hydrophobic pocket of Mdm2 binds to p53 and t...

journal_title：Oncogene

authors： Wade M,Li YC,Matani AS,Braun SM,Milanesi F,Rodewald LW,Wahl GM

更新日期：2012-11-08 00:00:00

abstract：:SCL, GATA-1, GATA-2 and GATA-3 encode lineage restricted haemopoietic transcription factors. We have previously shown that SCL, GATA-1 and GATA-2 are expressed in multipotent progenitors prior to lineage commitment, but are down-regulated during granulocyte/monocyte differentiation. The phenomenon of gene extinction i...

journal_title：Oncogene

authors： Murrell AM,Green AR

更新日期：1995-02-16 00:00:00

abstract：:Spindle cell sarcomas consist of tumors with different biological features, of which distant metastasis is the most ominous sign for a poor prognosis. However, metastasis is difficult to predict on the basis of current histopathological analyses. We have identified actin filament-associated protein 1-like 1 (AFAP1L1) ...

journal_title：Oncogene

authors： Furu M,Kajita Y,Nagayama S,Ishibe T,Shima Y,Nishijo K,Uejima D,Takahashi R,Aoyama T,Nakayama T,Nakamura T,Nakashima Y,Ikegawa M,Imoto S,Katagiri T,Nakamura Y,Toguchida J

更新日期：2011-09-22 00:00:00

abstract：:To investigate the role of protein kinase C (PKC) in apoptotic signaling induced by cytokine withdrawal, we expressed PKC-alpha, -delta and -epsilon individually in the 32D myeloid progenitor cells. The parental and PKC-delta- and PKC-epsilon-transfected 32D cells underwent apoptosis within 24 h in the absence of inte...

journal_title：Oncogene

authors： Li W,Zhang J,Flechner L,Hyun T,Yam A,Franke TF,Pierce JH

更新日期：1999-11-11 00:00:00

abstract：:Abnormalities of the p53 tumour suppressor gene occur in many types of cancer including approximately 60% of colorectal carcinomas. This study investigates in 47 colorectal carcinomas the relationship between stabilised p53 protein detected by immunocytochemistry (ICC), and p53 mutation. 27 cases stained positively wi...

journal_title：Oncogene

authors： Cripps KJ,Purdie CA,Carder PJ,White S,Komine K,Bird CC,Wyllie AH

更新日期：1994-09-01 00:00:00

abstract：:The requirement for cis-acting DNA sequences for transcriptional activity of the human lck type I promoter was investigated in two human cell lines that express type I transcripts, the leukemic T-cell line, Jurkat, and the colon carcinoma line, SW620. Transient transfection assays in Jurkat and SW620 cells revealed ne...

journal_title：Oncogene

authors： Leung S,McCracken S,Ghysdael J,Miyamoto NG

更新日期：1993-04-01 00:00:00

abstract：:The gene for von Recklinghausen neurofibromatosis type 1 (NF1) was recently identified by positional cloning and found to encode a protein with sequence similarity to a family of eucaryotic GTPase-activating proteins (GAPs). Expression of the NF1-GAP-related domain (NF1GRD) has been shown to complement yeast strains d...

journal_title：Oncogene

authors： Gutmann DH,Boguski M,Marchuk D,Wigler M,Collins FS,Ballester R

更新日期：1993-03-01 00:00:00

abstract：:Clinical and epidemiological data support a role for human papilloma virus (HPV) type 16 in the pathogenesis of cervical carcinoma. The W12 cell line contains HPV16 sequences, predominantly as a high copy number episome, and is immortalised in vitro, but non-tumourigenic. A morphologically distinct sub-line of the par...

journal_title：Oncogene

authors： Crook T,Greenfield I,Howard J,Stanley M

更新日期：1990-04-01 00:00:00

abstract：:The role of thromboxane A(2) (TxA(2)) in smoking-associated lung cancer is poorly understood. This study was conducted to study the role of TxA(2) in smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-promoted cell survival and growth in human lung cancer cells. We found that NNK increased TxA(2) ...

journal_title：Oncogene

authors： Huang RY,Li MY,Hsin MK,Underwood MJ,Ma LT,Mok TS,Warner TD,Chen GG

更新日期：2011-01-06 00:00:00

abstract：:Ewing sarcoma is characterized by the expression of the chimeric EWSR1-FLI1 transcription factor. Proteomic analyses indicate that the decrease of EWSR1-FLI1 expression leads to major changes in effectors of the dynamics of the actin cytoskeleton and the adhesion processes with a shift from cell-to-cell to cell-matrix...

journal_title：Oncogene

authors： Franzetti GA,Laud-Duval K,van der Ent W,Brisac A,Irondelle M,Aubert S,Dirksen U,Bouvier C,de Pinieux G,Snaar-Jagalska E,Chavrier P,Delattre O

更新日期：2017-06-22 00:00:00

abstract：:PML is a component of a multiprotein complex, termed nuclear bodies, and the PML protein was originally discovered in patients suffering from acute promyelocytic leukaemia (APL). APL is associated with a reciprocal chromosomal translocation of chromosomes 15 and 17, which results in a fusion protein comprising PML and...

journal_title：Oncogene

authors： Jensen K,Shiels C,Freemont PS

更新日期：2001-10-29 00:00:00

abstract：:To identify tyrosine kinases that may regulate regeneration of the mammalian intestinal epithelium, we amplified portions of the catalytic domains of protein kinases expressed in intestinal crypt cells, using the polymerase chain reaction technique with primers directed against two invariant amino acid sequence motifs...

journal_title：Oncogene

authors： Siyanova EY,Serfas MS,Mazo IA,Tyner AL

更新日期：1994-07-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) facilitates cancer invasion and metastasis and thus accelerates cancer progression. p21-activated kinase 4 (PAK4) is a critical regulator of prostate cancer (PC) progression. Here, we report that PAK4 activation promotes PC progression through the EMT regulator Slug. We find tha...

journal_title：Oncogene

authors： Park JJ,Park MH,Oh EH,Soung NK,Lee SJ,Jung JK,Lee OJ,Yun SJ,Kim WJ,Shin EY,Kim EG

更新日期：2018-09-01 00:00:00

abstract：:We determined whether proteins encoded by the nm23/nucleoside diphosphate (NDP) kinase gene, a potential metastasis-suppressor gene, are expressed on the cell surface. Monoclonal antibodies (mAb) specific for nm23-H1 or H2 proteins were prepared using the corresponding fusion proteins with glutathione S-transferase (G...

journal_title：Oncogene

authors： Urano T,Furukawa K,Shiku H

更新日期：1993-05-01 00:00:00

abstract：:Mammalian nuclear Dbf2-related (NDR) kinases (LATS1 and 2, NDR1 and 2) play a role in cell proliferation, apoptosis and morphological changes. These kinases are regulated by mammalian sterile 20-like kinases (MSTs) and Mps one binder (MOB) 1. Okadaic acid (OA), which activates MST2, facilitates the complex formation o...

journal_title：Oncogene

authors： Hirabayashi S,Nakagawa K,Sumita K,Hidaka S,Kawai T,Ikeda M,Kawata A,Ohno K,Hata Y

更新日期：2008-07-17 00:00:00