Human papillomavirus E7 proteins stimulate proliferation independently of their ability to associate with retinoblastoma protein.

abstract：:The REL gene is amplified in many human B-cell lymphomas and we have previously shown that expression of REL from a retroviral vector can malignantly transform chicken spleen cells in vitro. To identify REL protein functions necessary for malignant transformation, we have performed deletion analysis on REL sequences e...

journal_title：Oncogene

authors： Starczynowski DT,Reynolds JG,Gilmore TD

更新日期：2003-10-09 00:00:00

abstract：:Prostate cancer is one of the major causes of cancer-related death in the western world. Androgen-deprivation therapy (ADT) for the suppression of androgens binding to the androgen receptor (AR) has been the norm of prostate cancer treatment. Despite early success to suppress prostate tumor growth, ADT eventually fail...

journal_title：Oncogene

authors： Niu Y,Chang TM,Yeh S,Ma WL,Wang YZ,Chang C

更新日期：2010-06-24 00:00:00

abstract：:DSS1 is an evolutionarily conserved acidic protein that binds to BRCA2. However, study of the function of DSS1 in mammalian cells has been hampered because endogenous DSS1 has not been detectable by Western blotting. Here, we developed a modified Western blotting protocol that detects endogenous DSS1 protein, and used...

journal_title：Oncogene

authors： Li J,Zou C,Bai Y,Wazer DE,Band V,Gao Q

更新日期：2006-02-23 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a highly conserved serine-threonine kinase activated in response to growth factors and nutrients. Because of frequent dysregulation of the mTOR signaling pathway in diverse human cancers, this kinase is a key therapeutic target. Redd1 is a negative regulator of mTOR, mediati...

journal_title：Oncogene

authors： Jin HO,Seo SK,Kim YS,Woo SH,Lee KH,Yi JY,Lee SJ,Choe TB,Lee JH,An S,Hong SI,Park IC

更新日期：2011-09-01 00:00:00

abstract：:B-cell CLL/lymphoma 6 (BCL6) exerts oncogenic effects in several human hematopoietic malignancies including chronic myeloid leukemia (CML), where BCL6 expression was shown to be essential for CML stem cell survival and self-renewal during imatinib mesylate (IM) treatment. As several lines of evidence suggest that inte...

journal_title：Oncogene

authors： Madapura HS,Nagy N,Ujvari D,Kallas T,Kröhnke MCL,Amu S,Björkholm M,Stenke L,Mandal PK,McMurray JS,Keszei M,Westerberg LS,Cheng H,Xue F,Klein G,Klein E,Salamon D

更新日期：2017-08-10 00:00:00

abstract：:The mechanisms involved in the p53-dependent control of gene expression following DNA damage have not been completely elucidated. Here, we show that the p53 C terminus associates with factors that are required for the ultraviolet (UV)-induced inhibition of the mRNA 3' cleavage step of the polyadenylation reaction, suc...

journal_title：Oncogene

authors： Nazeer FI,Devany E,Mohammed S,Fonseca D,Akukwe B,Taveras C,Kleiman FE

更新日期：2011-07-07 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that governs cellular responses to reduced O2 availability by mediating crucial homeostatic processes. HIF-1 is composed of an HIF-1alpha subunit and an HIF-1beta subunit. HIF-1alpha is degraded following enzyme-dependent hydroxylation of prolines of HIF-1al...

journal_title：Oncogene

authors： Wang M,Kirk JS,Venkataraman S,Domann FE,Zhang HJ,Schafer FQ,Flanagan SW,Weydert CJ,Spitz DR,Buettner GR,Oberley LW

更新日期：2005-12-08 00:00:00

abstract：:Lineage-restricted transcription factors (TFs) are frequently mutated or overexpressed in cancer and contribute toward malignant behaviors; however, the molecular bases of their oncogenic properties are largely unknown. As TF activities are difficult to inhibit directly with small molecules, the genes and pathways the...

journal_title：Oncogene

authors： Sulahian R,Casey F,Shen J,Qian ZR,Shin H,Ogino S,Weir BA,Vazquez F,Liu XS,Hahn WC,Bass AJ,Chan V,Shivdasani RA

更新日期：2014-12-04 00:00:00

abstract：:Ectopic expression of the intracellular domain of NOTCH-4/INT-3 leads to tumorigenesis in the mouse mammary gland. This results from a gain-of-function mutation. To evaluate gain-of-function NOTCH-4/INT-3 activity in human cancers we have surveyed human breast, lung, and colon carcinoma tissue culture cell lines for e...

journal_title：Oncogene

authors： Imatani A,Callahan R

更新日期：2000-01-13 00:00:00

abstract：:Obesity is a highly prevalent and modifiable breast cancer risk factor. While the role of obesity in fueling breast cancer progression is well established, the mechanisms linking obesity to breast cancer initiation are poorly understood. A hallmark of breast cancer initiation is the disruption of apical polarity in ma...

journal_title：Oncogene

authors： Tenvooren I,Jenks MZ,Rashid H,Cook KL,Muhlemann JK,Sistrunk C,Holmes J,Wang K,Bonin K,Hodges K,Lo HW,Shaikh A,Camarillo IG,Lelièvre SA,Seewaldt V,Vidi PA

更新日期：2019-05-01 00:00:00

abstract：:Helicobacter pylori induces a strong motogenic response in infected gastric epithelial host cells, which is enhanced by translocation of the pathogenic factor cytotoxin-associated gene A (CagA) into host cells via a specialized type IV secretion system. Once injected into the cytosol CagA is rapidly tyrosine phosphory...

journal_title：Oncogene

authors： Poppe M,Feller SM,Römer G,Wessler S

更新日期：2007-05-24 00:00:00

abstract：:The mixed lineage leukemia (MLL) gene at chromosome band 11q23 is commonly involved in reciprocal translocations that are detected in acute leukemias. Evidence suggests that the resulting MLL fusion genes contribute to leukemogenesis. AF9 is a common MLL fusion partner in acute myeloid leukemia. The AF9 protein functi...

journal_title：Oncogene

authors： Srinivasan RS,de Erkenez AC,Hemenway CS

更新日期：2003-05-29 00:00:00

abstract：:In contrast to other cell cycle inhibitors, the tumor suppressor p16Ink4a is not detectable or expressed at very low levels in embryonic and adult mouse tissues, and therefore it has often been considered as a specialized checkpoint protein that does not participate in the control of normal cell cycle progression. How...

journal_title：Oncogene

authors： Bianchi T,Rufer N,MacDonald HR,Migliaccio M

更新日期：2006-07-06 00:00:00

abstract：:The product of the RB susceptibility gene has been shown to be differentially phosphorylated during the cell cycle, suggesting a role in the regulation of cell cycle progression. We examined the expression and phosphorylation status of the RB protein in senescent Syrian hamster embryo cells. Both phosphorylated and un...

journal_title：Oncogene

authors： Futreal PA,Barrett JC

更新日期：1991-07-01 00:00:00

abstract：:One of the hallmarks of malignancy is the polarization of tumor-associated macrophages (TAMs) from a pro-immune (M1-like) phenotype to an immune-suppressive (M2-like) phenotype. However, the molecular basis of the process is still unclear. MicroRNA (miRNA) comprises a group of small, non-coding RNAs that are broadly e...

journal_title：Oncogene

authors： Yang J,Zhang Z,Chen C,Liu Y,Si Q,Chuang TH,Li N,Gomez-Cabrero A,Reisfeld RA,Xiang R,Luo Y

更新日期：2014-06-05 00:00:00

abstract：:Telomerase-negative cancer cells can maintain their telomeres by a recombination-mediated alternative lengthening of telomeres (ALT) process. We reported previously that sequestration of MRE11/RAD50/NBS1 complexes represses ALT-mediated telomere length maintenance, and suppresses formation of ALT-associated promyelocy...

journal_title：Oncogene

authors： Jiang WQ,Zhong ZH,Henson JD,Reddel RR

更新日期：2007-07-12 00:00:00

abstract：:Whole chromosome instability (W-CIN) is a hallmark of human cancer and contributes to the evolvement of aneuploidy. W-CIN can be induced by abnormally increased microtubule plus end assembly rates during mitosis leading to the generation of lagging chromosomes during anaphase as a major form of mitotic errors in human...

journal_title：Oncogene

authors： Schmidt AK,Pudelko K,Boekenkamp JE,Berger K,Kschischo M,Bastians H

更新日期：2021-01-01 00:00:00

abstract：:The products of the proto-oncogenes c-jun and c-fos are known to form a complex in vivo. Complex formation appears to stabilize protein-DNA interactions and is thought to play an important functional role in transcriptional regulation. Here we show that the viral Jun oncoprotein, which differs structurally from cellul...

journal_title：Oncogene

authors： Bos TJ,Rauscher FJ 3rd,Curran T,Vogt PK

更新日期：1989-02-01 00:00:00

abstract：:Ubiquilin1 (UBQLN1) is a ubiquitin-like domain and a ubiquitin-associated domain containing protein that has been reported to be involved in shuttling proteins to the proteasome, especially during endoplasmic reticulum-associated protein degradation. Thus, UBQLN1 function has been shown to be critical for combating a ...

journal_title：Oncogene

authors： Shah PP,Lockwood WW,Saurabh K,Kurlawala Z,Shannon SP,Waigel S,Zacharias W,Beverly LJ

更新日期：2015-03-26 00:00:00

abstract：:TCR-mediated activation of T cell hybridomas induces programmed cell death by a Fas-dependent pathway. We now show that costimulation of 2B4 cells, in the absence or presence of transgenic Bcl-2, with anti-CD3 epsilon and forskolin, an activator of cAMP signaling, resulted in antagonism of Fas-dependent activation-ind...

journal_title：Oncogene

authors： Ivanov VN,Lee RK,Podack ER,Malek TR

更新日期：1997-05-22 00:00:00

abstract：:An Ets-related E1A-F has been characterized as an enhancer-binding protein for the adenovirus E1A gene. Here we show, in transient expression assays, that E1A-F can activate three different subclasses of the matrix metalloproteinase gene promoters. Expressions of the chloramphenicol acetyltransferase (CAT) reporter ge...

journal_title：Oncogene

authors： Higashino F,Yoshida K,Noumi T,Seiki M,Fujinaga K

更新日期：1995-04-06 00:00:00

abstract：:Topoisomerase IIalpha (topoIIalpha) is an essential mammalian enzyme that topologically modifies DNA and is required for chromosome segregation during mitosis. Previous research suggests that inhibition of topoII decatenatory activity triggers a G(2) checkpoint response, which delays mitotic entry because of insuffici...

journal_title：Oncogene

authors： Bower JJ,Karaca GF,Zhou Y,Simpson DA,Cordeiro-Stone M,Kaufmann WK

更新日期：2010-08-26 00:00:00

abstract：:Mice bred to carry germline Rb and p53 null alleles are associated with a tumor spectrum that overlaps with the inherited multiple endocrine neoplasia-1 (MEN1) and MEN2 syndromes in humans, including medullary thyroid cancer (MTC). To study the genetic basis for these tumors, we microdissected MTC specimens or obtaine...

journal_title：Oncogene

authors： Coxon AB,Ward JM,Geradts J,Otterson GA,Zajac-Kaye M,Kaye FJ

更新日期：1998-09-24 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is a process during which normal epithelial cells acquire mesenchymal characteristics. EMT has a critical role in various human diseases especially in cancer. EMT facilitates tumor initiation and progression by mediating cancer cell stemness and motility. Zinc finger transcripti...

journal_title：Oncogene

authors： Liu Y,Zhou H,Zhu R,Ding F,Li Y,Cao X,Liu Z

更新日期：2018-02-08 00:00:00

abstract：:The 5' untranslated region of the proto-oncogene c-myc contains an internal ribosome entry segment (IRES) (Nanbru et al., 1997; Stoneley et al., 1998) and thus c-myc protein synthesis can be initiated by a cap-independent as well as a cap-dependent mechanism (Stoneley et al., 2000). In cell lines derived from patients...

journal_title：Oncogene

authors： Chappell SA,LeQuesne JP,Paulin FE,deSchoolmeester ML,Stoneley M,Soutar RL,Ralston SH,Helfrich MH,Willis AE

更新日期：2000-09-07 00:00:00

abstract：:High-risk papillomavirus type 18 (HPV18) is one of the less represented HPV types in low-grade lesions of the anogenital tract, whereas it occupies the second place in cervical cancer, where it can be found in 16% of the cases worldwide, after HPV16 present in 54% of them. These epidemiological data indicate that HPV1...

journal_title：Oncogene

authors： Teissier S,Pang CL,Thierry F

更新日期：2010-09-09 00:00:00

abstract：:Somatic mutations of FLT3 involving internal tandem duplication (ITD) of the juxtamembrane domain or point mutations in the tyrosine kinase domain (TKD) appear to activate FLT3 in a FLT3 ligand (FL)-independent manner. To determine whether or not FLT3 mutants respond to FL for their activation, a FL-deficient (FL(-/-)...

journal_title：Oncogene

authors： Zheng R,Bailey E,Nguyen B,Yang X,Piloto O,Levis M,Small D

更新日期：2011-09-22 00:00:00

abstract：:Colon carcinogenesis is a multiple-step process involving the accumulation of a series of genetic and epigenetic alterations. The most commonly initiating event of intestinal carcinogenesis is mutation of the adenomatous polyposis coli (APC) gene, which leads to activation of the Wnt/β-catenin pathway. Olfactomedin 4 ...

journal_title：Oncogene

authors： Liu W,Li H,Hong SH,Piszczek GP,Chen W,Rodgers GP

更新日期：2016-10-06 00:00:00

abstract：:Artemis is a multifunctional phospho-protein with roles in V(D)J recombination, repair of double-strand breaks by nonhomologous end-joining and regulation of cell-cycle checkpoints after DNA damage. Here, we describe a new function of Artemis as a negative regulator of p53 in response to oxidative stress in both prima...

journal_title：Oncogene

authors： Zhang X,Zhu Y,Geng L,Wang H,Legerski RJ

更新日期：2009-06-04 00:00:00

abstract：:The recent identification of the mouse White spotting and Steel loci as genes encoding the c-kit receptor and its ligand, respectively, has shed light on the importance of this ligand and receptor in embryogenesis, melanogenesis and hematopoiesis. In order to determine if the c-kit proto-oncogene is involved in human ...

journal_title：Oncogene

authors： Vandenbark GR,deCastro CM,Taylor H,Dew-Knight S,Kaufman RE

更新日期：1992-07-01 00:00:00